Cited by 378Protein Kinase Regulation and GTPase SignalingCellular transport and secretionHippo pathway signaling and YAP/TAZ

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Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

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Cook, D R, Rossman, K L, Der, C J·2014·Oncogene

DOI 10.1038/onc.2013.362PMC PMC4875565

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Abstract

The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members) has been implicated in cancer and other human diseases. However, in contrast to the direct mutational activation of Ras found in cancer and developmental disorders, Rho GTPases are activated most commonly in disease by indirect mechanisms. One prevalent mechanism involves aberrant Rho activation via the deregulated expression and/or activity of Rho family guanine nucleotide exchange factors (RhoGEFs). RhoGEFs promote formation of the active GTP-bound state of Rho GTPases. The largest family of RhoGEFs is comprised of the Dbl family RhoGEFs with 70 human members. The multitude of RhoGEFs that activate a single Rho GTPase reflects the very specific role of each RhoGEF in controlling distinct signaling mechanisms involved in Rho activation. In this review, we summarize the role of Dbl RhoGEFs in development and disease, with a focus on Ect2 (epithelial cell transforming squence 2), Tiam1 (T-cell lymphoma invasion and metastasis 1), Vav and P-Rex1/2 (PtdIns(3,4,5)P3 (phosphatidylinositol (3,4,5)-triphosphate)-dependent Rac exchanger).

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Authors: Cook, D. R., Rossman, K. L., & Der, C. J.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Der, C J
ORCID: Rossman, K L
Der, C J
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2013-09-16
Volume: 33
Issue: 31
Pages: 4021-4035
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/onc.2013.362
PMC: PMC4875565
OpenAlex: W2024222958
Cited by: 378
References: 230
Citations by year: 2026: 14 · 2025: 15 · 2024: 17 · 2023: 26 · 2022: 35 · 2021: 45 · 2020: 43 · 2019: 33 · 2018: 37 · 2017: 29 · 2016: 34 · 2015: 24 · 2014: 23 · 2013: 3
FWCI: 2.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: Pancreatic Cancer Action Network
National Institutes of Health (5r01ca042978-30)
National Cancer Institute (CA159821, CA 71341, R01-CA042978, F31CA159821, T32CA071341)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords: RhoGEF, Rho GTPases, ECT2, Tiam1, Vav, Rho activation, cancer, developmental disorders, phosphatidylinositol 3,4,5-trisphosphate, small GTPase signaling
MeSH terms: Congenital Abnormalities, Animals, Cell Division, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, rho GTP-Binding Proteins, Genetic Diseases, Inborn, Proto-Oncogene Proteins c-vav, Rho Guanine Nucleotide Exchange Factors

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Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

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