Cited by 1,062Inflammasome and immune disordersCell death mechanisms and regulationImmune Response and Inflammation

The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Open access

Frank, Daniel, Vince, James E.·2019·Cell Death & Differentiation

DOI 10.1038/s41418-018-0212-6PMC PMC6294779

Open this paper in CoChat — free account Open PDF

Abstract

Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death. Although these cell death programmes can protect the host against microbial pathogens, their dysregulation has been implicated in a variety of autoimmune and auto-inflammatory conditions. The disease-promoting potential of necroptosis and pyroptosis is likely a consequence of their ability to induce a lytic cell death. This cell suicide mechanism, distinct from apoptosis, allows the release of immunogenic cellular content, including damage-associated molecular patterns (DAMPs), and inflammatory cytokines such as interleukin-1β (IL-1β), to trigger inflammation. In this Review, we discuss recent discoveries that have advanced our understanding on the primary functions of pyroptosis and necroptosis, including evidence for the specific cytokines and DAMPs responsible for driving inflammation. We compare the similar and unique aspects of pyroptotic- and necroptotic-induced membrane damage, and explore how these may functionally impact distinct intracellular organelles and signalling pathways. We also examine studies highlighting the crosstalk that can occur between necroptosis and pyroptosis signalling, and evidence supporting the physiological significance of this convergence. Ultimately, a better understanding of the similarities, unique aspects and crosstalk of pyroptosis and necroptosis will inform as to how these cell death pathways might be manipulated for therapeutic benefit.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41418-018-0212-6

Cites

170 of 170 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,980
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,777
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500

Show all 170 references

Research works printed but not linked: 1

Rickard JA, O’Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers TW, et al. RIPK1 regulates RIPK3-MLKL driven systemic inflammation and emergency hematopoiesis. Cell. 2014;157:1175–88. · DOI

