The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Copper homeostasis and cuproptosis in health and disease
Open accessAbstract
As an essential micronutrient, copper is required for a wide range of physiological processes in virtually all cell types. Because the accumulation of intracellular copper can induce oxidative stress and perturbing cellular function, copper homeostasis is tightly regulated. Recent studies identified a novel copper-dependent form of cell death called cuproptosis, which is distinct from all other known pathways underlying cell death. Cuproptosis occurs via copper binding to lipoylated enzymes in the tricarboxylic acid (TCA) cycle, which leads to subsequent protein aggregation, proteotoxic stress, and ultimately cell death. Here, we summarize our current knowledge regarding copper metabolism, copper-related disease, the characteristics of cuproptosis, and the mechanisms that regulate cuproptosis. In addition, we discuss the implications of cuproptosis in the pathogenesis of various disease conditions, including Wilson’s disease, neurodegenerative diseases, and cancer, and we discuss the therapeutic potential of targeting cuproptosis.
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Cites
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Copper induces cell death by targeting lipoylated TCA cycle proteins
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
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Oxidative stress and neurodegeneration: where are we now?
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Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
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Ferroptosis: Mechanisms and links with diseases
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Cited by
Guo, B., Yang, F., Zhang, L., Zhao, Q., Wang, W., Yin, L., Chen, D., Wang, M., Han, S., Xiao, H., et al. (2023) · Advanced Materials · doi:10.1002/adma.202212267 · Cited by 391
The role of lipid metabolic reprogramming in tumor microenvironment
Yang, K., Wang, X., Song, C., He, Z., Wang, R., Xu, Y., Jiang, G., Wan, Y., Mei, J., & Mao, W. (2023) · Theranostics · doi:10.7150/thno.82920 · Cited by 270
Copper neurotoxicity: Induction of cognitive dysfunction: A review
Feng, D., Zhao, Y., Li, W., Li, X., Wan, J., & Wang, F. (2023) · Medicine · doi:10.1097/md.0000000000036375 · Cited by 38
Self-citationLi, Y., Li, J., Zhong, Y., Zhang, Q., Wu, Y., Huang, J., Pang, K., Zhou, Y., Xiao, T., Wu, Z., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2024.122762 · Cited by 25
Li, Q., Xiao, X., Yan, T., Song, D., Li, L., Chen, Z., Zhong, Y., Deng, W., Liu, X., Song, Y., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c15715 · Cited by 20
Metadata
- Authors
- Chen, L., Min, J., & Wang, F.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2022-11-23
- Volume
- 7
- Issue
- 1
- Pages
- 378-378
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W4309673498
- Cited by
- 1,493
- References
- 22
- FWCI
- 148.63
- Type
- journal article
- Language
- en
- Open access
- gold
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