Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease
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Items 201–300 of 378
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- Optogenetic Control of RhoA to Probe Subcellular Mechanochemical CircuitryKate E. Cavanaugh, Patrick W. Oakes, Margaret Lise Gardel · 2020 · Current Protocols in Cell Biology
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- Regulation of the RhoA exchange factor GEF-H1 by profibrotic stimuli through a positive feedback loop involving RhoA, MRTF, and Sp1Shruthi Venugopal, Qinghong Dan, Veroni S. Sri Theivakadadcham, Brian Wu, Michael Kofler, Matthew D. Layne, Kim Alexander Connelly, Mark F. Rzepka, Mark Kevin Friedberg, András Kapùs et al. · 2024 · American Journal of Physiology-Cell Physiology
- A Proteomics Profiling Reveals the Neuroprotective Effects of Melatonin on Exogenous β‐amyloid‐42 Induced Mitochondrial Impairment, Intracellular β‐amyloid Accumulation and Tau Hyperphosphorylation in Human SH‐SY5Y CellsJiraporn Panmanee, Matthew Phanchana, Phorutai Pearngam, Nopphon Petchyam, Kornkanok Promthep, Ponlawit Wisomka, Suchanoot Kutpruek, Supitcha Pannengpetch, Tanya Prasertporn, Sujira Mukda et al. · 2025 · Cell Biology International
- The Rho guanine nucleotide exchange factor P-Rex1 as a potential drug target for cancer metastasis and inflammatory diseasesRichard D. Ye · 2020 · Pharmacological Research
- ARHGEF19 regulates MAPK/ERK signaling and promotes the progression of small cell lung cancerZiyang Wang, Guangyan Kan, Chunjie Sheng, Chen Yao, Yizhi Mao, Shuai Chen · 2020 · Biochemical and Biophysical Research Communications
- Exploitation of the host exocyst complex by bacterial pathogensKeith Ireton, Gaurav Chandra Gyanwali, Thilina U. B. Herath, Nicole MynYi Lee · 2023 · Molecular Microbiology
- Cell Division Cycle 42 plays a Cell type-Specific role in Lung TumorigenesisChao Zheng, Yuetong Wang, Yang Liu, Shuhua Zhou, Yijun Gao, Fuming Li, Yan Feng, Zuoyun Wang, Lixing Zhan, Qin Yan et al. · 2017 · Scientific Reports
- ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesisDawei Wang, Junyi Tang, Guoqing Zhang, Xiaotian Chang · 2020 · Bioscience Biotechnology and Biochemistry
- Rho GTPases in the Amygdala—A Switch for Fears?Tasnuva Sarowar, Andreas Martin Grabrucker · 2020 · Cells
- Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their ProgressionAlessandra Pecora, Justine Laprise, Manel Dahmene, Mélanie Laurin · 2021 · Cancers
- Overexpression of ECT2 is a strong poor prognostic factor in ER(+) breast cancerYingying Xiu, Wei Liu, Tianyi Wang, Yi Liu, HA Min-wen · 2019 · Molecular and Clinical Oncology
- Role of ARHGEF3 as a GEF and mTORC2 RegulatorSana Abdul Khaliq, Zobia Umair, Mee‐Sup Yoon · 2022 · Frontiers in Cell and Developmental Biology
- Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumorPauline Croisé, Laurent Brunaud, Petra Tóth, Stéphane Gasman, Stéphane Ory · 2016 · Small GTPases
- Modulation of small GTPase activity by NME proteinsVedrana Filić, Maja Marinović, Marko Šoštar, I.T. Weber · 2018 · Laboratory Investigation
- Two protein-coding genes act as a novel clinical signature to predict prognosis in patients with ovarian serous cystadenocarcinomaJue Zhang, Meng Xu, Han Jie Gao, Jin‐Chen Guo, Yulin Guo, Miao Zou, Xufeng Wu · 2018 · Oncology Letters
- Vascular Permeability: Flow-Mediated, Non-canonical Notch Signalling Promotes Barrier IntegrityAndreas Fischer, Vania M. M. Braga · 2018 · Current Biology
- The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signalingJakobus van Unen, Dennis Botman, Taofei Yin, Yi Wu, Mark A. Hink, Theodorus W. J. Gadella, Marten Postma, Joachim Goedhart · 2018 · BMC Cell Biology
