Cited by 335Estrogen and related hormone effectsRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity

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Mauvais-Jarvis, Franck·2011·Trends in Endocrinology & Metabolism

Abstract

Because of increasing life expectancy, the contribution of age-related estrogen or androgen deficiency to obesity and type 2 diabetes will become a new therapeutic challenge. This review integrates current concepts on the mechanisms through which estrogen receptors (ERs) and androgen receptor (AR) regulate energy homeostasis in rodents and humans. In females, estrogen maintains energy homeostasis via ERα and ERβ, by suppressing energy intake and lipogenesis, enhancing energy expenditure, and ameliorating insulin secretion and sensitivity. In males, testosterone is converted to estrogen and maintains fuel homeostasis via ERs and AR, which share related functions to suppress adipose tissue accumulation and improve insulin sensitivity. We suggest that ERs and AR could be potential targets in the prevention of age-related metabolic disorders.

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Authors
Mauvais-Jarvis, F.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2011-01
Volume
22
Issue
1
Pages
24-33
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2021664357
Cited by
335
References
100
Citations by year
2026: 20 · 2025: 23 · 2024: 16 · 2023: 20 · 2022: 28 · 2021: 28 · 2020: 19 · 2019: 23 · 2018: 22 · 2017: 30 · 2016: 19 · 2015: 14 · 2014: 23 · 2013: 18 · 2012: 19
FWCI
1.66
Type
journal article
Language
en
Open access
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK074970)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD044405)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
estrogen receptor alpha, estrogen receptor beta, androgen receptor, energy homeostasis, type 2 diabetes, obesity, insulin sensitivity, insulin secretion, lipogenesis, energy expenditure, testosterone, adipose tissue accumulation, metabolic disorders
MeSH terms
Animals, Diabetes Mellitus, Female, Homeostasis, Humans, Male, Obesity, Receptors, Androgen, Receptors, Estrogen

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