The DOI matches its Crossref record; 284 of the 284 references it cites were found in a registry or an index.
Ribosome biogenesis in disease: new players and therapeutic targets
Open accessAbstract
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1, Myc, and noncoding RNA signaling pathways are the primary mediators that work jointly with RNA polymerases and ribosome proteins to control ribosome biogenesis and protein synthesis. Activation of mTORC1 is required for normal fetal growth and development and tissue regeneration after birth. Myc is implicated in cancer development by enhancing RNA Pol II activity, leading to uncontrolled cancer cell growth. The deregulation of noncoding RNAs such as microRNAs, long noncoding RNAs, and circular RNAs is involved in developing blood, neurodegenerative diseases, and atherosclerosis. We review the similarities and differences between eukaryotic and bacterial ribosomes and the molecular mechanism of ribosome-targeting antibiotics and bacterial resistance. We also review the most recent findings of ribosome dysfunction in COVID-19 and other conditions and discuss the consequences of ribosome frameshifting, ribosome-stalling, and ribosome-collision. We summarize the role of ribosome biogenesis in the development of various diseases. Furthermore, we review the current clinical trials, prospective vaccines for COVID-19, and therapies targeting ribosome biogenesis in cancer, cardiovascular disease, aging, and neurodegenerative disease.
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“These include chromatin remodeling at rDNA loci, the possibility of ribosomal heterogeneity, the contribution of non-coding RNAs, the role of nuclear mechanotransduction, and the systems involved in ribosomal quality control and turnover [174,175].”
Metadata
- Authors
- Jiao, L., Liu, Y., Yu, X.-Y., Pan, X., Zhang, Y., Tu, J., Song, Y.-H., & Li, Y.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2023-01-09
- Volume
- 8
- Issue
- 1
- Pages
- 15-15
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W4313800177
- Cited by
- 313
- References
- 284
- FWCI
- 23.91
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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