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High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study

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Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

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Implications of reactive oxygen species on cancer formation and its treatment

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Self-sufficing H2O2-responsive nanocarriers through tumor-specific H2O2 production for synergistic oxidation-chemotherapy

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Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge

Carr, A. C., & Cook, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01182 · Cited by 133 · see citing works

Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA

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O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate

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Impacts of oxidative stress on acetylcholinesterase transcription, and activity in embryos of zebrafish (Danio rerio) following Chlorpyrifos exposure

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Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer

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Intravenous Vitamin C and Cancer: A Systematic Review

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High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial

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Oxidative Stress: A New Target for Pancreatic Cancer Prognosis and Treatment

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In-silico Prediction of Synergistic Anti-Cancer Drug Combinations Using Multi-omics Data

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Multifunctional Polymeric Micelles with Amplified Fenton Reaction for Tumor Ablation

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Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells

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Is There a Role for Oral or Intravenous Ascorbate (Vitamin C) in Treating Patients With Cancer? A Systematic Review

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Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

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Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment

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The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia

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Metabolic interplays between the tumour and the host shape the tumour macroenvironment

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Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials

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Intravenous vitamin C in the supportive care of cancer patients: A review and rational approach

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Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond

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The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life

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Vitamin C as a Modulator of the Response to Cancer Therapy

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Epigenetic Regulation of Genomic Stability by Vitamin C

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Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention

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Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer

Zhou, L., Zhao, B., Zhang, L., Wang, S., Dong, D., Lv, H., & Shang, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051545 · Cited by 102 · see citing works

Nuclear and Cytoplasmic Functions of Vitamin C

Zhitkovich, A. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00348 · Cited by 106 · see citing works

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells

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The Tumorigenic Roles of the Cellular REDOX Regulatory Systems

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Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

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Boosting the Ferroptotic Antitumor Efficacy via Site-Specific Amplification of Tailored Lipid Peroxidation

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Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies

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Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation

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Vitamin C supplementation in the critically ill patient

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Press-pulse: a novel therapeutic strategy for the metabolic management of cancer

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Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment

Ali, T., Li, D., Ponnamperumage, T. N. F., Peterson, A. K., Pandey, J., Fatima, K., Brzezinski, J., Jakusz, J. A. R., Gao, H., Koelsch, G. E., et al. (2024) · Cancers · doi:10.3390/cancers16122171 · Cited by 87 · see citing works

Oxidative stress-induced protein damage inhibits DNA repair and determines mutation risk and therapeutic efficacy

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Iron and lung cancer

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First-in-Human Phase I Clinical Trial of Pharmacologic Ascorbate Combined with Radiation and Temozolomide for Newly Diagnosed Glioblastoma

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Targeting Cancer Stem Cell Redox Metabolism to Enhance Therapy Responses

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Therapeutic Use of Vitamin C in Cancer: Physiological Considerations

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Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis

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Integrated Nanoparticles To Synergistically Elevate Tumor Oxidative Stress and Suppress Antioxidative Capability for Amplified Oxidation Therapy

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TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy

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High-Dose Vitamin C for Cancer Therapy

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Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

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The potential role of vitamin C in empowering cancer immunotherapy

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The role of iron homeostasis and iron-mediated ROS in cancer.

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Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer

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TET2 as a tumor suppressor and therapeutic target in T-cell acute lymphoblastic leukemia

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Polarization of Tumor-Associated Macrophages Promoted by Vitamin C-Loaded Liposomes for Cancer Immunotherapy

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Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?

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GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment

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Energy‐Free, Singlet Oxygen‐Based Chemodynamic Therapy for Selective Tumor Treatment without Dark Toxicity

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Dynamics of ascorbic acid content in apple (Malus x domestica) during fruit development and storage

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High-Dose Vitamin C in Advanced-Stage Cancer Patients

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Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma

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The Role of Antioxidants in Cancer, Friends or Foes?

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Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

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Revisiting vitamin C and cancer

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Low-intensity focused ultrasound-augmented Cascade chemodynamic therapy via boosting ROS generation

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Pharmacological Ascorbate Suppresses Growth of Gastric Cancer Cells with GLUT1 Overexpression and Enhances the Efficacy of Oxaliplatin Through Redox Modulation

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Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue

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Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic Acid

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Fasting and fasting mimicking diets in cancer prevention and therapy

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Parenteral Ascorbate Is Beneficial in Ovarian Cancer Therapy

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Parenteral Ascorbate As a Cancer Therapeutic: A Reassessment Based on Pharmacokinetics

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Pharmacological Ascorbate Induces Osteosarcoma Cells Death via H2O2 Mediated-Oxidative Stress and Enhances the Efficacy of Cisplatin in OsteosarcomaPreprint

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Intravenous pharmacologic ascorbate as a redox modulator and chemosensitizer in targeted Cancer therapies

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The role of redox-active iron metabolism in the selective toxicity of pharmacological ascorbate in cancer therapy

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