Cited by 169Neonatal and Maternal InfectionsSepsis Diagnosis and TreatmentInfant Development and Preterm Care

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants

Open access

Wynn, James L., Polin, Richard A.·2020·Pediatric Research

DOI 10.1038/s41390-019-0517-2PMC PMC7007331

Open this paper in CoChat — free account

Abstract

Background An operational definition of organ dysfunction applicable to neonates that predicts mortality in the setting of infection is lacking. We determined the utility of an objective, electronic health record (EHR)-automated, neonatal sequential organ failure assessment (nSOFA) score to predict mortality from late-onset sepsis (LOS) in premature, very low birth weight (VLBW) infants.Methods Retrospective, single-center study of bacteremic preterm VLBW newborns admitted between 2012 and 2016. nSOFA scores were derived for patients with LOS at multiple time points surrounding the sepsis evaluation.Results nSOFA scores at evaluation and at all points measured after evaluation were different between survivors and non-survivors. Among patients with an nSOFA score of >4, mortality was higher at evaluation (13% vs 67%, p < 0.001), +6 h (15% vs 64%, p = 0.002), and +12 h (7% vs 71%, p < 0.001) as compared to patients with a score of ≤4. Receiver operating characteristics area under the curve was 0.77 at evaluation (95% CI 0.62-0.92; p = 0.001), 0.78 at +6 h (0.66-0.92; p < 0.001), and 0.93 at +12 h (0.86-0.997; p < 0.001).Conclusions The nSOFA scoring system predicted mortality in VLBW infants with LOS and this automated system was integrated into our EHR. Prediction of LOS mortality is a critical step toward improvements in neonatal sepsis outcomes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41390-019-0517-2

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The third international consensus definitions for sepsis and septic shock (Sepsis-3).
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0287 · Cited by 28,250
Late-Onset Sepsis in Very Low Birth Weight Neonates: The Experience of the NICHD Neonatal Research Network
Stoll, B. J., Hansen, N. I., Fanaroff, A. A., Wright, L. L., Carlo, W. A., Ehrenkranz, R. A., Lemons, J. A., Donovan, E. F., Stark, A. R., Tyson, J. E., et al. (2002) · PEDIATRICS · doi:10.1542/peds.110.2.285 · Cited by 2,349
Neonatal sepsis
Shane, A. L., Sánchez, P. J., & Stoll, B. J. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31002-4 · Cited by 1,226
Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children
Matics, T. J., & Sanchez-Pinto, L. N. (2017) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.2352 · Cited by 676
Defining neonatal sepsis
Wynn, J. L. (2016) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000315 · Cited by 349
Self-citation
Treatment of Neonatal Sepsis with Intravenous Immune Globulin
The INIS Collaborative Group (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100441 · Cited by 321
Time for a Neonatal-Specific Consensus Definition for Sepsis
Wynn, J. L., Wong, H. R., Shanley, T. P., Bizzarro, M. J., Saiman, L. M., & Polin, R. A. (2014) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000157 · Cited by 302
Self-citation
Neonatal Sepsis of Early Onset, and Hospital-Acquired and Community-Acquired Late Onset: A Prospective Population-Based Cohort Study
Giannoni, É., Agyeman, P., Stocker, M., Posfay-Barbe, K. M., Heininger, U., Spycher, B. D., Bernhard‐Stirnemann, S., Niederer-Loher, A., Kahlert, C. R., Donas, A., et al. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2018.05.048 · Cited by 267
Neurodevelopmental Impairment Among Extremely Preterm Infants in the Neonatal Research Network
Adams-Chapman, I. S., Heyne, R. J., DeMauro, S. B., Duncan, A. F., Hintz, S. R., Pappas, A., Vohr, B. R., McDonald, S. A., Das, A., Newman, J. E., et al. (2018) · PEDIATRICS · doi:10.1542/peds.2017-3091 · Cited by 232
Late-onset Sepsis in Extremely Premature Infants
