Insulin Sensitivity in African‐American and White Women: Association With Inflammation

Hyatt, Tanya C.; Phadke, Radhika P.; Hunter, Gary R.; Bush, Nikki C.; Muñoz, A. Julian; Gower, Barbara A.

doi:10.1038/oby.2008.549

Cited by 67Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsAdipose Tissue and Metabolism

Insulin Sensitivity in African‐American and White Women: Association With Inflammation

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Hyatt, Tanya C., Phadke, Radhika P., Hunter, Gary R., Bush, Nikki C., Muñoz, A. Julian, Gower, Barbara A.·2009·Obesity

DOI 10.1038/oby.2008.549PMC PMC2748773

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Abstract

Whether the contribution of inflammation to risk for chronic metabolic disease differs with ethnicity is not known. The objective of this study was to determine: (i) whether ethnic differences exist in markers of inflammation and (ii) whether lower insulin sensitivity among African Americans vs. whites is due to greater inflammatory status. Subjects were African-American (n = 108) and white (n = 105) women, BMI 27-30 kg/m(2). Insulin sensitivity was assessed with intravenous glucose tolerance test and minimal modeling; fat distribution with computed tomography; body composition with dual-energy X-ray absorptiometry; markers of inflammation (tumor necrosis factor (TNF)-alpha, soluble tumor necrosis factor receptor (sTNFR)-1, sTNFR-2, C-reactive protein (CRP), and interleukin (IL)-6) with enzyme-linked immunosorbent assay (ELISA). Whites had greater intra-abdominal adipose tissue (IAAT), insulin sensitivity, and concentrations of TNF-alpha, sTNFR-1, and sTNFR-2 than African Americans. Greater TNF-alpha in whites vs. African Americans was attributed to greater IAAT in whites. Among whites, but not African Americans, CRP was independently and inversely associated with insulin sensitivity, after adjusting for IAAT (r = -0.29 P < 0.05, and r = -0.13 P = 0.53, respectively). Insulin sensitivity remained lower in African Americans after adjusting for CRP (P < 0.001). In conclusion, greater IAAT among whites may be associated with greater inflammation. Insulin sensitivity was lower among African Americans, independent of obesity, fat distribution, and inflammation.

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Markers of inflammation are inversely associated with insulin sensitivity.
“Markers of inflammation are inversely associated with insulin sensitivity (37), and elevated biomarkers of inflammation are a risk factor for T2D (50).”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [37]
On a cross-sectional basis, tumor necrosis factor alpha was associated with intra-abdominal adipose tissue but not with total fat mass or any other individual fat depot.
“Furthermore, on a cross-sectional basis, TNF-a was associated with IAAT but not with total fat mass or any other individual fat depot (37).”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [37]

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Authors: Hyatt, T. C., Phadke, R. P., Hunter, G. R., Bush, N. C., Muñoz, A. J., & Gower, B. A.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Gower, Barbara A.
ORCID: Hunter, Gary R.
Gower, Barbara A.
Venue: Obesity
Publisher: Wiley
Published: 2009-02
Volume: 17
Issue: 2
Pages: 276-282
ISSN: 1930-7381 (ISSN-L)
1930-739X
DOI: 10.1038/oby.2008.549
PMC: PMC2748773
OpenAlex: W1977218988
Cited by: 67
References: 57
Citations by year: 2025: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 6
FWCI: 5.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1313 d)
Locations: Obesity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Institute of Advanced Aerospace Technology, Seoul National University
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK49779, R01DK049779, R01 DK-51684, P30-DK56336, R01DK051684, P30DK056336)
National Center for Research Resources (M01RR00032, M01RR000032)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: insulin sensitivity, inflammation, African American women, ethnic differences, C-reactive protein, TNF-α, soluble TNF receptors, interleukin-6, intra-abdominal adipose tissue, abdominal fat distribution, insulin resistance, metabolic disease risk
MeSH terms: Adult, Black or African American, Body Composition, C-Reactive Protein, Female, Glucose Tolerance Test, Humans, Inflammation, Insulin Resistance, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Linear Models, White People, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Intra-Abdominal Fat, Adiponectin

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Insulin Sensitivity in African‐American and White Women: Association With Inflammation

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