Cited by 289Hormonal and reproductive studiesAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

The role of androgens in metabolism, obesity, and diabetes in males and females

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Navarro, Guadalupe, Allard, Camille, Xu, Weiwei, Mauvais‐Jarvis, Franck·2015·Obesity

Abstract

Objective: In men, androgen deprivation contributes to the development of metabolic syndrome and type 2 diabetes (T2D). In women, androgen excess predisposes to insulin resistance and T2D. There is a bidirectional modulation of glucose homeostasis by androgens in males and females that is analyzed in this review. Methods: We reviewed the literature in both rodents and humans on the role of androgens and the androgen receptor (AR) in the control of glucose and energy metabolism in health, obesity, and T2D. Results: Sex‐specific activation of AR in the hypothalamus, skeletal muscle, liver, adipose tissue, and pancreatic islet β‐cells accounts for maintenance or disruption in energy metabolism and glucose homeostasis. Conclusions: We argue that AR is a target to prevent androgen‐related metabolic disorders.

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  • The major contributors of sex dimorphisms in glucose and energy homeostasis are the activational effects of estrogens and androgens acting on their receptors after the onset of puberty.

    “The major contributors of sex dimorphisms in glucose and energy homeostasis are the “activational” effects of estrogens and androgens acting on their receptors after the onset of puberty.”

    From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [52]

    The Introduction (page unavailable) reviews testosterone and androgen-receptor actions in glucose and energy homeostasis, and the Conclusions (page unavailable) describe sex-dependent metabolic effects of androgen-receptor activation. The paper also discusses estrogen-receptor effects in males, but our copy does not establish that post-pubertal “activational” effects of both hormones are the major contributors to these sex differences. (LLM, conf=0.84)

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1 of the 79 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [12]Keating NL O'Malley A Freedland SJ Smith MR Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer Journal of the National Cancer Institute 2012 104 1518 1523 23210129 PMC3634556

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Authors
Navarro, G., Allard, C., Xu, W., & Mauvais‐Jarvis, F.
Affiliations
  • Stanford Medicine (US)
  • Tulane University (US)
Corresponding author
Mauvais‐Jarvis, Franck
Venue
Obesity
Publisher
Wiley
Published
2015-03-06
Volume
23
Issue
4
Pages
713-719
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
OpenAlex
W1544346946
Cited by
289
References
79
Citations by year
2026: 22 · 2025: 24 · 2024: 37 · 2023: 31 · 2022: 26 · 2021: 38 · 2020: 26 · 2019: 20 · 2018: 19 · 2017: 24 · 2016: 19 · 2015: 3
FWCI
3.28
Type
journal article
Language
en
Open access
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (DK074970, HD044405)
  • American Heart Association (11IRG5570010)
  • American Diabetes Association (7-13-BS-101)
  • Price-Goldsmith Chair in Nutrition at Tulane University Health Sciences Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
androgens, androgen receptor, type 2 diabetes, metabolic syndrome, insulin resistance, glucose homeostasis, energy metabolism, sex differences, androgen deprivation therapy, hyperandrogenism, hypothalamus, skeletal muscle, adipose tissue, pancreatic beta cells, liver
MeSH terms
Adipose Tissue, Androgens, Animals, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Male, Metabolic Diseases, Obesity, Receptors, Androgen, Sex Factors, Muscle, Skeletal, Metabolic Syndrome

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