One‐Year Changes in Symptoms of Depression and Weight in Overweight/Obese Individuals With Type 2 Diabetes in the Look AHEAD Study

Faulconbridge, Lucy F.; Wadden, Thomas A.; Rubin, Richard R.; Wing, Rena R.; Walkup, Michael P.; Fabricatore, Anthony N.; Coday, Mace; Van Dorsten, Brent; Mount, David L.; Ewing, Linda J.; Look AHEAD Research Group

doi:10.1038/oby.2011.315

Cited by 117Diabetes Management and EducationDiabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, Diet

One‐Year Changes in Symptoms of Depression and Weight in Overweight/Obese Individuals With Type 2 Diabetes in the Look AHEAD Study

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Faulconbridge, Lucy F., Wadden, Thomas A., Rubin, Richard R., Wing, Rena R., Walkup, Michael P., Fabricatore, Anthony N., Coday, Mace, Van Dorsten, Brent +3 more·2012·Obesity

DOI 10.1038/oby.2011.315PMC PMC3298842

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Abstract

Depressed individuals are frequently excluded from weight loss trials because of fears that weight reduction may precipitate mood disorders, as well as concerns that depressed participants will not lose weight satisfactorily. The present study examined participants in the Look AHEAD study to determine whether moderate weight loss would be associated with incident symptoms of depression and suicidal ideation, and whether symptoms of depression at baseline would limit weight loss at 1 year. Overweight/obese adults with type 2 diabetes (n = 5,145) were randomly assigned to an Intensive Lifestyle Intervention (ILI) or a usual care group, Diabetes Support and Education (DSE). Of these, 5,129 participants completed the Beck Depression Inventory (BDI) and had their weight measured at baseline and 1 year. Potentially significant symptoms of depression were defined by a BDI score ≥10. Participants in ILI lost 8.6 ± 6.9% of initial weight at 1 year, compared to 0.7 ± 4.8% for DSE (P < 0.001, effect size = 1.33), and had a reduction of 1.4 ± 4.7 points on the BDI, compared to 0.4 ± 4.5 for DSE (P < 0.001, effect size = 0.23). At 1 year, the incidence of potentially significant symptoms of depression was significantly lower in the ILI than DSE group (6.3% vs. 9.6%) (relative risk (RR) = 0.66, 95% confidence interval (CI) = 0.5, 0.8; P < 0.001). In the ILI group, participants with and without symptoms of depression lost 7.8 ± 6.7% and 8.7 ± 6.9%, respectively, a difference not considered clinically meaningful. Intentional weight loss was not associated with the precipitation of symptoms of depression, but instead appeared to protect against this occurrence. Mild (or greater) symptoms of depression at baseline did not prevent overweight/obese individuals with type 2 diabetes from achieving significant weight loss.

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Intensive lifestyle intervention has been associated with improvements in urinary incontinence, sleep apnea, depression, quality of life, physical function, and mobility in the early years of the trial.
“Other benefits identified during the early years of the trial have included improvements in urinary incontinence,20 sleep apnea,21 depression,22 quality of life,23 physical function,24 and mobility.”
From Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes (2013) · cites this paper as [22]

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Authors: Faulconbridge, L. F., Wadden, T. A., Rubin, R. R., Wing, R. R., Walkup, M. P., Fabricatore, A. N., Coday, M., Van Dorsten, B., Mount, D. L., Ewing, L. J., & Look AHEAD Research Group
Affiliations: University of Pennsylvania (US)
Johns Hopkins University (US)
Brown University (US)
Wake Forest University Health Sciences (US)
University of Tennessee Health Science Center (US)
University of Pittsburgh (US)
Corresponding author: Faulconbridge, Lucy F.
ORCID: Faulconbridge, Lucy F.
Wadden, Thomas A.
Wing, Rena R.
Fabricatore, Anthony N.
Coday, Mace
Ewing, Linda J.
Venue: Obesity
Publisher: Wiley
Published: 2012-04
Volume: 20
Issue: 4
Pages: 783-793
ISSN: 1930-7381 (ISSN-L)
1930-739X
DOI: 10.1038/oby.2011.315
PMC: PMC3298842
OpenAlex: W2057113309
Cited by: 117
References: 38
Citations by year: 2026: 3 · 2025: 3 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 15 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 14 · 2015: 11 · 2014: 21 · 2013: 19 · 2012: 1
FWCI: 10.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 163 d)
Locations: Obesity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5p30dk046204-15)
National Heart, Lung, and Blood Institute (K23HL109235)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-57171, DK 57136, DK57149, P30DK050456, DK 57002, DK57182, DK56990, (DK 046204, DK57008, DK57177, DK 57078, DK57219, U01DK057149, DK-57178, U01DK057151, U01DK057135, U01DK057131, U01DK056990, DK-57135, U01DK057136, DK-56992, DK57154, U01DK057178, U01DK057182, U01DK057078, U01DK057154, P30DK079637, U01DK057008, U01DK057171, DK57131, U01DK057002, U01DK057219, U01DK056992, U01DK057177, P30DK017047, P30DK048520, DK 57151, P30-DK046204, P30-DK 48520)
National Center for Research Resources (M01-RR-0021140, M01RR-00051, M01RR002719, M01RR000056, M01RR01346, M01RR000051, M01RR001066, M01RR001346, UL1RR024153, M0-1-RR-02719, M01-RR01066)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords: depression, type 2 diabetes, overweight, weight loss, intensive lifestyle intervention, suicidal ideation, depressive symptoms, diabetes support and education
MeSH terms: Aged, Depression, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Obesity, Time Factors, Weight Loss, Body Mass Index, Treatment Outcome, Patient Selection, Suicidal Ideation

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One‐Year Changes in Symptoms of Depression and Weight in Overweight/Obese Individuals With Type 2 Diabetes in the Look AHEAD Study

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