USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability.
Open accessAbstract
DNA polymerase eta (Polη) has unique and pivotal functions in several DNA damage-tolerance pathways. Steady-state level of this short-lived protein is tightly controlled by multiple mechanisms including proteolysis. Here, we have identified the deubiquitinating enzyme (DUB), ubiquitin-specific protease 7 (USP7), as a novel regulator of Polη stability. USP7 regulates Polη stability through both indirect and direct mechanisms. Knockout of USP7 increased the steady-state level of Polη and slowed down the turnover of both Polη and p53 proteins through destabilizing their E3 ligase murine double minute 2 (Mdm2). Also, USP7 physically binds Polη in vitro and in vivo. Overexpression of wild-type USP7 but not its catalytically-defective mutants deubiquitinates Polη and increases its cellular steady-state level. Thus, USP7 directly serves as a specific DUB for Polη. Furthermore, ectopic expression of USP7 promoted the UV-induced proliferating cell nuclear antigen (PCNA) monoubiquitination in Polη-proficient but not in Polη-deficient XPV (Xeroderma pigmentosum variant) cells, suggesting that USP7 facilitates UV-induced PCNA monoubiquitination by stabilizing Polη. Taken together, our findings reveal a modulatory role of USP7 in PCNA ubiquitination-mediated stress-tolerance pathways by fine-tuning Polη turnover.
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USP7 has been proposed to regulate the stability of the TLS polymerase DNA polymerase eta (Pol η).
“USP7 has also been proposed to regulate the stability of the TLS polymerase, DNA polymerase eta (Pol η) (Qian et al., 2015).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Qian et al., 2015
Both depletion and over-expression of USP7 in cells were reported to enhance Pol η protein levels.
“Indeed, as evidence of this complexity, both the depletion and over-expression of USP7 in cells were reported to enhance Pol η protein levels (Qian et al., 2015).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Qian et al., 2015
This defect seems due to a role of USP7 in regulating ubiquitination of the PCNA sliding clamp.
“This defect seems due to a role of USP7 in regulating ubiquitination of the PCNA sliding clamp (Kashiwaba et al., 2015; Qian et al., 2015; Masuda et al., 2019).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Qian et al., 2015
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- Authors
- Qian, J., Pentz, K., Zhu, Q., Wang, Q., He, J., Srivastava, A. K., & Wani, A. A.
- Affiliations
- The Ohio State University (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Corresponding author
- Qian, J
- Wani, A A
- Venue
- Oncogene
- Published
- 2014-12-01
- Volume
- 34
- Issue
- 36
- Pages
- 4791-4796
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC4451444
- OpenAlex
- W2044856539
- Cited by
- 61
- References
- 22
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 1 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 6
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences (ES012991, ES023883, R01ES002388, R01ES012991, R21ES023883)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- USP7, DNA polymerase eta, PCNA monoubiquitination, protein stability, deubiquitination, MDM2, p53, UV-induced DNA damage, DNA damage tolerance, xeroderma pigmentosum variant, protein turnover
- MeSH terms
- Ubiquitin-Specific Peptidase 7, Y-Family DNA Polymerases, Animals, DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Enzyme Stability, Humans, Ultraviolet Rays, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Proliferating Cell Nuclear Antigen, Ubiquitin Thiolesterase, HCT116 Cells, Mice, Proto-Oncogene Proteins c-mdm2, Ubiquitination, Gene Knockout Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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