Colorectal liver metastasis: molecular mechanism and interventional therapy

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109

Global cancer statistics

Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077

Cancer metastasis in vitro models – can 3D biofabrication and microfluidics sow the seeds in the right soil

Sbirkov, Y., Koev, I. G., Ozanian, A., Hristamyan, M., Hagenbuchner, J., Ausserlechner, M. J., & Sarafian, V. S. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1794850 · Cited by 2

Intracellular lipid droplets positively regulate the dormancy of colorectal cancer cells depending on ELF1-ACSL5 signaling

Liao, W., Yin, R., Zuo, F., Li, Y., Deng, J., Li, Y., Li, X., 陶德定, Luo, X. P., 季维克, et al. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-026-03754-y · Cited by 2

Ultrasound-programmable tumor extracellular vesicles delivery system for dual immune–epigenetic therapy against colorectal cancer metastasis

Wen, C., Xiong, B., Shu, Y., Guo, W., Wang, S., Lin, L., Zhu, M., Liu, H., Ping, J., Xie, J., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115114 · Cited by 2

A predictive model for early death in elderly colorectal cancer patients: a population-based study

Wang, Q., Shen, K., Fei, B., Luo, H., Li, R., Wang, Z., Wei, M., & Xie, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1278137 · Cited by 2

Comparison of systemic treatments for previously treated patients with unresectable colorectal liver metastases: a systematic review and network meta-analysis

Jiang, Y., Zhao, M., Tang, W., & Zheng, X. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1293598 · Cited by 2

Dual-Time-Point Radiomics for Prognosis Prediction in Colorectal Liver Metastasis Treated with Neoadjuvant Therapy Before Radical Resection: A Two-Center Study

Li, Z., Zhang, J., Tian, S., Sun, C., Ma, Y., & Ye, Z. (2025) · Annals of Surgical Oncology · doi:10.1245/s10434-025-16941-6 · Cited by 2

Survival in stage IV colorectal cancer at diagnosis

Chang, J., Dornbush, C., Mott, S. L., Loeffler, B. T., Guyton, K. L., Hrabe, J. E., & Gribovskaja‐Rupp, I. (2025) · Surgical Oncology Insight · doi:10.1016/j.soi.2025.100144 · Cited by 2

Liver Transplantation for Unresectable Colorectal Liver Metastases: A Scoping Review on Redefining Boundaries in Transplant Oncology

Demirors, B., Sethi, V., Abdullah, A., Elias, C., Spitz, F. J., Mial-Anthony, J., Packiaraj, G., Subedi, S., Han, S. P., Fokken, T., et al. (2025) · Current Oncology · doi:10.3390/curroncol32090481 · Cited by 2

Identifying TP53RK as a key regulator of colorectal cancer survival and a potential therapeutic target

Choi, Y. H., Park, S., Yang, S.-J., Kim, E., Cho, Y., Yang, H.-J., Yi, E. C., Song, S., & Kim, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-21082-7 · Cited by 2

Development of 14‐gene signature prognostic model based on metastasis for colorectal cancer

Li, T., Yu, Q., Liu, T., Yang, W., Chen, W., Jin, A., Wang, H., Ding, L., Zhang, C., Pan, B., et al. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24800 · Cited by 2

Surgical management of liver metastasis from colorectal cancer

Tschöegl, M.-M., & Gruenberger, T. (2023) · memo - Magazine of European Medical Oncology · doi:10.1007/s12254-022-00868-9 · Cited by 2

Biomarkers of systemic treatment response: MR images of intratumoral fat deposition in colorectal liver metastases (CRLM) after chemotherapy

Morawska, I., Pasicz, K., & Cieszanowski, A. (2024) · International Journal of Colorectal Disease · doi:10.1007/s00384-024-04762-0 · Cited by 1

Colorectal cancer liver metastases: immune environment and therapeutic perspectives

