Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease
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Items 301–378 of 378
- Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancerMarie Sorbara, Nicolas Béry · 2021 · Biochemical Society Transactions
- Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumorsLiying Sheng, Meili Liang, Yueli Wang, Zhimei Zhou, Yajing Xie, Yumin Ke, Zhuna Wu · 2025 · Frontiers in Cell and Developmental Biology
- Optogenetic Tools for Spatiotemporal Interrogation of Cytoskeletal DynamicsDanica Du, Anna Price, Tien‐Hung Lan, Yubin Zhou · 2026 · Bioconjugate Chemistry
- The anti-Rac1-GTP antibody and the detection of active Rac1: a tool with a fundamental flawMartin J. Baker, Marcelo G. Kazanietz · 2021 · Small GTPases
- ARHGEF5 binds Drebrin and affects α-tubulin acetylation to direct neuronal morphogenesis and migration during mouse brain developmentJi-Ye Kim, Hee-Gon Hwang, Hye-Jin Jeon, Seung Il Kim, Min‐Kyu Kim, Jeong‐Yoon Kim · 2024 · Frontiers in Molecular Neuroscience
- Identification of hub genes and pathways in Uterine corpus endometrial carcinoma (UCEC): A comprehensive in silico studyMahsa Ejlalidiz, Ameneh Mehri Ghahfarrokhi, Mohammadreza Saberiyan · 2024 · Biochemistry and Biophysics Reports
- PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesionJassy Mary S. Lazarte, Kweku Ofosu-Asante, Syreeta L. Tilghman, Nazarius Saah Lamango · 2025 · Oncotarget
- Liposome-Based Methods to Study GTPase Activation by PhosphoinositidesJulien Viaud, Laurie Ceccato, Bernard Payrastre, Frédérique Gaits‐Iacovoni · 2021 · Methods in molecular biology
- Novel mutations in breast cancer patients from southwestern ColombiaMelissa Solarte, Carolina Cortes-Urrea, Nelson Rivera-Franco, Guillermo Barreto, Pedro A. Moreno · 2020 · Genetics and Molecular Biology
- Rho guanine nucleotide exchange factor 39 increases the viability, migration and invasion of clear cell renal cell carcinoma cells via the activation of the AKT/ERK signaling pathwayShuzhong Wang, Yanmei Wang, Chuanyun Wang · 2020 · Genetics and Molecular Biology
- The RGS-RhoGEFs control the amplitude of YAP1 activation by serumBrandon S. Lane, Brigitte L. Heller, Morley Donald Hollenberg, Clark D. Wells · 2021 · Scientific Reports
- Contribution of C3G and other GEFs to liver cancer development and progressionAlmudena Porrás, Celia Sequera, Paloma Bragado, Álvaro Gutiérrez-Uzquiza, Carmen Guerrero · 2021 · Hepatoma Research
- Quantitative proteomics discloses monacolin K-induced alterations in triple-negative breast cancer cell proteomes and phosphoproteomesFederica Del Gaudio, Ida Chiara Guerrera, Raffaele Riccio, Maria Chiara Monti · 2019 · Molecular Omics
- Multiplexed Quantitative Screens of Single Cell Shape and YAP/TAZ Localisation Identify DOCK5 as a Coincident Detector of Polarity and Adhesion During MigrationPatricia Pascual Vargas, Mar Arias-García, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Chris Bakal · 2020 · SSRN Electronic Journal