Sorted by citations

Items 901–1,000 of 1,000

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy
Zheng, H., Li, Q., Luo, H., Yuan, Y., Zhang, N., Lu, Y., Duan, S., Zhong, J., Hb, Z., Liu, C. G., et al. (2026) · Advanced Science · doi:10.1002/advs.76761 · Cited by 1
Pathogenicity and virulence of PRRSV: From regulated cell death reprogramming landscape and immune subversion to precision vaccinology
Cao, S., Zhou, M., Wu, Z., & Zhu, S. (2026) · Virulence · doi:10.1080/21505594.2026.2718552 · Cited by 1
MDS Stem Cell Biology
Villaume, M. T., Ferrell, P. B., & Savona, M. R. (2020) · Springer eBooks · doi:10.1007/978-3-030-51878-3_4 · Cited by 1
COVID-19 and pathology: What do we know?
y Cajal, S. R. (2020) · ANALES RANM · doi:10.32440/ar.2020.137.02.rev06 · Cited by 1
The Growing Clinical Relevance of Cellular Stress Responses and Regulated Cell Death
Land, W. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-53868-2_4 · Cited by 1
Establishment of a Novel Prognostic Prediction Model for Gastric Cancer Based on Necroptosis-Related Genes
Zhu, Z.-Z., Zhang, G., & Liu, J. (2022) · Pathology & Oncology Research · doi:10.3389/pore.2022.1610641 · Cited by 1
A new pyroptosis-related signature for predicting the immune status and injury of liver ischemia-reperfusion.
Huang, M., Xie, J., Xie, X., He, J., Xiong, M., Yi, T., & Chen, Y. (2022) · PubMed Central · Cited by 1
GSDMD inhibitor protects chondrocyte from mechanical injury in human articular cartilage
Tan, C., Li, L., Ma, W., Zhang, J., & Ling, W. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.10.33 · Cited by 1
Recognition and combination of multiple cell-death features showed good predictive value in lung adenocarcinoma
Meng, F., Sun, X., Guo, W., Shi, Y., Cheng, W., & Zhao, L. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22434 · Cited by 1
A pyroptosis-related lncRNA-based prognostic index for hepatocellular carcinoma by relative expression orderings
Tan, J., & Yu, X. (2024) · Translational Cancer Research · doi:10.21037/tcr-23-1804 · Cited by 1
Alterations in Adipocytokine Signaling Pathway and Pyroptosis in Neonatal Hypoxic-ischemic Encephalopathy
Ran, M., Yin, L., Guo, Y., & Zhang, W. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673293975240214091034 · Cited by 1
Different effects of TCBPA exposure on liver cancer cells and liver cells: two sides of the coin
Wang, X. (2024) · American Journal of Cancer Research · doi:10.62347/ysxw8940 · Cited by 1
Cytokine storm modulation using cholecalciferol and low dose gamma radiation in Escherichia coli infected mice
Abdel‐Hamid, G. R., Mostafa, D. M., Fathy, R. M., Lotfy, D. M., & Osman, S. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4026 · Cited by 1
Pyroptosis and its therapeutic potential
Алексеевна, О. И., Семёнович, Ч. В., Радиковна, С. Д., Andreeva, E. A., & Ионовна, Б. Т. (2024) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2024-2-142-150 · Cited by 1
The Biological Effects of Nano-curcumins against Drugs and Chemicals-induced Nephrotoxicity: A Systematic Review
Beigi, F. M. A., Jouneghani, A. S., Heidari-Soureshjani, S., Sherwin, C. M. T., & Mohajeri, S. (2025) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010360420250409111751 · Cited by 1
Cardiomyocyte pyroptosis inhibited by dental pulp-derived mesenchymal stem cells via the miR-19a-3p/IRF-8/MAPK pathway in ischemia–reperfusion
Li, Y., Wang, X., Weng, S., Xia, C., Meng, X., Yang, C., Guo, Y., Pei, Z., Gao, H., & Wang, F. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003623 · Cited by 1
Programmed cell death in human respiratory syncytial virus infection
Yao, P., Ma, C., & Liu, C. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1719352 · Cited by 1
Machine Learning for Prognosis of Clear Cell Renal Cell Carcinoma Based on Pyroptosis RegulatorsPreprint
Yang, C., Tian, Y., Li, Q., & Lin, Q. (2022) · Research Square · doi:10.21203/rs.3.rs-1600390/v1 · Cited by 1
