DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.
Abstract
Correct control of DNA replication is crucial to maintain genomic stability in dividing cells. Inappropriate re-licensing of replicated origins is associated with chromosomal instability (CIN), a hallmark of cancer progression that at the same time provides potential opportunities for therapeutic intervention. Geminin is a critical inhibitor of the DNA replication licensing factor Cdt1. To properly achieve its functions, Geminin levels are tightly regulated through the cell cycle by ubiquitin-dependent proteasomal degradation, but the de-ubiquitinating enzymes (DUBs) involved had not been identified. Here we report that DUB3 and USP7 control human Geminin. Overexpression of either DUB3 or USP7 increases Geminin levels through reduced ubiquitination. Conversely, depletion of DUB3 or USP7 reduces Geminin levels, and DUB3 knockdown increases re-replication events, analogous to the effect of Geminin depletion. In exploring potential clinical implications, we found that USP7 and Geminin are strongly correlated in a cohort of invasive breast cancers (P<1.01E-08). As expected, Geminin expression is highly prognostic. Interestingly, we found a non-monotonic relationship between USP7 and breast cancer-specific survival, with both very low or high levels of USP7 associated with poor outcome, independent of estrogen receptor status. Altogether, our data identify DUB3 and USP7 as factors that regulate DNA replication by controlling Geminin protein stability, and suggest that USP7 may be involved in Geminin dysregulation during breast cancer progression.
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USP7 over-expression contributes to breast cancer progression by stabilizing Geminin.
“As Geminin is a substrate of USP7, these findings suggest USP7 over-expression contributes to breast cancer progression by stabilizing Geminin (Hernández-Pérez et al., 2017).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Hernández-Pérez et al., 2017
USP7 and Geminin protein levels were strongly correlated in a cohort of invasive breast cancers.
“In this study, USP7 and Geminin protein levels were strongly correlated in a cohort of invasive breast cancers.”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Hernández-Pérez et al., 2017
A non-monotonic relationship was observed between USP7 expression and breast cancer survival, where both low and high levels of USP7 were associated with poor outcome.
“Indeed, in one study, a non-monotonic relationship was observed between USP7 expression and breast cancer survival, where both low and high levels of USP7 were associated with poor outcome (Hernández-Pérez et al., 2017).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Hernández-Pérez et al., 2017
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- Authors
- Hernández-Pérez, S., Cabrera, E., Salido, E., Lim, M., Reid, L., Lakhani, S. R., Khanna, K. K., Saunus, J. M., & Freire, R.
- Affiliations
- Hospital Universitario de Canarias (ES)
- The University of Queensland (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Corresponding author
- Saunus, J M
- Freire, R
- Venue
- Oncogene
- Published
- 2017-03-13
- Volume
- 36
- Issue
- 33
- Pages
- 4802-4809
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2595502531
- Cited by
- 61
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 8 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 8
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Update notices
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Economía y Competitividad
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- geminin, USP7, deubiquitinase, DNA replication licensing, Cdt1, chromosomal instability, re-replication, ubiquitination, protein stability, breast cancer, prognostic factors, breast cancer-specific survival, estrogen receptor status
- MeSH terms
- Ubiquitin-Specific Peptidase 7, Breast Neoplasms, Cell Cycle, DNA Replication, Humans, Neoplasm Invasiveness, Endopeptidases, Prognosis, Disease Progression, Cell Cycle Proteins, Ubiquitin, RNA, Small Interfering, Chromosomal Instability, Ubiquitin Thiolesterase, Cell Line, Tumor, Kaplan-Meier Estimate, Ubiquitination, Protein Stability, HEK293 Cells, Geminin
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