ZRF1 controls oncogene-induced senescence through the INK4-ARF locus

Ribeiro, J D; Morey, L; Mas, A; Gutierrez, A; Luis, N M; Mejetta, S; Richly, H; Benitah, S A; Keyes, W M; Di Croce, L

doi:10.1038/onc.2012.241

Cited by 41Telomeres, Telomerase, and SenescenceEpigenetics and DNA MethylationCancer-related Molecular Pathways

ZRF1 controls oncogene-induced senescence through the INK4-ARF locus

Ribeiro, J D, Morey, L, Mas, A, Gutierrez, A, Luis, N M, Mejetta, S, Richly, H, Benitah, S A +2 more·2013·Oncogene

DOI 10.1038/onc.2012.241

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Abstract

The reactivation of the INK4-ARF locus, which is epigenetically repressed by Polycomb proteins in healthy cells, is a hallmark of senescence. One mechanism of reactivating Polycomb-silenced genes is mediated by the epigenetic factor ZRF1, which associates with ubiquitinated histone H2A. We show that cells undergoing senescence following oncogenic Ras expression have increased ZRF1 levels, and that this binds to the p15INK4b, ARF and p16INK4a promoters. Furthermore, ZRF1 depletion in oncogenic Ras-expressing cells restores proliferation by preventing Arf and p16Ink4a expression, consequently bypassing senescence. Thus, ZRF1 regulates the INK4-ARF locus during cellular proliferation and senescence, and alterations in ZRF1 may contribute to tumorigenesis.

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MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence
Culerrier, R. M., Carraz, M., Mann, C., & Djabali, M. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-11-0772 · Cited by 8 · see citing works

Authors: Ribeiro, J. D., Morey, L., Mas, A., Gutierrez, A., Luis, N. M., Mejetta, S., Richly, H., Benitah, S. A., Keyes, W. M., & Di Croce, L.
Affiliations: Universitat Pompeu Fabra (ES)
Institució Catalana de Recerca i Estudis Avançats (ES)
ORCID: Ribeiro, J D
Morey, L
Luis, N M
Richly, H
Benitah, S A
Keyes, W M
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2012-06-25
Volume: 32
Issue: 17
Pages: 2161-2168
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/onc.2012.241
OpenAlex: W2043390820
Cited by: 41
References: 40
Citations by year: 2026: 3 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 1
FWCI: 2.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: oncogene-induced senescence, INK4/ARF locus, Polycomb group proteins, epigenetic repression, CDKN2B, ARF, p16INK4a, oncogenic Ras, senescence bypass, carcinogenesis, cell proliferation
MeSH terms: Animals, Cell Differentiation, Cell Line, Cell Transformation, Neoplastic, DNA-Binding Proteins, Humans, Mice, Inbred C57BL, Genes, ras, Tretinoin, Oncogene Proteins, Gene Expression Regulation, Neoplastic, RNA-Binding Proteins, Cellular Senescence, Cell Cycle Proteins, Molecular Chaperones, Cyclin-Dependent Kinase Inhibitor p16, Gene Silencing, Cell Proliferation, Mice

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ZRF1 controls oncogene-induced senescence through the INK4-ARF locus

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