Cited by 84Reproductive tract infections researchGut microbiota and healthVitamin D Research Studies

Relationship between vitamin D status and the vaginal microbiome during pregnancy

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Jefferson, Kimberly K., Parikh, Hardik I., Garcia, Erin M., Edwards, David J., Serrano, Myrna G., Hewison, Martin, Shary, Judith R., Powell, Anna M. +5 more·2019·Journal of Perinatology

Abstract

Objective Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome.Study design Subjects were assigned to a treatment (4400 IU) or a control group (400 IU vitamin D daily), sampled three times during pregnancy, and vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D [25(OH)D] concentrations were examined.Result Gestational age and ethnicity were significantly associated with the microbiome. Megasphaera correlated negatively (p = 0.0187) with 25(OH)D among women of African ancestry. Among controls, women of European ancestry exhibited a positive correlation between plasma 25(OH)D and L. crispatus abundance.Conclusion Certain vaginal bacteria are associated with plasma 25(OH)D concentration.

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  • The PTB-associated vaginal taxa were also associated with low levels of vitamin D.

    “Notably, these taxa were also associated with low levels of vitamin D63”

    From The Integrative Human Microbiome Project (2019) · cites this paper as [63]

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Authors
Jefferson, K. K., Parikh, H. I., Garcia, E. M., Edwards, D. J., Serrano, M. G., Hewison, M., Shary, J. R., Powell, A. M., Hollis, B. W., Fettweis, J. M., Strauss III, J. F., Buck, G. A., & Wagner, C. L.
Affiliations
  • Virginia Commonwealth University (US)
  • University of Birmingham (GB)
  • Medical University of South Carolina (US)
  • Johns Hopkins University (US)
Corresponding author
  • Buck, Gregory A.
  • Wagner, Carol L.
Venue
Journal of Perinatology
Published
2019-03-11
Volume
39
Issue
6
Pages
824-836
ISSN
  • 0743-8346 (ISSN-L)
  • 1476-5543
OpenAlex
W2920797095
Cited by
84
References
62
Citations by year
2026: 4 · 2025: 9 · 2024: 5 · 2023: 11 · 2022: 14 · 2021: 30 · 2020: 8 · 2019: 3
FWCI
10.10
Type
journal article
Language
en
Open access
Locations
  • Journal of Perinatology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Health & Human Services | National Institutes of Health (U54 DE023786, U54 DE023786-01)
  • W.K. Kellogg Foundation (UL1 TR000062)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
Keywords
vitamin D status, vaginal microbiota, bacterial vaginosis, pregnancy, 25-hydroxyvitamin D, Lactobacillus crispatus, Megasphaera, African ancestry, ethnicity, gestational age, 16S rRNA gene sequencing, plasma vitamin D
MeSH terms
Adolescent, Adult, Female, Gestational Age, Humans, Pregnancy, Vagina, Vitamin D, Vitamins, Vaginosis, Bacterial, Microbiota

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