The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
Open accessAbstract
Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which makes this lipid a versatile signaling molecule. This differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis; and also, how it can act as a powerful mediator of pathological conditions, such as neuropathic pain, neurodegenerative diseases, and cancer progression. Ultimately, we review the preclinical and clinical uses of Autotaxin, LPA, and its receptors as therapeutic targets, approaching the most recent data of promising molecules modulating both LPA production and signaling. This review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.
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Cited by
Cheng, P. T. W., Kaltenbach, R. F., Zhang, H., Shi, J., Tao, S., Li, J., Kennedy, L. J., Walker, S. J., Shi, Y., Wang, Y., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01256 · Cited by 61
Lipid and lipoprotein metabolism in microglia: Alzheimer’s disease mechanisms and interventions
Sprenger, K. G., Lietzke, E. E., Melchior, J. T., & Bruce, K. D. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100872 · Cited by 42
GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator
Kitakaze, K., Ali, H., Kimoto, R., Takenouchi, Y., Ishimaru, H., Yamashita, A., Ueda, N., Tanaka, T., Okamoto, Y., & Tsuboi, K. (2023) · Communications Biology · doi:10.1038/s42003-023-04900-4 · Cited by 9
Metadata
- Authors
- Geraldo, L. H. M., Spohr, T. C. L. D. S., Amaral, R. F. D., Fonseca, A. C. C. D., Garcia, C., Mendes, F. D. A., Freitas, C., dosSantos, M. F., & Lima, F. R. S.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2021-02-01
- Volume
- 6
- Issue
- 1
- Pages
- 45-45
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W3126556456
- Cited by
- 313
- References
- 215
- FWCI
- 12.95
- Type
- journal article
- Language
- en
- Open access
- gold
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- Geraldo, L. H. M., Spohr, T. C. L. D. S., Amaral, R. F. D., Fonseca, A. C. C. D., Garcia, C., Mendes, F. D. A., Freitas, C., dosSantos, M. F., & Lima, F. R. S. (2021). Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-020-00367-5
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