Cited by 299Colorectal Cancer Treatments and StudiesCancer Cells and MetastasisHepatocellular Carcinoma Treatment and Prognosis

The DOI matches its Crossref record; 435 of the 435 references it cites were found in a registry or an index.

Colorectal liver metastasis: molecular mechanism and interventional therapy

Open access

Zhou, Hui, Liu, Zhongtao, Wang, Yongxiang, Wen, Xiaoyong, Amador, Eric H., Yuan, Liqin, Ran, Xin, Xiong, Li, Ran, Yuping, Chen, Wei, Wen, Yu·2022·Signal Transduction and Targeted Therapy

DOI 10.1038/s41392-022-00922-2PMC PMC8897452

Open this paper in CoChat — free account Open PDF

Abstract

Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41392-022-00922-2

Cites

435 of 435 references verified0 citation errors · 0 not checkable

Statistics

Fig. 1 Schematic showing the liver metastasis cascade of CRCCC BY · PubMed Central

Fig. 2 CRC-derived exosomes content and mechanisms for CRLMCC BY · PubMed Central

Fig. 3 Schematic illustration the exosomal interaction between CRC cells and TAMs that reveals the molecular mechanism of CRLMCC BY · PubMed Central

Fig. 4 HGF/c‐MET signaling pathways and its role in cellular activityCC BY · PubMed Central

Fig. 5 The roles of PRL3 in cellular activityCC BY · PubMed Central

Fig. 6 Schematic illustration of Notch pathway regulatory mechanismsCC BY · PubMed Central

Fig. 7 Schematic illustration of TGF-β pathway regulatory mechanismsCC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

7 retracted

MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
Cheng, D., Zhao, S., Tang, H., Zhang, D., Sun, H., Yu, F., Jiang, W., Yue, B., Wang, J., Zhang, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9900 · Cited by 120
Self-citation
Retracted
RETRACTED ARTICLE: miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer
Zhang, J., Xiao, Z., Lai, D., Sun, J., He, C., Chu, Z., Ye, H., Chen, S., & Wang, J. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.251 · Cited by 114
Retracted
RETRACTED ARTICLE: FOXC2 promotes colorectal cancer metastasis by directly targeting MET
Cui, Y.-M., Jiao, H.-L., Ye, Y.-P., Chen, C.-M., Wang, J.-X., Tang, N., Li, T.-T., Lin, J., Qi, L., Wu, P., et al. (2014) · Oncogene · doi:10.1038/onc.2014.368 · Cited by 82
Retracted
Retracted: GNA 13 promotes tumor growth and angiogenesis by upregulating CXC chemokines via the NF ‐κB signaling pathway in colorectal cancer cells
Zhang, Z., Tan, X., Luo, J., Cui, B., Lei, S., Si, Z., Shen, L., & Yao, H. (2018) · Cancer Medicine · doi:10.1002/cam4.1783 · Cited by 47
Retracted
Retracted: Exosomal miR‐1255b‐5p targets human telomerase reverse transcriptase in colorectal cancer cells to suppress epithelial‐to‐mesenchymal transition
Zhang, X., Bai, J., Yin, H., Long, L., Zheng, Z., Wang, Q., Chen, F., Yu, X., & Zhou, Y. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12765 · Cited by 47
Retracted
MicroRNA‑432‑5p inhibits cell migration and invasion by targeting CXCL5 in colorectal cancer
Luo, M., Hu, Z., Kong, Y., & Li, L. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9732 · Cited by 30
Retracted
PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway
Tang, B., Liang, W., Liao, Y., Li, Z., Wang, Y., & Yan, C. (2018) · Oncology Reports · doi:10.3892/or.2018.6825 · Cited by 28
Self-citation
Retracted
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109
Global cancer statistics
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077

Show all 435 references

Research works printed but not linked: 1

Ma, L., Zou, X., Chen, W. & New, A. X-ray Induced Nanoparticle Photosensitizers For Cancer Treatment. J. Biomed. Nanotechnol. 10, 1501–1508 (2014). · DOI

