The DOI matches its Crossref record; 435 of the 435 references it cites were found in a registry or an index.
Colorectal liver metastasis: molecular mechanism and interventional therapy
Open accessAbstract
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.
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“only 45% can be resected with current methodology.”
From First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure (2024) · cites this paper as [43]
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“Of the approximately 1 million patients diagnosed worldwide with colorectal cancer liver metastases each year,43”
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Items 401–435 of 435
Riddiough, G. E., Fifis, T., Muralidharan, V., Perini, M. V., & Christophi, C. (2019) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14644 · Cited by 25
Losi, L., Luppi, G., & Benhattar, J. (2004) · Oncology Reports · doi:10.3892/or.12.6.1221 · Cited by 24
A comprehensive look at the role of hyperlipidemia in promoting colorectal cancer liver metastasis
Shen, Y., Wang, C., Ren, Y., & Ye, J. (2018) · Journal of Cancer · doi:10.7150/jca.25640 · Cited by 24
miR‐298 plays a pivotal role in colon cancer invasiveness by targeting PTEN
Arabsorkhi, Z., Gharib, E., Khojini, J. Y., Farhadieh, M., Mojarad, E. N., & Zali, M. R. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29310 · Cited by 24
Liu, W., Li, W., Ma, S., Liang, L., Kou, Z.-Y., & Yang, J. H. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101011 · Cited by 24
Li, Y., Lv, Z., Xie, H., & Zheng, S. (2019) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2019.08.006 · Cited by 23
Clinical response and prognostic significance of serum miR-497 expression in colorectal cancer
Zou, G.-C., Wang, R., & Wang, M. (2019) · Cancer Biomarkers · doi:10.3233/cbm-181902 · Cited by 22
Yorozuya, K., Kubota, T., Watanabe, M., Hasegawa, H., Ozawa, S., Kitajima, M., Chikahisa, L., & Yamada, Y. (2005) · Oncology Reports · doi:10.3892/or.14.3.677 · Cited by 21
Jia, G., Zhang, M., Wang, K., Zhao, G., Pang, M., & Chen, Z. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27031 · Cited by 21
Zhang, W., Wang, B., Wang, Q., Zhang, Z., Shen, Z., Ye, Y., Jiang, K., & Wang, S. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00628 · Cited by 21
Schrötzlmair, F., Kopitz, C., Halbgewachs, B., Lu, F., Algül, H., Brünner, N., Gänsbacher, B., & Krüger, A. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00951.x · Cited by 20
Hansen, T. F., Nielsen, B. S., Jakobsen, A. K. M., & Sørensen, F. B. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-014-0359-y · Cited by 20
MiRNA-21 Expression Decreases from Primary Tumors to Liver Metastases in Colorectal Carcinoma
Feiersinger, F., Nolte, E., Wach, S., Rau, T. T., Vassos, N., Geppert, C. I., Konrad, A., Merkel, S., Taubert, H. W., Stürzl, M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148580 · Cited by 20
Zhou, L., Zhang, S., Zou, X., Lu, J., Yang, X., Xu, Z., Shan, A., Jia, W., Liu, F., Yan, X., et al. (2019) · Cancer Management and Research · doi:10.2147/cmar.s208631 · Cited by 20
DEFB4A is a potential prognostic biomarker for colorectal cancer
Wu, Q., Wang, D., Zhang, Z., Wang, Y., Yu, W., Sun, K., Maimela, N. R., Sun, Z., Liu, J., Yuan, W., et al. (2020) · Oncology Letters · doi:10.3892/ol.2020.11975 · Cited by 19
Self-citationCristóbal, I., Caramés, C., Madoz‐Gúrpide, J., Rojo, F., Aguilera, O., & García‐Foncillas, J. (2014) · International Journal of Colorectal Disease · doi:10.1007/s00384-014-1872-4 · Cited by 17
Hypoxia‐induced hsa_circ_0000826 is linked to liver metastasis of colorectal cancer
Shi, L., Tao, C., Tang, Y., Xia, Y., Li, X., & Wang, X. (2020) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23405 · Cited by 17
Shao, S., Zhu, Y., Meng, T., Liu, Y., Hong, Y. K., Yuan, M., Yuan, H., & Hu, F. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00013 · Cited by 16
Ding, M., Zhang, T., Li, S., Zhang, Y., Qiu, Y., & Zhang, B. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7538 · Cited by 16
The Long Noncoding RNA LOC441461 (STX17-AS1) Modulates Colorectal Cancer Cell Growth and Motility
Wang, J., Lu, T., Kung, M., Yang, Y., Yeh, C.-Y., Tu, Y.-T., Chen, W.-S., & Tsai, K. (2020) · Cancers · doi:10.3390/cancers12113171 · Cited by 15
Self-citationSerum Level of Long Noncoding RNA B3GALT5-AS1 as a Diagnostic Biomarker of Colorectal Cancer
Ding, Y., Feng, W., Ge, J.-K., Dai, L., Liu, T., Hua, X.-Y., Xu, L., Ju, S., & Yu, J. (2020) · Future Oncology · doi:10.2217/fon-2019-0820 · Cited by 15
Circ_ 0115744 acts as miR-144 sponge to promote and predict the metastasis of colorectal cancer
Ma, X., Lv, L., & Xing, C. (2021) · Aging · doi:10.18632/aging.202513 · Cited by 15
