Prospective Investigation of Metabolic Characteristics in Relation to Weight Gain in Older Adults: The Hoorn Study
Open accessAbstract
The objective of this investigation was to determine the relation between baseline glucose, insulin, adiponectin, and leptin levels and subsequent 6‐year weight and waist change in older men and women without diabetes in a prospective cohort study. Participants were 1,198 Dutch men and women without diabetes who were aged 50–77 years when baseline metabolic and anthropometric measurements were evaluated (1989–1991). Approximately 6 years later, body weight and waist circumference were re‐measured at a follow‐up examination (1996–1998). Metabolic variables (fasting plasma glucose, 2‐h postchallenge plasma glucose, homeostasis model assessment of insulin resistance (HOMA‐IR), adiponectin, and leptin) were evaluated as predictors of changes in weight and waist circumference. Postchallenge plasma glucose (mmol/l) significantly predicted less gain in both weight and waist circumference (β = −0.28 kg, s.e. = 0.11; β = −0.31 cm, s.e. = 0.14, respectively) during follow‐up. Leptin (µg/l) significantly predicted greater increases in weight (β = 0.29 kg, s.e. = 0.07) and waist (β = 0.16 cm, s.e. = 0.08) among men and in waist among women (β = 0.06 cm, s.e. = 0.02). Fasting plasma glucose (mmol/l) predicted an increase in waist among women (β = 1.59 cm, s.e. = 0.63), but not in men (β = −0.74 cm, s.e. = 0.55). Adiponectin and insulin did not predict weight or waist change. The authors conclude that lower postchallenge plasma glucose and higher fasting leptin levels significantly predicted long‐term increases in weight and waist circumference. In contrast, measures of insulin resistance and adiponectin were not associated with weight change in this cohort of older persons without diabetes.
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In animals and humans, an increase in body weight is accompanied by an increase in skeletal muscle insulin resistance.
“Studies in experimental animals and in man have demonstrated that the increase in body weight is accompanied with an increase in skeletal muscle insulin resistance [48–52].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [50]
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- Authors
- Wedick, N. M., Snijder, M. B., Dekker, J. M., Heine, R. J., Stehouwer, C. D. A., Nijpels, G., & van Dam, R. M.
- Affiliations
- Harvard University (US)
- Vrije Universiteit Amsterdam (NL)
- Amsterdam Public Health (NL)
- Eli Lilly (United States) (US)
- Maastricht University Medical Centre (NL)
- Corresponding author
- Wedick, Nicole M.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2009-08
- Volume
- 17
- Issue
- 8
- Pages
- 1609-1614
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2004393408
- Cited by
- 18
- References
- 60
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- weight gain, older adults, waist circumference, fasting blood glucose, leptin, adiponectin, insulin resistance, HOMA-IR, insulin, obesity prediction, sex differences
- MeSH terms
- Aged, Anthropometry, Blood Glucose, Body Weight, Female, Homeostasis, Humans, Insulin Resistance, Male, Middle Aged, Netherlands, Prospective Studies, Time Factors, Cohort Studies, Weight Gain, Waist Circumference
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