The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Liver‐Fat Accumulation and Insulin Resistance in Obese Women with Previous Gestational Diabetes
Open accessAbstract
Objective:We determined whether fat accumulation in the liver is associated with features of insulin resistance independent of obesity. Research Methods and Procedures:We recruited 27 obese nondiabetic women in whom liver fat (LFAT) content was determined by proton spectroscopy, intra‐abdominal and subcutaneous fat by magnetic resonance imaging, and insulin sensitivity by the euglycemic insulin clamp technique. The women were divided based on their median LFAT content (5%) to groups with low (3.2 ± 0.3%) and high (9.8 ± 1.5%) liver fat. The groups were almost identical with respect to age (36 ± 1 vs. 38 ± 1 years in low vs. high‐LFAT), body mass index (32.2 ± 0.6 vs. 32.8 ± 0.5 kg/m 2), waist‐to‐hip ratio, intra‐abdominal, subcutaneous, and total fat content. Results:Women with high LFAT had features of insulin resistance including higher fasting serum triglyceride (1.93 ± 0.21 vs. 1.11 ± 0.09 mM,p< 0.01) and insulin (14 ± 3 vs. 10 ± 1 mU/L,p< 0.05) concentrations than women with low LFAT. The group with high LFAT also had higher 24‐hour blood pressures, and lower whole‐body insulin sensitivity compared with the low‐LFAT group. Discussion:In obese women with previous gestational diabetes, LFAT, rather than any measure of body composition, is associated with features of insulin resistance.
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Cites
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Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice
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Self-citationFatty liver hepatitis and cirrhosis in obese patients
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“However, it has been recently shown that intramyocellular lipid content can be increased with a high- as compared with a low-fat diet in humans (”
BackgroundQuantification of liver fat using magnetic resonance spectroscopy
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Insulin resistance: a metabolic pathway to chronic liver disease
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Age-related changes in total and regional fat distribution
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What aspects of body fat are particularly hazardous and how do we measure them?
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Metadata
- Authors
- Tiikkainen, M., Tamminen, M., Häkkinen, A., Bergholm, R., Vehkavaara, S., Halavaara, J., Teramo, K., Rissanen, A., & Yki‐Järvinen, H.
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 2002-09
- Volume
- 10
- Issue
- 9
- Pages
- 859-867
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W2088407989
- Cited by
- 162
- References
- 12
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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