Sorted by citations

Items 101–200 of 299

Intracellular and extracellular factors of colorectal cancer liver metastasis: a pivotal perplex to be fully elucidated
Niu, Y., Yang, W., Qian, H., & Sun, Y. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02766-w · Cited by 10
Functional Proteomics Characterization of the Role of SPRYD7 in Colorectal Cancer Progression and Metastasis
Montero‐Calle, A., de Ocaña, S. J., Benavente-Naranjo, R., Rejas‐González, R., Bartolomé, R. A., Martínez‐Useros, J., Sanz, R., Dziaková, J., Fernández‐Aceñero, M. J., Mendiola, M., et al. (2023) · Cells · doi:10.3390/cells12212548 · Cited by 9
Exploring immune status in peripheral blood and tumor tissue in association with survival in patients with multi-organ metastatic colorectal cancer
Bakkerus, L., Subtil, B., Bontkes, H. J., Gootjes, E. C., Reijm, M., Vullings, M., Verrijp, K. C. N., Bokhorst, J., Woortman, C., Nagtegaal, I. D., et al. (2024) · OncoImmunology · doi:10.1080/2162402x.2024.2361971 · Cited by 9
Cancer Metastases to the Liver: Mechanisms of Tumor Cell Colonization
Andryszkiewicz, W., Misiąg, P., Karwowska, A., Resler, Z., Wojno, A., Kulbacka, J., Szewczyk, A., & Rembiałkowska, N. (2024) · Pharmaceuticals · doi:10.3390/ph17091251 · Cited by 9
Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery
Abdeljaoued, S., Doussot, A., Kroemer, M., Laloy, E., Pallandre, J., Kaddissi, A. E., Spehner, L., Khelil, M. B., Bouard, A., Mougey, V., et al. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2455176 · Cited by 10
Tumor Immune Microenvironment and Current Status of Immune Checkpoint Inhibitor Therapy in Colorectal Cancer Liver Metastasis
Cao, D., & Zhou, A. (2025) · Current Oncology · doi:10.3390/curroncol32090493 · Cited by 9
Studies on the mechanism of local and extra-intestinal tissue manifestations in AOM-DSS-induced carcinogenesis in BALB/c mice: role of PARP-1, NLRP3, and autophagy
Singla, S., & Jena, G. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02878-8 · Cited by 8
Evolving landscape of treatments targeting the microenvironment of liver metastases in non-small cell lung cancer
Zhu, L., Yu, X., Tang, X., Hu, C., Wu, L., Liu, Y., & Zhou, Q. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002981 · Cited by 8
Fe 3 O 4 nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis
Fan, X., Lv, C., Xue, M., Meng, P., & Qian, X.-P. (2024) · Cell Adhesion & Migration · doi:10.1080/19336918.2024.2427585 · Cited by 8
Molecular landscape of colorectal cancer liver metastasis: Tumor microenvironment heterogeneity and driver inference
Zhang, A., Zhang, Y., Xu, J., Zhu, R., Liang, T., & Guo, L. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104946 · Cited by 8
Cell-free chromatin state tracing reveals disease origin and therapy responses
Chen, X., Meng, X., Zhang, W., Zhang, X., Zhang, Y., Yang, P., Liu, Y., Bao, F., Li, S., Wang, J., et al. (2026) · Nature · doi:10.1038/s41586-026-10224-0 · Cited by 12
Self-citation
Rebound increase in microRNA levels at the end of 5-FU-based therapy in colorectal cancer patients
Badr, D. M., Fouad, M. A., Hussein, M. M., Salem, S., Zekri, A. N., & Shouman, S. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-41030-7 · Cited by 9
Establishment of a Novel Anti-Mouse CCR1 Monoclonal Antibody C 1 Mab-6
Ouchida, T., Isoda, Y., Nakamura, T., Yanaka, M., Tanaka, T., Handa, S., Kaneko, M. K., Suzuki, H., & Kato, Y. (2024) · Monoclonal Antibodies in Immunodiagnosis and Immunotherapy · doi:10.1089/mab.2023.0032 · Cited by 8
Estrogen Receptor Blockade Potentiates Immunotherapy for Liver Metastases by Altering the Liver Immunosuppressive Microenvironment
Benslimane, Y., Amalfi, K., Lapin, S., Perrino, S., & Brodt, P. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0196 · Cited by 10
Antiproliferative and Apoptotic Effects of Solenostemma argel Leaf Extracts on Colon Cancer Cell Line HCT-116
Maad, A. H., AL-Gamli, A. H., Shamarekh, K. S., Refat, M., & Shayoub, M. E. A. (2024) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/3001 · Cited by 8
PDT-regulated immune gene prognostic model reveals tumor microenvironment in colorectal cancer liver metastases
Xu, J., Zhou, H., Liu, Z., Huang, Y., Zhang, Z., Zou, H., & Wang, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-97667-z · Cited by 8
Self-citation
Prognostic circulating proteomic biomarkers in colorectal liver metastases
Kim, D., Gupta, B., & Wong, G. Y. M. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.03.011 · Cited by 8
HIPK2 in Colon Cancer: A Potential Biomarker for Tumor Progression and Response to Therapies
Verdina, A., Garufi, A., D’Orazi, V., & D’Orazi, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147678 · Cited by 7