Wen, J., Jiang, J., Zhang, J., Wu, Z., Hu, D. X., Wang, W., Zhang, Z., & Xia, L. (2025) · Gastrointestinal Tumors · doi:10.48130/git-0025-0002 · Cited by 2

lncSLERT Promotes Liver Metastasis in Colorectal Cancer by Down-Regulating HUNK Expression via RBM15-Mediated m6A Modification

Wang, L., Zhao, L., Liu, J., Cheng, P., Han, M., & Zheng, Z. (2025) · OncoTargets and Therapy · doi:10.2147/ott.s514001 · Cited by 1

Multimodal therapy and precision-imaging extends the limits of treatment for a patient with initially unresectable synchronous colorectal liver metastases

Sidhom, M., Morrison-Jones, V., Harinarayanan, S., Nolan, L., & Welsh, F. K. S. (2025) · Annals of The Royal College of Surgeons of England · doi:10.1308/rcsann.2025.0031 · Cited by 1

SLC38A4 as a prognostic biomarker and correlated with immune infiltration in colorectal liver metastasis

Liu, Y., Wei, X., Chen, N., & Wang, W. (2025) · Discover Oncology · doi:10.1007/s12672-025-03509-9 · Cited by 1

Long-term survival benefit from third-line treatment for advanced colon cancer: a case report

Su, J., Kuang, Y., Wu, Y., Chen, Q., & Min, S.-D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1639287 · Cited by 2

SNHG5 enhances colorectal cancer metastasis through RNA–protein interaction with GNB2 and activation of canonical Wnt signaling

Chen, X., Yang, M., Luo, X., & Yuan, X. (2026) · Non-coding RNA Research · doi:10.1016/j.ncrna.2025.12.002 · Cited by 1

KDM5D epigenetically represses FERD3L to inhibit tumor growth in male colorectal cancer

Yu, J., Zhong, X., Lan, Q., Lan, S., Lin, S. J., Qi, Y., Su, X., & Ding, J. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112402 · Cited by 1

Poliovirus receptor (PVR) expression as a predictor of relapse in colorectal cancer: bioinformatics and virtual screening

Alhudaithi, S. S., Salih, M. H. R., AlHusseini, Z. H., Almufadhili, S. M., Alelayani, N., Bakheit, A. H. H., Alkahtani, H. M., Asiri, H. H., Alshamrani, A. A., Alhoshani, A., et al. (2026) · Experimental Biology and Medicine · doi:10.3389/ebm.2026.10745 · Cited by 1

Research progress on immune tolerance mechanisms in liver metastatic tumors and the “Liver-metastasis-oriented shared-mechanism therapeutic strategy” approach

Zhang, Q., Wang, W., Yu, H., Wang, F., Chen, X., Liang, Z., & Lu, Y. (2026) · Medical Review · doi:10.1515/mr-2025-0077 · Cited by 1

New advances in the use of patient-derived organoids and mouse models for assessing heterogeneity among metastatic colorectal cancers

Wang, S., Li, Y., Wu, W., Yan, B., Li, J., Li, C., & Yan, J. (2026) · Cell Transplantation · doi:10.1177/09636897261433327 · Cited by 1

Discovery of APO-50815, a potent WEE1 kinase inhibitor with exceptional efficacy against patient-derived colorectal cancer organoids

Syphers, J. L., Wright, J. A., de Nys, R., Silva, T. N., Vrbanac, L., Barratt, K. R., Leeflang, J., Hasan, S. T., Thomson, S. F., Kumar, A., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118838 · Cited by 1

Impact of an AI prognostic tool on clinician performance in colorectal liver metastases

Chen, Q., Tong, J., Deng, Y., Bi, X., Li, Y., Li, K., & Zhao, H. (2026) · npj Digital Medicine · doi:10.1038/s41746-026-02606-5 · Cited by 1

Liver Transplantation as a Salvage Therapy Option in Colorectal Liver Metastases: Feasibility, Oncologic Outcomes, and Survival After Failure of Conventional Therapy—A Systematic Review and Meta-Analysis