- Role of Rho guanine nucleotide exchange factors in non-small cell lung cancerRuijie Zeng, Weijie Xie, Chunwen Zheng, Wanxian Chen, Si-Meng Wang, Zheng Li, Chi-Bin Cheng, Haiying Zou, Li‐Yan Xu, En‐Min Li · 2021 · Bioengineered
- Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and SpongeBridget H. Biersmith, Zong-Heng Wang, Erika R. Geisbrecht · 2015 · Genetics
- Ligand-dependent serum response factor activation by the human CC chemokine receptors CCR2a and CCR2b is mediated by G proteins of the Gq familyPetra Vatter, Julia Schuhholz, Carolin Koenig, Mariana Pfreimer, Barbara Moepps · 2016 · Journal of Leukocyte Biology
- A caspase–RhoGEF axis contributes to the cell size threshold for apoptotic death in developing Caenorhabditis elegansAditya Sethi, Hai Wei, Nikhil Mishra, Ioannis Segos, Eric J. Lambie, Esther Zanin, Barbara Conradt · 2022 · PLoS Biology
- Discovery and validation of combined biomarkers for the diagnosis of esophageal intraepithelial neoplasia and esophageal squamous cell carcinomaYa-Qi Zheng, Haihua Huang, Shuxian Chen, Xiu‐E Xu, Zhi‐Mao Li, Yuehong Li, Su-Zuan Chen, Wen-Xiong Luo, Yi Guo, Wei Liu et al. · 2024 · Journal of Proteomics
- A High-Throughput Assay for Rho Guanine Nucleotide Exchange Factors Based on the Transcreener GDP AssayMelvin Reichman, Amanda Schabdach, Meera Ajeet Kumar, Tom Zielinski, Preston S. Donover, Lisa D. Laury‐Kleintop, Robert G. Lowery · 2015 · SLAS DISCOVERY
- BAR Domain Proteins Regulate Rho GTPase SignalingPontus Aspenström · 2018 · Advances in experimental medicine and biology
- Rac Family Small GTPase 3 Correlates with Progression and Poor Prognosis in Bladder CancerWenjie Zheng, Jie Zhang, Qianqian Song, Yuqing Xu, Mengqi Zhu, Jianguo Ma · 2021 · DNA and Cell Biology
- Epithelial cell transforming factor ECT2 is an important regulator of DNA double-strand break repair and genome stabilityCheng Cao, Peiyi Han, Ling Liu, Yiman Tang, Shanshan Tian, Kai Zhang, Lei Shi, Zhiqiang Liu, Dexiang Zhuo, Wenshu Ge et al. · 2021 · Journal of Biological Chemistry
- Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental PhenotypesMasashi Nishikawa, Hidenori Ito, Hidenori Tabata, Hiroshi Ueda, Koh‐ichi Nagata · 2022 · Cells
- Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cellsJoachim Goedhart, Jakobus van Unen · 2017 · Small GTPases
- Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic TargetsZexing Lin, Chujun Ni, Haiyang Jiang, Huan Yang, Liting Deng, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Runnan Wang et al. · 2025 · MedComm
- CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegansYujie Li, Sandra Finkbeiner, Athina Ganner, Julia P. Gerber, Marinella Klein, Manuel Grafe, Jakob Kandzia, Antje Thien, Kathrin Thedieck, G. Breves et al. · 2018 · Oncotarget
- SWAP70 undergoes dynamic conformational regulation at the leading edge of migrating cellsNisha Kriplani, R. R. Duncan, Nicholas R. Leslie · 2019 · FEBS Letters
- Identification of a novel mouse Dbl proto-oncogene splice variant: Evidence that SEC14 domain is involved in GEF activity regulationMarzia Ognibene, Cristina Vanni, Fabiola Blengio, Daniela Segalerba, Patrizia Mancini, Patrizia De Marco, Maria Rosaria Torrisi, Maria Carla Bosco, Luigi Varesio, Alessandra Eva · 2014 · Gene
- High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinomaZhenpeng Zhu, Lanruo Lin, Tongde Lv, Chunru Xu, Tian‑Yu Cai, Jian Lin · 2020 · Oncology Reports
- Exploiting fly models to investigate rare human neurological disordersTomomi TANAKA, Hyung-Lok Chung · 2024 · Neural Regeneration Research
- Solo and Keratin Filaments Regulate Epithelial Tubule MorphologyRyosuke Nishimura, Kagayaki Kato, Sachiko Fujiwara, Kazumasa Ohashi, Kensaku Mizuno · 2018 · Cell Structure and Function