- P-Rex2 exhibits unique structural features and regulatory mechanisms distinct from the closely related RhoGEF P-Rex1Lauren K. Anderson, Rohan Marde, Grace Muma, Veda Nayak, Chi Phan, Sheng Li, Jennifer N. Cash · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- An ancient monoaminergic signaling system coordinates contractility in a nerveless spongeRong Xuan Zang, Nawaphat Malaiwong, Ling Wang, Jamie D. Maziarz, Kejue Jia, Bernhard Drotleff, Frank Stein, Mah Noor, C. Jackson Roberts, Mandy Rettel et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Paramutation-Like Behavior of Genic piRNA-Producing Loci in Drosophila virilisAlina V. Bespalova, Dina A. Kulikova, Elena S. Zelentsova, Alexander P. Rezvykh, Iuliia O. Guseva, Ana P. Dorador, Михаил Б. Евгеньев, S. Yu. Funikov · 2025 · International Journal of Molecular Sciences
- Principles Driving the Spatial Organization of Rho GTPase Signaling at SynapsesScott H. Soderling, Linda Van Aelst · 2014 · Springer eBooks
- Oncogenic Gαq activates RhoJ through PDZ-RhoGEFRodolfo Daniel Cervantes‐Villagrana, Víctor Manuel Color-Aparicio, Alejandro Castillo‐Kauil, Irving García‐Jiménez, Yarely Mabell Beltrán‐Navarro, Guadalupe Reyes‐Cruz, José Vázquez‐Prado · 2023 · International Journal of Molecular Sciences
- DeepCBS: shedding light on the impact of mutations occurring at CTCF binding sitesYiheng Wang, Xingli Guo, Zhixin Niu, Xiaotai Huang, Bingbo Wang, Lin Gao · 2024 · Frontiers in Genetics
- RhoGEF Tiam2 Regulates Glutamatergic Synaptic Transmission in Hippocampal CA1 Pyramidal NeuronsSadhna Rao, Feng Liang, Bruce E. Herring · 2024 · eNeuro
- The Role of the Swollen State in Cell ProliferationBehor Eleazar Cohen · 2024 · The Journal of Membrane Biology
- Leveraging AAV1-Rac1T17N to prevent experimental proliferative vitreoretinopathyDuo Li, Minli Linghu, Jisen Tang, Gukun Yang, Chuanwu Li, Hang Yao, Hetian Lei, Yikeng Huang, Xionggao Huang · 2025 · Journal of Translational Medicine
- Screening for Rho GTPase Modulators in Actin-Dependent Processes Exemplified by PhagocytosisDaniel Schlam, Sergio Grinstein, Spencer A. Freeman · 2018 · Methods in molecular biology
- Rac1b: An emerging therapeutic target for chemoresistance in colorectal cancerErik T. Goka, Marc E. Lippman · 2020 · Elsevier eBooks
- RETRACTED: ECT2 Increases the stability of EGFR and Tumorigenicity by Inhibiting Grb2 Ubiquitination in Pancreatic CancerJunxiong Wang, Shuo Yang, Li Min, Shengtao Zhu, Shuilong Guo, Shutian Zhang · 2021 · Frontiers in Oncology · Retracted
- LUAD And LUSC Cancer Classification, Biomarker Identification, and Pathway Analysis Using Overlapping Feature Selection MethodsJoseph M. Dhahbi, Joe W. Chen · 2021 · Research Square
- Association analysis of the perturbation of interactions in biological pathways and anticancer drug activityJunehawk Lee, Doheon Lee · 2016 · Biochemical and Biophysical Research Communications
- Targeting Rho, Rac, CDC42 GTPase Effector p21 Activated Kinases in Mutant K-Ras-Driven CancerAsfar Sohail Azmi, P. A. Philip · 2016 · Elsevier eBooks
- Short cationic peptides for gene delivery into cancer cellsSilvia Cirillo · 2017 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
- The Function of Fission Yeast Rho1-GEFs in the Control of Cell Growth and DivisionTomás Edreira, Elvira Manjón, Yolanda Sánchez · 2018 · InTech eBooks
- Nueva función del Rho-GEF Rgf1p en el mantenimiento de la estabilidad genómica en Schizosaccharomyces pombeElvira Manjón · 2017
