Association of Major Depression and Binge Eating Disorder with Weight Loss in a Clinical Setting
Open accessAbstract
Objective: Obesity has been linked to both major depressive disorder (MDD) and binge eating disorder (BED) in clinical and epidemiological studies. The present study compared weight loss among patients with and without MDD and BED who participated in a hospital‐based weight loss program modeled after the Diabetes Prevention Program. Research Methods and Procedures: Of 131 obese patients who enrolled in treatment, 17% were diagnosed with MDD only, 13% were diagnosed with BED only, 17% were diagnosed with both MDD and BED, and 53% lacked either diagnosis in a pretreatment clinical interview. Results: After treatment, patients with MDD only attained 63% of the weight loss that non‐depressed patients attained. Patients with BED only attained 55% of the weight loss that non‐binge eaters attained. The effect of MDD on weight loss was not accounted for by the presence of BED or vice versa. Only 27% of patients with both MDD and BED achieved clinically significant weight loss compared with 67% of patients who had neither disorder. Results were not significantly altered when gender, age, and diabetes status were adjusted. Conclusion: Both MDD and BED were prevalent among this obese clinical population, and each disorder was independently associated with worse outcomes. Research is needed to investigate how to increase the efficacy of behavioral weight loss programs for individuals with MDD and/or BED.
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Depression is an important factor in BED obese patients, linked to poorer weight loss outcome and higher dropout rates.
“Depression is an important factor in BED obese patients, linked to poorer weight loss outcome and higher dropout rates [55].”
From Acceptance and efficacy of a guided internet self-help treatment program for obese patients with binge eating disorder (2011) · cites this paper as [55]
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- Authors
- Pagoto, S., Bodenlos, J. S., Kantor, L., Gitkind, M., Curtin, C., & Ma, Y.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Lahey Hospital and Medical Center (US)
- Corresponding author
- Pagoto, Sherry
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2007-11
- Volume
- 15
- Issue
- 11
- Pages
- 2557-2559
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2162128398
- Cited by
- 119
- References
- 15
- Citations by year
- 2025: 2 · 2023: 2 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 16 · 2014: 11 · 2013: 12 · 2012: 12
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K23HL073381)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- major depressive disorder, binge eating disorder, weight loss, behavioral weight loss program, Diabetes Prevention Program, comorbidities, treatment outcomes
- MeSH terms
- Adult, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Obesity, Retrospective Studies, Weight Loss, Case-Control Studies, Treatment Outcome, Disease Management, Bulimia Nervosa
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