Cited by 334Cell death mechanisms and regulationDNA Repair MechanismsCancer-related Molecular Pathways

Various modes of cell death induced by DNA damage

Surova, O, Zhivotovsky, B·2013·Oncogene

Abstract

The consequences of DNA damage depend on the cell type and the severity of the damage. Mild DNA damage can be repaired with or without cell-cycle arrest. More severe and irreparable DNA injury leads to the appearance of cells that carry mutations or causes a shift towards induction of the senescence or cell death programs. Although for many years it was argued that DNA damage kills cells via apoptosis or necrosis, technical and methodological progress during the last few years has helped to reveal that this injury might also activate death by autophagy or mitotic catastrophe, which may then be followed by apoptosis or necrosis. The molecular basis underlying the decision-making process is currently the subject of intense investigation. Here, we review current knowledge about the response to DNA damage and subsequent signaling, with particular attention to cell death induction and the molecular switches between different cell death modalities following damage.

Integrity signals

Registry

Crossref · 10.1038/onc.2012.556

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Surova, O., & Zhivotovsky, B.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Zhivotovsky, B
Venue
Oncogene
Published
2012-12-03
Volume
32
Issue
33
Pages
3789-3797
ISSN
  • 0950-9232 (ISSN-L)
  • 1476-5594
OpenAlex
W2090408878
Cited by
334
References
72
Citations by year
2026: 12 · 2025: 23 · 2024: 21 · 2023: 30 · 2022: 51 · 2021: 37 · 2020: 30 · 2019: 8 · 2018: 18 · 2017: 11 · 2016: 26 · 2015: 27 · 2014: 28 · 2013: 11
FWCI
1.93
Type
journal article
Language
en
Open access
closed
Locations
  • Oncogene (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
DNA damage, cell death, apoptosis, necrosis, autophagy, mitotic catastrophe, cell cycle arrest, DNA repair, cellular senescence
MeSH terms
Animals, DNA Damage, Humans, Cell Death

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review