HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence
Abstract
This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor (HGF) /mesenchymal-epithelial transition factor (c-MET)) signaling pathway in cancers. First, we generalize the compelling influence of HGF/c-MET pathway on multiple cellular processes. Then, we present the genomic characterization of HGF/c-MET pathway in carcinogenesis. Furthermore, we extensively illustrate the malignant biological behaviors of HGF/c-MET pathway in cancers, in which hyperactive HGF/c-MET signaling is considered as a hallmark. In addition, we investigate the current clinical trials of HGF/c-MET-targeted therapy in cancers. We find that although HGF/c-MET-targeted therapy has led to breakthroughs in certain cancers, monotherapy of targeting HGF/c-MET has failed to demonstrate significant clinical efficacy in most cancers. With the advantage of the combinations of HGF/c-MET-targeted therapy, the exploration of more options of combinational targeted therapy in cancers may be the major challenge in the future.
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c-MET signaling is hyperactivated in multiple cancers due to MET mutations, amplification, or rearrangement.
“c-MET signaling is hyperactivated in multiple cancers, due to MET mutations, amplification, or rearrangement [238].”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [238]
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HGF as a Circulating Biomarker of Onartuzumab Treatment in Patients with Advanced Solid Tumors
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- Authors
- Fu, J., Su, X., Li, Z., Deng, L., Liu, X., Feng, X., & Peng, J.
- Affiliations
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Corresponding author
- Feng, Xuancheng
- Peng, Juan
- Venue
- Oncogene
- Published
- 2021-06-18
- Volume
- 40
- Issue
- 28
- Pages
- 4625-4651
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W3171106033
- Cited by
- 235
- References
- 203
- Citations by year
- 2026: 39 · 2025: 63 · 2024: 54 · 2023: 48 · 2022: 25 · 2021: 5
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- HGF/c-Met signaling pathway, hepatocyte growth factor, c-Met, carcinogenesis, tumor progression, combination targeted therapy, clinical trials
- MeSH terms
- Animals, Humans, Neoplasms, Signal Transduction, Hepatocyte Growth Factor, Proto-Oncogene Proteins c-met, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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