The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin
Open accessAbstract
Bromodomain protein 4 (BRD4) is a chromatin-binding protein implicated in cancer and autoimmune diseases that functions as a scaffold for transcription factors at promoters and super-enhancers. Although chromatin decompaction and transcriptional activation of target genes are associated with BRD4 binding, the mechanisms involved are unknown. We report that BRD4 is a histone acetyltransferase (HAT) that acetylates histones H3 and H4 with a pattern distinct from those of other HATs. Both mouse and human BRD4 have intrinsic HAT activity. Importantly, BRD4 acetylates H3 K122, a residue critical for nucleosome stability, thus resulting in nucleosome eviction and chromatin decompaction. Nucleosome clearance by BRD4 occurs genome wide, including at its targets MYC, FOS and AURKB (Aurora B kinase), resulting in increased transcription. These findings suggest a model wherein BRD4 actively links chromatin structure and transcription: it mediates chromatin decompaction by acetylating and evicting nucleosomes at target genes, thereby activating transcription.
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Cites
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DeMars, K. M., Yang, C., Castro-Rivera, C. I., & Candelario-Jalil, E. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.096 · Cited by 66
Metadata
- Authors
- Devaiah, B. N., Case-Borden, C., Gegonne, A., Hsu, C. H., Chen, Q., Meerzaman, D., Dey, A., Ozato, K., & Singer, D. S.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2016-05-09
- Volume
- 23
- Issue
- 6
- Pages
- 540-548
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2346509327
- Cited by
- 361
- References
- 50
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Devaiah, B. N., Case-Borden, C., Gegonne, A., Hsu, C. H., Chen, Q., Meerzaman, D., Dey, A., Ozato, K., & Singer, D. S. (2016). BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.3228
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