Soomro, F. H., Kazmi, T. F., Ansar, M., Gulnaz, N., Arshad, R., & Aiste, G. (2026) · Cancers · doi:10.3390/cancers18081254 · Cited by 1

CT radiomics for survival risk stratification in resectable colorectal liver metastases: a multi-centre study

Mian, A., Young, R., Lakha, A. S., Leptidis, I., Jones, R. P., & Gordon-Weeks, A. N. (2026) · Scientific Reports · doi:10.1038/s41598-026-48659-0 · Cited by 1

Prognostic significance of socioeconomic deprivation in patients with colorectal liver metastasis undergoing liver resection: a retrospective cohort study

Hajibandeh, S., Scarpa, E., Kaur, N., Alessandri, G., & Kumar, N. (2024) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-023-03220-9 · Cited by 1

Metastatic colorectal cancer cells upregulate SMLR1 that interacts with tumor-associated macrophages in the liver

Wong, C. W., Wang, L., Balcazar, J. P., Chen, Y., & Shen, X. (2024) · Cancer Heterogeneity and Plasticity · doi:10.47248/chp2401010003 · Cited by 1

NUDT21 Functions as a Pro-Tumorigenic Gene in Colorectal Cancer by Upregulating the TAZ Protein Expression

Chen, X., Dai, Z., Wang, Q., Chen, W., Liu, Y., & Wang, Z. (2025) · Biocell · doi:10.32604/biocell.2025.059286 · Cited by 1

Interferon regulatory factor 5 suppresses epithelial‐to‐mesenchymal transition and metastasis by inducing GATA2 expression in colorectal cancer

Pan, T., Liu, Z., Feng, X., Zhang, D., Li, L., Song, Y., Luo, Q., Luo, X., Chen, X., Yao, Y., et al. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70077 · Cited by 1

Editorial: Optimizing the first-line treatment for metastatic colorectal cancer

Ciardiello, D., & Petrillo, A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1366383 · Cited by 1

[Silenced ANP32A inhibits the growth, invasion and migration of colorectal cancer in vitro via the inactivation of AKT pathway].

Ding, H., Li, X., Zhou, L., Cui, Z., Meng, H., & Wang, J. (2023) · PubMed Central · doi:10.12122/j.issn.1673-4254.2023.01.07

Dissecting the heterogeneities of the tumor microenvironment between metastatic and nonmetastatic primary colorectal cancer patients by single-cell RNA sequencing

Wang, S., Deng, S., Jin, X., Chen, W., Wang, X., Zhan, H., Fang, X., & Fu, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121576

5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic targetPreprint

Lin, J., Xu, N., Gao, Z., Wu, D., Chen, H., Zhang, Z., Zhu, H., Zhang, L., Wang, Y., Lu, X., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2950290/v1

Protein Signatures for Distinguishing Colorectal Cancer Liver Metastases from Primary Liver Cancer Using Tissue Slide Proteomics

Zhou, X., Wang, X., Bai, R., Li, H., Hua, D., Gao, X., Yang, G., & Liu, Q. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2901003

Nucleolar protein interacting with the FHA domain of MKI67 may be an important factor in promoting the development of colorectal cancer: a comprehensive study integrating bulk RNA-seq, scRNA-seq, protein immunohistochemistry and CRISPRPreprint

Li, H., Tang, Y.-X., Chen, Y., Huang, W., He, R., Huang, Z., Zeng, D.-T., Xia, Z.-Y., Song, R., Zhang, H. J., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4156321/v1

Enhancing Outcomes Through Preoperative Risk Evaluation in Colorectal Cancer SurgeryPreprint

Li, J., Zhao, H., & Liu, J. (2024) · Research Square · doi:10.21203/rs.3.rs-4264261/v1

New Insights into Risk Factors for Postoperative Infections in Colorectal CancerPreprint

Li, J., Zhao, H., & Liu, J. (2024) · Research Square · doi:10.21203/rs.3.rs-4262701/v1

METTL3-mediated m6A modification of CDCA7 mRNA promotes COAD progression

Hua, M., Zhai, X., Chen, Y., & Yin, D. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155437

