Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women
Open accessAbstract
Significance: Premature birth (PTB) is a major global public health burden. Previous studies have suggested an association between altered vaginal microbiota composition and PTB, although findings across studies have been inconsistent. To address these inconsistencies, improve upon our previous signature, and better understand the vaginal microbiota’s role in PTB, we conducted a case-control study in two cohorts of pregnant women: one predominantly Caucasian at low risk of PTB, the second predominantly African American at high risk. With the results, we were able to replicate our signature in the first cohort and refine our signature of PTB for both cohorts. Our findings elucidate the ecology of the vaginal microbiota and advance our ability to predict and understand the causes of PTB.
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Women who went on to experience spontaneous PTB were less likely to exhibit a vaginal microbiota dominated by Lactobacillus crispatus.
“Women who went on to experience spontaneous PTB were less likely to exhibit a vaginal microbiota dominated by Lactobacillus crispatus, as previously reported in other populations59–62”
From The Integrative Human Microbiome Project (2019) · cites this paper as [60]
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- Authors
- Callahan, B. J., DiGiulio, D. B., Goltsman, D. S. A., Sun, C. L., Costello, E. K., Jeganathan, P., Biggio, J. R., Wong, R. J., Druzin, M. L., Shaw, G. M., Stevenson, D. K., Holmes, S. P., & Relman, D. A.
- Affiliations
- North Carolina State University (US)
- VA Palo Alto Health Care System (US)
- Stanford Medicine (US)
- Stanford University (US)
- University of Alabama at Birmingham (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-08-28
- Volume
- 114
- Issue
- 37
- Pages
- 9966-9971
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5604014
- OpenAlex
- W2749873900
- Cited by
- 391
- References
- 48
- Citations by year
- 2026: 24 · 2025: 28 · 2024: 49 · 2023: 54 · 2022: 62 · 2021: 55 · 2020: 49 · 2019: 37 · 2018: 29 · 2017: 3
- FWCI
- 26.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- March of Dimes Foundation (Prematurity Research Center at Stanford)
- HHS | NIH | National Center for Advancing Translational Sciences (UL1 TR001085)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- preterm birth, vaginal microbiota, microbial signatures, bacterial vaginosis, African American women, white women, racial differences, pregnancy, microbial ecology, preterm birth prediction
- MeSH terms
- Adult, Black or African American, DNA Replication, Female, Gardnerella vaginalis, Humans, Lactobacillus, Pregnancy, RNA, Ribosomal, 16S, United States, Vagina, Cohort Studies, Case-Control Studies, White People, Premature Birth, Microbiota
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