Obesity, diabetes and the central nervous system

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

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Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works

Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

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Identification and expression cloning of a leptin receptor, OB-R.

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Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works

Abnormal splicing of the leptin receptor in diabetic mice

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A role for glucagon-like peptide-1 in the central regulation of feeding

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

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Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

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Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

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The role of neuropeptide Y in the antiobesity action of the obese gene product

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Identification of targets of leptin action in rat hypothalamus.

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The role of depot fat in the hypothalamic control of food intake in the rat

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Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function

Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405 · see citing works

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

Coleman, D. L. (1978) · Diabetologia · doi:10.1007/bf00429772 · Cited by 1,307 · see citing works

The Leptin Receptor

Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289 · see citing works

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984) · Endocrinology · doi:10.1210/endo-115-1-427 · Cited by 1,276 · see citing works

Leptin enters the brain by a saturable system independent of insulin

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Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1995) · Nature · doi:10.1038/374479a0 · Cited by 1,125 · see citing works

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

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Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

Chua, S. C., Chung, W. K., Wu-Peng, X. S., Zhang, Y., Liu, S.-M., Tartaglia, L. A., & Leibel, R. L. (1996) · Science · doi:10.1126/science.271.5251.994 · Cited by 1,071 · see citing works

Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

Boss, O., Samec, S., Paoloni‐Giacobino, A., Rossier, C., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00384-0 · Cited by 1,041 · see citing works

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033 · see citing works

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014 · see citing works

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

Erickson, J. C., Clegg, K. E., & Palmiter, R. D. (1996) · Nature · doi:10.1038/381415a0 · Cited by 1,009 · see citing works

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in <i>ob/ob</i> Mice

Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904 · see citing works

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

Mercer, J. G., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., & Trayhurn, P. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00473-5 · Cited by 880 · see citing works

Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity

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Effects of gender, body composition, and menopause on plasma concentrations of leptin.

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Effect of fasting on serum leptin in normal human subjects

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Insulin in the Brain: A Hormonal Regulator of Energy Balance*

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Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat

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Feast and Famine: Critical Role of Glucocorticoids with Insulin in Daily Energy Flow

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Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

Erickson, J. C., Hollopeter, G., & Palmiter, R. D. (1996) · Science · doi:10.1126/science.274.5293.1704 · Cited by 794 · see citing works

Defective STAT signaling by the leptin receptor in diabetic mice.

Ghilardi, N., Ziegler, S., Wiestner, A. C., Stoffel, R., Heim, M. H., & Skoda, R. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6231 · Cited by 793 · see citing works

Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.

Sinha, M. K., Ohannesian, J. P., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Magosin, S., Marco, C. C., & Caro, J. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118551 · Cited by 785 · see citing works

UCP3: An Uncoupling Protein Homologue Expressed Preferentially and Abundantly in Skeletal Muscle and Brown Adipose Tissue

Vidal‐Puig, A., Solanes, G., Grujić, D., Flier, J. S., & Lowell, B. B. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6740 · Cited by 711 · see citing works

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

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Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro

Kolaczynski, J. W., Nyce, M. R., Considine, R. V., Boden, G., Nolan, J. J., Henry, R., Mudaliar, S. R., Olefsky, J., & Caro, J. F. (1996) · Diabetes · doi:10.2337/diab.45.5.699 · Cited by 700 · see citing works

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

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Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

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Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats

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Serotonin and appetite

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Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

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Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves

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Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

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Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity

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Receptor-Mediated Transport of Insulin Across Endothelial Cells

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Body fat distribution, insulin resistance, and metabolic diseases

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Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus

Mercer, J. G., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., Morgan, P. J., & Trayhurn, P. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05161.x · Cited by 460 · cited 1× · see citing works

Confronting the failure of behavioral and dietary treatments for obesity

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Diabetes mellitus · A

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Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue

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Melanin-Concentrating Hormone Acutely Stimulates Feeding, But Chronic Administration Has No Effect on Body Weight

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Recombinant ob protein reduces feeding and body weight in the ob/ob mouse.

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Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism

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Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss

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Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K+ Channels in Pancreatic β-Cells

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Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

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The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism

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Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats

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Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity.

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Insulin In The Brain

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Glucocorticoids and insulin: reciprocal signals for energy balance

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Insulin resistance associated with lower rates of weight gain in Pima Indians.

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Regulation of Food Intake and Obesity

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Human Insulin Receptor Monoclonal Antibody Undergoes High Affinity Binding to Human Brain Capillaries in Vitro and Rapid Transcytosis Through the Blood–Brain Barrier in Vivo in the Primate

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Receptor-Mediated Peptide Transport through the Blood-Brain Barrier*

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Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance

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Gender differences in plasma leptin concentrations

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Interactions Between Leptin and Hypothalamic Neuropeptide Y Neurons in the Control of Food Intake and Energy Homeostasis in the Rat

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Leptin Receptor (OB-R) Signaling

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Phenotype of fatty Due to Gln269Pro Mutation in the Leptin Receptor (Lepr)

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The uncoupling protein ucp: A membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue

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Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse

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Neuroendocrine Responses to Starvation and Weight Loss

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