Pathogenetic development, diagnosis and clinical therapeutic approaches for liver metastasis from colorectal cancer (Review)
Jin, Z., Li, Y., Hao, Y., Wang, M., Wang, C., Du, S., Zeng, W., & Zong, Z. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5728 · Cited by 8
Discovery of WEE1 Kinase Inhibitors with Potent Activity against Patient-Derived, Metastatic Colorectal Cancer Organoids
Syphers, J. L., Wright, J. A., Liu, S., Gee, Y. S., Gao, F., Mudududdla, R., Che, D. Q., Chang, A., Sloan, E. K., Narasimhan, V., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02541 · Cited by 7
ATRA upregulates OTUD6B to recruit CD8+ T cells to suppress colorectal liver metastasis by stabilizing DDX5/STAT3/CXCL11 axis
Li, J., Huang, K., Yang, B., Hu, X., Mei, B., Cheng, X., Zhong, X., Cao, C., Chen, Z., Wang, H., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07837-0 · Cited by 7
Ex vivo modelling of human colorectal cancer liver metastasis by normothermic machine perfusion
Trebo, M., Maurer, T., Krendl, F. J., Salcher, S., Martowicz, A., Hautz, T., Sopper, S., Amann, A., Cardini, B., Poelsler, L. H., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02430-7 · Cited by 7
Manganese-engineered Lactobacillus Reuteri with enhanced antitumor and immunomodulatory activities for colorectal cancer prevention and treatment
Cao, P., Li, Q., Li, Y., Guo, H., Wei, C., Xu, R., Ouyang, C., Chen, W., Wang, L., & Wang, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-67437-6 · Cited by 11
Self-citation
Evaluation of clinical applicability of automated liver parenchyma segmentation of multi-center magnetic resonance images
Nainamalai, V., Prasad, P. J. R., Pelanis, E., Edwin, B., Albregtsen, F., Elle, O. J., & Kumar, R. P. (2022) · European Journal of Radiology Open · doi:10.1016/j.ejro.2022.100448 · Cited by 9
The Interplay between Anti-Angiogenics and Immunotherapy in Colorectal Cancer
Maiorano, B. A., Parisi, A., Maiello, E., & Ciardiello, D. (2022) · Life · doi:10.3390/life12101552 · Cited by 8
A novel prognostic gene set for colon adenocarcinoma relative to the tumor microenvironment, chemotherapy, and immune therapy
Zhou, H., Wang, Y., Zhang, Z., Xiong, L., Liu, Z., & Wen, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.975404 · Cited by 7
Self-citation
Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer
Yue, C., Chen, J., Li, Z.-Y., Li, L., Chen, J., Xie, H., Zhang, B., & Guo, Y.-M. (2023) · Cell Biology and Toxicology · doi:10.1007/s10565-023-09837-2 · Cited by 7
CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer
Wang, Z. P., Zhang, C., Guo, J., Yang, Y., Li, P., Wang, Z., Liu, S., Zhang, L., Zeng, X., Zhai, J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109676 · Cited by 7
Emerging roles and biomarker potential of WNT6 in human cancers
Ferreira, J. M., Gonçalves, C. S., & Costa, B. M. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01892-4 · Cited by 6
A machine learning-based prediction model for colorectal liver metastasis
Feng, S., Zhou, M., Huang, Z., Xiao, X., & Zhong, B. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01699-8 · Cited by 6
Circ_0084927 promotes progression of intrahepatic cholangiocarcinoma by sponging miR-4725-5p to activate the PDPK1/AKT/mTOR signaling pathway
Xie, C., Zhou, G., Chen, T., Li, Q., Yuan, H., Xu, Y., Zhang, K., Wang, C., Hao, X., & Yu, H. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111965 · Cited by 6
Orally Deliverable Engineered Porphyrin Nanohybrids Activate the cGAS-STING Axis and Enable Fusobacterium-Specific Targeting for Robust Immune Remodeling and Colorectal Cancer Regression
Liang, R., Lin, F., Mo, X., Long, J., Tang, W., Luo, T., & Huang, Y. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c09122 · Cited by 7
A spatially resolved single-cell landscape of colorectal cancer liver metastasis reveals a stromal-tumor glycolytic signaling interaction
Chen, J., Wang, Z., Zhu, B., & Guan, G. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1687485 · Cited by 7
Hypoxic migrasomes drive colorectal cancer liver metastasis by mediating CD5L+ macrophage efferocytosis via NRP2/PROX1 axis
Luo, Y., Huang, Y., Huang, Y., & Chen, L. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07485-0 · Cited by 6
Feedback regulation between histone H3 lysine 18 lactylation and TROP2‐mediated glycolysis drives metastatic progression of colorectal cancer
Wang, W., Deng, Y., Li, W., Wang, R., Zhou, C., Xu, Y., He, J., Liao, L. E., Lan, J., Yu, L., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70562 · Cited by 8
PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on 18F-FDG
