The DOI matches its Crossref record; 216 of the 217 references it cites were found in a registry or an index.
Hypothalamic control of energy expenditure and thermogenesis
Open accessAbstract
Energy expenditure and energy intake need to be balanced to maintain proper energy homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the hypothalamus is the primary center for the regulation of energy balance. The hypothalamus exerts its effect through both humoral and neuronal mechanisms, and each hypothalamic area has a distinct role in the regulation of energy expenditure. Recent studies have advanced the understanding of the molecular regulation of energy expenditure and thermogenesis in the hypothalamus with targeted manipulation techniques of the mouse genome and neuronal function. In this review, we elucidate recent progress in understanding the mechanism of how the hypothalamus affects basal metabolism, modulates physical activity, and adapts to environmental temperature and food intake changes.
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“The hypothalamus has a critical role in maintaining body temperature via circulating humoral signals (eg, thyroid hormone) and regulation of nervous system inputs (eg, sympathetic tone) (78).”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [78]
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Obesity: A Review of Pathophysiology and Classification
Busebee, B. T., Ghusn, W., Cifuentes, L., & Acosta, A. J. (2023) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2023.05.026 · Cited by 192
Reytor-González, C., Simancas-Racines, D., Román-Galeano, N. M., Annunziata, G., Galasso, M., Zambrano-Villacres, R., Verde, L., Muscogiuri, G., Frias-Toral, E., & Barrea, L. (2025) · Nutrients · doi:10.3390/nu17132135 · Cited by 88
Diagnostic criteria for the hypothalamic syndrome in childhood
van Santen, H. M., van Schaik, J., van Roessel, I. M. A. A., Beckhaus, J., Boekhoff, S., & Müller, H. L. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad009 · Cited by 67
An Expanding Role for Nonvisual Opsins in Extraocular Light Sensing Physiology
Andrabi, M., Upton, B. A., Lang, R. A., & Vemaraju, S. (2023) · Annual Review of Vision Science · doi:10.1146/annurev-vision-100820-094018 · Cited by 69
Obesity: A Global Health Challenge Demanding Urgent Action
Abad‐Jiménez, Z., & Vezza, T. (2025) · Biomedicines · doi:10.3390/biomedicines13020502 · Cited by 67
Metadata
- Authors
- Tran, L. T., Park, S., Kim, S. K., Lee, J. S., Kim, K. W., & Kwon, O.
- Affiliations
- Seoul National University (KR)
- Yonsei University (KR)
- Corresponding author
- Kim, Seul Ki
- Kim, Ki Woo
- Kwon, Obin
- Venue
- Experimental & Molecular Medicine
- Published
- 2022-03-17
- Volume
- 54
- Issue
- 4
- Pages
- 358-369
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- PMC
- PMC9076616
- OpenAlex
- W4220699785
- Cited by
- 208
- References
- 217
- Citations by year
- 2026: 47 · 2025: 60 · 2024: 58 · 2023: 35 · 2022: 6
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Experimental & Molecular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Research Foundation of Korea (2018R1C1B5086453, 2020R1C1C1008033, 2016R1A5A2008630, 2021R1A2C4002011)
- Creative-Pioneering Researchers Program through Seoul National University
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- hypothalamus, energy expenditure, thermogenesis, energy homeostasis, basal metabolic rate, physical activity, dietary intake, neuronal regulation, molecular regulation
- MeSH terms
- Animals, Energy Metabolism, Homeostasis, Hypothalamus, Neurons, Thermogenesis, Mice
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