- TARGETING THE ERK MAPK PATHWAY IN RAS-DRIVEN CANCERSMeagan B. Ryan · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
- Rho GTPases and RhoGDIs in the Regulation of Mast Cell DegranulationAvinash Sheshachalam · 2018 · ERA: Education and Research Archive (University of Alberta)
- Rho exchange factors in the regulation of squamous cell stemness and carcinogenesisLuis Francisco Lorenzo Martín · 2019 · Dialnet (Universidad de la Rioja)
- Validação de parceiros moleculares de Cdc42 em linhagens de células tumorais humanas submetidas a estresse genotóxicoLuiz Eduardo da Silva · 2019 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Examination of clinically-derived p210 BCR/ABL1 RhoGEF mutations in a murine bone marrow transplantation model of CMLBryan T. Ciccarelli, Tinghui Hu, Qing Wang, Julia J. Kim, Ian P. Whitehead · 2020 · Leukemia Research
- Global gene-expression analysis reveals the molecular processes underlying ClC-5 loss-of-function in novel Dent Disease 1 cellular modelsMónica Durán, Carla Burballa, Gerard Cantero-Recasens, Cristian M. Butnaru, Vivek Malhotra, Gema Ariceta, Eduard Sarró, Anna Meseguer · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Cytoskeletal Remodeling and Exocytosis During Mast Cell Activation is Controlled by the RhoA GEF, GEF-H1Yitian Guo · 2021 · ERA: Education and Research Archive (University of Alberta)
- WNT5A-RHOA axis is a new vulnerability in small-cell lung cancerKee‐Beom Kim, Dong Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bingliang Fang, Jae‐Il Park, Yi Zheng, Kwon-Sik Park · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Functional Interactions Between the Apoptosis Pathway and Cell Size Are Coordinated by the ced-3 Caspase – ect-2 RhoGEF AxisAditya Sethi, Hai Wei, Nikhil Mishra, Ioannis Segos, Eric J. Lambie, Esther Zanin, Barbara Conradt · 2022 · SSRN Electronic Journal
- Rho GTPasesMichael J. Lukey, Richard A. Cerione · 2015 · Elsevier eBooks
- Patent HighlightsHermann AM Mucke · 2013 · Pharmaceutical Patent Analyst
- The Radiobiology of Particle TherapyPiero Fossati, Slavisa Tubin, Eugen Boris Hug · 2022 · Wiley eBooks
- Rho GTPasesMichael J. Lukey, Yijian Qiu, Wen‐Hsuan Yang, Richard A. Cerione · 2022 · Elsevier eBooks
- ARHGEF18 is a flow-responding exchange factor controlling endothelial tight junctions and vascular leakageSurya Prakash Rao Batta, Marc Rio, Corentin Lebot, Céline Baron‐Menguy, Reda Moutaoukil, Robin Le Ruz, Gervaise Loirand, Anne-Clémence Vion · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung CancerKee‐Beom Kim, Dong-Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bong-Jun Kim, Bingliang Fang, Jae‐Il Park, Yi Zheng et al. · 2023
- Data from Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and GrowthDanielle R. Cook, Melissa S Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza, Dimitri G. Trembath, Verline Justilien, Karen A. Pickering, David F. Vincent, Armin Jarosch et al. · 2023
- Potential Mechanism of CDC42 Promoting HCC MetastasisMiaoling Tang, Rongni Feng, Jun Li · 2023 · Journal of Cellular Signaling
- Chromosome 5Sayooj Madhusoodanan, Saurav Panicker, Satish Ramalingam · 2023 · BENTHAM SCIENCE PUBLISHERS eBooks