Zadeh, M. Z. (2023) · Clinical & Experimental Metastasis · doi:10.1007/s10585-023-10231-9 · Cited by 6
Cytochrome P450 F3 promotes colorectal cancer via inhibiting NRF2-mediated ferroptosis
Xu, Z., Xu, C., Lu, J., He, C., Wang, X., Zhu, D., Wang, A., Zhang, Z., & Jiang, C. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102077 · Cited by 6
Construction of a prognostic signature associated with liver metastases for prognosis and immune response prediction in colorectal cancer
Liu, C., Lü, Z., Yan, J., Dong, X., He, X., Huang, W., Sun, Q., Zhao, W., & Li, F. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1234045 · Cited by 6
Investigation of the enhanced antitumour potency of CD46-specific chimeric antigen receptor-T cells in human colorectal cancer liver metastases after combination with nanotherapeutics
Meng, Q., Xu, J., Wang, J., Zhang, X., Yang, H., Sun, H. X., Wu, S., Aschner, M., Li, X., Zhang, L., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101985 · Cited by 6
Detection of Liver Lesions in Colorectal Cancer Patients Using 18F-FDG PET/CT Dual-Time-Point Scan Imaging
Boanova, L. G., Altmayer, S., Watte, G., Raupp, A. A., Francisco, M. Z., de Oliveira, G. S., Hochhegger, B., & Andrade, R. G. F. (2023) · Cancers · doi:10.3390/cancers15225403 · Cited by 7
Study Deciphering the Crucial Involvement of Notch Signaling Pathway in Human Cancers
Pandey, P., Khan, F., Singh, M., verma, A., Kumar, H., Mazumder, A., & Rakhra, G. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/0118715303261691231107113548 · Cited by 6
Exosomal FGG promotes colorectal cancer liver metastases through inducing angiogenic pre-metastatic niche formation
Yang, L., Chen, L., Chen, X., Huang, H., Zhu, H., Zeng, L., Huang, J., & Ding, H. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110625 · Cited by 5
Delta-Radiomics Biomarker in Colorectal Cancer Liver Metastases Treated with Cetuximab Plus Avelumab (CAVE Trial)
Nardone, V., Patanè, V., Marinelli, L., D’Ambrosio, L., Tufo, S. D., Chiara, M. D., Brunese, M. C., Rubini, D., Grassi, R., Russo, A., et al. (2025) · Diagnostics · doi:10.3390/diagnostics15222914 · Cited by 5
Liver transplantation for colorectal metastasis – selection criteria, outcomes, and management recurrence: a systematic review and meta-analysis
Ahmed, A. F. S., Wehrle, C. J., Ring, T., Jr., Wu, J. C., Hong, H., Nadeem, M. A., Byrne, M., Iuppa, G., Linganna, M. W., Esfeh, J. M., et al. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000004018 · Cited by 6
Integrated single-cell and spatial transcriptomics uncover SPP1⁺ and HLA-DRB5⁺ macrophages as key modulators of the immune microenvironment in colorectal cancer liver metastasis
Xie, S., Li, J., Heng, S., Xiao, J., Chen, J., & Qi, X. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07853-4 · Cited by 6
Generation and assessment of cytokine-induced killer cells for the treatment of colorectal cancer liver metastases
Li, C. M. Y., Tomita, Y., Dhakal, B., Tin, T., Li, R., Wright, J. A., Vrbanac, L., Woods, S. L., Drew, P. A., Price, T. J., et al. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-023-03591-4 · Cited by 5
Optimized Deep Learning Model for Predicting Liver Metastasis in Colorectal Cancer Patients
Wang, M., Chen, J., & Liu, Y. (2025) · Symmetry · doi:10.3390/sym17010103 · Cited by 5
5‐hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target
Xu, N., Gao, Z., Wu, D., Chen, H., Zhang, Z., Zhang, L., Wang, Y., Lu, X., Xu, Y., Liu, X., et al. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70189 · Cited by 5
Self-citation
Metastatic hepatic carcinoma: Mechanisms, emerging therapeutics, and future perspectives
Zhou, J., Sui, Y., & chen, Z. (2025) · iScience · doi:10.1016/j.isci.2025.112902 · Cited by 6
Cohort study of long-term survival and recurrence patterns following operative management of colorectal liver metastasis — is follow-up beyond 5 years warranted?
Hajibandeh, S., Mowbray, N. G., Chin, C. Y. S., Alessandri, G., Duncan, T., O’Reilly, D. J., & Kumar, N. (2022) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-022-02707-1 · Cited by 5
Knockdown of long non-coding RNA LINC01123 plays a molecular sponge on miR-625-5p to inhibit the process of colorectal cancer cells via LASP1
Shang, T., Pang, S., & Dong, Y. (2023) · Journal of Molecular Histology · doi:10.1007/s10735-023-10141-w · Cited by 5
Machine learning-based radiomic analysis and growth visualization for ablation site recurrence diagnosis in follow-up CT
Yin, Y., de Haas, R. J., Alves, N. A., Pennings, J. P., Ruiter, S. J. S., Kwee, T. C., & Yakar, D. (2024) · Abdominal Radiology · doi:10.1007/s00261-023-04178-4 · Cited by 5