A Novel Defined Pyroptosis-Related Gene Signature for Predicting Prognosis of Acute Myeloid LeukemiaPreprint
Wang, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1792097/v2 · Cited by 1
CDDO-imidazolide ameliorates sepsis-mediated alveolar macrophage pyroptosis by promoting mitophagy via the Nrf2/PINK1 pathwayPreprint
Liu, Y., Zhao, Y., Tang, C., Shen, Y., Liu, C., Wang, Q., Liu, Z., Yang, Z., Wang, X., & Hou, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3277992/v1 · Cited by 1
Targeting PRKACA inhibits proliferation and sensitizes glioma cells to temozolomide via pyroptosis pathwayPreprint
Ge, Y., Gu, L., Huang, W., Peng, Y., Gu, J., Zong, D., & He, X. (2023) · Research Square · doi:10.21203/rs.3.rs-3544645/v1 · Cited by 1
Inflammasomes and pyroptosis of intestinal epithelial cells: their contribution to Crohn’s disease and ulcerative colitis
Tkachenko, A. S. (2019) · Vestnik of Vitebsk State Medical University · doi:10.22263/2312-4156.2019.4.28
Developing a Model of H5N1 Influenza Pathogenesis in Precision-Cut Human Lung Slices
Kettenburg, G. (2020) · D-Scholarship@Pitt (University of Pittsburgh)
Co-expression Network and Prognosis Analyses of Pyroptosis-related Genes in Non-small Cell Lung CancerPreprint
Liu, Z., Liu, X., Zhang, Y. L., Zhou, Y., Lian, S., & Wang, L. (2021) · Research Square · doi:10.21203/rs.3.rs-627404/v1
The role of Lymphoblastic leukemia 1 (Lyl1) in Mycobacterium tuberculosis (Mtb) infection
Jones, S.-S. (2021) · Open University of Cape Town (University of Cape Town)
A Novel Pyroptosis-related Genes Prognostic Signature Affects the Immune Infiltration Patterns in Hepatocellular CarcinomaPreprint
Jin, Y., & Xue-song, B. (2021) · Research Square · doi:10.21203/rs.3.rs-1020197/v1
Exploring the Pyroptosis-related Genes of Breast Cancer and their Effects on Tumor Immune MicroenvironmentPreprint
Jia, C., Yang, F., & Li, R. (2021) · Research Square · doi:10.21203/rs.3.rs-1049643/v1
El plátano canario en el contexto internacional: su historia agrocomercial
Marrero, L. M. P. (2000) · Dialnet (Universidad de la Rioja)
A Novel Established Pyroptosis-participant Genes Signature for Predicting the Prognosis of Idiopathic Pulmonary FibrosisPreprint
He, Q., Cao, Y., Zhao, Y., Shen, Y., Xu, X., & Zhang, Q.-D. (2021) · Research Square · doi:10.21203/rs.3.rs-1129674/v1
Sustained Down Regulation of Plasma Tetranectin Contributes to Liver Injury in Pneumonia-Associated SepsisPreprint
Wang, S., Bai, Y., Guo, Y., Bai, Q., Wei, X., Zhang, Y., Chen, N., Miller, E. J., & Li, W. (2020) · doi:10.21203/rs.3.rs-96624/v1
Development and validation of novel defined pyroptosis-related gene signature for progression-free survival prediction in patients with breast invasive carcinoma
Chen, Y., Zhang, Y., Wang, Y., Li, F., & Han, X. (2022) · Minerva Surgery · doi:10.23736/s2724-5691.21.09402-8
Immunology and defence mechanisms
Stefano, A. D., & Balbi, B. (2019) · doi:10.1183/9781849840798.024818
Nod-like Receptor Protein 3 (Nlrp3) Inflammasomes Inhibition by Metformin Limits Myocardial Ischemia/reperfusion InjuryPreprint
Zhang, J., Liu, Y., Zhang, Q., Shi, X., Hua, F., Ma, J., Zhu, W., Liu, X., Zhang, J., Cai, X., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-45928/v1
Faculty Opinions recommendation of Chronic inflammation in the etiology of disease across the life span.
Nieman, D. C. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737032981.793575943
A Novel Defined Pyroptosis-Related Gene Signature for Predicting Prognosis of Acute Myeloid LeukemiaPreprint
Wang, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1792097/v1
Pyroptosis-Related Gene Markers Can Effectively Diagnose Endometriosis and Predict PrognosisPreprint
S., J. M., Thilsath Parveen, S., Liu, Y., J.S., C., X.L., Y., D.Y., L., B., J., Yadavalli Srujana, S., & Y.S., M. (2022) · Research Square · doi:10.21203/rs.3.rs-1935526/v1
