International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators
Open accessAbstract
Depression is disabling and highly prevalent. Intravenous (IV) ketamine displays rapid-onset antidepressant properties, but little is known regarding which patients are most likely to benefit, limiting personalized prescriptions. We identified randomized controlled trials of IV ketamine that recruited individuals with a relevant psychiatric diagnosis (e.g., unipolar or bipolar depression; post-traumatic stress disorder), included one or more control arms, did not provide any other study-administered treatment in conjunction with ketamine (although clinically prescribed concurrent treatments were allowable), and assessed outcome using either the Montgomery-Åsberg Depression Rating Scale or the Hamilton Rating Scale for Depression (HRSD-17). Individual patient-level data for at least one outcome was obtained from 17 of 25 eligible trials [pooled n = 809]. Rates of participant-level data availability across 33 moderators that were solicited from these 17 studies ranged from 10.8% to 100% (median = 55.6%). After data harmonization, moderators available in at least 40% of the dataset were tested sequentially, as well as with a data-driven, combined moderator approach. Robust main effects of ketamine on acute [~24-hours; β *(95% CI) = 0.58 (0.44, 0.72); p < 0.0001] and post-acute [~7 days; β *(95% CI) = 0.38 (0.23, 0.54); p < 0.0001] depression severity were observed. Two study-level moderators emerged as significant: ketamine effects (relative to placebo) were larger in studies that required a higher degree of previous treatment resistance to federal regulatory agency-approved antidepressant medications (≥2 failed trials) for study entry; and in studies that used a crossover design. A comprehensive data-driven search for combined moderators identified statistically significant, but modest and clinically uninformative, effects (effect size r ≤ 0.29, a small-medium effect). Ketamine robustly reduces depressive symptoms in a heterogeneous range of patients, with benefit relative to placebo even greater in patients more resistant to prior medications. In this largest effort to date to apply precision medicine approaches to ketamine treatment, no clinical or demographic patient-level features were detected that could be used to guide ketamine treatment decisions. Review Registration: PROSPERO Identifier: CRD42021235630
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Clinical response to ketamine/esketamine is highly heterogeneous, and robust predictors are lacking.
“Clinical response is highly heterogeneous, and robust predictors are lacking, underscoring the need for biomarkers and stratified treatment strategies [85,91,92,93].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [91]
The Conclusions report substantial individual differences in response to IV ketamine and limited ability to predict response before a first infusion. The Limitations state that intranasal esketamine trials were not included, so this paper does not establish the same point for esketamine. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410 · see citing works
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
Self-citationA randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
Self-citationMeta-analysis of individual participant data: rationale, conduct, and reporting
Riley, R. D., Lambert, P. C., & Abo-Zaid, G. (2010) · BMJ · doi:10.1136/bmj.c221 · Cited by 1,701 · see citing works
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Zanos, P., Moaddel, R., Morris, P. J., Georgiou, P., Fischell, J., Elmer, G. I., Alkondon, M., Yuan, P., Pribut, H. J., Singh, N. S., et al. (2016) · Nature · doi:10.1038/nature17998 · Cited by 1,609 · see citing works
Self-citationMurrough, J. W., Iosifescu, D. V., Chang, L. C., Al Jurdi, R. K., Green, C. E., Perez, A. M., Iqbal, S., Pillemer, S., Foulkes, A., Shah, A., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13030392 · Cited by 1,205 · see citing works
Self-citationDiazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., Kammerer, W. A., Quezado, Z., Luckenbaugh, D. A., Salvadore, G., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.90 · Cited by 963 · see citing works
Self-citationZarate, C. A., Brutsche, N. E., Ibrahim, L., Franco-Chaves, J., Diazgranados, N., Cravchik, A., Selter, J., Marquardt, C. A., Liberty, V., & Luckenbaugh, D. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.010 · Cited by 811 · see citing works
Self-citationMcIntyre, R. S., Rosenblat, J. D., Nemeroff, C. B., Sanacora, G., Murrough, J. W., Berk, M., Brietzke, E., Dodd, S., Gorwood, P., Ho, R., et al. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20081251 · Cited by 731 · see citing works
Self-citationFeder, A., Parides, M. K., Murrough, J. W., Perez, A. M., Morgan, J. E., Saxena, S., Kirkwood, K., aan het Rot, M., Lapidus, K. A. B., Wan, L.-B., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.62 · Cited by 613 · see citing works