Greenberg, R. G., Kandefer, S. C., Do, B. T., Smith, P. B., Stoll, B. J., Bell, E. F., Carlo, W. A., Laptook, A. R., Sánchez, P. J., Shankaran, S., et al. (2017) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001570 · Cited by 188

Show all 17 references

Sorted by citations

Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoOBS)
Russell, N., Stöhr, W., Plakkal, N., Cook, A., Berkley, J. A., Adhisivam, B., Agarwal, R. K., Ahmed, A. N. U., Balasegaram, M., Ballot, D. E., et al. (2023) · PLoS Medicine · doi:10.1371/journal.pmed.1004179 · Cited by 188
Challenges in developing a consensus definition of neonatal sepsis
on behalf of the Infection, I., McGovern, M., Giannoni, É., Küster, H., Turner, M. A., van den Hoogen, A., Bliss, J. M., Koenig, J. M., Keij, F. M., Mazela, J. L., et al. (2020) · Pediatric Research · doi:10.1038/s41390-020-0785-x · Cited by 153
Self-citation
Neonatal sepsis definitions from randomised clinical trials
Hayes, R., Hartnett, J., Semova, G., Murray, C., Murphy, K., Carroll, L., Plapp, H. M., Hession, L., O’Toole, J., McCollum, D., et al. (2021) · Pediatric Research · doi:10.1038/s41390-021-01749-3 · Cited by 123
Self-citation
Evaluation of the neonatal sequential organ failure assessment and mortality risk in preterm infants with late-onset infection
Fleiss, N., Coggins, S. A., Lewis, A. N., Zeigler, A., Cooksey, K. E., Walker, L. A., Husain, A. N., de Jong, B. S., Wallman-Stokes, A., Alrifai, M. W., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.36518 · Cited by 121
Self-citation
Neonatal sepsis: need for consensus definition, collaboration and core outcomes
Molloy, E. J., Wynn, J. L., Bliss, J. M., Koenig, J. M., Keij, F. M., McGovern, M., Küster, H., Turner, M. A., Giannoni, É., Mazela, J. L., et al. (2020) · Pediatric Research · doi:10.1038/s41390-020-0850-5 · Cited by 110
Self-citation
Biomarkers for the Diagnosis of Neonatal Sepsis
Cantey, J. B., & Lee, J. H. (2021) · Clinics in Perinatology · doi:10.1016/j.clp.2021.03.012 · Cited by 117
Neonatal Sepsis: A Comprehensive Review
Kariniotaki, C., Thomou, C., Gkentzi, D., Panteris, E., Dimitriou, G., & Hatzidaki, E. (2024) · Antibiotics · doi:10.3390/antibiotics14010006 · Cited by 92
Vital signs as physiomarkers of neonatal sepsis
Sullivan, B. A., & Fairchild, K. D. (2021) · Pediatric Research · doi:10.1038/s41390-021-01709-x · Cited by 70
Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates
Kurul, Ş., Simons, S. H. P., Ramakers, C. R. B., de Rijke, Y. B., Kornelisse, R. F., Reiss, I. K. M., & Taal, H. R. (2021) · Critical Care · doi:10.1186/s13054-020-03423-2 · Cited by 62
Operational Recommendations for Scarce Resource Allocation in a Public Health Crisis
Ehmann, M. R., Zink, E. K., Levin, A., Suárez, J. I., Belcher, H. M. E., Biddison, E. L. D., Doberman, D. J., D’Souza, K., Fine, D. M., Garibaldi, B. T., et al. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.09.246 · Cited by 60
Clinical Value of Prognostic Nutritional Index in Prediction of the Presence and Severity of Neonatal Sepsis
Li, T., Qi, M., Dong, G., Li, X., Xu, Z., Wei, Y., Feng, Y., Ren, C., Wang, Y., & Yang, J. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s343992 · Cited by 48
A Proposed Framework for the Clinical Management of Neonatal “Culture-Negative” Sepsis
Cantey, J. B., & Prusakov, P. A. (2022) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2022.01.006 · Cited by 47
A narrative review of heart rate and variability in sepsis
Wee, B., Lee, J. H., Mok, Y. H., & Chong, S. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-148 · Cited by 46
Diagnosis and Management of Neonatal Bacterial Sepsis: Current Challenges and Future Perspectives
Rose, D. U. D., Ronchetti, M. P., Martini, L., Rechichi, J., Iannetta, M., Dotta, A., & Auriti, C. (2024) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed9090199 · Cited by 44
Predicting mortality risk for preterm infants using random forest
Lee, J., Cai, J., Li, F., & Vesoulis, Z. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-86748-4 · Cited by 40