A Novel Defined Pyroptosis-Related Gene Signature for Predicting Prognosis of Acute Myeloid LeukemiaPreprint
Wang, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1792097/v3
Mechanisms of enterococcus faecalis-mediated Immunomodulation
Kao, P. H. N. (2021) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/160631
Protective Effects of Apocynin on Streptozotocin-Induced Diabetic Muscular Atrophy
Xianchu, L., Changhao, C., Beiwang, D., & Ming, L. (2022) · International Journal of Pharmacology · doi:10.3923/ijp.2022.1420.1428
Identification of Pyroptosis Genes in cervical cancer and construction of a prognostic model for pyroptosis-associated mRNAPreprint
Kang, H., Wu, Y., Yan, Y., Bai, S., Li, R., Feng, Z., Wang, X., Li, G., Li, W., Liu, W., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2110804/v1
Oligodendrocyte responses after spinal cord injury.
Wei, G. (2021) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/3682
THE MOLECULAR MECHANISM OF PYROPTOSIS AND ITS RELATED DISEASES
Kasianenko, O., & Liu, M. (2022) · Bulletin of Sumy National Agrarian University The series Veterinary Medicine · doi:10.32845/bsnau.vet.2022.2.3
Scalp acupuncture attenuates brain injury after intracerebral hemorrhage in rats by inhibiting necroptosisPreprint
Yao, J., Dai, X., Yu, X., Teng, W., Yu, W., Kuang, B., Li, M., Liu, X., Zheng, L., Cao, H., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1990560/v1
Der programmierte Zelltod – Apoptose, Nekroptose, Ferroptose und Pyroptose
Heinrich, P. C., Wajant, H., Koch, H.-G., & Brix, J. (2022) · Springer eBooks · doi:10.1007/978-3-662-60266-9_51
The activation of AIM2/Caspase-1/GSDMD pathway contributes to pyroptosis of keratinocytes in Stevens-Johnson syndrome/toxic epidermal necrolysisPreprint
Yang, L., Shou, Y., Li, F., Du, J., Zhu, X., Wang, S.-S., Xie, L., Zhou, L.-J., Zhou, J.-Q., Yang, Y., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2447588/v1
A New Necroptosis-Related lncRNA Signature Predicts the Prognosis of Kidney Renal Clear Cell Carcinoma PatientsPreprint
Zhao, B., Gui, L., Zhang, Z., Xiang, Y., Sun, X., Fan, J., & Huang, L. (2023) · Research Square · doi:10.21203/rs.3.rs-2488288/v1
PCD-otofajinin bitki immünitesiyle korelasyonu
BAŞ, B. (2023) · Ege Üniversitesi Ziraat Fakültesi Dergisi · doi:10.20289/zfdergi.1074706
Data from USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
Ren, Y., Feng, M., Hao, X., Liu, X., Li, J., Li, P., Gao, J., Qi, Q., Du, L., Wang, C., et al. (2023) · doi:10.1158/0008-5472.c.6487386.v2
Repurposed Drugs/Potential Pharmacological Agents Targeting Cytokine Release and Induction of Coagulation in COVID-19
Singh, A., Verma, A. K., Pandey, A. K., & Bajpai, J. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815123197123010008
Paneth and Paneth-like cells undergoing necroptosis fuel intestinal epithelial cell proliferation following IFN-γ stimulationPreprint
Encarnacion‐Garcia, M. R., la Torre‐Baez, R. D., Hernandez‐Cueto, M. A., Velázquez‐Villegas, L. A., Candelario‐Martínez, A., Horta‐López, P. H., Montoya‐García, A., Jaimes‐Ortega, G. A., Lopez-Bailon, L. U., Piedra-Quintero, Z. L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.13.540666
Pyroptosis-related genes expression and nomogram predict overall survival of gastric cancerPreprint
Wang, S., Li, X.-C., Zhu, J.-R., Ran, J.-T., & Guan, Q. (2023) · Research Square · doi:10.21203/rs.3.rs-2993160/v1
Transcriptome analysis constructed the necroptosis associated prognostic signature in endometrial cancer and identified EZH2 as a potential biomarker
(2023) · European Journal of Gynaecological Oncology · doi:10.22514/ejgo.2023.060
Robustness of mixed population under heterogeneity
Singh, U., Chandrasekar, V. K., & Senthilkumar, D. V. (2023) · The European Physical Journal Plus · doi:10.1140/epjp/s13360-023-04567-0
Studies regarding influences of ethanol on hypoxemic stress in neuroblastoma cells