Copper-cysteamine nanoparticle-mediated microwave dynamic therapy promotes colorectal cancer metastasis by inhibiting promoting ferroptosis via downregulating PTK2BPreprint

Zhou, H., Zhang, Z., Liu, Z., Xiong, L., Wen, Y., Liu, J., Chen, W., & Xu, J. (2024) · Research Square · doi:10.21203/rs.3.rs-4546526/v1

TGF-β and SMAD2/4 Expression in Nonmetastatic and Metastatic Colorectal Cancer Patients

Mardiah, A., Susanto, H., & Lestari, S. R. (2024) · BIO Web of Conferences · doi:10.1051/bioconf/202411701001

Helicobacter Pylori Infection as the Predominant High-Risk Factor for Gastric Cancer Recurrence Post-Gastrectomy: An 8-Year Multicenter Retrospective Study

Liu, Y., Shang, X., Du, W., Shen, W., & Zhu, Y. (2024) · International Journal of General Medicine · doi:10.2147/ijgm.s485347

The search for CT imaging subtypes of colorectal liver metastases and the impacts of slice thickness

Kobayashi, K. S., Ali, D. A., Mojtahedi, R., Peoples, J., Hamghalam, M., Gangai, N. C., Gönen, M., Gian, R. K., Chun, Y. S., Kang, H. C., et al. (2025) · SPIE Medical Imaging: Computer-Aided Diagnosis · doi:10.1117/12.3048815

Connecting concentrations of copper, selenium, and zinc with transcriptomic and proteomic data of well-characterized human colorectal cancer cell lines

Meyer, C. E., Vukelic, N., Mariadason, J. M., & Kipp, A. P. (2025) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2025.127638

Sinle-Cell Transcriptomics and Machine Learning Algorithms Unveil Metastasis-Associated Cellular Subtypes and Prognostic Signatures in Colorectal CancerPreprint

Pu, K. (2025) · Research Square · doi:10.21203/rs.3.rs-6479548/v1

Knowledge Mapping of liver metastases from colonrectal cazncer: A bibliometric analysis (2018–2024) and reflectionsPreprint

Zhang, X., Chen, B., Zhou, W., Ma, Y., & Wang, Q. (2025) · Research Square · doi:10.21203/rs.3.rs-6792171/v1

Research Progress of PKM2 in Digestive System Diseases

杨, 少. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1561883

Thermoablation oder Operation bei kleinen kolorektalen Lebermetastasen: COLLISION-Studie

Mustafov, O., & Alakus, H. (2025) · Die Onkologie · doi:10.1007/s00761-025-01800-6

m1A methylation-mediated upregulation of RILsPL1 promotes colorectal cancer progression via the CaMKII/CREB signaling pathway

Yang, S., Long, X., Diao, W., Yang, J., Jiang, A., & Wu, H. (2025) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2025.130856

Proteomic landscape of colorectal cancer liver metastasis

Ju, W., Liu, L., Chang, Y., Duan, X., Chen, X., He, L., Wang, Z., Guo, L., & Yin, J. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102558

Understanding Surgery Refusal in Patients with Colorectal Liver Metastases

Andreasen, L. A., Knøfler, L. A., Akdag, D., Nordkild, S. B., & Pommergaard, H. (2025) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-026-01503-0

Efficacy and survival prognosis analysis of surgical resection combined with targeted therapy in patients with colorectal cancer liver metastasis

Yan, F., Shi, Y., Kang, Z., Wang, H., & Li, X. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1692800

Assessment of the correlation between visceral adiposity and liver fat in metastatic colorectal cancer patients

Celik, C. E., Chalabiyev, E., Gürler, V., Onur, M. R., Şahin, T. K., Dızdar, Ö., & Özmen, F. (2025) · International Journal of Colorectal Disease · doi:10.1007/s00384-025-04967-x