Sepsis and Mortality Prediction in Very Low Birth Weight Infants: Analysis of HeRO and nSOFA
Zeigler, A. C., Ainsworth, J. E., Fairchild, K. D., Wynn, J. L., & Sullivan, B. A. (2021) · American Journal of Perinatology · doi:10.1055/s-0041-1728829 · Cited by 40
Self-citation
Higher blood urea nitrogen level is independently linked with the presence and severity of neonatal sepsis
Li, X., Li, T., Wang, J., Dong, G., Zhang, M., Xu, Z., Hu, Y., Xie, B., Yang, J., & Wang, Y. (2021) · Annals of Medicine · doi:10.1080/07853890.2021.2004317 · Cited by 40
Multicenter validation of the neonatal sequential organ failure assessment score for prognosis in the neonatal intensive care unit
Wynn, J. L., Mayampurath, A., Carey, K., Slattery, S., Andrews, B., & Sanchez-Pinto, L. N. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.05.037 · Cited by 37
Self-citation
Evaluation of the neonatal sequential organ failure assessment and mortality risk in preterm infants with necrotizing enterocolitis
Lewis, A. N., de la Cruz, D., Wynn, J. L., Frazer, L. C., Yakah, W., Martin, C. R., Yang, H., Itriago, E., Unger, J., Hair, A. B., et al. (2022) · Neonatology · doi:10.1159/000522560 · Cited by 36
Self-citation
Maximum vasoactive-inotropic score and mortality in extremely premature, extremely low birth weight infants
Aziz, K. B., Lavilla, O. C., Wynn, J. L., Lure, A. C., Gipson, D. R., & de la Cruz, D. (2021) · Journal of Perinatology · doi:10.1038/s41372-021-01030-9 · Cited by 36
Self-citation
Development and validation of a sepsis diagnostic scoring model for neonates with suspected sepsis
Sokou, R., Ioakeimidis, G., Piovani, D., Parastatidou, S., Konstantinidi, A., Tsantes, A. G., Lampridou, M., Houhoula, D. P., Iacovidou, N. M., Kokoris, S. I., et al. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.1004727 · Cited by 37
Neonatal Sepsis—Newer Insights
Adhisivam, B., & Bhat, B. V. (2021) · The Indian Journal of Pediatrics · doi:10.1007/s12098-021-03852-z · Cited by 31
Developing a Triage Protocol for the COVID-19 Pandemic: Allocating Scarce Medical Resources in a Public Health Emergency
Tolchin, B. D., Latham, S. R., Bruce, L., Ferrante, L. E., Kraschel, K., Jubanyik, K. J., Hull, S. C., Herbst, J. L., Kapo, J. M., MORITZ, E. D., et al. (2020) · The Journal of Clinical Ethics · doi:10.1086/jce2020314303 · Cited by 28
Inflammation, sepsis severity and neurodevelopmental outcomes of late-onset sepsis in preterm neonates
Kurul, Ş., Beckers, F. L. M., Vermeulen, M. J., Suurland, J., Hasbek, J. E., Ramakers, C. R. B., Simons, S. H. P., Reiss, I. K. M., & Taal, H. R. (2023) · Pediatric Research · doi:10.1038/s41390-023-02742-8 · Cited by 27
Improving child health through Big Data and data science
Vesoulis, Z. A., Husain, A. N., & Cole, F. S. (2022) · Pediatric Research · doi:10.1038/s41390-022-02264-9 · Cited by 29
Whole blood transcriptional responses of very preterm infants during late-onset sepsis
Ng, S., Strunk, T., Lee, A. H., Gill, E. E., Falsafi, R., Woodman, T., Hibbert, J., Hancock, R. E. W., & Currie, A. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233841 · Cited by 27
Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial
Ruoss, J. L., Bazacliu, C., Russell, J. T., de la Cruz, D., Li, N., Gurka, M. J., Filipp, S. L., Polin, R. A., Triplett, E. W., & Neu, J. (2020) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2020.09.056 · Cited by 25
Self-citation
Predictors of Mortality in Early Neonatal Sepsis: A Single-Center Experience
Jovičić, M., Milosavljević, M. N., Folić, M., Pavlović, R., & Јаnkovic, S. (2023) · Medicina · doi:10.3390/medicina59030604 · Cited by 24
The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants
Ortgies, T., Rullmann, M., Ziegelhöfer, D., Bläser, A., & Thome, U. H. (2021) · BMC Pediatrics · doi:10.1186/s12887-021-02738-5 · Cited by 23
Risk Factors for Mortality From Late-Onset Sepsis Among Preterm Very-Low-Birthweight Infants: A Single-Center Cohort Study From Singapore