Stoica, S. I., Onose, G., Bleoţu, C., Neagu, A. I., Pitica, I. M., & Dragu, D. (2023) · Balneo and PRM Research Journal · doi:10.12680/balneo.2023.626
Interactions of nontyphoidal Salmonella with host cells
Santana, C. H., & Santos, R. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-818619-0.00112-x
Robust network of globally coupled heterogeneous limit cycle oscillators due to inertia
Singh, U., Zou, W., Chandrasekar, V. K., & Senthilkumar, D. V. (2024) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2024.114691
Nouvelles stratégies vaccinales anti-tumorales par vecteurs AAVs recombinants : manipulation de la mort cellulaire immunogénique dans le contexte tumoral
Scarpitta, A. (2023) · theses.fr (ABES) · doi:10.70675/e6bc2455ze497z4a6bz87b7z7db1b1cba930
Additional file 3 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J. W., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622852
Additional file 1 of Pyroptosis related genes signature predicts prognosis and immune infiltration of tumor microenvironment in hepatocellular carcinoma
Fang, G., Zhang, Q., Fan, J., Li, H., Ding, Z., Fu, J., Wu, Y., Zeng, Y., & Liu, J. (2022) · Figshare · doi:10.6084/m9.figshare.21172171
Additional file 6 of Eimeria falciformis secretes extracellular vesicles to modulate proinflammatory response during interaction with mouse intestinal epithelial cells
Olajide, J. S., Xiong, L., Yang, S., Qu, Z., Xu, X. J., Yang, B., Wang, J., Liu, B., Ma, X., & Cai, J. (2022) · Figshare · doi:10.6084/m9.figshare.20278988
Additional file 4 of Comprehensive analysis of pyroptosis regulators and tumor immune microenvironment in clear cell renal cell carcinoma
Zhang, Y., Chen, X., Fu, Q., Wang, F., Zhou, X., Xiang, J., He, N., Hu, Z., & Jin, X. (2021) · Figshare · doi:10.6084/m9.figshare.17204686
Additional file 7 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J. W., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622864
Additional file 10 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J. W., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622873
Additional file 2 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J. W., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622849
Additional file 5 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J. W., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622858
Additional file 2 of Pyroptosis related genes signature predicts prognosis and immune infiltration of tumor microenvironment in hepatocellular carcinoma
Fang, G., Zhang, Q., Fan, J., Li, H., Ding, Z., Fu, J., Wu, Y., Zeng, Y., & Liu, J. (2022) · Figshare · doi:10.6084/m9.figshare.21172177
Additional file 6 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J. W., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622861
Additional file 1 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J. W., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622846
Additional file 4 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J. W., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622855
Additional file 9 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J. W., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622870
Pre-Clinical Investigation of Histotripsy for Non-Invasive Ablation of Liver Cancer
Worlikar, T. (2022) · Deep Blue (University of Michigan) · doi:10.7302/4673
Advancements in the Research of Cell Death in Tumors
赖, 鑫. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1471987
Biomarkers of Pan-Cancer-Associated Necroptosis Studied Based on Single-Cell Data
杜, 兆. (2024) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2024.143049
Physiological, biochemical, pharmacological, and genetic manipulations of charnolosome in personalized nanotheranostics of chronic MDR diseases
Sharma, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21752-4.00054-7
Identification and validation of pyroptosis patterns with a novel quantification system for the prediction of prognosis in lung squamous cell carcinoma
