The role of androgens in metabolism, obesity, and diabetes in males and females
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Objective: In men, androgen deprivation contributes to the development of metabolic syndrome and type 2 diabetes (T2D). In women, androgen excess predisposes to insulin resistance and T2D. There is a bidirectional modulation of glucose homeostasis by androgens in males and females that is analyzed in this review. Methods: We reviewed the literature in both rodents and humans on the role of androgens and the androgen receptor (AR) in the control of glucose and energy metabolism in health, obesity, and T2D. Results: Sex‐specific activation of AR in the hypothalamus, skeletal muscle, liver, adipose tissue, and pancreatic islet β‐cells accounts for maintenance or disruption in energy metabolism and glucose homeostasis. Conclusions: We argue that AR is a target to prevent androgen‐related metabolic disorders.
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The major contributors of sex dimorphisms in glucose and energy homeostasis are the activational effects of estrogens and androgens acting on their receptors after the onset of puberty.
“The major contributors of sex dimorphisms in glucose and energy homeostasis are the “activational” effects of estrogens and androgens acting on their receptors after the onset of puberty.”
From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [52]
The Introduction (page unavailable) reviews testosterone and androgen-receptor actions in glucose and energy homeostasis, and the Conclusions (page unavailable) describe sex-dependent metabolic effects of androgen-receptor activation. The paper also discusses estrogen-receptor effects in males, but our copy does not establish that post-pubertal “activational” effects of both hormones are the major contributors to these sex differences. (LLM, conf=0.84)
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- Authors
- Navarro, G., Allard, C., Xu, W., & Mauvais‐Jarvis, F.
- Affiliations
- Stanford Medicine (US)
- Tulane University (US)
- Corresponding author
- Mauvais‐Jarvis, Franck
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2015-03-06
- Volume
- 23
- Issue
- 4
- Pages
- 713-719
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC4380643
- OpenAlex
- W1544346946
- Cited by
- 289
- References
- 79
- Citations by year
- 2026: 22 · 2025: 24 · 2024: 37 · 2023: 31 · 2022: 26 · 2021: 38 · 2020: 26 · 2019: 20 · 2018: 19 · 2017: 24 · 2016: 19 · 2015: 3
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DK074970, HD044405)
- American Heart Association (11IRG5570010)
- American Diabetes Association (7-13-BS-101)
- Price-Goldsmith Chair in Nutrition at Tulane University Health Sciences Center
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- androgens, androgen receptor, type 2 diabetes, metabolic syndrome, insulin resistance, glucose homeostasis, energy metabolism, sex differences, androgen deprivation therapy, hyperandrogenism, hypothalamus, skeletal muscle, adipose tissue, pancreatic beta cells, liver
- MeSH terms
- Adipose Tissue, Androgens, Animals, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Male, Metabolic Diseases, Obesity, Receptors, Androgen, Sex Factors, Muscle, Skeletal, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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