Nanoemulsion encapsulation enhanced the anti-tumor potency of pomegranate polysaccharides by suppressing oxidative stress, inflammation, and tumor metastasis induced by 1,2-dimethylhydrazine in rats

Sadek, S. A., Hoseny, S. S., Fahmy, A. M., Ali, S. B., Kotb, M. A., Soliman, A. M., & Fahmy, S. R. (2025) · Medical Oncology · doi:10.1007/s12032-025-03123-3 · Cited by 2

Impact of TGF-β1 on tumor immune microenvironment and prognosis in colorectal liver oligometastasis

Wang, S., He, J., Liao, Y., Li, W., Zhang, W., Kang, D., Wang, W., Wang, R., Zhou, C., Lin, J., et al. (2025) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2025.101059

Evaluation of Thermal Damage Thresholds and Coagulation Behavior of 809 nm Diode Laser in Liver Tissue

Sapmaz, O. E., & Sarp, A. S. K. (2025) · Medical Technologies Congress (TIPTEKNO) · doi:10.1109/tiptekno68206.2025.11270097

Safety and efficacy of percutaneous ultrasound-guided radiofrequency ablation for patients with colorectal liver metastases ≥5 lesions

Zhang, Z., Wang, H., Wang, S., Wu, W., Yan, K., Wang, Z., & Yang, W. (2025) · International Journal of Hyperthermia · doi:10.1080/02656736.2025.2596118

Additional file 1 of Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer

Li, K., Xue, W., Lu, Z., Wang, S., Zheng, J., Lu, K., Li, M., Zong, Y., Xu, F., Dai, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25302947

Additional file 2 of Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3

Li, X., Wang, Z., Jiao, C., Zhang, Y., Xia, N. L., Yu, W., Chen, X., Wikana, L. P., Liu, Y., Sun, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26568550

Additional file 1 of Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3

Li, X., Wang, Z., Jiao, C., Zhang, Y., Xia, N., Yu, W., Chen, X., Wikana, L. P., Liu, Y., Sun, L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26568547

Additional file 1 of Hsa_circ_0009092/miR-665/NLK signaling axis suppresses colorectal cancer progression via recruiting TAMs in the tumor microenvironment

Song, J., Liu, Q., Han, L., Song, T., Huang, S., Zhang, X., He, Q., Liang, C., Zhu, S., & Xiong, B. (2023) · Figshare · doi:10.6084/m9.figshare.24636488

SIMULTANEOUS VS STAGED RESECTIONS IN COLON CANCER PATIENTS WITH SYNCHRONOUS LIVER METASTASES: PROGNOSTIC IMPACT OF LYMPH NODE RATIO AND TUMOR BURDEN SCORE

Burlaka, A., Bezverkhnyi, V., Bankovska, N., Zvirych, V. V., Skyba, V. V., Beznosenko, A., Lisnyy, I. I., Sorokin, B. V., & Yatsyna, O. I. (2025) · Experimental Oncology · doi:10.15407/exp-oncology.2025.03.347

Surgery for liver metastases

Ballabrera, F. S., & Pastor, P. G. (2026) · Revisiones en cáncer · doi:10.20960/revcancer.00132

Regulation Mechanism of p-Akt and lncRNA H19 in Colorectal Cancer

Wenhan, Y. I. N. (2026) · BIO Web of Conferences · doi:10.1051/bioconf/202621401002

TCF21-WNT5A axis drives metastasis of colorectal cancer via stromal-tumor cell communication

Huang, Q., Ren, A., Cui, X., Tian, D., Liu, H., Wang, L., & Cao, A. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07835-6

NRP2-Dependent Migrasomal Signaling Drives Pro-Efferocytic Macrophage Polarization in Colorectal Cancer Liver Metastasis

Alvarez, D. V., Soto, M. A., Perez, R. T., Molina, J. S., Rojas, A. F., & Castro, E. N. (2022) · Journal of Medical Sciences and Interdisciplinary Research · doi:10.51847/z6oxshzvgl

Anlotinib in combination with trifluridine-tipiracil in patients with refractory metastatic colorectal cancers: a phase II, single arm study