A multidimensional recommendation framework for identifying biological targets to aid the diagnosis and treatment of liver metastasis in patients with colorectal cancer
Qi, F., Gao, N., Li, J., Zhou, C.-F., Jiang, J., Zhou, B., Guo, L.-T., Feng, X., Ji, J., Cai, Q., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02155-z · Cited by 10
Growth regulated oncogene-α contribute to EMT/MMPs pathway by binding its receptors in head and neck squamous cell carcinoma
Chan, L., Tseng, Y., Wang, H., Chien, C., Wu, C., Wang, L., & Liang, C. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120791 · Cited by 5
New Potential Immune Biomarkers in the Era of Precision Medicine: Lights and Shadows in Colorectal Cancer
Damato, A., Rotolo, M., Caputo, F., Borghi, E., Iachetta, F., & Pinto, C. (2022) · Life · doi:10.3390/life12081137 · Cited by 5
Extensive Phenotypic Characterization of T Cells Infiltrating Liver Metastasis from Colorectal Cancer: A Potential Role in Precision Medicine
Sampaio-Ribeiro, G., Ruivo, A. D. S., Silva, A., Santos, A. L., Oliveira, R. C., Laranjeira, P., Gama, J. M., Cipriano, M. A., Tralhão, J. G., & Paiva, A. A. (2022) · Cancers · doi:10.3390/cancers14246069 · Cited by 5
The role of tumor-associated fibroblast-derived exosomes in chemotherapy resistance of colorectal cancer and its application prospect
Liu, M., Li, T.-Z., & Xu, C. (2025) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2025.130796 · Cited by 5
Exosomal circUBQLN1 facilitates M2 polarization of macrophages and enhances colorectal cancer progression by modulating the miR-34c-5p/CSF1R axis
Wang, W., Ren, X., Chu, Q., Wang, W., Quan, Y., Zhang, L., & Zhang, X. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156049 · Cited by 4
The survival analysis of stage III and IV inoperable lung large cell neuroendocrine carcinoma and the role of LIPI in immunological stratification
Li, R., Xie, W., Chen, R., Wu, J., Wang, L., Sun, Y., Lin, X., Xie, X., Xie, Z., Liu, L., et al. (2025) · Lung Cancer · doi:10.1016/j.lungcan.2025.108698 · Cited by 4
Yanggan Yizhong decoction prevents liver metastasis from colorectal cancer by targeting myeloid-derived suppressor cells through the regulation of bile acid metabolism in the gut microbiota
Xie, H., Zhu, S., Xue, P., Xie, F., Zhao, L., & Chu, X. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1639442 · Cited by 4
Clinicopathological insights and management of liver metastases: Current advances and future perspectives
Ebrahim, N. A. A., Farghaly, T. A., El-Sherif, A. A., Fahmy, A., Othman, M. O., Tahoun, N. S., Korany, O. M., Arafat, A. M. A., Oreaba, R., & Soliman, S. M. A. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i10.110026 · Cited by 6
Microwave dynamic therapy induces ferroptosis in colorectal cancer by targeting PTK2B to regulate STAT3-mediated GPX4 expression
Zhou, H., Zhang, Z., Liu, Z., Xiong, L., Ran, X., Liu, J., Ran, Y., Wen, Y., Chen, W., & Xu, J. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00322-2 · Cited by 4
Self-citation
USP11 promotes colorectal cancer progression by stabilizing EGFR and TRAF6: a potential therapeutic target in EGFR- and TLR-driven tumorigenesis
Shin, J. H., Kim, J. Y., Kim, S. H., Kang, Y.-T., Lee, H.-J., Kim, M., Choi, J., Jeong, S., Park, S.-O., Cho, Y. B., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08266-9 · Cited by 4
Development and independent validation of explainable radiomics-based machine learning models for prognosis in colorectal liver metastases
Brunetti, A., Zaccaria, G. M., Sibilano, E., Marzi, S., Vidiri, A., & Bevilacqua, V. (2026) · Frontiers in Digital Health · doi:10.3389/fdgth.2025.1752699 · Cited by 5
Colorectal cancer liver metastases: A radiologic point of view
Reginelli, A., Patanè, V., & Cappabianca, S. (2025) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v17.i8.103473 · Cited by 4
Clinical and molecular heterogeneity associated with tumor sidedness in colorectal liver metastasis: a multicenter propensity cohort study
Wu, Y., Zhou, J., Wang, H., Fang, G., Weiping, Z., Cai, S., & Wang, L. (2023) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn-22-285 · Cited by 4
Direct-Current Electrical Field Stimulation of Patient-Derived Colorectal Cancer Cells
Lange, F., Porath, K., Sellmann, T., Einsle, A., Jaster, R., Linnebacher, M., Köhling, R., & Kirschstein, T. (2023) · Biology · doi:10.3390/biology12071032 · Cited by 4
Knockdown LIMP2 inhibits colorectal cancer cells migration, invasion, and metastasis
Tian, Y., Liang, L., Chen, J., Liu, J., Su, Y., Shi, M., Li, W., Zhang, J., Feng, Y., He, L., et al. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113757 · Cited by 4
