Cited by 1,062Inflammasome and immune disordersCell death mechanisms and regulationImmune Response and Inflammation

The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Open access

Frank, Daniel, Vince, James E.·2019·Cell Death & Differentiation

DOI 10.1038/s41418-018-0212-6PMC PMC6294779

Open this paper in CoChat — free account Open PDF

Abstract

Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death. Although these cell death programmes can protect the host against microbial pathogens, their dysregulation has been implicated in a variety of autoimmune and auto-inflammatory conditions. The disease-promoting potential of necroptosis and pyroptosis is likely a consequence of their ability to induce a lytic cell death. This cell suicide mechanism, distinct from apoptosis, allows the release of immunogenic cellular content, including damage-associated molecular patterns (DAMPs), and inflammatory cytokines such as interleukin-1β (IL-1β), to trigger inflammation. In this Review, we discuss recent discoveries that have advanced our understanding on the primary functions of pyroptosis and necroptosis, including evidence for the specific cytokines and DAMPs responsible for driving inflammation. We compare the similar and unique aspects of pyroptotic- and necroptotic-induced membrane damage, and explore how these may functionally impact distinct intracellular organelles and signalling pathways. We also examine studies highlighting the crosstalk that can occur between necroptosis and pyroptosis signalling, and evidence supporting the physiological significance of this convergence. Ultimately, a better understanding of the similarities, unique aspects and crosstalk of pyroptosis and necroptosis will inform as to how these cell death pathways might be manipulated for therapeutic benefit.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41418-018-0212-6

Cites

170 of 170 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,773
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500

Show all 170 references

Research works printed but not linked: 1

Rickard JA, O’Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers TW, et al. RIPK1 regulates RIPK3-MLKL driven systemic inflammation and emergency hematopoiesis. Cell. 2014;157:1175–88. · DOI