Goh, G. L., Lim, C. S. E., Sultana, R., Puerta, R. D., Rajadurai, V. S., & Yeo, K. T. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2021.801955 · Cited by 23
Association of Procalcitonin to Albumin Ratio with the Presence and Severity of Sepsis in Neonates
Li, T., Li, X., Liu, X., Zhu, Z., Zhang, M., Xu, Z., Wei, Y., Feng, Y., Qiao, X., Yang, J., et al. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s358067 · Cited by 23
Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants
Berka, I., Korček, P., Janota, J., & Straňák, Z. (2022) · Diagnostics · doi:10.3390/diagnostics12061342 · Cited by 23
C-Reactive Protein-to-Albumin Ratio as an Early Biomarker to Identify Sepsis in Neonates with Pneumonia
Kang, P., Kang, W., Li, Y., & Li, T. (2022) · Mediators of Inflammation · doi:10.1155/2022/4711018 · Cited by 22
Hourly kinetics of critical organ dysfunction in extremely preterm infants
Lavilla, O. C., Aziz, K. B., Lure, A. C., Gipson, D., de la Cruz, D., & Wynn, J. L. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202106-1359oc · Cited by 22
Self-citation
The Role of Biomarkers in Suspected Neonatal Sepsis
Weitkamp, J.-H. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa869 · Cited by 21
Introducing heart rate variability monitoring combined with biomarker screening into a level IV NICU: a prospective implementation study
Kurul, Ş., van Ackeren, N., Goos, T. G., Ramakers, C. R. B., Been, J. V., Kornelisse, R. F., Reiss, I. K. M., Simons, S. H. P., & Taal, H. R. (2022) · European Journal of Pediatrics · doi:10.1007/s00431-022-04534-4 · Cited by 21
Neonatal Sequential Organ Failure Assessment as a late-onset sepsis mortality predictor in very low birth weight newborns: a Brazilian cohort study
Lobo, B. B. P., Marba, S. T. M., Machado, H. D. C., & Caldas, J. P. D. S. (2022) · European Journal of Pediatrics · doi:10.1007/s00431-022-04583-9 · Cited by 17
Validity of the vasoactive-inotropic score in preterm neonates receiving cardioactive therapies
Kharrat, A., Ripstein, G., Baczynski, M., Zhu, F., Ye, X. Y., Joye, S., & Jain, A. (2022) · Early Human Development · doi:10.1016/j.earlhumdev.2022.105657 · Cited by 17
Do Neonatal Infections Require a Positive Blood Culture?
Bromiker, R., Elron, E., & Klinger, G. (2020) · American Journal of Perinatology · doi:10.1055/s-0040-1714079 · Cited by 16
Sequential organ failure assessment scores to predict outcomes: from adults to neonates
Fleiss, N., & Polin, R. A. (2022) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001207 · Cited by 17
Self-citation
The principles of whole-hospital predictive analytics monitoring for clinical medicine originated in the neonatal ICU
Moorman, J. R. (2022) · npj Digital Medicine · doi:10.1038/s41746-022-00584-y · Cited by 12
Evaluation of the neonatal sequential organ failure assessment and mortality risk in neonates with early-onset infection
Yeo, K. T., Goh, G. L., Park, W. Y., Wynn, J. L., & Aziz, K. B. (2023) · Neonatology · doi:10.1159/000533467 · Cited by 13
Self-citation
Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology
Duignan, S. M., Lakshminrusimha, S., Armstrong, K. R., de Boode, W. P., EL-Khuffash, A. F., Franklin, O., Molloy, E. J., de Boode, W. P., Plötz, F. B., Strunk, T., et al. (2023) · Pediatric Research · doi:10.1038/s41390-023-02926-2 · Cited by 13
Stop in Time: How to Reduce Unnecessary Antibiotics in Newborns with Late-Onset Sepsis in Neonatal Intensive Care
Rose, D. U. D., Ronchetti, M. P., Santisi, A., Bernaschi, P., Martini, L., Porzio, O., Dotta, A., & Auriti, C. (2024) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed9030063 · Cited by 13
Prognostic accuracy of Neonatal SOFA score versus SIRS criteria in preterm infants with late-onset sepsis
Poggi, C., Ciarcià, M., Miselli, F., & Dani, C. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-05143-5 · Cited by 15
Bloodstream Infections in Preterm Neonates and Mortality-Associated Risk Factors