- Ovarian Cancer G-Protein-Coupled Receptor 1 Inhibits Prostate Cancer Cell Migration Through the Downregulation of Casein Kinase 2 Alpha GenePuyam Milan Meitei, Naorem Tarundas Singh, Adhikarimayum Lakhikumar Sharma, Lisam Shanjukumar Singh · 2023 · Springer eBooks
- Pan-cancer Analysis of a Cytoskeleton Mobility related ARHGAP44 gene with Potential Implications in Cancer Prognosis Risk Prediction and Immune Landscape ModulationNingning Shen, Huijun Yang, Xuzhi Wang, Juan Du, Zhiqing Yang, Lei Miao, Siying Liu, Lifang Gao, Wenxia Ma, Chen Wang · 2023 · Research Square
- Interaction between Solo and PDZ-RhoGEF is involved in actin cytoskeletal remodeling and response to substrate stiffnessAoi Kunitomi, Shuhei Chiba, Nahoko Higashitani, Atsushi Higashitani, Shinichi Sato, Kensaku Mizuno, Kazumasa Ohashi · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Investigação da expressão de genes da família Rho GTPase em leucemia mieloide aguda e em síndromes mielodisplásicas e avaliação dos efeitos de um inibidor de Rho em células leucêmicasLuciana Bueno de Paiva · 2019
- Análise da fusão dos genes CLDN18-ARGHGAP26 no adenocarcinoma gástrico pós neodjuvância e sua correlação com expressão imuno-histoquímica das proteínas ARHGAP26, CLAUDINA 18, E-CADERINA em associação com aspectos clínicos-patológicosCarolline Fontes Alves Mariano · 2023
- Gα13 controls pharyngeal endoderm convergence by regulating E-cadherin expression and RhoA activationBo Hu, Joshua Pinzour, Asmi Patel, Faith Rooney, Amie Zerwic, Yuanyuan Gao, Nhan T. Nguyen, Huaping Xie, Ye Ding, Fang Hua Lin · 2024 · Development
- Missense variants at the p.Arg225 residue in ARHGEF40 identified in individuals with multiple congenital anomalies and developmental delayMelanie P. Napier, Erin Ryan, Adi Reich, Joshua A. Suhl, Diane Masser‐Frye, Marilyn C. Jones, Celese Beaudreau, Nathaniel H. Robin, Dana H. Goodloe, Leandra Folk et al. · 2025 · Human Genetics and Genomics Advances
- Actin cytoskeletal remodeling requires the interaction between Solo and LARG in response to substrate stiffnessAoi Kunitomi, Yusuke Toyofuku, Shuhei Chiba, Nahoko Higashitani, Atsushi Higashitani, Shinichi Sato, Kensaku Mizuno, Kazumasa Ohashi · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Rax1/2 promote memory of growth by early Ras1 activation to maintain polarity across generationsWalker H. Vickers, Maitreyi E. Das · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Mitogen-activated protein kinase pathway and four genes involved in the development of benign prostatic hyperplasia: in vivo and vitro validationJia‐Min Gu, Xing‐Pei Guo, Lan Wu, Luyao Li, Cong Zhu, Tong Deng, Shuang-Ying Wang, Cheng Fang, Xian‐Tao Zeng · 2025 · Frontiers in Immunology
- C3G deregulation uncovers a dual role in B-cell lymphoma: tumor suppression and enhanced metastasis via Rap1 and Rac2 signalingAlba Morán-Vaquero, Óscar Herranz, Ana Dávila-Hidalgo, Antonio Rodríguez-Blázquez, Cristina Fernández‐Infante, Ignacio García‐Tuñón, Elena Vuelta, Femke S. van der Meer, Coert Margadant, Carmen Guerrero et al. · 2025 · Cell Communication and Signaling
- Identification and validation of small molecule inhibitors for the Tiam1/SDC1 interactionJosue Alan Lopez · 2014
- Additional file 1 of Increased expression of ECT2 predicts the poor prognosis of breast cancer patientsYi, Ming, Zhang, Di, Song, Bin, Zhao, Bin, Mengke Niu, Yuze Wu, Zhijun Dai, Kongming Wu · 2023 · Figshare