- Endothelial cell sprouting driven by RhoJ directly activated by a membrane-anchored Intersectin 1 (ITSN1) RhoGEF moduleVíctor Manuel Color-Aparicio, Rodolfo Daniel Cervantes‐Villagrana, Irving García‐Jiménez, Yarely Mabell Beltrán‐Navarro, Alejandro Castillo‐Kauil, Estanislao Escobar‐Islas, Guadalupe Reyes‐Cruz, José Vázquez‐Prado · 2020 · Biochemical and Biophysical Research Communications
- The N-terminal domain of the adaptor protein p140Cap interacts with Tiam1 and controls Tiam1/Rac1 axis.Jennifer Chapelle, Annalisa Baudino, Federico Torelli, Aurora Savino, Alessandro Morellato, Costanza Angelini, Vincenzo Salemme, Giorgia Centonze, Dora Natalini, Marta Gai et al. · 2020 · PubMed Central
- Combinatorial Effects of RhoA and Cdc42 on the Actin Cytoskeleton Revealed by Photoswitchable GEFsHyunjoo Ryu, Hae Nim Lee, Jeong-Min Ju, Jae‐Bong Park, Eunkyoo Oh, Michael Z. Lin, Jihye Seong · 2022 · Sensors and Actuators B Chemical
- Dock10 Regulates Cardiac Function under Neurohormonal StressLiad Segal, Sharon Etzion, Sigal Elyagon, Moran Shahar, Hadar Klapper‐Goldstein, Aviva Levitas, Michael S. Kapiloff, Ruti Parvari, Yoram Etzion · 2022 · International Journal of Molecular Sciences
- Fission Yeast Rho1p-GEFs: From Polarity and Cell Wall Synthesis to Genome StabilityPatricia García, Rubén Celador, Jorge Pérez-Parrilla, Yolanda Sánchez · 2022 · International Journal of Molecular Sciences
- Tools for live imaging of active Rho GTPases in XenopusRachel E. Stephenson, Ann Louise Miller · 2017 · genesis
- Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeastElvira Manjón, Tomás Edreira, Sofía Muñoz, Yolanda Sánchez · 2017 · Nucleic Acids Research
- Bioinformatics Analysis of Microarray Datasets to Identify Prognostic Factors in Lung AdenocarcinomaXiang Jin, Lijun Xu, Yinghui Guan, Zhen Zhang, Hongyu Li · 2020 · DNA and Cell Biology
- Swimming under elevated hydrostatic pressure increases glycolytic activity in gas gland cells of the European eelGabriel Schneebauer, Constantin Lindemann, Victoria Drechsel, Lasse Marohn, Klaus Wysujack, Elena Santidrián Yebra-Pimentel, Ron P. Dirks, Reinhold Hanel, Bernd Pelster · 2020 · PLoS ONE
- Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept StudiesKate Connor, David W. Murray, Monika A. Jarzabek, Nhan L. Tran, Kieron White, Patrick Dicker, Kieron J. Sweeney, Philip J. O’Halloran, Brian MacCarthy, Liam P. Shiels et al. · 2020 · Cancers
- P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor MicroenvironmentYarely Mabell Beltrán‐Navarro, Guadalupe Reyes‐Cruz, José Vázquez‐Prado · 2022 · Frontiers in Oncology
- Regulation of Rho GTPases in the Vasculature by Cullin3-Based E3 Ligase ComplexesFabienne Podieh, Peter Lodewijk Hordijk · 2021 · Frontiers in Cell and Developmental Biology
- Apatinib Through Activating the RhoA/ROCK Signaling Pathway to Cause Dysfunction of Vascular Smooth Muscle CellsWenjuan Wang, Qingjian He, Chenchen Zhuang, Haodong Zhang, Xin Fan, Qiongying Wang, Miaomiao Qi, Runmin Sun, Caie Li, Jing Yu · 2022 · Applied Biochemistry and Biotechnology
- A Gs-RhoGEF interaction: An old G protein finds a new jobVladlen Z. Slepak, Alexey N. Pronin · 2020 · Journal of Biological Chemistry
- ARHGEF9 regulates melanoma morphogenesis in environments with diverse geometry and elasticity by promoting filopodial-driven adhesionVicky Bousgouni, Oliver C K Inge, David Mark Robertson, Ian Jones, Innes Clatworthy, Chris Bakal · 2022 · iScience
- P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora diseaseLorena Kumarasinghe, Maria Adelaida García-Gimeno, J. Ramirez, Ugo Mayor, José L. Zugaza, Pascual Sanz · 2023 · Neurobiology of Disease
- Proteomic Profiling of Cerebrospinal Fluid and Its Extracellular Vesicles from Extraventricular Drainage in Pediatric Pilocytic Astrocytoma, towards Precision OncologySonia Spinelli, Xhuliana Kajana, Andrea Garbarino, Martina Bartolucci, Andrea Petretto, Marco Pavanello, Enrico Eugenio Verrina, Giovanni Candiano, Isabella Panfoli, Maurizio Bruschi · 2024 · Cancers
