The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Goblet cells: multifaceted players in immunity at mucosal surfaces
Open accessAbstract
Goblet cells (GCs) are specialized epithelial cells that line multiple mucosal surfaces and have a well-appreciated role in barrier maintenance through the secretion of mucus. Moreover, GCs secrete anti-microbial proteins, chemokines, and cytokines demonstrating functions in innate immunity beyond barrier maintenance. Recently it was appreciated that GCs can form goblet cell-associated antigen passages (GAPs) and deliver luminal substances to underlying lamina propria (LP) antigen-presenting cells (APCs) in a manner capable of inducing adaptive immune responses. GCs at other mucosal surfaces share characteristics with the GAP forming intestinal GCs, suggesting that GAP formation may not be restricted to the gut, and that GCs may perform this gatekeeper function at other mucosal surfaces. Here we review observations of how GCs contribute to immunity at mucosal surfaces through barrier maintenance, the delivery of luminal substances to APCs, interactions with APCs, and secretion of factors modulating immune responses.
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Cites
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Cited by
Nutritional immunity of fish intestines: important insights for sustainable aquaculture
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Gut barrier disruption and chronic disease
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Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
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Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH
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Metadata
- Authors
- Knoop, K. A., & Newberry, R. D.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 11
- Issue
- 6
- Pages
- 1551-1557
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2806840045
- Cited by
- 315
- References
- 9
- FWCI
- 17.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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