The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension

Engeli, Stefan; Sharma, Arya M.

doi:10.1007/s001090000144

Cited by 225Renin-Angiotensin System StudiesBlood Pressure and Hypertension StudiesAdipokines, Inflammation, and Metabolic Diseases

The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension

Engeli, Stefan, Sharma, Arya M.·2001·Journal of Molecular Medicine

DOI 10.1007/s001090000144

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Abstract

Excessive accumulation of adipose tissue is associated with profound alterations in the cardiovascular system. including an increase in systemic blood pressure. It now appears clear that a central feature of obesity-associated hypertension is related to changes in sodium handling that may result from abnormalities in sympathetic nervous system activity, the renin-angiotensin-aldosterone system, natriuretic peptides, and kidney function. In this paper we review the role of these factors in the development of obesity-associated hypertension, thereby focusing on the potential role of adipose tissue in these alterations.

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Experimental animals and people with obesity generally have modest increases in most components of the renin-angiotensin-aldosterone system, including angiotensin II and aldosterone.
“Experimental animals and people with obesity generally have modest increases in most components of the RAAS, including angiotensin II (AngII) and aldosterone6,59.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [59]
Obese subjects, especially those with visceral obesity, often have mild to moderate increases in plasma renin activity (PRA), angiotensinogen, ACE activity, AngII, and aldosterone.
“Obese subjects, especially those with visceral obesity, often have mild to moderate increases in plasma renin activity (PRA), angiotensinogen, ACE activity, AngII, and aldosterone40.”
From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [40]

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Authors: Engeli, S., & Sharma, A. M.
Affiliations: Humboldt-Universität zu Berlin (DE)
ORCID: Engeli, Stefan
Sharma, Arya M.
Venue: Journal of Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2000-10-18
Volume: 79
Issue: 1
Pages: 21-29
ISSN: 0946-2716 (ISSN-L)
1432-1440
DOI: 10.1007/s001090000144
OpenAlex: W2135961756
Cited by: 225
References: 117
Citations by year: 2026: 3 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 17
FWCI: 3.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: obesity-related hypertension, renin-angiotensin system, natriuretic peptides, adipose tissue, sodium handling, sympathetic activity, renin-angiotensin-aldosterone system, renal function, blood pressure regulation
MeSH terms: Adipose Tissue, Hypertension, Models, Biological, Atrial Natriuretic Factor, Obesity, Renin-Angiotensin System, Research Personnel, Sodium

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The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension

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