- Additional file 1 of ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42Zhang, Xin, Ren, Liangliang, Wu, Junhua, Rongni Feng, Yunyang Chen, Li, Ronggang, Wu, Meimei, Mingzhu Zheng, Xing Gui Wu, Luo, Wanjun et al. · 2022 · Figshare
- The Role of the RhoA Activating Protein Net1 in Cancer Initiation and ProgressionYan Zuo, Stephanie A. Planque, Jeffrey A. Frost · 2025 · Molecular and Cellular Biology
- Solo regulates the localization and activity of LARG for actin cytoskeletal remodeling in cell-substrate adhesionsAoi Kunitomi, Yusuke Toyofuku, Chikaya Fujimori, Shuhei Chiba, Nahoko Higashitani, Atsushi Higashitani, Shinichi Sato, Kensaku Mizuno, Kazumasa Ohashi · 2026 · Molecular Biology of the Cell
- ARHGAP44 gene: a cytoskeleton mobility-related modulator with implications in pan-cancer prognostic risk and immune regulationWenxia Ma, Jiayao Li, H. J. Yang, Xuzhi Wang, Siying Liu, Lei Miao, Ningning Shen, Zhiqing Yang, Lifang Gao, Chen Wang · 2026 · Frontiers in Oncology
- Rôle de la GTPase atypique RhoU dans l'homéostasie intestinaleChaker Slaymi · 2014 · theses.fr (ABES)
- Identification and functional characterization of a novel Scribble phosphorylation siteMônica Silveira Wagner · 2019 · theses.fr (ABES)
- Conception de nano-anticorps conformationnels comme nouveaux outils d'étude de l'activité des GTPases de la sous-famille RHOALaura Keller · 2017 · theses.fr (ABES)
- Étude des paralogues ARHGAP35/p190A et ARHGAP5/p190B et de leur impact dans le cancer de l’endomètreM. Pinault · 2022 · theses.fr (ABES)
- Retinal ribbon synapses and the potential functional role of TIAM1: A structural and molecular perspectiveMartha Emil Adly · 2026 · Molecular vision
- GEFmeso restricts JAK/STAT signaling to regulate border cell migration in Drosophila melanogasterLiying Shi, Yuanyuan Song, Jiahang Li, Xiping Yu, Yanchao Wang, Ling Jiang, Enhui Shao, Ping Wan · 2026 · Insect Biochemistry and Molecular Biology
- Specificity Profiling of the RhoGEF Domain of FP10 with Rho GTPases Involved in Cytoskeleton Remodeling from Entamoeba histolyticaAvinash Kumar Gautam, Preeti Umarao, Samudrala Gourinath · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- ARHGEF18, un facteur d’échange nucléotidique mécano-sensible contrôlant les jonctions serrées de l’endothélium vasculaireIbtissam Babahnini, Surya Prakash Rao Batta, Céline Baron‐Menguy, Gervaise Loirand, Anne-Clémence Vion · 2026 · médecine/sciences
- The Rho guanine-nucleotide exchange factor P-Rex2 exhibits structural and regulatory features distinct from the related RhoGEF P-Rex1Lauren K. Anderson, Rohan Marde, Grace Muma, Veda Nayak, Chi Phan, Sheng Li, Jennifer N. Cash · 2026 · Journal of Biological Chemistry
- Early induction of the Rho-GEF ECT2 drives MEK/ERK oncogenic signaling in pancreatic ductal adenocarcinomaDania S. Al-Qasrawi, Nayya N. Murray, Ryan A. Argo, Alicia K. Fleming Martinez, Prita Pandya, Anaya Y. Clarke, Kayla C. Winter, Krishna Murli, Peter Störz, Nicole R. Murray et al. · 2026 · Oncogene
- Evaluation of FGD3 Expression in Advanced Prostate CancerBartosz Malinowski, Paulina Antosik, Layla Settaf-Cherif, Dariusz Grzanka, Michał Wiciński · 2026 · Biomedicines