Qin, X., Wu, J., Qin, F., Zheng, Y., Chen, J., Liu, Z., Tan, J. W., Cai, W., He, S., Jian, B., et al. (2024) · Translational Lung Cancer Research · doi:10.21037/tlcr-24-1003
Nanomaterials‐Induced Pyroptosis and Immunotherapy
Chen, H., Ding, B., Lin, J., & Ma, P. (2025) · Wiley eBooks · doi:10.1002/9783527845347.ch11
COVID-19 Induces Greater NLRP3 Inflammasome Activation in Obese Patients than Other Chronic Illnesses: A Case–Control Study
D’Amico, R. C., Nagashima, S., Carstens, L. B., Bertoldi, K., Mataruco, S., D’Agostini, J. C. H., Hlatchuk, E. C., da Silva, S. B., de Noronha, L., & Baena, C. P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041541
Current Evidence and Therapeutic Implications of PANoptosis in Sepsis
王, 增. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.153885
Structural and temporal dynamics analysis on PANoptosis in sepsis: a bibliometric analysisPreprint
Li, Z., Nie, D., Yin, L., Qin, Q., Yang, C., Li, R., Gao, X., Yu, X., & Wang, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.02.657552
Heavy ion radiation induces pyroptosis in skin keratinocytes through a mitogen-activated protein kinase signaling pathway
Zhang, Z., Wang, H., Huang, Y., Zhu, L., Wang, X., Du, Y., Zhou, G., & Zhao, Y. (2025) · International Journal of Radiation Biology · doi:10.1080/09553002.2025.2561813
(−)‐Epigallocatechin Gallate Ameliorates Chronic Stress‐Induced Depression‐Like Behavior in Rats by Inhibiting the NF ‐ κB /Caspase‐1 Signaling Pathway and Reducing IL ‐1β and IL ‐18 Expression
Wu, G., Xu, J., Wu, W., Jin, J., Li, S., Huang, Y. M., Zhang, Z., Hu, Y., Zhang, Y., Liu, Y., et al. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70961
Tubastatin A alleviates post-resuscitation myocardial damage possibly via inhibiting GSDME-mediated pyroptosis and MLKL-mediated necroptosis in a porcine model of cardiac arrest
Lai, L., Fang, Y., Xie, L., Zhao, X. H., Xu, J., & Lan, P. (2025) · Resuscitation Plus · doi:10.1016/j.resplu.2025.101158
The AMPK/ULK1/autophagy pathway: FGF23’s weapon against GSDME-mediated pyroptosis in folic acid-induced acute kidney injury
Zhang, L., Wang, L., Yan, B., Wang, N., Li, M., Liu, W., Wang, Y., Yan, L., Cao, H., Shao, F., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115937
Comprehensive analysis of genes associated with necroptosis and pyroptosis in intestinal ischemia-reperfusion injury
Bao, S., Sun, Y., Hu, Y., Lei, X., Zhao, Y., & Li, W. (2025) · PLoS ONE · doi:10.1371/journal.pone.0338420
Additional file 2 of FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion
Xia, M., Li, X., Ye, S., Zhang, Q., Zhao, T., Li, R., Zhang, Y., Xian, M., Li, T., Li, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20003476
Additional file 1 of BML-111 inhibit H2O2-induced pyroptosis and osteogenic dysfunction of human periodontal ligament fibroblasts by activating the Nrf2/HO-1 pathway
Xu, Y., Chu, Y., Yang, W., Chu, K., Li, S., & Guo, L. (2024) · Figshare · doi:10.6084/m9.figshare.24965955
Additional file 5 of Eimeria falciformis secretes extracellular vesicles to modulate proinflammatory response during interaction with mouse intestinal epithelial cells
Olajide, J. S., Xiong, L., Yang, S., Qu, Z., Xu, X., Yang, B., Wang, J., Liu, B., Ma, X., & Cai, J. (2022) · Figshare · doi:10.6084/m9.figshare.20278985
Additional file 1 of Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults
Nidadavolu, L. S., Feger, D. M., Chen, D., Wu, Y., Grodstein, F., Gross, A. L., Bennett, D. A., Walston, J. D., Oh, E. S., & Abadir, P. M. (2023) · Figshare · doi:10.6084/m9.figshare.23118956
Additional file 2 of Human umbilical cord mesenchymal stem cell exosome-derived miR-874-3p targeting RIPK1/PGAM5 attenuates kidney tubular epithelial cell damage
Yu, Y., Chen, M., Guo, Q., Shen, L., Liu, X., Pan, J., Zhang, Y., Xu, T., Zhang, D., & Wei, G. (2024) · Figshare · doi:10.6084/m9.figshare.26566985