ANP32A Knockdown Attenuates the Malignant Biological Behavior of Colorectal Cancer Cells by Suppressing Epithelial-mesenchymal Transition and ERK Activation
Li, X., Li, X., Liu, G., Zhou, L., Liu, Y., Dou, T., Chen, X., & Wang, J. (2023) · Journal of Cancer · doi:10.7150/jca.84687 · Cited by 4
A network meta-analysis of efficacy and safety for first-line and maintenance therapies in patients with unresectable colorectal liver metastases
Jiang, Y., Shao, T., Zhao, M., Xue, Y., & Zheng, X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1374136 · Cited by 4
Rapid detection of liver metastasis risk in colorectal cancer patients through blood test indicators
Zhou, Y., Li, G., & Xu, W. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1460136 · Cited by 4
Surgical microwave ablation of 3035 liver tumors in 1416 patients: a retrospective analysis of 16 years of experience
Wells, A. B., Butano, V. W., Phillips, M. C., Young, R. W., Cavallo, K. M., Blanco, D. G., McKillop, I. H., Baker, E. H., Martinie, J. B., & Iannitti, D. A. (2025) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2025.102176 · Cited by 4
Engineered protein circuits for cancer therapyPreprint
Lu, A. C., Moeller, L., Moore, S., Ho, K., Tobin, V., Qiang, A., Zhang, E., Li, Z., Wang, M., Xia, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.16.647665 · Cited by 5
Impact of Positive Lymph Nodes after Systematic Perihilar Lymphadenectomy in Colorectal Liver Metastases
Hess, G. F., Aegerter, N. L. E., Zeindler, J., Vosbeck, J., Neuschütz, K., Müller, P. C., Muenst, S. E., Däster, S., Bolli, M., Kollmar, O., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13175301 · Cited by 3
E-cadherin inhibits the proliferation and migration of human colorectal cancer cells through Hippo signaling pathway
Wang, Z., Qin, X., Liu, S., Wen, Y., Lan, B., Liao, H., & Wei, H. (2025) · European Journal of Histochemistry · doi:10.4081/ejh.2025.4196 · Cited by 3
Self-citation
Exploiting network-based drug repositioning to target metastasis in colorectal cancer: In-Silico prediction and in-vitro evidence
Bazyari, M. J., Firouzjaei, A. A., Ahmadi, S. M., Khorashadizadeh, M., & Aghaee‐Bakhtiari, S. H. (2025) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2025.102053 · Cited by 3
Artificial Intelligence in the Evolution of Interventional Therapy for Liver Cancer: Navigating the Tumor Microenvironment
Xiu, Z., Zeng, W., Guo, J., Tu, G., Chen, X., Sheng, J., & Chen, H. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl37633 · Cited by 3
Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis
Zhang, Y., Zhang, Y., Shen, C., Li, J., Wang, H., Hamad, A. B., Cao, C., Moheb, M. E., Wang, Y., Xia, Y., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102589 · Cited by 3
Self-citation
Long non-coding RNA H19 transported by colorectal cancer small extracellular vesicles promotes alternative splicing in healthy hepatocytes: new insights on liver pre-metastatic niche formation
Loria, M., Anello, D., Cordaro, A., Zichittella, C., Fontana, S., Alessandro, R., & Conigliaro, A. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02738-x · Cited by 3
Gender-based variations in surgical management of colorectal liver metastases: comprehensive analysis
Koch, P. F., Ludwig, K., Hillebrandt, K. H., Freitag, H., Blank, M., Knitter, S., Modest, D. P., Krenzien, F., Lurje, G., Schöning, W., et al. (2025) · BMC Cancer · doi:10.1186/s12885-025-13612-3 · Cited by 3
Prognostic analysis of patients with CRLM based on CRS score: a single-center retrospective study
Xue, J.-S., Maimaitiming, N., Zhang, B.-L., Xu, B., Yin, X., Huang, Z. J., Che, X., Zhao, H., & Cai, J.-Q. (2025) · BMC Cancer · doi:10.1186/s12885-025-14135-7 · Cited by 3
Targeting colorectal cancer liver metastasis through repurposing metabolic and immune inhibitors: A theoretical study
Mondal, M., Lahiri, A., & Datta, A. A. (2025) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2025.108689 · Cited by 5
Gemcitabine-loaded synthetic high-density lipoprotein preferentially eradicates hepatic monocyte-derived macrophages in mouse liver with colorectal cancer metastases
Xiong, F., Zhang, W., Zheng, C., Li, Y., Gong, X., Zhang, Y., Wang, H., Zhang, P.-C., & Li, Y. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01110-w · Cited by 3
RETRACTED: Evaluation of bevacizumab biosimilar on wound healing complications in patients with colorectal cancer undergoing endoscopic mucosal resection: A systematic review and meta‐analysis in anorectal medicine
Li, Y., Mei, Z., Shi, L., Wan, Y., Zhou, X., Zeng, T., Liu, Y., Yang, J. Y., & Shi, Z. (2024) · International Wound Journal · doi:10.1111/iwj.14638 · Cited by 3