- PKA modulation of Rac in neuronal cellsAkihiro Goto, Yuji Kamioka, Michiyuki Matsuda · 2014 · Frontiers in Cellular Neuroscience
- Bioblockades join the assault on small G protein signallingHelen R. Mott, Darerca Owen · 2018 · Seminars in Cancer Biology
- Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3Jennifer N. Cash, Prateek V. Sharma, John J. G. Tesmer · 2018 · Journal of Structural Biology X
- Arhgef1 Plays a Vital Role in Platelet Function and ThrombogenesisHanan Qasim, Zubair A. Karim, Keziah R. Hernandez, Dante Lozano, Fadi T. Khasawneh, Fatima Z. Alshbool · 2019 · Journal of the American Heart Association
- Na/H exchanger NHE1 acts upstream of rho GTPases to promote neurite outgrowthWun Chey Sin, Nicola M. Tam, David Matthew Moniz, Connie Lee, John Church · 2020 · Journal of Cell Communication and Signaling
- The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell functionLuis Francisco Lorenzo‐Martín, Mauricio Menacho-Márquez, Natalia Fernández-Parejo, Sonia Rodríguez‐Fdez, Gloria Pascual, Antonio Abad, Piero Crespo, Mercedes Dosil, Salvador Aznar Benitah, Xosé R. Bustelo · 2022 · Oncogene
- Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1Sumit J. Bandekar, Chun-Liang Chen, Sandeep Kaur Ravala, Jennifer N. Cash, Larisa V. Avramova, Mariya V. Zhalnina, Jorge Silvio Gutkind, Sheng Li, John J. G. Tesmer · 2022 · Journal of Biological Chemistry
- Species-Deconvolved Proteomics for In Situ Investigation of Tumor-Stroma Interactions after Treatment of Pancreatic Cancer Patient-Derived Xenografts with Combined Gemcitabine and PaclitaxelXue Wang, Jin Niu, Shuo Qian, Shichen Shen, Robert M. Straubinger, Jun Qu · 2023 · Journal of Proteome Research
- Roles of the Dbl family of RhoGEFs in mechanotransduction – a reviewKazumasa Ohashi, Aoi Kunitomi, Shuhei Chiba, Kensaku Mizuno · 2024 · Frontiers in Cell and Developmental Biology
- ARHGEF18 is a flow-responsive exchange factor controlling endothelial tight junctions and vascular leakage.S. Batta, M. Rio, Corentin Lebot, Céline Baron-Menguy, Maxence Bodet, Reda Moutaoukil, R. Le Ruz, Ibtissam Babahnini, G. Loirand, Anne-Clémence Vion · 2025 · Cell Reports
- VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate CancerMartin J. Baker, Suli Zhang, Daniel Zhang, Joshua Searle, Priti Lal, Cornelis P. Vlaar, Suranganie Dharmawardhane, Martı́n C. Abba, Marcelo G. Kazanietz, Mariana Cooke · 2025 · Molecular Cancer Research
- A novel BRET ‐Based GAP assay reveals phosphorylation‐dependent regulation of the RAC ‐specific GTPase activating protein ARHGAP25Éva Wisniewski, Domonkos Czárán, Fanni Kovács, Enikő Bahurek, Afrodíté Németh, Péter Sasvári, Gergő Szanda, Aladár Pettkó‐Szandtner, Éva Klement, Erzsébet Ligeti et al. · 2022 · The FASEB Journal
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- GEF-H1 Transduces FcεRI Signaling in Mast Cells to Activate RhoA and Focal Adhesion Formation during ExocytosisYitian Guo, Judeah Negre, Gary Eitzen · 2023 · Cells
- Back to the Basics: Usefulness of Naturally Aged Mouse Models and Immunohistochemical and Quantitative Morphologic Methods in Studying Mechanisms of Lung Aging and Associated DiseasesGilberto Jaramillo‐Rangel, María-de-Lourdes Chávez-Briones, Adriana Ancer-Arellano, Ivett C. Miranda-Maldonado, Marta Ortega‐Martínez · 2023 · Biomedicines
- T-lymphoma invasion and metastasis 1 promotes invadopodia formation and is regulated by the PI3K/Akt signaling pathway in hepatocellular carcinomaBaolin Wang, Bowen Zheng, Li Cao, Kexi Liao, Huang Deng, Yujun Zhang, Yan Jiang, Shuguo Zheng · 2021 · Experimental Cell Research
