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Cited by 299Colorectal Cancer Treatments and StudiesCancer Cells and MetastasisHepatocellular Carcinoma Treatment and Prognosis

The DOI matches its Crossref record; 435 of the 435 references it cites were found in a registry or an index.

Colorectal liver metastasis: molecular mechanism and interventional therapy

Open access
Zhou, Hui, Liu, Zhongtao, Wang, Yongxiang, Wen, Xiaoyong, Amador, Eric H., Yuan, Liqin, Ran, Xin, Xiong, Li, Ran, Yuping, Chen, Wei, Wen, Yu·2022·Signal Transduction and Targeted Therapy
DOI 10.1038/s41392-022-00922-2PMC PMC8897452
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Abstract

Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

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Crossref · 10.1038/s41392-022-00922-2

Cites

435 of 435 references verified0 citation errors · 0 not checkable

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Figures

Fig. 1 Schematic showing the liver metastasis cascade of CRC
Fig. 1 Schematic showing the liver metastasis cascade of CRCCC BY · PubMed Central
Fig. 2 CRC-derived exosomes content and mechanisms for CRLM
Fig. 2 CRC-derived exosomes content and mechanisms for CRLMCC BY · PubMed Central
Fig. 3 Schematic illustration the exosomal interaction between CRC cells and TAMs that reveals the molecular mechanism of CRLM
Fig. 3 Schematic illustration the exosomal interaction between CRC cells and TAMs that reveals the molecular mechanism of CRLMCC BY · PubMed Central
Fig. 4 HGF/c‐MET signaling pathways and its role in cellular activity
Fig. 4 HGF/c‐MET signaling pathways and its role in cellular activityCC BY · PubMed Central
Fig. 5 The roles of PRL3 in cellular activity
Fig. 5 The roles of PRL3 in cellular activityCC BY · PubMed Central
Fig. 6 Schematic illustration of Notch pathway regulatory mechanisms
Fig. 6 Schematic illustration of Notch pathway regulatory mechanismsCC BY · PubMed Central
Fig. 7 Schematic illustration of TGF-β pathway regulatory mechanisms
Fig. 7 Schematic illustration of TGF-β pathway regulatory mechanismsCC BY · PubMed Central

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Research works printed but not linked: 1

  1. Ma, L., Zou, X., Chen, W. & New, A. X-ray Induced Nanoparticle Photosensitizers For Cancer Treatment. J. Biomed. Nanotechnol. 10, 1501–1508 (2014). · DOI

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Metadata

Authors
Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., & Wen, Y.
Affiliations
  • Central South University (CN)
  • The University of Texas at Arlington (US)
  • Sichuan University (CN)
Corresponding author
  • Xiong, Li
  • Chen, Wei
  • Wen, Yu
ORCID
Venue
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Published
2022-03-04
Volume
7
Issue
1
Pages
70-70
ISSN
2059-3635 (ISSN-L)
DOI
10.1038/s41392-022-00922-2
PMC
PMC8897452
OpenAlex
W4214924743
Cited by
298
References
435
Citations by year
2026: 55 · 2025: 99 · 2024: 68 · 2023: 60 · 2022: 16
FWCI
7.45
Type
journal article
Language
en
Open access
Licence
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Anglia Ruskin Research Online (Anglia Ruskin University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
  • University of Texas at Arlington
  • National Natural Science Foundation of China (82000756, 81873640, 81970569, 81773293)
  • Hunan Provincial Science and Technology Department (2017WK2063, 2015GK3117)
Topics
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
Keywords
colorectal liver metastases, colorectal cancer, molecular mechanisms, tumor microenvironment, targeted therapy, diagnosis, treatment, prognosis
MeSH terms
Humans, Liver Neoplasms, Colorectal Neoplasms, Tumor Microenvironment

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