Retracted
Anti-Metastatic Effects of Standardized Polysaccharide Fraction from Diospyros kaki Leaves via GSK3β/β-Catenin and JNK Inactivation in Human Colon Cancer Cells
Lee, W., Shin, J., Jang, S.-Y., Chung, K., Kim, S.-D., Cho, C., Hong, H., Rhee, Y. K., & Lee, K. (2024) · Polymers · doi:10.3390/polym16091275 · Cited by 4
Hypoxia‐Associated GPNMB + Macrophages Promote Malignant Progression of Colorectal Cancer and Its Related Risk Signature Are Powerful Predictive Tool for the Treatment of Colorectal Cancer Patients
Zhang, J., Hu, S., Jin, X., Zheng, Y., Yu, L., Ma, J., Gu, B., Wang, F., & Wu, W. (2024) · Environmental Toxicology · doi:10.1002/tox.24426 · Cited by 3
Upregulation of ABLIM1 Differentiates Intrahepatic Cholangiocarcinoma from Hepatocellular Carcinoma and Both Colorectal and Pancreatic Adenocarcinoma Liver Metastases
Draškovič, T., Ranković, B., Zidar, N., & Hauptman, N. (2024) · Genes · doi:10.3390/genes15121545 · Cited by 3
Deep learning model for predicting the RAS oncogene status in colorectal cancer liver metastases
Zhang, B., Wang, K., Xu, T., Zhu, H., Wang, K., Wang, J., Xiang, Y., He, X., Zhu, S., An, C., et al. (2025) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_1910_24 · Cited by 3
SCGB3A1 ‐Epi and KLK10 ‐Epi Crosstalk With Fibroblasts Promotes Liver Metastasis of Breast Cancer and Pancreatic Ductal Adenocarcinoma
Xuan, Z., Wu, Z., Cheng, L., Jiang, J., Zhang, Y., & Xia, Y. (2025) · Cancer Medicine · doi:10.1002/cam4.70904 · Cited by 2
TRIM29 promotes liver metastasis via enhancing hepatic colonization by stabilizing FAM83H to regulate keratin network in colorectal cancer
Fu, Y., Huang, R., Qin, G., Huang, S., Li, J., Zhan, W., Bai, F., Xie, X., Ling, J., Cai, Y., et al. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111871 · Cited by 2
UFMylation maintains tumor suppressor pVHL stability by activating the deubiquitinase BAP1
Yang, X., Wen, Y., Qin, S.-Y., Zhou, Y., Zhang, C., Huang, L., Li, M., Ma, X., Wan, R., Chen, J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adt8800 · Cited by 2
Self-citation
The challenge of disappearing colorectal liver metastasis: balancing considerations between tumor biology and clinical consequence for liver surgery
Ansari, D., Rystedt, J. L., Søreide, K., Lindberg, M., & Andersson, R. (2025) · Clinical & Experimental Metastasis · doi:10.1007/s10585-025-10357-y · Cited by 2
Amentoflavone inhibits colorectal tumor growth, stemness, and metastasis, prolonging survival through GLI-1/IL6/STAT3 axis targeting
Fang, Y., Chen, C., Ku, H., Dong, D.-C., Liao, T.-L., & Hsu, F. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118435 · Cited by 2
Deciphering the central role of TMOD2 in colorectal cancer progression and metastasis
Montero‐Calle, A., de Ocaña, S. J., Rejas‐González, R., Benavente-Naranjo, R., Sanz-López, R., Dziaková, J., Martínez‐Useros, J., Peláez‐García, A., Rı́os, V. D. L., Bartolomé, R. A., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03184-1 · Cited by 2
Analysis of risk and prognostic factors for pulmonary metastasis in colorectal cancer: A study based on the surveillance, epidemiology, and end results database
Kong, W., & Li, S. (2025) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2025.101908 · Cited by 2
A novel 1,2,4-triazole derivative inhibits epithelial-mesenchymal transition in metastatic colorectal cancer via β-catenin suppression
Abdelmegeed, H., Abo‐Salem, H. M., Salam, H. A. A. E., & El-Sawy, E. R. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118279 · Cited by 3
COMP promotes the progression of colorectal cancer by regulating epithelial mesenchymal transition
Huang, H., Wang, L., Gao, S., & Wang, H. (2025) · BMC Cancer · doi:10.1186/s12885-025-15000-3 · Cited by 2
PRL-3 as a metastasis-associated phosphatase in colorectal cancer: Mechanisms and therapeutic strategies
Greenstein, S. J., Ramlogan‐Steel, C. A., Wise, I. A., Wilson, R. J., & Steel, J. C. (2025) · Clinical & Experimental Metastasis · doi:10.1007/s10585-025-10385-8 · Cited by 2
RNF39 promotes colorectal cancer progression by driving RINT1 degradation and suppressing ER stress‐induced apoptosis
Chen, L., Yuan, C., Yu, T., Hui, K., Li, X., Shen, X., Jiang, X., & Liu, B. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70577 · Cited by 2
Orosomucoid 2 promotes colorectal cancer liver metastasis by suppressing natural killer cell-mediated antitumor immunity by remodeling the serine and one-carbon metabolism pathway
Zhou, J., He, X., Xiang, Z., Wang, M., Xu, W., Wang, Y., Chen, Y., Zhang, T., Wang, L., & 毛岸荣 (2026) · Molecular Cancer · doi:10.1186/s12943-026-02616-7 · Cited by 2
Self-citation