Liu, Q., Zhang, C., Liu, M., Ke, P., Xu, X., Yu, Y., & Liu, T. (2026) · The Oncologist · doi:10.1093/oncolo/oyag019

Predicting intrahepatic recurrence of colorectal cancer liver metastases after curative hepatectomy using a machine learning model with data integration of ultrasound radiomics and clinicopathological parameters

Hu, T., Liu, Z., Kuang, P., Li, Y., Kong, W., Zheng, W., Li, J., Liu, G., Zhang, H., Chen, X., et al. (2026) · Insights into Imaging · doi:10.1186/s13244-026-02227-2

Potential role of leptin in colorectal cancer liver metastasis involving lipid metabolic reprogramming and immunosuppressive macrophage polarization

Xie, Y., Wang, H., Dong, X., Chen, Y., Xia, Y., Huang, X., Zhang, W., Dai, S., Zhou, Y., & Qian, X. (2026) · Scientific Reports · doi:10.1038/s41598-026-48506-2

Targeting CAFs-derived PCSK6 inhibits redistribution of PD-L1 and restores response of CD8+T cells against colorectal cancer

Du, Q., Fei, Y., Li, T., Wang, D., Hu, S., Yang, Y., Tang, W., ZHANG, X., Diao, H., & Liu, C. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01736-3

Neurochondrin drives colorectal cancer progression by modulating the PODXL–Ezrin axis and mitochondrial function

Garranzo‐Asensio, M., Carral-Ibarra, E., Montero‐Calle, A., de Cedrón, M. G., Velázquez-Gutiérrez, J., Molina, S., Dziaková, J., Sanz-López, R., Poves, C. F., de Molina, A. R., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08747-5

ASCL2 drives colorectal cancer metastasis through transcriptional activation of TDGF1

Li, D., Wang, H., Yu, Z., Zhang, Y., Zhang, J., Tao, X., Wang, F., Luo, S., & Lu, Q. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01213-6

Targeting cancer-associated fibroblast by biomimetic nanomissiles to remodel tumor stromal microenvironment for colorectal cancer liver metastasis

Wu, Y., Rong, C., Yi, J., Chen, G. D., 吴东平, Li, Z., Tang, W., Liang, X., & Wei, M. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100799

Systemic inflammation and liver fibrosis as predictors of surgical outcomes in colorectal cancer liver metastasis: a biomarker-based survival study.

Zeng, D., Saad, S., Lu, J., You, Z., & Li, B. (2026) · Updates in Surgery · doi:10.1007/s13304-025-02504-7

Tumoricidal efficacy of DZ-1 dye conjugated to dihydroartemisinin in patient-derived colorectal liver metastasis tumoroids

Vafaeinik, F., Badrinath, N., Helmueller, S., Zhang, Y., Gangi, A., Lee, H., Song, C., Figlin, R. A., Sargsyan, K., & Lee, Y. J. (2026) · Molecular Therapy Oncology · doi:10.1016/j.omton.2026.201257

Sini decoction inhibits colorectal cancer liver metastasis by suppressing HIF-1α–dependent exosomal integrin signaling

Zheng, X., Wang, W., Zhu, J., Yang, L., Du, Y., Zhou, H., Jiang, Y., Yu, Z., Zhongzhu, T., Hu, D., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121951

Colorectal cancer liver metastasis: immunosuppressive microenvironment, signaling pathways, and emerging therapeutic strategies

Yang, H., Wu, S., & Chen, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1855761

A magnetic resonance imaging-guided drug delivery system for premetastatic niche theranostics and colorectal cancer liver metastasis intervention

Luo, W., Yang, X., Wang, Y., Xu, J., Lou, Y., Chen, J., Hou, J., Wang, X., 鲁远飞, Mao, J., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04725-3

Colorectal Cancer Liver Metastasis‐Associated Ferroptosis‐Related Genes Modulate Lipid Peroxidation in Colorectal Cancer Cells