- Hyperactive Rac1 drives MAPK-independent proliferation in melanoma by assembly of a mechanosensitive dendritic actin networkAshwathi S. Mohan, Kevin M. Dean, Stacy Y. Kasitinon, Tadamoto Isogai, Vasanth Siruvallur Murali, Sangyoon J. Han, Philippe Roudot, Alex Groisman, Erik S. Welf, Gaudenz M. Danuser · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domainJesus F. Moreno, Jae‐Sung You, Carlos C. Rodriguez, Shashank Pant, Adriana Reyes‐Ordoñez, R.B. Abdullah, Nilmani Singh, Maxine J van der Donk, Emad Tajkhorshid, Jie Chen · 2025 · iScience
- Dbl family RhoGEFs in cancer: different roles and targeting strategiesXinyi Chen, Ao-yu Cheng, Ziying Wang, Jinmei Jin, Jia-Yi Lin, Bei Wang, Ying‐Yun Guan, Hao Zhang, Yi-Xin Jiang, Xin Luan et al. · 2024 · Biochemical Pharmacology
- Rho GTPases in cancer resistance: mechanisms, vulnerabilities, and therapeutic opportunitiesAmy Beaudin, Philippe Lefrançois, Mélanie Laurin · 2026 · Biochemical Society Transactions
- Classical Rho Proteins: Biochemistry of Molecular Switch Function and RegulationSi-Cai Zhang, Kazem Nouri, Ehsan Amin, Mohamed S. Taha, Hossein Nakhaeizadeh, Saeideh Nakhaei‐Rad, Radovan Dvorský, Mohammad Reza Ahmadian · 2014 · Springer eBooks
- The RAS Signaling Network and CancerPriya S. Hibshman, Channing J. Der · 2024 · Springer eBooks
- Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3Irène Dang, Joseph A. Brazzo, Joseph A. Brazzo, Richard K. Assoian · 2023 · Journal of Cell Science
- Calcium influx promotes PLEKHG4B localization to cell–cell junctions and regulates the integrity of junctional actin filamentsKomaki Ninomiya, Kai Ohta, Ukyo Kawasaki, Shuhei Chiba, Takanari Inoue, Erina Kuranaga, Kazumasa Ohashi, Kensaku Mizuno · 2023 · Molecular Biology of the Cell
- Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and MenLinnet Bischof, Franziska Schweitzer, Jürgen J. Heinisch · 2024 · Cells
- Solo regulates the localization and activity of PDZ-RhoGEF for actin cytoskeletal remodeling in response to substrate stiffnessAoi Kunitomi, Shuhei Chiba, Nahoko Higashitani, Atsushi Higashitani, Shinichi Sato, Kensaku Mizuno, Kazumasa Ohashi · 2024 · Molecular Biology of the Cell
- Molecular and clinical analyses with neuropsychological assessment of a case of del(10)(q26.2qter) without intellectual disability: Genomic and transcriptomic combined approach and review of the literatureBéatrice Laudier, Tiphanie Epiais, Arnaud Pâris, Arnaud Menuet, Sylvain Briault, Canan Özsancak, Olivier Perche · 2016 · American Journal of Medical Genetics Part A
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- Epithelial cell transforming sequence 2 expression is associated with the progression of laryngeal squamous cell carcinomaLin Zhu, Gang Qin, Lin Ye, Lizhu Jiang, Tiejun Zhou, Bo Luo, Taoyu Wen, Ya‐Lan Liu, Hongyan Chen · 2019 · Oncology Letters
- Further refining the critical region of 10q26 microdeletion syndrome: A possible involvement of INSYN2 and NPS in the cognitive phenotypeFlorian Cherik, Mathis Lepage, Ganaëlle Remérand, Christine Francannet, A. Delabaere, Gaëlle Salaün, Céline Pebrel‐Richard, Laëtitia Gouas, Philippe Vago, Andréï Tchirkov et al. · 2021 · European Journal of Medical Genetics
- srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeabilityAlba López Rioja, Ashton Faulkner, Harry Mellor · 2022 · Vascular Biology
- ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in miceYu-Jun Wang, Shuang Li, Hai-Ping Tao, Xiaona Zhang, You-Gui Fang, Qi‐En Yang · 2023 · Reproductive Biology
- Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinomaMariana Cooke · 2021 · Molecular & Cellular Oncology
- β-Arrestin2 Is Critically Involved in the Differential Regulation of Phosphosignaling Pathways by Thyrotropin-Releasing Hormone and TaltirelinZdeňka Drastichová, Radka Trubacova, Jiří Novotný · 2022 · Cells