Estradiol‐Induced Anorexia Is Independent of Leptin and Melanin‐Concentrating Hormone
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Objective: Treatment of male rodents with estradiol (E 2) is associated with anorexia and weight loss by poorly understood mechanisms. We examined the role of the orexigenic hypothalamic peptide melanin‐concentrating hormone (MCH) and the appetite‐inhibiting, fat‐derived hormone leptin in mediating E 2‐induced anorexia. Research Methods and Procedures: We studied the effect of E 2 treatment (implantation of either E 2 pellet or matching placebo) in male C57Bl/6J mice, as well as in a lean mouse model (MCH knockout mice) and an obese model (leptin‐deficient ob/ob mice). We also studied the effect of E 2 treatment in the context of high‐fat diet. Results: We confirmed E 2 dose‐dependent anorexia in male wild type mice fed a normal chow diet. E 2 treatment was associated with a significant decrease in body fat, serum leptin levels, and arcuate hypothalamic proopiomelanocortin expression. E 2‐implanted mice also showed increased hypothalamic neuropeptide Y and MCH expression. As MCH has been implicated in E 2‐induced hypophagia, we performed E 2 pellet implantation in MCH knockout mice and observed hypophagia and weight loss, indicating that MCH is not an essential mediator of E 2‐induced anorexia. E 2‐implanted ob/ob mice also had hypophagia and weight loss, indicating that leptin is not essential for E 2‐induced anorexia. High‐fat diet significantly exacerbated the effect of E 2 treatment, leading to a 99.6% decrease in food intake at 48 hours and a 30% loss of body weight within 1 week. Discussion: The anorectic effects of E 2 were independent of MCH and leptin. Our results suggested that E 2 may have effects on nutrient preferences.
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Estrogen levels in premenopausal women are closely associated with leptin levels.
“Estrogen levels in premenopausal women are closely associated with leptin levels [129, 130].”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [129]
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Xu, Y., & Clegg, D. J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9896-5_11
The neural basis of estradiol conditioned taste aversion learning and estradiol anorexia
Hintiryan, H. (2012) · ProQuest Demo Repository · doi:10.25549/usctheses-m2130
Pieronne-Deperrois, M. (2022) · theses.fr (ABES) · doi:10.70675/71ef46cfz0230z4862za32aze1072fe4be66
- Authors
- Tritos, N. A., Segal‐Lieberman, G., Vezeridis, P. S., & Maratos‐Flier, E.
- Affiliations
- Joslin Diabetes Center (US)
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 2004-04
- Volume
- 12
- Issue
- 4
- Pages
- 716-724
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W1998870692
- Cited by
- 47
- References
- 50
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 2
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01dk053978-01, DK46200)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK56116, R01DK056113, P01DK056116, 5R01DK56113, P30DK046200, 5R01DK53978, P30 DK-46200)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- estradiol, anorexia, hypophagia, melanin-concentrating hormone, leptin, hypothalamic neuropeptides, proopiomelanocortin, neuropeptide Y, weight loss, high-fat diet, ob/ob mice, sex differences
- MeSH terms
- Animals, Anorexia, Dietary Fats, Dose-Response Relationship, Drug, Drug Implants, Estradiol, Hypothalamic Hormones, Male, Melanins, Mice, Inbred C57BL, Mice, Obese, Pituitary Hormones, Mice, Knockout, Leptin, Mice
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