Baczynski, M., Kharrat, A., Zhu, F., Ye, X. Y., Shah, P. S., Weisz, D. E., & Jain, A. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.06.031 · Cited by 12
Editorial: Sepsis in Neonates and Children
Giannoni, É., & Schlapbach, L. J. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.621663 · Cited by 12
Blood pressure, organ dysfunction, and mortality in preterm neonates with late-onset sepsis
Zhu, F., Baczynski, M., Kharrat, A., Ye, X. Y., Weisz, D. E., & Jain, A. (2021) · Pediatric Research · doi:10.1038/s41390-021-01768-0 · Cited by 11
Evaluation of the neonatal sequential organ failure assessment and mortality risk in neonates with respiratory distress syndrome: A retrospective cohort study
Shi, S., Guo, J., Liao, L., Tu, J., Xiong, J., Liao, Q., 陈伟华, Chen, W., Fu, M., & Liao, Y. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.911444 · Cited by 12
Lymphocyte to C-Reactive Protein Ratio as an Early Biomarker to Distinguish Sepsis from Pneumonia in Neonates
Liu, X., & Yuan, M. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s424897 · Cited by 11
Thromboelastometry and prediction of in‐hospital mortality in neonates with sepsis
Sokou, R., Tsantes, A. G., Lampridou, M., Tsante, K. A., Houhoula, D. P., Piovani, D., Bonovas, S., Boutsikou, Τ., Iliodromiti, Z., Iacovidou, N. M., et al. (2023) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.14165 · Cited by 11
Contribution of Concurrent Comorbidities to Sepsis-Related Mortality in Preterm Infants ≤32 Weeks of Gestation at an Academic Neonatal Intensive Care Network
Barnette, B. W., Schumacher, B. T., Armenta, R. F., Wynn, J. L., Richardson, A. C., Bradley, J. S., Lazar, S., & Lawrence, S. M. (2021) · American Journal of Perinatology · doi:10.1055/a-1675-2899 · Cited by 11
Self-citation
A Global Assessment of Coagulation Profile and a Novel Insight into Adamts-13 Implication in Neonatal Sepsis
Papadogeorgou, P., Boutsikou, Τ., Boutsikou, M., Pergantou, H., Mantzou, A., Papassotiriou, I., Iliodromiti, Z., Sokou, R., Bouza, E. F., Politou, M., et al. (2023) · Biology · doi:10.3390/biology12101281 · Cited by 10
Early prediction of mortality after birth asphyxia with the nSOFA
Dathe, A.-K., Stein, A., Bruns, N., Craciun, E.-D., Tuda, L., Bialas, J., Brasseler, M., Felderhoff-Mueser, U., & Huening, B. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134322 · Cited by 13
The frequency and timing of sepsis-associated coagulopathy in the neonatal intensive care unit
Aziz, K. B., Saxonhouse, M. A., Mahesh, D., Wheeler, K. E., & Wynn, J. L. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2024.1364725 · Cited by 11
Self-citation
Comparing nSOFA, CRIB-II, and SNAPPE-II for predicting mortality and short-term morbidities in preterm infants ≤32 weeks gestation
Hao, Q., Chen, J., Chen, H., Zhang, J., Du, Y., & Cheng, X. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2426752 · Cited by 10
Low technology, mild controlled hypothermia for necrotizing enterocolitis treatment: an initiative to improve healthcare to preterm neonates.
Gonçalves‐Ferri, W. A., Ferreira, C. H. F., Couto, L. D. C. D. A., Souza, T. R., Peres, T. D. C., Carmona, F., Aragon, D. C., Crott, G. C., Mussi‐Pinhata, M. M., Camelo, J. S., et al. (2021) · European Journal of Pediatrics · doi:10.1007/s00431-021-04014-1 · Cited by 9
Evaluation of the validity of the nSOFA score in newborns with sepsis
Миронов, П. И., & Au, L. (2021) · Messenger of Anesthesiology and Resuscitation · doi:10.21292/2078-5658-2021-18-2-56-61 · Cited by 9
Sepsis in newborns (Draft federal guidelines)
Аleksаndrovich, Y. S., Balashova, E. N., Боронина, И. В., Zavyalova, A. N., Zolotareva, L. S., Иванов, Д. О., Кирилочев, О. К., Лисица, И. А., Makulova, A. I., Миронов, П. И., et al. (2024) · Pediatrician (St Petersburg) · doi:10.17816/ped1545-53 · Cited by 8
Thromboelastometry-Based Profiling of Haemostatic Alterations in Neonatal Sepsis by Causative Pathogens