Self-citationA Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders
Sanacora, G., Frye, M. A., McDonald, W., Mathew, S. J., Turner, M. S., Schatzberg, A. F., Summergrad, P., Nemeroff, C. B., & for the American Psychiatric Association (APA) Council of Research Task Force on Novel Biomarkers and Treatments (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0080 · Cited by 576 · see citing works
Self-citationFava, M., Freeman, M. P., Flynn, M., Judge, H., Hoeppner, B. B., Cusin, C., Ionescu, D. F., Mathew, S. J., Chang, L. C., Iosifescu, D. V., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0256-5 · Cited by 433 · see citing works
Self-citationGrunebaum, M. F., Galfalvy, H. C., Choo, T.-H., Keilp, J. G., Moitra, V. K., Parris, M. S., Marver, J. E., Burke, A. K., Milak, M. S., Sublette, M. E., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17060647 · Cited by 431 · see citing works
Self-citationPhillips, J. L., Norris, S., Talbot, J., Birmingham, M., Hatchard, T., Ortiz, A., Owoeye, O., Batten, L. A., & Blier, P. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.18070834 · Cited by 418 · see citing works
Self-citationSuicidal risk factors and completed suicide: meta-analyses based on psychological autopsy studies
Yoshimasu, K., Kiyohara, C., Miyashita, K., & The Stress Research Group of the Japanese Society for Hygiene (2008) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-008-0037-x · Cited by 375 · see citing works
Esketamine for Treatment-Resistant Depression — First FDA-Approved Antidepressant in a New Class
Kim, J., Farchione, T., Potter, A., Chen, Q., & Temple, R. (2019) · New England Journal of Medicine · doi:10.1056/nejmp1903305 · Cited by 333 · see citing works
Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial
Murrough, J. W., Soleimani, L., DeWilde, K. E., Collins, K. A., Lapidus, K. A., Iacoviello, B. M., Lener, M., Kautz, M., Kim, J., Stern, J. B., et al. (2015) · Psychological Medicine · doi:10.1017/s0033291715001506 · Cited by 297 · see citing works
Self-citationMeta‐analysis of continuous outcomes combining individual patient data and aggregate data
Riley, R. D., Lambert, P. C., Staessen, J. A., Wang, J., Gueyffier, F., Thijs, L., & Boutitie, F. (2007) · Statistics in Medicine · doi:10.1002/sim.3165 · Cited by 280 · see citing works
Salvadore, G., Cornwell, B. R., Colon-Rosario, V., Coppola, R., Grillon, C., Zarate, C. A., & Manji, H. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.014 · Cited by 277 · see citing works
Self-citationEmpirical Evaluation of Very Large Treatment Effects of Medical Interventions
Pereira, T. V., Horwitz, R. I., & Ioannidis, J. P. A. (2012) · JAMA · doi:10.1001/jama.2012.13444 · Cited by 257 · see citing works
Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects
Nugent, A. C., Ballard, E. D., Gould, T. D., Park, L. T., Moaddel, R., Brutsche, N. E., & Zarate, C. A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0028-2 · Cited by 250 · see citing works
Self-citationFeder, A., Costi, S., Rutter, S. B., Collins, A. B., Govindarajulu, U., Jha, M. K., Horn, S. R., Kautz, M., Corniquel, M., Collins, K. A., et al. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20050596 · Cited by 246 · cited 1× · see citing works
“Although previous studies suggest that response to a single, first infusion of ketamine is a fairly robust predictor of response to subsequent, serial infusions [45], some [46, 47] (but not all [48]) findings suggest enhanced outcomes can be achieved even among first infusion non-responders through sustained treatment.”
ResultSelf-citationMarcantoni, W. S., Akouamba, B. S., Wassef, M., Mayrand, J., Lai, H., Richard‐Devantoy, S., & Beauchamp, S. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.007 · Cited by 246 · see citing works
Xu, Y., Hackett, M., Carter, G., Loo, C., Gálvez, V., Glozier, N., Glue, P., Lapidus, K., McGirr, A., Somogyi, A. A., et al. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv124 · Cited by 226 · see citing works
Salvadore, G., Cornwell, B. R., Sambataro, F., Latov, D. R., Colon-Rosario, V., Carver, F. W., Holroyd, T., Diazgranados, N., Machado‐Vieira, R., Grillon, C., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.24 · Cited by 217 · see citing works
Self-citationLaje, G., Lally, N., Mathews, D., Brutsche, N., Chemerinski, A., Akula, N., Kelmendi, B., Simen, A., McMahon, F. J., Sanacora, G., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.031 · Cited by 213 · see citing works
Self-citationMatveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209 · cited 11× · see citing works
“PubMed was searched over the period from inception to 01/19/2021 using the auto-expanding option encompassing all terms and synonyms related to the following search: “ketamine AND (randomized or RCT) AND depress*”.”
