Cited by 235Liver physiology and pathologyCancer Mechanisms and TherapyHepatocellular Carcinoma Treatment and Prognosis

HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence

Fu, Jianjiang, Su, Xiaorui, Li, Zhihua, Deng, Ling, Liu, Xiawei, Feng, Xuancheng, Peng, Juan·2021·Oncogene

Abstract

This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor (HGF) /mesenchymal-epithelial transition factor (c-MET)) signaling pathway in cancers. First, we generalize the compelling influence of HGF/c-MET pathway on multiple cellular processes. Then, we present the genomic characterization of HGF/c-MET pathway in carcinogenesis. Furthermore, we extensively illustrate the malignant biological behaviors of HGF/c-MET pathway in cancers, in which hyperactive HGF/c-MET signaling is considered as a hallmark. In addition, we investigate the current clinical trials of HGF/c-MET-targeted therapy in cancers. We find that although HGF/c-MET-targeted therapy has led to breakthroughs in certain cancers, monotherapy of targeting HGF/c-MET has failed to demonstrate significant clinical efficacy in most cancers. With the advantage of the combinations of HGF/c-MET-targeted therapy, the exploration of more options of combinational targeted therapy in cancers may be the major challenge in the future.

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Crossref · 10.1038/s41388-021-01863-w

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203 of 203 references verified0 citation errors · 0 not checkable

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Authors
Fu, J., Su, X., Li, Z., Deng, L., Liu, X., Feng, X., & Peng, J.
Affiliations
  • Third Affiliated Hospital of Guangzhou Medical University (CN)
  • Sun Yat-sen University Cancer Center (CN)
Corresponding author
  • Feng, Xuancheng
  • Peng, Juan
Venue
Oncogene
Published
2021-06-18
Volume
40
Issue
28
Pages
4625-4651
ISSN
  • 0950-9232 (ISSN-L)
  • 1476-5594
OpenAlex
W3171106033
Cited by
235
References
203
Citations by year
2026: 39 · 2025: 63 · 2024: 54 · 2023: 48 · 2022: 25 · 2021: 5
FWCI
4.40
Type
journal article
Language
en
Open access
closed
Locations
  • Oncogene (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
Keywords
HGF/c-Met signaling pathway, hepatocyte growth factor, c-Met, carcinogenesis, tumor progression, combination targeted therapy, clinical trials
MeSH terms
Animals, Humans, Neoplasms, Signal Transduction, Hepatocyte Growth Factor, Proto-Oncogene Proteins c-met, Molecular Targeted Therapy

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