Ge, Z., Guo, W., Li, J., Wang, Y., & Wang, K. (2026) · Molecular Carcinogenesis · doi:10.1002/mc.70143

Norisoboldine suppresses epithelial–mesenchymal transition in colorectal cancer by simultaneously inhibiting the CXCR4/CXCR7 chemokine receptors and the JAK/STAT3 signaling pathway

Kim, N. Y., Hong, Y., Baek, S. H., Nam, D., Le, D., Lee, M., Um, J., & Ahn, K. S. (2026) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgag071

Turning the tide: combined resection and radiofrequency ablation of synchronous liver metastases in colorectal cancer

Gökçe, K., Üner, M., Adil, N., & Sheikhvatan, M. (2026) · South African Journal of Surgery · doi:10.36303/sajs.04062

Thermal ablation versus liver resection for small colorectal liver metastases (≤ 3 cm): a systematic review and meta-analysis of randomized and propensity score-matched studies

Su, L., Yu, C., Zhang, C., Hu, W., Qu, W., Zhang, Z., & Luan, J. (2026) · Surgical Endoscopy · doi:10.1007/s00464-026-13140-6

Thermal Ablation for Colorectal Liver Metastases: Current Evidence and Future Horizons

Xf, L., Wq, Q., Hu, Z., & Liu, Q. M. (2026) · Diagnostics · doi:10.3390/diagnostics16142239

Multimodal prediction of metachronous liver metastasis in stage I-III colorectal cancer patients: multicenter cohort study employing machine learning

Liang, L., Zhang, Y., Yang, L., Li, J., Alburiahi, T. A. H., Lin, W., Yang, Y., Zhou, R., Yang, Z., 刘习红, et al. (2026) · Abdominal Radiology · doi:10.1007/s00261-026-05700-0

ZNF556 serves as an immunological and prognostic biomarker in colon adenocacinoma

Huang, C., Feng, S., Yi, H., Tao, W., Li, Y., & Liao, Z. (2026) · BMC Cancer · doi:10.1186/s12885-026-16596-w

Study the inhibition impact of Folic acid-Bi2O3-MgO NPs on HCT116 colorectal cancer cells by inducing cytotoxic, cell migration and antioxidant assay

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Protocol for surgical stress-promoted colorectal cancer liver metastasis in mice

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Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids

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Trends and projections in cause-specific mortality among patients with colorectal cancer in the United States, 1999–2040

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Urban-Rural Disparities in Treatment and Outcomes for Colorectal Liver Metastases in the United States: A SEER-Medicare Analysis

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YAP-mediated mechanotransduction promotes hepatocellular carcinoma progression by targeting ATP1A1/CXCL1 axis.

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Enhancing Anti-Cancer Efficacy in Colorectal Cancer Through Cannabinoid and Sodium Pentaborate Co-Therapy

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O-GlcNAcylated TCF4 Drives Ferroptosis Resistance and Tumor-Associated Macrophage Infiltration to Promote Colorectal Cancer Liver Metastasis

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Multipathway pharmacological interventions targeting liver-derived immune resistance in colorectal cancer liver metastasis

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When Neutrophils Do Not Die: Senescence as a New Axis of Tumor Immunosuppression

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Paired Transcriptomic Profiling Identifies Shared Liver Metastasis-Associated Molecular Features in Colorectal Cancer

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Transcription factor CTCF activates KIAA1199 expression to inhibit ferroptosis and promote malignant behaviors in colorectal cancer based on bioinformatics and machine learning

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BindingDB Entry 50023588: Discovery of WEE1 Kinase Inhibitors with Potent Activity against Patient-Derived, Metastatic Colorectal Cancer Organoids.

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Pathogenetic development, diagnosis and clinical therapeutic approaches for liver metastasis from colorectal cancer (Review)

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Colorectal cancer liver metastases: mechanism and therapy

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Molecular pathways and targeted therapies in colorectal liver metastasis: from bench to bedside

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Liver metastasis of colorectal cancer: Mechanism and clinical therapy (Review)

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Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment

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