Shoji, Y., Takamura, H., Ninomiya, I., Fushida, S., Tada, Y., Yokota, T., Ohta, T., & Koide, H. (2019) · Journal of Surgical Research · doi:10.1016/j.jss.2018.11.014 · Cited by 14
Association of Notch and Hedgehog Pathway Activation With Prognosis in Early-stage Colorectal Cancer
Rallis, G., Κoletsa, T., Saridaki, Z., Manousou, K., Koliou, G.-A., Kostopoulos, I. S., Kotoula, V., Makatsoris, T., Kourea, H. P., Raptou, G., et al. (2019) · Anticancer Research · doi:10.21873/anticanres.13326 · Cited by 14
Wang, L., Chen, X., Sun, X., & Suo, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s254489 · Cited by 14
Li, C., Pan, B., Liu, X., Qin, J., Wang, X., He, B., Pan, Y., Sun, H., Xu, T., Xu, X., et al. (2021) · Aging · doi:10.18632/aging.202354 · Cited by 14
Correlation of PRL3 expression with colorectal cancer progression
Leiphrakpam, P. D., Lazenby, A. J., Smith, L. M., Brattain, M. G., Black, J. D., Wang, J., & Are, C. (2020) · Journal of Surgical Oncology · doi:10.1002/jso.26253 · Cited by 12
The incidence of mismatch repair gene defects in colorectal liver metastases
Alvarado, R., Smith, A., Gundara, J. S., Kuo, S., Gill, A. J., Samra, J. S., & Hugh, T. J. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2257 · Cited by 11
Zhang, L., Liu, J., Lin, S., Tan, J., Huang, B., & Lin, J. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/5264651 · Cited by 10
Mahdi, M. R., Georges, R. B., Ali, D. M., Bedeer, R. F., Eltahry, H., Gabr, A., & Berger, M. R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00180 · Cited by 9
Larsen, C. (2015) · Bulletin du Cancer · doi:10.1016/j.bulcan.2015.05.005 · Cited by 8
Hirata, F., Ishiyama, K., Tanaka, Y., Kobayashi, T., Hashimoto, M., Saeki, Y., Ishida, N., Taguchi, K., Tanaka, J., Arihiro, K., et al. (2018) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12195 · Cited by 8
Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells
Řehulka, J., Annadurai, N., Frydrych, I., Džubák, P., Miller, J. H., Hajdúch, M., & Das, V. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b00961 · Cited by 7
Kim, N. W., Chu, C. W., Ahn, T. S., Kim, C. J., Jung, D. J., Son, M. W., Bae, S. H., Lee, M. S., Kim, C. H., & Baek, M. J. (2011) · Journal of the Korean Society of Coloproctology · doi:10.3393/jksc.2011.27.5.231 · Cited by 6
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Research works printed but not linked: 1
- Ma, L., Zou, X., Chen, W. & New, A. X-ray Induced Nanoparticle Photosensitizers For Cancer Treatment. J. Biomed. Nanotechnol. 10, 1501–1508 (2014). · DOI
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Sorted by citations
Advances in single-cell RNA sequencing and its applications in cancer research
Huang, D., Ma, N., Li, X., Gou, Y., Duan, Y., Liu, B., Xia, J., Zhao, X., Wang, X., Li, Q., et al. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01494-6 · Cited by 224
IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction
Shiri, A. M., Zhang, T., Bedke, T., Zazara, D. E., Zhao, L., Lücke, J., Sabihi, M., Fazio, A., Zhang, S., Tauriello, D. V. F., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.12.015 · Cited by 142
Update on Targeted Therapy and Immunotherapy for Metastatic Colorectal Cancer
Underwood, P. W., Ruff, S. M., & Pawlik, T. M. (2024) · Cells · doi:10.3390/cells13030245 · Cited by 130
Nano-enabled colorectal cancer therapy
Pan, Q., Xi, F., Xie, L. W., Wu, D., Liu, R., Gao, W., Luo, K., He, B., & Pu, Y. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.014 · Cited by 93
Li, Y., Yuan, R., Luo, Y., Guo, X., Yang, G., Li, X., & Zhou, S. (2023) · Advanced Materials · doi:10.1002/adma.202300216 · Cited by 81
Metadata
- Authors
- Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., & Wen, Y.
- Affiliations
- Central South University (CN)
- The University of Texas at Arlington (US)
- Sichuan University (CN)
- Corresponding author
- Xiong, Li
- Chen, Wei
- Wen, Yu
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2022-03-04
- Volume
- 7
- Issue
- 1
- Pages
- 70-70
- ISSN
- 2059-3635 (ISSN-L)
- PMC
- PMC8897452
- OpenAlex
- W4214924743
- Cited by
- 298
- References
- 435
- Citations by year
- 2026: 55 · 2025: 99 · 2024: 68 · 2023: 60 · 2022: 16
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Anglia Ruskin Research Online (Anglia Ruskin University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- University of Texas at Arlington
- National Natural Science Foundation of China (82000756, 81873640, 81970569, 81773293)
- Hunan Provincial Science and Technology Department (2017WK2063, 2015GK3117)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- colorectal liver metastases, colorectal cancer, molecular mechanisms, tumor microenvironment, targeted therapy, diagnosis, treatment, prognosis
- MeSH terms
- Humans, Liver Neoplasms, Colorectal Neoplasms, Tumor Microenvironment
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