Additional file 8 of Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.22622867
Additional file 5 of Comprehensive analysis of pyroptosis regulators and tumor immune microenvironment in clear cell renal cell carcinoma
Zhang, Y., Chen, X., Fu, Q., Wang, F., Zhou, X., Xiang, J., He, N., Hu, Z., & Jin, X. (2021) · Figshare · doi:10.6084/m9.figshare.17204689
Additional file 2 of Comprehensive analysis of pyroptosis regulators and tumor immune microenvironment in clear cell renal cell carcinoma
Zhang, Y., Chen, X., Fu, Q., Wang, F., Zhou, X., Xiang, J., He, N., Hu, Z., & Jin, X. (2021) · Figshare · doi:10.6084/m9.figshare.17204680
Additional file 2 of MALAT1 knockdown alleviates the pyroptosis of microglias in diabetic cerebral ischemia via regulating STAT1 mediated NLRP3 transcription
Zhao, N., Hua, W., Liu, Q., Wang, Y., liu, Z., Jin, S., Wang, B., Pang, Y., Jiping, Q., & Song, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26580080
Additional file 3 of MALAT1 knockdown alleviates the pyroptosis of microglias in diabetic cerebral ischemia via regulating STAT1 mediated NLRP3 transcription
Zhao, N., Hua, W., Liu, Q., Wang, Y., liu, Z., Jin, S., Wang, B., Pang, Y., Jiping, Q., & Song, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26580083
Additional file 3 of Comprehensive analysis of pyroptosis regulators and tumor immune microenvironment in clear cell renal cell carcinoma
Zhang, Y., Chen, X., Fu, Q., Wang, F., Zhou, X., Xiang, J., He, N., Hu, Z., & Jin, X. (2021) · Figshare · doi:10.6084/m9.figshare.17204683
Additional file 1 of System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma
Zhao, S., Zhu, Y., Liu, H., He, X., & Xie, J. (2024) · Figshare · doi:10.6084/m9.figshare.26638299
Additional file 1 of SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis
Mao, X., Wu, W., Nan, Y., Sun, W., & Wang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26609367
Additional file 1 of Comprehensive analysis of pyroptosis regulators and tumor immune microenvironment in clear cell renal cell carcinoma
Zhang, Y., Chen, X., Fu, Q., Wang, F., Zhou, X., Xiang, J., He, N., Hu, Z., & Jin, X. (2021) · Figshare · doi:10.6084/m9.figshare.17204677
Additional file 1 of Human umbilical cord mesenchymal stem cell exosome-derived miR-874-3p targeting RIPK1/PGAM5 attenuates kidney tubular epithelial cell damage
Yu, Y., Chen, M., Guo, Q., Shen, L., Liu, X., Pan, J., Zhang, Y., Xu, T., Zhang, D., & Wei, G. (2024) · Figshare · doi:10.6084/m9.figshare.26566982
Additional file 1 of FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion
Xia, M., Li, X., Ye, S., Zhang, Q., Zhao, T., Li, R., Zhang, Y., Xian, M., Li, T., Li, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20003473

Authors: Frank, D., & Vince, J. E.
Affiliations: The University of Melbourne (AU)
Corresponding author: Vince, James E.
ORCID: Frank, Daniel
Vince, James E.
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2018-10-19
Volume: 26
Issue: 1
Pages: 99-114
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/s41418-018-0212-6
PMC: PMC6294779
OpenAlex: W2895833591
Cited by: 1,062
References: 170
Citations by year: 2026: 88 · 2025: 142 · 2024: 151 · 2023: 202 · 2022: 237 · 2021: 137 · 2020: 68 · 2019: 34 · 2018: 1
FWCI: 5.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Melbourne
National Health and Medical Research Council (1141466)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: pyroptosis, necroptosis, necrosis, damage-associated molecular patterns, IL-1β, inflammation, autoimmune disease, autoinflammation, membrane damage, intracellular signaling
MeSH terms: Alarmins, Pyroptosis, Necroptosis, Gasdermins, Animals, Humans, Inflammation, Necrosis, Protein Kinases, Signal Transduction, Cytokines, Caspase 1, HMGB1 Protein, Phosphate-Binding Proteins, Intracellular Signaling Peptides and Proteins, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks