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Cited by 198Nutrition and Health in AgingHormonal and reproductive studiesProstate Cancer Treatment and Research

Reduced muscle strength and functional performance in men with prostate cancer undergoing androgen suppression: a comprehensive cross-sectional investigation

Galvão, D A, Taaffe, D R, Spry, N, Joseph, D, Turner, D, Newton, R U·2009·Prostate Cancer and Prostatic Diseases
DOI 10.1038/pcan.2008.51
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Abstract

This study examined the effects of androgen suppression therapy (AST) on upper and lower body muscle strength and a range of direct measures of physical performance using a cross-sectional design with 118 men (48 men undertaking AST for prostate cancer and 70 healthy aged-matched controls) from a single tertiary center. Primary end points included muscle strength for the upper- and lower-body; functional performance--repeated chair rise, usual and fast 6-m walk, 6-m backwards walk and 400-m walk time; and dual-energy X-ray absorptiometry assessment--whole body, regional soft tissue composition and bone mineral density (BMD). Men on AST had significantly reduced muscle strength for the upper- and lower-body and impaired functional performance compared to controls (P<0.05). As expected, AST patients had significantly lower whole-body and hip BMD and higher percent of body fat than controls (P<0.05), and tended to have lower whole-body lean mass (-2.3 kg, P=0.077). Appendicular skeletal muscle was positively associated with upper-body (r=0.400-0.606, P<0.001) and lower-body (r=0.549-0.588, P<0.001) muscle strength, and strength was related to functional performance. Men undertaking AST were consistently impaired across a broad range of physical and functional musculoskeletal performance assessments compared with their age-matched normal controls. These findings are relevant for those patients considering AST for subclinical disease management, but whose physical reserve is marginal. Strategies to counter these adverse effects of AST need to be initiated so that independent living and quality of life can be maintained.

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Authors
Galvão, D. A., Taaffe, D. R., Spry, N., Joseph, D., Turner, D., & Newton, R. U.
Affiliations
  • The University of Queensland (AU)
  • The University of Western Australia (AU)
  • Edith Cowan University (AU)
ORCID
Venue
Prostate Cancer and Prostatic Diseases
Publisher
Springer Science and Business Media LLC
Published
2008-10-14
Volume
12
Issue
2
Pages
198-203
ISSN
  • 1365-7852 (ISSN-L)
  • 1476-5608
DOI
10.1038/pcan.2008.51
OpenAlex
W1990869186
Cited by
198
References
35
Citations by year
2026: 2 · 2025: 1 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 13 · 2019: 12 · 2018: 13 · 2017: 14 · 2016: 8 · 2015: 17 · 2014: 15 · 2013: 23 · 2012: 13
FWCI
6.09
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Prostate Cancer and Prostatic Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Australasian Journal of Paramedicine (submittedVersion)
Funders
Cancer Australia
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Keywords
androgen deprivation therapy, prostate cancer, muscle strength, functional performance, physical performance, bone mineral density, lean body mass, fat mass, walking performance, quality of life, older men
MeSH terms
Aged, Androgen Antagonists, Cross-Sectional Studies, Exercise Therapy, Humans, Gonadotropin-Releasing Hormone, Male, Physical Endurance, Prostatic Neoplasms, Absorptiometry, Photon, Bone Density, Muscle, Skeletal, Muscle Weakness, Muscle Strength

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