Cited by 299Colorectal Cancer Treatments and StudiesCancer Cells and MetastasisHepatocellular Carcinoma Treatment and Prognosis

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Colorectal liver metastasis: molecular mechanism and interventional therapy

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Zhou, Hui, Liu, Zhongtao, Wang, Yongxiang, Wen, Xiaoyong, Amador, Eric H., Yuan, Liqin, Ran, Xin, Xiong, Li, Ran, Yuping, Chen, Wei, Wen, Yu·2022·Signal Transduction and Targeted Therapy

DOI 10.1038/s41392-022-00922-2PMC PMC8897452

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Abstract

Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

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MACC1 mRNA Levels Predict Cancer Recurrence After Resection of Colorectal Cancer Liver Metastases
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microRNA‐497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor‐A
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Is there a survival benefit from adjuvant chemotherapy for patients with liver oligometastases from colorectal cancer after curative resection?
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The Effectiveness and Safety of X-PDT for Cutaneous Squamous Cell Carcinoma and Melanoma
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miR-365a-3p regulates ADAM10-JAK-STAT signaling to suppress the growth and metastasis of colorectal cancer cells
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Authors: Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., & Wen, Y.
Affiliations: Central South University (CN)
The University of Texas at Arlington (US)
Sichuan University (CN)
Corresponding author: Xiong, Li
Chen, Wei
Wen, Yu
ORCID: Zhou, Hui
Liu, Zhongtao
Amador, Eric H.
Yuan, Liqin
Ran, Xin
Xiong, Li
Ran, Yuping
Chen, Wei
Wen, Yu
Venue: Signal Transduction and Targeted Therapy
Publisher: Springer Science and Business Media LLC
Published: 2022-03-04
Volume: 7
Issue: 1
Pages: 70-70
ISSN: 2059-3635 (ISSN-L)
DOI: 10.1038/s41392-022-00922-2
PMC: PMC8897452
OpenAlex: W4214924743
Cited by: 298
References: 435
Citations by year: 2026: 55 · 2025: 99 · 2024: 68 · 2023: 60 · 2022: 16
FWCI: 7.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Anglia Ruskin Research Online (Anglia Ruskin University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: University of Texas at Arlington
National Natural Science Foundation of China (82000756, 81873640, 81970569, 81773293)
Hunan Provincial Science and Technology Department (2017WK2063, 2015GK3117)
Topics: Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
Keywords: colorectal liver metastases, colorectal cancer, molecular mechanisms, tumor microenvironment, targeted therapy, diagnosis, treatment, prognosis
MeSH terms: Humans, Liver Neoplasms, Colorectal Neoplasms, Tumor Microenvironment

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Colorectal liver metastasis: molecular mechanism and interventional therapy

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