Sokou, R., Gounari, E. A., Tsante, K. A., Konstantinidi, A., Lampridou, M., Theodoraki, M., Kriebardis, A. G., Fortis, S. P., Iacovidou, N. M., & Tsantes, A. G. (2025) · Antibiotics · doi:10.3390/antibiotics14010101 · Cited by 8
Clinical characteristics and risk factors for neonatal bloodstream infection due to carbapenem-resistant Enterobacteriaceae: A single-centre Chinese retrospective study
Fang, P., Gao, K., Yang, J., Li, T., Sun, Q., Shan, Z., & Wang, Y. (2024) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2024.02.004 · Cited by 8
Diagnosis of Neonatal Late-Onset Infection in Very Preterm Infant: Inter-Observer Agreement and International Classifications
Bury, G., Leroux, S., León, C., Guen, C. G., Mitanchez, D., Gascoin-Lachambre, G., Thollot, A., Roué, J., Carrault, G., Pladys, P., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18030882 · Cited by 8
Assessing neonatal sequential organ failure (nSOFA) scores in suspected late-onset neonatal sepsis among preterm infants: implications for morbidity and mortality
Kurul, Ş., Reijnierse, J. J., Koppens, H. J., Onland, W., Simons, S. H. P., Reiss, I. K. M., Taal, H. R., & Visser, D. H. (2024) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2024-002884 · Cited by 10
Mild controlled hypothermia for necrotizing enterocolitis treatment to preterm neonates: low technology technique description and safety analysis
Gonçalves‐Ferri, W. A., Ferreira, C. H. F., Albuquerque, L. M. S., Silva, J. B. C., Caixeta, M. V., Carmona, F., Calixto, C., Aragon, D. C., Crott, G. C., Mussi‐Pinhata, M. M., et al. (2022) · European Journal of Pediatrics · doi:10.1007/s00431-022-04558-w · Cited by 7
Associations between maternal bacteremia during the peripartum period and early-onset neonatal sepsis: a retrospective cohort study
Gad, A., Alkhdr, M., Terkawi, R. S., Alsharif, H., Ibrahim, M. M., Amin, R., Algibali, E., Chandra, P., Hamed, M. M. M., Petkar, H. M., et al. (2024) · BMC Pediatrics · doi:10.1186/s12887-024-04980-z · Cited by 7
Absence of relationship between serum cortisol and critical illness in premature infants
Prelipcean, I., Wynn, J. L., Thompson, L. A., Burchfield, D. J., James-Woodley, L., Chase, P. B., Barnes, C. P., & Bernier, A. V. (2021) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2020-319970 · Cited by 7
Self-citation
Pathogenesis, Prognosis and Outcomes of Multiple Organ Failure in Newborns (Review)
Golomidov, A. V., Grigoryev, E. V., Moses, V. G., & Мозес, К. Б. (2022) · General Reanimatology · doi:10.15360/1813-9779-2022-6-37-49 · Cited by 8
Organ dysfunction and mortality in preterm neonates with late-onset bloodstream infection
Kharrat, A., Zhu, F., Baczynski, M., Ye, X. Y., Weisz, D. E., & Jain, A. (2023) · Pediatric Research · doi:10.1038/s41390-023-02541-1 · Cited by 7
Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in neonatal sepsis
Doughty, C., O’Driscoll, D. N., Smith, S., O’Currain, E. M., Grant, T., O'Hare, F. M., Culliton, M., Watson, R. W. G., O’Neill, A., & Molloy, E. J. (2020) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2020.1786520 · Cited by 7
The utility of neonatal sequential organ failure assessment in mortality risk in all neonates with suspected late-onset infection
Gharaibeh, F. N. A., Liu, S., Wynn, J. L., & Aziz, K. B. (2025) · Journal of Perinatology · doi:10.1038/s41372-025-02304-2 · Cited by 6
Self-citation
Computerized Clinical Decision Support Systems for the Early Detection of Sepsis Among Pediatric, Neonatal, and Maternal Inpatients: Scoping Review
Ackermann, K., Baker, J., Festa, M. S., McMullan, B. J., Westbrook, J. I., & Li, L. (2022) · JMIR Medical Informatics · doi:10.2196/35061 · Cited by 6
Use of an electronic medical record to optimize a neonatal sepsis score for mortality prediction
Husain, A. N., Eiden, E., & Vesoulis, Z. A. (2022) · Journal of Perinatology · doi:10.1038/s41372-022-01573-5 · Cited by 6
Comparative assessment of the predictive ability of the nSOFA and NEOMOD scales in preterm newborns
Гильфановна, И. Р., Amirova, V. R., Миронов, П. И., & Au, L. (2022) · Russian Journal of Pediatric Surgery Anesthesia and Intensive Care · doi:10.17816/psaic1278 · Cited by 7
Genetic Testing and Hospital Length of Stay in Neonates With Epilepsy
Akbari, H., Sunderraj, A., Sanchez-Pinto, L. N., Berg, A. T., George, A. L., & Pardo, A. C. (2022) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2022.05.011 · Cited by 6
The Value of Perinatal Factors, Blood Biomarkers and Microbiological Colonization Screening in Predicting Neonatal Sepsis
Cao, I., Lippmann, N., & Thome, U. H. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195837 · Cited by 7
Neonatal Sepsis from 2014 to 2024: The Resurgence of Gram-Negative Rods
Fleiss, N., Murray, T. S., Feinn, R., Peaper, D. R., Gallagher, P. G., & Bizzarro, M. J. (2026) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2026.115031 · Cited by 7
Allocating Resources Across the Life Span During COVID-19—Integrating Neonates and Children Into Crisis Standards of Care Protocols
Lemmon, M. E., Truog, R. D., & Ubel, P. A. (2020) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2020.5215 · Cited by 5
Physiologically Based Pharmacokinetic Modeling of Vancomycin in Critically Ill Neonates: Assessing the Impact of Pathophysiological Changes
Shuai, W., Cao, J., Qian, M., & Tang, Z. (2024) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.6107 · Cited by 5
Assessment of Severity and Prediction of Outcomes in Premature Newborns Based on the nSOFA Scale
Миронов, П. И., Au, L., Amirova, V. R., & Гильфановна, И. Р. (2022) · Messenger of Anesthesiology and Resuscitation · doi:10.21292/2078-5658-2022-19-5-87-92 · Cited by 5
Use of vasopressors for septic shock in the neonatal intensive care unit
Foote, H. P., Benjamin, D. K., Greenberg, R. G., Clark, R. H., & Hornik, C. P. V. (2023) · Journal of Perinatology · doi:10.1038/s41372-023-01667-8 · Cited by 5
Neonatal Sequential Organ Failure Assessment Score Predicts Respiratory Outcomes in Preterm Newborns with Late-Onset Sepsis: A Retrospective Study
Poggi, C., Sarcina, D., Miselli, F., Ciarcià, M., & Dani, C. (2024) · Neonatology · doi:10.1159/000539526 · Cited by 5
Neonatal sepsis and septic shock: towards the implementation of phenotyping into clinical practice
Smolkina, E. O., & Au, L. (2025) · Russian Journal of Pediatric Surgery Anesthesia and Intensive Care · doi:10.17816/psaic1873 · Cited by 4
Multidrug-Resistant Bacteria Isolated from Blood Culture Samples in a Moroccan Tertiary Hospital: True Bacteremia or Contamination?
Nachate, S., Rouhi, S., Ouasif, H., Bennani, H., Hachimi, A., Mouaffak, Y., Younous, S., Bennaoui, F., Slitine, N. E. I., Maoulainine, F. M. R., et al. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s373065 · Cited by 4
Cardiopulmonary Physiology of Hypoxemic Respiratory Failure Among Preterm Infants with Septic Shock
Kharrat, A., Nissimov, S., Zhu, F., Deshpande, P., & Jain, A. (2024) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2024.114384 · Cited by 4
Cardiac dysfunction in newborns with intraamniotic infection
Аleksаndrovich, Y. S., Иванов, Д. О., Pavlovskaya, E. Y., Pshenisnov, K. V., & Bykov, Y. V. (2023) · Russian Journal of Anesthesiology and Reanimatology · doi:10.17116/anaesthesiology202303117 · Cited by 4
The NeoSep Severity and Recovery scores to predict mortality in hospitalized neonates and young infants with sepsis derived from the global NeoOBS observational cohort studyPreprint
Russell, N., Stöhr, W., Cook, A., Berkley, J. A., Adhisivam, B., Agarwal, R. K., Ahmed, A. N. U., Balasegaram, M., Chami, N., Bekker, A., et al. (2022) · medRxiv · doi:10.1101/2022.06.21.22276677 · Cited by 4
Neonatal Sepsis as Organ Dysfunction: Prognostic Accuracy and Clinical Utility of the nSOFA in the NICU—A Systematic Review
Cerbu, B., Boia, M., Pantea, M., Ignat, T., Dima, M. A., Enătescu, I., Rotea, B., Rotea, A., David, V. L., & Iacob, D. (2026) · Diagnostics · doi:10.3390/diagnostics16020349 · Cited by 3
Neonatal Sepsis-Induced Coagulopathy in the Light of Developmental Hemostasis: Friend or Foe?
Papadogeorgou, P., Sokou, R., Fortis, S. P., Mougiou, V., Boutsikou, T., Iacovidou, N. M., & Valsami, S. I. (2026) · Medicina · doi:10.3390/medicina62030584 · Cited by 3
Markers of platelet activation foR identification of late onset sEpsis in infaNTs: PARENT study protocol
O’Reilly, D. P., Murphy, C. A., Moore, C. M., Áinle, F. N., Gormley, I. C., Morrell, C. N., Curley, A., Callion, N. M., & Maguire, P. B. (2023) · Pediatric Research · doi:10.1038/s41390-023-02812-x · Cited by 3
Acute kidney injury in late-onset neonatal bacteraemia: The role of the neonatal sequential organ failure assessment tool in predicting kidney injury
Wildes, D. M., O’Reilly, D. P., Brennan, E., Drew, R. J., Awan, A., & Boyle, M. A. (2025) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2025-003336 · Cited by 3
Utility of Neonatal Sequential Organ Failure Assessment (nSOFA) Score for Neonatal Mortality Prediction
Srikanth, M., & Kumar, N. (2022) · Journal of Neonatology · doi:10.1177/09732179221113672 · Cited by 3
Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants
Xu, D., Dong, Z., Yin, X., Yang, Y., & Wang, Y. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1233189 · Cited by 3
Own Mother's Milk Protects against Necrotizing Enterocolitis, Sepsis and Poor Outcome of Preterm Infants.
Houchi, S. Z. E., Ismail, S., & Elmazzahy, E. A. (2022) · Pediatric Sciences Journal · doi:10.21608/cupsj.2022.141694.1057 · Cited by 3
Intensity of Vasopressor Therapy and In-Hospital Mortality for Infants and Children: An Opportunity for Counseling Families
Aziz, K. B., Boss, R. D., Yarborough, C. C., Raisanen, J. C., Neubauer, K., & Donohue, P. (2020) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2020.09.016 · Cited by 3
25-Hydroxy Vitamin D Deficiency – A Potential Risk Factor Neonatal Sepsis Correlation with Biochemical Markers and Neonatal Sequential Organ Failure Assessment Score
Mahmoud, N. M. S., & Elela, M. A. E. S. A. A. (2021) · Journal of Clinical Neonatology · doi:10.4103/jcn.jcn_30_21 · Cited by 2
Utility of the neonatal and pediatric sequential organ failure assessment scores in critically ill term neonates
Nicolas, L., Wynn, J. L., & de la Cruz, D. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1546408 · Cited by 3
Self-citation
The neonatal SOFA score in very preterm neonates with early-onset sepsis
Tagerman, M., Sahni, R., & Polin, R. A. (2025) · Pediatric Research · doi:10.1038/s41390-025-04068-z · Cited by 2
Self-citation
Development and Validation of a Diagnostic Prediction Model for Neonatal Sepsis in a Low-Resource Setting, Ethiopia
Teshager, N. W., Limenih, M. A., Lakew, A. M., & Alemu, D. S. (2025) · Journal of Epidemiology and Global Health · doi:10.1007/s44197-025-00486-8 · Cited by 2
Global Trends in Neonatal Sepsis: A Scopus Bibliometric Analysis of Publications from 2015 to 2025
Mulakoli, F. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1013122 · Cited by 2
Comparative characterization of scales used to assess the severity of newborns in the early neonatal period
Арсеновна, А. Д., Chistyakova, G. N., Владимировна, Б. С., Remizova, I. I., Валерьевна, Я. Г., & Андреевна, К. П. (2024) · Neonatology News Opinions Training · doi:10.33029/2308-2402-2024-12-1-18-26 · Cited by 2

Authors: Wynn, J. L., & Polin, R. A.
Affiliations: University of Florida Health (US)
Columbia University Irving Medical Center (US)
Corresponding author: Wynn, James L.
ORCID: Wynn, James L.
Polin, Richard A.
Venue: Pediatric Research
Publisher: Springer Science and Business Media LLC
Published: 2019-08-08
Volume: 88
Issue: 1
Pages: 85-90
ISSN: 0031-3998 (ISSN-L)
1530-0447
DOI: 10.1038/s41390-019-0517-2
PMC: PMC7007331
OpenAlex: W2966373709
Cited by: 169
References: 17
Citations by year: 2026: 31 · 2025: 23 · 2024: 20 · 2023: 24 · 2022: 34 · 2021: 24 · 2020: 13
FWCI: 16.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Pediatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM128452)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD089939)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
Keywords: late-onset sepsis, mortality prediction, organ dysfunction, bacteremia
MeSH terms: Neonatal Sepsis, Female, Humans, Infant, Newborn, Infant, Premature, Male, Retrospective Studies, Risk, ROC Curve, Severity of Illness Index, Case-Control Studies, Bacteremia, Disease Progression, Infant, Very Low Birth Weight, Electronic Health Records

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks