Dihydrotestosterone Treatment Results in Obesity and Altered Lipid Metabolism in Orchidectomized Mice
Open accessAbstract
Objective: To determine the role of androgen receptor (AR) activation for adipose tissue metabolism. Sex steroids are important regulators of adipose tissue metabolism in men. Androgens may regulate the adipose tissue metabolism in men either directly by stimulation of the AR or indirectly by aromatization of androgens into estrogens and, thereafter, by stimulation of the estrogen receptors. Previous studies have shown that estrogen receptor α stimulation results in reduced fat mass in men. Research Methods and Procedures: Orchidectomized mice were treated with the non‐aromatizable androgen 5α‐dihydrotestosterone (DHT), 17β‐estradiol, or vehicle. VO2, VCO2, resting metabolic rate, locomotor activity, and food consumption were measured. Furthermore, changes in hepatic gene expression were analyzed. Results: DHT treatment resulted in obesity, associated with reduced energy expenditure and fat oxidation. In contrast, DHT did not affect food consumption or locomotor activity. Furthermore, DHT treatment resulted in increased high‐density lipoprotein‐cholesterol and triglyceride levels associated with markedly decreased 7α‐hydroxylase gene expression, indicating decreased bile acid production. Discussion: We showed that AR activation results in obesity and altered lipid metabolism in orchidectomized mice. One may speculate that AR antagonists might be useful in the treatment of obesity in men.
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Movérare-Skrtic et al. reported in male orchidectomized mice treated with DHT for 5 weeks an increase in gonadal and retroperitoneal fat mass.
“Movérare‐Skrtic et al., who reported in male orchidectomized mice treated with DHT for 5 weeks has been shown to increase gonadal and retroperitoneal fat mass.”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [178]
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- Authors
- Movérare‐Skrtic, S., Venken, K., Andersson, N., Lindberg, M. K., Svensson, J., Swanson, C., Vanderschueren, D., Oscarsson, J., Gustafsson, J., & Ohlsson, C.
- Affiliations
- Sahlgrenska University Hospital (SE)
- KU Leuven (BE)
- Corresponding author
- Ohlsson, Claes
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2006-04
- Volume
- 14
- Issue
- 4
- Pages
- 662-672
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2172208311
- Cited by
- 111
- References
- 54
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 10 · 2020: 10 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Chalmers Research (Chalmers University of Technology) (submittedVersion)
- Funders
- European Commission
- Stiftelsen för Strategisk Forskning
- Novo Nordisk
- Novo Nordisk Fonden
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- dihydrotestosterone, androgen receptor, lipid metabolism, adipose tissue metabolism, energy expenditure, fat oxidation, hepatic gene expression, bile acid synthesis, 7alpha-hydroxylase, estrogen receptor alpha, aromatization, estradiol, androgen receptor antagonists, resting metabolic rate
- MeSH terms
- Animals, Body Weight, Calorimetry, Indirect, Cholesterol, Gene Expression Regulation, Cholesterol, HDL, Liver, Male, Mice, Inbred C57BL, Obesity, Orchiectomy, Receptors, Androgen, Dihydrotestosterone, Triglycerides, Mice, Knockout, Estrogen Receptor alpha, Adiposity, Lipid Metabolism, Mice
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