Authors: Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., & Wen, Y.
Affiliations: Central South University (CN)
The University of Texas at Arlington (US)
Sichuan University (CN)
Corresponding author: Xiong, Li
Chen, Wei
Wen, Yu
ORCID: Zhou, Hui
Liu, Zhongtao
Amador, Eric H.
Yuan, Liqin
Ran, Xin
Xiong, Li
Ran, Yuping
Chen, Wei
Wen, Yu
Venue: Signal Transduction and Targeted Therapy
Publisher: Springer Science and Business Media LLC
Published: 2022-03-04
Volume: 7
Issue: 1
Pages: 70-70
ISSN: 2059-3635 (ISSN-L)
DOI: 10.1038/s41392-022-00922-2
PMC: PMC8897452
OpenAlex: W4214924743
Cited by: 298
References: 435
Citations by year: 2026: 55 · 2025: 99 · 2024: 68 · 2023: 60 · 2022: 16
FWCI: 7.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Anglia Ruskin Research Online (Anglia Ruskin University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: University of Texas at Arlington
National Natural Science Foundation of China (82000756, 81873640, 81970569, 81773293)
Hunan Provincial Science and Technology Department (2017WK2063, 2015GK3117)
Topics: Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
Keywords: colorectal liver metastases, colorectal cancer, molecular mechanisms, tumor microenvironment, targeted therapy, diagnosis, treatment, prognosis
MeSH terms: Humans, Liver Neoplasms, Colorectal Neoplasms, Tumor Microenvironment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Colorectal liver metastasis: molecular mechanism and interventional therapy

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks