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Colorectal liver metastasis: molecular mechanism and interventional therapy
Open accessAbstract
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.
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Metadata
- Authors
- Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., & Wen, Y.
- Affiliations
- Central South University (CN)
- The University of Texas at Arlington (US)
- Sichuan University (CN)
- Corresponding author
- Xiong, Li
- Chen, Wei
- Wen, Yu
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2022-03-04
- Volume
- 7
- Issue
- 1
- Pages
- 70-70
- ISSN
- 2059-3635 (ISSN-L)
- PMC
- PMC8897452
- OpenAlex
- W4214924743
- Cited by
- 298
- References
- 435
- Citations by year
- 2026: 55 · 2025: 99 · 2024: 68 · 2023: 60 · 2022: 16
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Anglia Ruskin Research Online (Anglia Ruskin University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- University of Texas at Arlington
- National Natural Science Foundation of China (82000756, 81873640, 81970569, 81773293)
- Hunan Provincial Science and Technology Department (2017WK2063, 2015GK3117)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- colorectal liver metastases, colorectal cancer, molecular mechanisms, tumor microenvironment, targeted therapy, diagnosis, treatment, prognosis
- MeSH terms
- Humans, Liver Neoplasms, Colorectal Neoplasms, Tumor Microenvironment
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