BackgroundInfluentialSu, T., Chen, M., Li, C., Lin, W.-C., Hong, C., Gueorguieva, R. V., Tu, P., Bai, Y., Cheng, C., & Krystal, J. H. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.94 · Cited by 208 · see citing works
Self-citationFranceschelli, A., Sens, J. P., Herchick, S., Thelen, C., & Pitychoutis, P. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.008 · Cited by 195 · see citing works
(2013) · PubMed · Cited by 192 · see citing works
Kiraly, D. D., Horn, S. R. G.-V., Dam, N. T. V., Costi, S., Kirshenbaum, J. S., Kim‐Schulze, S., Patel, M., Hodes, G. E., Russo, S. J., Mérad, M., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.31 · Cited by 188 · see citing works
Self-citationThe effect of intravenous, intranasal, and oral ketamine in mood disorders: A meta-analysis
McIntyre, R. S., Carvalho, I. P., Lui, L. M. W., Majeed, A., Masand, P. S., Gill, H., Rodrigues, N. B., Lipsitz, O., Coles, A. C., Lee, Y., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.06.050 · Cited by 187 · see citing works
Ketamine and other glutamate receptor modulators for depression in adults
Caddy, C., Amit, B. H., McCloud, T. L., Rendell, J. M., Furukawa, T. A., McShane, R., Hawton, K., & Cipriani, A. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011612.pub2 · Cited by 174 · see citing works
Grunebaum, M. F., Ellis, S. P., Keilp, J. G., Moitra, V. K., Cooper, T. B., Marver, J. E., Burke, A. K., Milak, M. S., Sublette, M. E., Oquendo, M. A., et al. (2017) · Bipolar Disorders · doi:10.1111/bdi.12487 · Cited by 174 · see citing works
Self-citationDwyer, J. B., Landeros‐Weisenberger, A., Johnson, J. A., Tobón, A. L., Flores, J. M., Nasir, M., Couloures, K. G., Sanacora, G., & Bloch, M. H. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20010018 · Cited by 172 · see citing works
Wallace, M. L., Frank, E., & KRAEMER, H. C. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1960 · Cited by 166 · see citing works
Self-citationClinical Predictors of Ketamine Response in Treatment-Resistant Major Depression
Niciu, M. J., Luckenbaugh, D. A., Ionescu, D. F., Guevara, S., Machado-Vieira, R., Richards, E. M., Brutsche, N. E., Nolan, N. M., & Zarate, C. A. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08698 · Cited by 165 · see citing works
Self-citationMurrough, J. W., Burdick, K. E., Levitch, C. F., Perez, A. M., Brallier, J. W., Chang, L. C., Foulkes, A., Charney, D. S., Mathew, S. J., & Iosifescu, D. V. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.298 · Cited by 142 · see citing works
Self-citationA Survey of the Clinical, Off-Label Use of Ketamine as a Treatment for Psychiatric Disorders
Wilkinson, S. T., Toprak, M., Turner, M. S., Levine, S. P., Katz, R. B., & Sanacora, G. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17020239 · Cited by 125 · see citing works
Self-citationTranslating the HAM-D into the MADRS and vice versa with equipercentile linking
Leucht, S., Fennema, H., Engel, R. R., Kaspers–Janssen, M., & Szegedi, A. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.042 · Cited by 117 · see citing works
Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate
Downey, D., Dutta, A., McKie, S., Dawson, G. R., Dourish, C. T., Craig, K., Smith, M. A., McCarthy, D. J., Harmer, C. J., Goodwin, G. M., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.006 · Cited by 116 · see citing works
Shiroma, P. R., THURAS, P. D., Wels, J., Albott, C. S., Erbes, C. R., Tye, S. J., & Lim, K. O. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00897-0 · Cited by 115 · see citing works
Self-citationRong, C., Park, C., Rosenblat, J. D., Subramaniapillai, M., Zuckerman, H., Fus, D., Lee, Y. L., Pan, Z., Brietzke, E., Mansur, R. B., et al. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15040771 · Cited by 114 · see citing works
Ketamine and other glutamate receptor modulators for depression in bipolar disorder in adults
McCloud, T. L., Caddy, C., Jochim, J., Rendell, J. M., Diamond, P. R., Shuttleworth, C., Brett, D., Amit, B. H., McShane, R., Hamadi, L., et al. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011611.pub2 · Cited by 102 · see citing works
A Word to the Wise About Ketamine
Schatzberg, A. F. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13101434 · Cited by 102 · see citing works
Tiger, M., Veldman, E. R., Ekman, C.-J., Halldin, C., Svenningsson, P., & Lundberg, J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0844-4 · Cited by 81 · see citing works
Self-citationPennybaker, S. J., Niciu, M. J., Luckenbaugh, D. A., & Zarate, C. A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.10.026 · Cited by 77 · see citing works
Self-citationAbdallah, C. G., Dutta, A., Averill, C. L., McKie, S., Akiki, T. J., Averill, L. A., & William Deakin, J. F. (2018) · Chronic Stress · doi:10.1177/2470547018796102 · Cited by 70 · see citing works
Self-citationSumner, R. L., McMillan, R. L., Spriggs, M. J., Campbell, D. A., Malpas, G. A., Maxwell, E., Deng, C., Hay, J., Ponton, R., Kirk, I. J., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.07.002 · Cited by 69 · see citing works
Self-citationSimultaneous EEG/fMRI recorded during ketamine infusion in patients with major depressive disorder
McMillan, R. L., Sumner, R. L., Forsyth, A., Campbell, D. A., Malpas, G. A., Maxwell, E., Deng, C., Hay, J., Ponton, R., Sundram, F., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109838 · Cited by 63 · see citing works
Self-citationA retrospective analysis of ketamine intravenous therapy for depression in real-world care settings
McInnes, L. A., Qian, J. J., Gargeya, R. S., DeBattista, C., & Heifets, B. D. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.12.097 · Cited by 63 · see citing works
Niciu, M. J., Luckenbaugh, D. A., Ionescu, D. F., Richards, E. M., Voort, J. L. V., Ballard, E. D., Brutsché, N. E., Furey, M. L., & Zarate, C. A. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu039 · Cited by 56 · see citing works
Self-citationThe Antidepressant Effect of Ketamine Is Dampened by Concomitant Benzodiazepine Medication
Andrashko, V., Novák, T., Brunovský, M., Klírová, M., Šóš, P., & Horáček, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00844 · Cited by 48 · see citing works
A randomized, prospective pilot study of patient expectancy and antidepressant outcome
Rutherford, B., Marcus, S., Wang, P., Sneed, J. R., Pelton, G. H., Devanand, D. P., Duan, N., & Roose, S. P. (2012) · Psychological Medicine · doi:10.1017/s0033291712001882 · Cited by 43 · see citing works
The role of day-to-day emotions, sleep, and social interactions in pediatric anxiety treatment
Wallace, M. L., McMakin, D. L., Tan, P. Z., Rosen, D. K., Forbes, E. E., Ladouceur, C. D., Ryan, N. D., Siegle, G. J., Dahl, R. E., Kendall, P. C., et al. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2016.12.012 · Cited by 39 · see citing works
Self-citationSmagula, S. F., Wallace, M. L., Anderson, S., Karp, J. F., Lenze, E. J., Mulsant, B. H., Butters, M. A., Blumberger, D. M., Diniz, B. S., Lotrich, F. E., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.005 · Cited by 33 · see citing works
Self-citationChen, M., Kao, C., Tsai, S., Li, C., Lin, W.-C., Hong, C., Bai, Y., Tu, P., & Su, T. (2020) · Genomics · doi:10.1016/j.ygeno.2020.12.030 · Cited by 33 · see citing works
Self-citationLijffijt, M., Murphy, N., Iqbal, S., Green, C. E., Iqbal, T., Chang, L. C., Haile, C. N., Hirsch, L. C., Ramakrishnan, N., Fall, D. A., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01242-9 · Cited by 28 · see citing works
Self-citationMcGrory, C. L., Ryan, K. M., Gallagher, B., & McLoughlin, D. M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.04.013 · Cited by 19 · see citing works
Self-citationDistinct trajectories of antidepressant response to intravenous ketamine
O’Brien, B., Lijffijt, M., Lee, J., Kim, Y. S., Wells, A. A., Murphy, N., Ramakrishnan, N., Swann, A. C., & Mathew, S. J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.03.006 · Cited by 17 · see citing works
Self-citationVeldman, E. R., Mamula, D., Jiang, H., Tiger, M., Ekman, C. J., Lundberg, J., & Svenningsson, P. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.04.055 · Cited by 10 · see citing works
Self-citationZilcha‐Mano, S., Wallace, M. L., Brown, P. J., Sneed, J. R., Roose, S. P., & Rutherford, B. R. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01606-1 · Cited by 10 · see citing works
Self-citationWallace, M. L., Banihashemi, L., O'Donnell, C. P., Nimgaonkar, V. L., Kodavali, C. V., McNamee, R. L., & Germain, A. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.07.051 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [26]Collaboration TC: Chapter 8: assessing risk of bias in included studies. In: Higgins JPGS, editor. Cochrane Handbook for Systematic Reviews of Interventions Version 510 (http://handbookcochraneorg/), The Cochrane Collaboration, 2011
Cited by
Sorted by citations
History repeating: guidelines to address common problems in psychedelic science
van Elk, M., & Fried, E. I. (2023) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253231198466 · Cited by 137 · see citing works
Jha, M. K., & Mathew, S. J. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230025 · Cited by 117 · see citing works
Self-citationLullau, A. P. M., Haga, E. M. W., Ronold, E. H., & Dwyer, G. E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1223145 · Cited by 63 · see citing works
Pettorruso, M., Guidotti, R., d’Andrea, G., Risio, L. D., D’Andrea, A., Chiappini, S., Carullo, R., Barlati, S., Zanardi, R., Rosso, G., et al. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115378 · Cited by 60 · see citing works
Hashimoto, K. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01770-7 · Cited by 54 · see citing works
Medeiros, G. C., Matheson, M., Demo, I., Reid, M. J., Matheson, S., Twose, C., Smith, G. S., Gould, T. D., Zarate, C. A., Barrett, F. S., et al. (2023) · The Lancet Psychiatry · doi:10.1016/s2215-0366(23)00183-9 · Cited by 49 · see citing works
Self-citationPersonalized use of ketamine and esketamine for treatment-resistant depression
Medeiros, G. C., Demo, I., Goes, F. S., Zarate, C. A., & Gould, T. D. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03180-8 · Cited by 41 · see citing works
Self-citationKetamine vs Electroconvulsive Therapy for Treatment-Resistant Depression
Jha, M. K., Wilkinson, S. T., Krishnan, K., Collins, K. A., Sanacora, G., Murrough, J. W., Goes, F. S., Altinay, M. I., Aloysi, A. S., Asghar‐Ali, A. A., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.17786 · Cited by 30 · see citing works
Self-citationDuarte, Y., Quintana-Donoso, D., Moraga‐Amaro, R., Jiménez-Dinamarca, I., Lemunao-Inostroza, Y., Cárdenas, K., Bahamonde, T., Barrientos, T., Olivares, P., Navas, C., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2307953121 · Cited by 30 · see citing works
History repeating: A roadmap to address common problems in psychedelic sciencePreprint
van Elk, M., & Fried, E. I. (2023) · doi:10.31234/osf.io/ak6gx · Cited by 30 · see citing works
Ketamine-assisted psychotherapy in adolescents with multiple psychiatric diagnoses
Wolfson, P. E., Andries, J., Ahlers, D., & Whippo, M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1141988 · Cited by 31 · see citing works
Jiang, Y., Wang, X., Chen, J., Zhang, Y., Hashimoto, K., Yang, J., & Zhou, Z. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2310603 · Cited by 23 · see citing works
Matsingos, A., Wilhelm, M., Noor, L., Yildiz, C., Rief, W., Hofmann, S. G., Falkenberg, I., & Kircher, T. T. J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1346697 · Cited by 20 · see citing works
Constantino, J. L., Godschalk, M., van Dalfsen, J. H., Veraart, J. K. E., Spijker, J., van Exel, E. R., Schoevers, R. A., & Kamphuis, J. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116355 · Cited by 19 · see citing works
Exploring Predictors of Ketamine Response in Adolescent Treatment-Resistant Depression
Lineham, A., Avila-Quintero, V. J., Bloch, M. H., & Dwyer, J. B. (2024) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2023.0047 · Cited by 17 · see citing works
Ballard, E. D., GREENSTEIN, D. K., Reiss, P. T., Crainiceanu, C. M., Cui, E., Duncan, W. C., Hejazi, N. S., & Zarate, C. A. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02956-2 · Cited by 17 · see citing works
Self-citationTu, P., Chang, W.-C., Su, T., Lin, W.-C., Li, C., Bai, Y., Tsai, S., & Chen, M. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02640-3 · Cited by 16 · see citing works
Self-citationClinical pharmacological innovation in the treatment of depression
Witkin, J. M., Golani, L. K., & Smith, J. L. (2023) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2023.2198703 · Cited by 16 · see citing works
Castillo, A., Dubois, J., Field, R. M., Fishburn, F. A., Gundran, A., Ho, W. C., Jawhar, S., Kates‐Harbeck, J., Aghajan, Z. M., Miller, N., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38258-8 · Cited by 16 · see citing works
Self-citationLiu, J. J. W., Ein, N., Gervasio, J., Baker, C., Plouffe, R. A., Wanklyn, S. G., Burhan, A. M., Lau, B., Abreu, E., Wasiuta, T., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1338581 · Cited by 15 · see citing works
Autism, youth suicide, and psychedelics: A review of the 21st century evidence
Chen, M., Su, T., Hsu, J.-W., & Tsai, S. (2024) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000001150 · Cited by 14 · see citing works
Self-citationOhtani, Y., Tani, H., Nomoto‐Takahashi, K., Yatomi, T., Yonezawa, K., Tomiyama, S., Nagai, N., Kusudo, K., Honda, S., Moriyama, S., et al. (2024) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13734 · Cited by 14 · see citing works
New and emerging pharmacologic treatments for MDD
Uyar, A., & Gönül, A. S. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1621887 · Cited by 13 · see citing works
Lin, W., Su, T., Li, C., Wu, H.-J., Bai, Y., Liu, Y., Tu, P., & Chen, M. (2023) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad045 · Cited by 13 · see citing works
Self-citationMiller, E. A., Afshar, H. T., Mishra, J., McIntyre, R. S., & Ramanathan, D. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115858 · Cited by 12 · see citing works
Pattanaseri, K., Lortrakul, J., Jaisin, K., Srifuengfung, M., Sanguanpanich, N., Viravan, N., Pariwatcharakul, P., Makarasara, W., & Ratta‐apha, W. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05951-5 · Cited by 12 · see citing works
Replication of distinct trajectories of antidepressant response to intravenous ketamine
O’Brien, B., Lee, J., Kim, S., Nandra, G. S., Pannu, P., Swann, A. C., Murphy, N., Tamman, A. J. F., Amarneh, D. Y., Lijffijt, M., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.10.031 · Cited by 12 · see citing works
Self-citationThe possible place for psychedelics in pharmacotherapy of mental disorders
Wojtas, A. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00550-9 · Cited by 11 · see citing works
Repple, J., Bayas, M., Möser, C., Kobayashi, N. F., & Reif, A. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.02.903 · Cited by 10 · see citing works
Esketamine Nasal Spray in Major Depressive Disorder: A Meta‐Analysis of Randomized Controlled Trials
Wang, Z., Jiang, L., Ma, W., Li, X., Gao, Q., Lian, S., & Yu, W. (2025) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3555 · Cited by 9 · see citing works
Świeczkowski, D., Kwaśny, A., Sadko, K. G., Pruc, M., Gaca, Z., Szarpak, Ł., & Cubała, W. J. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116559 · Cited by 8 · see citing works
Ultrabrief pulse electroconvulsive therapy for depression: a systematic review and meta-analysis
Jelovac, A., & McLoughlin, D. M. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03327-z · Cited by 8 · see citing works
Self-citationGeraci, J., Qorri, B., Tsay, M. J., Cumbaa, C. A., Leonczyk, P., Alphs, L. D., Ballard, E. D., Zarate, C. A., & Pani, L. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-02143-7 · Cited by 10 · see citing works
Self-citationKetamine for depression: a potential role in requests for Medical Aid in Dying?
Garel, N., Nazon, M., Naghi, K., Willis, E., Looper, K. J., Rej, S., & Greenway, K. T. (2023) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000462 · Cited by 8 · see citing works
Let’s Move Towards Precision Suicidology
Courtet, P., & Saiz, P. A. (2025) · Current Psychiatry Reports · doi:10.1007/s11920-025-01605-9 · Cited by 7 · see citing works
Hippocampal subfield volumes in treatment resistant depression and serial ketamine treatment
Zavaliangos‐Petropulu, A., McClintock, S. M., Joshi, S. H., Taraku, B., Al‐Sharif, N., Espinoza, R. T., & Narr, K. L. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1227879 · Cited by 7 · see citing works
Sumner, R. L., McMillan, R. L., Forsyth, A., Muthukumaraswamy, S. D., & Shaw, A. D. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02738-w · Cited by 7 · see citing works
Self-citationGilani, M., Abak, N., & Saberian, M. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173897 · Cited by 6 · see citing works
Su, T., Cheng, L., Tu, P., Chen, L., Lin, W., Li, C., Bai, Y., Tsai, S., & Chen, M. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116377 · Cited by 6 · see citing works
Self-citationLuan, W.-W., Gu, H., Qiu, D., Ding, X., Liu, P., Hashimoto, K., Yang, J., & Wang, X. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.105961 · Cited by 6 · see citing works
Assche, E. V., Hohoff, C., Zang, J. C. S., Knight, M. J., & Baune, B. T. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1223216 · Cited by 6 · see citing works
Chen, M., Su, T., Li, C., Lin, W., Wu, H.-J., Tsai, S., Bai, Y., Mao, W., & Tu, P. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01735-2 · Cited by 6 · see citing works
Self-citationOhtani, Y., Tani, H., Honda, S., Nomoto‐Takahashi, K., Yatomi, T., Yonezawa, K., Tomiyama, S., Nagai, N., Kusudo, K., Moriyama, S., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.04.165 · Cited by 5 · see citing works
Hossein, S., Rengasamy, M. L., Uzamere, A., Spotts, C., Howland, R. H., Wallace, M. L., Mathew, S. J., & Price, R. B. (2025) · The British Journal of Psychiatry · doi:10.1192/bjp.2024.276 · Cited by 5 · see citing works
Self-citationAnhedonia as a Core Symptom of Depression and a Construct for Biological Research
Al‐Soleiti, M., Voort, J. L. V., & Singh, B. (2025) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20240050 · Cited by 4 · see citing works
Courtes, A. C., Jones, G. H., Henter, I. D., Shahani, L., Fries, G. R., Juruena, M. F., Soares, J. C., Zarate, C. A., & Machado‐Vieira, R. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120016 · Cited by 4 · see citing works
Self-citationAnti-suicidal effects of IV ketamine in a real-world setting
O’Brien, B., Lee, J., Kim, S., Nandra, G. S., Pannu, P., Tamman, A. J. F., Amarneh, D. Y., Swann, A. C., Murphy, N., Averill, L. A., et al. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115604 · Cited by 4 · see citing works
Self-citationKetamine in psychiatry: Ethical imperatives in harnessing a controversial yet promising therapy
Can, A., Lagopoulos, J., Fitzgerald, P. B., Bailey, N. W., & Dutton, M. (2025) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674251396009 · Cited by 3 · see citing works
Karp, J. F., Brinton, R. D., Fournier, J. C. J., Harding, L., Jha, M. K., Lenze, E. J., Mathew, S. J., Meltzer-Brody, S. E., Mohr, D. C., Riva‐Posse, P., et al. (2024) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.psprmdd2408ah · Cited by 3 · see citing works
Self-citationLin, W.-C., Cheng, L., Su, T., Chen, L., Tu, P., Li, C., Bai, Y., Tsai, S., & Chen, M. (2025) · The British Journal of Psychiatry · doi:10.1192/bjp.2025.14 · Cited by 3 · see citing works
Self-citationA long, strange trip: Ketamine treatment in psychiatry
Nutt, D., Morgan, C. J. A., Erritzøe, D., Greenway, K. T., & Young, A. H. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251379393 · Cited by 5 · see citing works
Chen, M.-H., Su, T., Lin, W.-C., Li, C., Wu, H.-J., Tsai, S., Bai, Y., Mao, W., & Tu, P. (2024) · Pharmacopsychiatry · doi:10.1055/a-2499-7207 · Cited by 2 · see citing works
Self-citationYadav, E., Tekkalaki, B. V., Gadadavar, K. P., Yadawad, V. S., Chate, S. S., Patil, S., & Koparde, V. (2025) · Indian Journal of Psychological Medicine · doi:10.1177/02537176251334446 · Cited by 2 · see citing works
Huc, M., Siddiqi, S., Myers, M., Colman, I., Salmaso, N., Jaworska, N., & Aguilar‐Valles, A. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03493-8 · Cited by 2 · see citing works
Wang, B., Cui, C., Chen, Y., & Liang, Z. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1328143 · Cited by 2 · see citing works
Regen, F., & Benkert, O. (2023) · Springer eBooks · doi:10.1007/978-3-662-67685-1_1 · Cited by 1 · see citing works
Peters, E. M., Halpape, K., Cheveldae, I., Jacobson, P., & Wanson, A. (2024) · Personalized Medicine in Psychiatry · doi:10.1016/j.pmip.2024.100119 · Cited by 1 · see citing works
Kheirkhah, M., Mcdonald, N., Aepfelbacher, J., Rengasamy, M. L., Shivanekar, S. P., Spotts, C., Cooper, I., Baumeister, A., Bell, E., Do-Nguyen, K., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1642025 · Cited by 3 · see citing works
Self-citationLi, C., Wang, Z., Ye, X., Lv, J., Chen, F., Zhang, Y., Liu, J., Li, X., Duan, J., Wang, Y., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1692751 · Cited by 1 · see citing works
Donegan, K. R., Hossein, S., Panny, B., Brown, V. M., Lee, C. T., Harty, S., Lynch, K., Fox, C. A., Hanlon, A. K., O’Keane, V., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03722-8 · Cited by 1 · see citing works
Self-citationPsychedelic Therapy: A Primer for Primary Care Clinicians—5-Methoxy-N,N-Dimethyltryptamine
Tabaac, B. J., Shinozuka, K., Weisman, A., Chaudhry, S., Seynaeve, M., & Muir, O. S. (2026) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000002106 · Cited by 1 · see citing works
Syed, O. A., Sobolenko, V., Nestor, S. M., Husain, M. I., Lipsman, N., Alam, F., & Giacobbe, P. (2026) · CNS Drugs · doi:10.1007/s40263-026-01296-7 · Cited by 1 · see citing works
Kynurenine pathway profiles as markers of ketamine response in treatment-resistant depression
Pedraz-Petrozzi, B., Marszałek‐Grabska, M., Fornal, E., Wielgosz, A., Stachniuk, A., Marzec, P., Neumann, E., Riedinger, E., Gilles, M., Gründer, G., et al. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106889 · Cited by 1 · see citing works
Vázquez, G. H., Kang, M. J. Y., & Gutierrez, G. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122368 · Cited by 1 · see citing works
Reilly, T. J. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15872 · Cited by 1 · see citing works
Placebo’s role in the rapid antidepressant effect
Sanacora, G., & Colloca, L. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00141-w · Cited by 1 · see citing works
Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery
Tanaka, M. (2026) · Biomedicines · doi:10.3390/biomedicines14061265
Predicting non-response to ketamine for depression: a symptom-level analysis of real-world dataPreprint
Miller, E. A., Afshar, H. T., Mishra, J., & Ramanathan, D. (2023) · medRxiv · doi:10.1101/2023.07.03.23292094
Efficacy of Ketamine Therapy in the Treatment of Refractory Major Depressive Disorder
van Oers, H. (2023) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2023.00023
Janski, A. M., Hristidis, V. C., Zorumski, C. F., & Conway, C. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95702-1.00064-6
Interventional therapeutics in psychiatry: Beyond psychopharmacology and psychotherapy?
Padberg, F., & Burkhardt, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18496-3.00001-x
Pham, G. S., & Mathew, S. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18496-3.00014-8
Self-citationGenetic ablation of the isoform γ of PI3K decreases antidepressant efficacy of ketamine in male mice
Vaz, G. N., Turcato, F. C., Lima, I. A. V., Scarante, F. F., Araújo, M. R., Brigante, T. A. V., Rodrigues, L. C. M., Guimarães, F. S., Hallak, J. E. C., Crippa, J. A. S., et al. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.06.002
Huc, M., Siddiqi, S., Myers, M., Colman, I., Salmaso, N., Jaworska, N., & Aguilar‐Valles, A. (2025) · medRxiv · doi:10.1101/2025.06.26.25330356
The Potential of Psychedelics in the Treatment of Eating Disorders
Gukasyan, N., Hilbert, S. N., & Guarda, Á. S. (2025) · doi:10.1093/9780197675212.003.0027
Pattanaseri, K., Lortrakul, J., Jaisin, K., Srifuengfung, M., Sanguanpanich, N., Viravan, N., Pariwatcharakul, P., Makarasara, W., & Ratta-apha, W. (2024) · Figshare · doi:10.6084/m9.figshare.26333225
Phantom pain syndrome. History, pathophysiology and treatment
Tikhonovsky, A. A. (2025) · Russian Journal of Pain · doi:10.17116/pain20252304160
Yonezawa, K., Nakajima, S., Shibukawa, S., Kan, H., Ohtani, Y., Nomoto‐Takahashi, K., Yatomi, T., Tomiyama, S., Nagai, N., Kusudo, K., et al. (2026) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2026.112229
Constantino, J. L., Freimann, T. S., van Dalfsen, J. H., van der Meij, A., Veraart, J. K. E., Smith-Apeldoorn, S. Y., Schoevers, R. A., & Kamphuis, J. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.06.013
Jones, G. H., Gilbert, J. R., Johnston, J. N., Akula, N., Schulmann, A., Arakelian, M. H., Peng, S., Yuan, P., Winful, E. A., Yavi, M., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03777-z
Self-citationTowards precision psychiatry: initial foundations and future directions
Etkin, A., O’Donnell, P., Ressler, K. J., & Manji, H. K. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-026-01509-0 · Cited by 1 · see citing works
Malewska-Kasprzak, M., Rybakowski, F., & Dmitrzak‐Węglarz, M. (2026) · CNS Spectrums · doi:10.1017/s1092852926101187
- Authors
- Price, R. B., Kissel, N., Baumeister, A., Rohac, R., Woody, M. L., Ballard, E. D., Zarate, C. A., Deakin, W., Abdallah, C. G., Feder, A., Charney, D. S., Grunebaum, M. F., Mann, J. J., Mathew, S. J., Gallagher, B., McLoughlin, D. M., Murrough, J. W., Muthukumaraswamy, S., McMillan, R., Sumner, R., Papakostas, G., Fava, M., Hock, R., Phillips, J. L., Blier, P., Shiroma, P., Šóš, P., Su, T.-P., Chen, M.-H., Tiger, M., Lundberg, J., Wilkinson, S. T., & Wallace, M. L.
- Affiliations
- University of Pittsburgh (US)
- Carnegie Mellon University (US)
- National Institutes of Health (US)
- Michael E. DeBakey VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- Columbia University (US)
- Trinity College Dublin (IE)
- University of Auckland (NZ)
- Harvard University (US)
- University of Ottawa (CA)
- Minneapolis VA Medical Center (US)
- National Yang Ming University (TW)
- Karolinska Institutet (SE)
- Yale University (US)
- Corresponding author
- Price, Rebecca B.
- ORCID
- Price, Rebecca B.
- Kissel, Nicholas
- Woody, Mary L.
- Ballard, Elizabeth D.
- Zarate, Carlos A.
- Deakin, William
- Abdallah, Chadi G.
- Feder, Adriana
- Charney, Dennis S.
- Grunebaum, Michael F.
- Mann, J. John
- Mathew, Sanjay J.
- Gallagher, Bronagh
- McLoughlin, Declan M.
- Murrough, James W.
- Muthukumaraswamy, Suresh
- McMillan, Rebecca
- Sumner, Rachael
- Papakostas, George
- Hock, Rebecca
- Phillips, Jennifer L.
- Blier, Pierre
- Shiroma, Paulo
- Šóš, Peter
- Su, Tung-Ping
- Chen, Mu-Hong
- Tiger, Mikael
- Lundberg, Johan
- Wilkinson, Samuel T.
- Wallace, Meredith L.
- Venue
- Molecular Psychiatry
- Published
- 2022-09-07
- Volume
- 27
- Issue
- 12
- Pages
- 5096-5112
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC9763119
- OpenAlex
- W4294876995
- Cited by
- 82
- References
- 65
- Citations by year
- 2026: 11 · 2025: 24 · 2024: 24 · 2023: 21 · 2022: 2
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Molecular Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR001863)
- National Institute of Mental Health (K23MH119225, R01MH113857)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- ketamine, depression, intravenous ketamine, treatment-resistant depression, precision medicine, individual patient data, depression severity, bipolar depression, post-traumatic stress disorder, antidepressant treatment resistance, crossover design
- MeSH terms
- Antidepressive Agents, Bipolar Disorder, Depression, Humans, Ketamine, Treatment Outcome, Administration, Intravenous
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