Sorted by citations

Items 501–600 of 1,000

Recent Therapeutic Strategies for Excessive Chondrocyte Death in Osteoarthritis: A Review
Xiang, W., Zheng, Q., Liu, A., Huang, S., Chen, R., Qiu, J., Su, Q., Chen, X., & Wu, J. (2023) · Orthopaedic Surgery · doi:10.1111/os.13718 · Cited by 16
CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis
Zhang, H., Deng, Z., Wang, Y., Zheng, X., Zhou, L., Shu, Y., Wang, Y., Dai, Y., Kanwar, Y. S., & Deng, F. (2023) · iScience · doi:10.1016/j.isci.2023.107762 · Cited by 16
A proteomics analysis of the ovarian development in females of Haemaphysalis longicornis
Wang, M., Hu, Y., Li, M., Xu, Q., Zhang, X., Wang, X., Xue, X., Xiao, Q., Liu, J., & Wang, H. (2020) · Experimental and Applied Acarology · doi:10.1007/s10493-020-00469-3 · Cited by 16
Identification of molecular subtypes, risk signature, and immune landscape mediated by necroptosis-related genes in non-small cell lung cancer
Zhu, J., Wang, J., Wang, T., Zhou, H., Xu, M., Zha, J., Chen, F., Shen, Z., Jiang, Y., & Chen, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.955186 · Cited by 15
Identification of a pyroptosis-related lncRNA signature in the regulation of prognosis, metabolism signals and immune infiltration in lung adenocarcinoma
Zhou, S., Cai, Y., Xu, Z., Peng, B., Liang, Q., Peng, J., & Yan, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.964362 · Cited by 15
Differential effects of oleate on vascular endothelial and liver sinusoidal endothelial cells reveal its toxic features in vitro
Geng, Y., Arroyave-Ospina, J. C., Buist‐Homan, M., Plantinga, J. A., Olinga, P., Reijngoud, D., van Vilsteren, F. G. I., Blokzijl, H., Kamps, J. A. A. M., & Moshage, H. J. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109255 · Cited by 15
Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma
Yang, X., Wang, H., Zhang, L., Yao, S., Dai, J., Wen, G., An, J., Jin, H., Du, Q., Hu, Y., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114792 · Cited by 15
Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis
Tang, L., Zhang, D., Zhang, Y., Peng, Y., Li, M., Song, H., Chen, H. H., Li, W., & Li, X. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01878-6 · Cited by 15
The development of necroptosis: what we can learn
Ma, D., Wang, X., Liu, J., Cui, Y., Luo, S., & Wang, F. (2023) · Cell Stress and Chaperones · doi:10.1007/s12192-023-01390-5 · Cited by 15
Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions
Sun, H.-J., Jiao, B., Wang, Y., Zhang, Y.-H., Chen, G., Wang, Z.-X., Zhao, H., Xie, Q., & Song, X. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i14.1968 · Cited by 15
The involvement of autophagy in the maintenance of endothelial homeostasis: The role of mitochondria
Dymkowska, D. (2021) · Mitochondrion · doi:10.1016/j.mito.2020.12.013 · Cited by 15
Cytotoxicity and radiosensitizing potency of Moscatilin in cancer cells at low radiation doses of X-ray and UV-C
Pujari, I., Thomas, A., Thomas, J., Jhawar, N., Guruprasad, K. P., Padmalatha, S., Satyamoorthy, K., & Babu, V. S. (2021) · 3 Biotech · doi:10.1007/s13205-021-02827-3 · Cited by 15
Interleukin‐1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed‐Pattern Psoriasis
Frers, R. K., Losada, M. E. O., Kobiec, T., Herrera, M. I., Udovin, L., Kusnier, C. F., & Capani, F. (2021) · Mediators of Inflammation · doi:10.1155/2021/2503378 · Cited by 15
Development and Validation of a Pyroptosis-Related Signature for Predicting Prognosis in Hepatocellular Carcinoma
Ding, J., He, X., Luo, W., Zhou, W., Chen, R., Cao, G., Chen, B., & Xiong, M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.801419 · Cited by 15
Inhibition of RIP3 increased ADSC viability under OGD and modified the competency of adipogenesis, angiogenesis, and inflammation regulation
Yang, Z., Qi, Z., Yang, X., Gao, Q., Hu, Y., & Yuan, X. (2022) · Bioscience Reports · doi:10.1042/bsr20212808 · Cited by 15
A novel pyroptosis-related prognostic lncRNAs signature, tumor immune microenvironment and the associated regulation axes in bladder cancer
Mo, X., Hu, D., Li, Y., Nai, A., Ma, F., Bashir, S., Jia, G., & Xu, M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.936305 · Cited by 15
Prognostic value and immunological characteristics of a novel cuproptosis-related long noncoding RNAs risk signature in kidney renal clear cell carcinoma
Hong, P., Huang, W., Du, H., Hu, D., Cao, Q., Wang, Y., Zhang, H., Tong, S., Li, Z., & Tong, M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1009555 · Cited by 15
Substantial induction of non-apoptotic CD4 T-cell death during the early phase of HIV-1 infection in a humanized mouse model
Terahara, K., Iwabuchi, R., Iwaki, R., Takahashi, Y., & Tsunetsugu‐Yokota, Y. (2020) · Microbes and Infection · doi:10.1016/j.micinf.2020.10.003 · Cited by 15
Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein–protein interactions, and cross-pathway communication
Sorokin, O., Hause, F., Wedler, A., Alakhras, T., Bauchspiess, T., Dietrich, A., Günther, W. F., Guha, C., Obika, K. B., Kraft, J., et al. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02161-6 · Cited by 14
A Newly Defined Pyroptosis-Related Gene Signature for the Prognosis of Bladder Cancer
Chen, W., Zhang, W., Zhou, T. Y., Cai, J., Yu, Z., & Wu, Z. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s337735 · Cited by 14
Differential expression of pyroptosis-related genes in the hippocampus of patients with Alzheimer’s disease
Xia, P., Ma, H., Chen, J., Liu, Y., Cui, X., Wang, C., Zong, S., Wang, L., Liu, Y., & Lu, Z. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01479-x · Cited by 14
Cadmium‐induced pyroptosis is mediated by PERK / TXNIP / NLRP3 signaling in SH‐SY5Y cells
Li, Z., Shi, Y., Wang, Y., Qi, H., Chen, H., Li, J., & Li, L. (2023) · Environmental Toxicology · doi:10.1002/tox.23861 · Cited by 14
Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy
Scimeca, M., Rovella, V., Palumbo, V., Scioli, M. P., Bonfiglio, R., Melino, G., Piacentini, M., Frati, L., Agostini, M., Candi, E., et al. (2023) · Cancers · doi:10.3390/cancers15143638 · Cited by 14
The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions
Wang, J., Wang, H., Gao, M., Zhang, Y., Zhang, L., Huang, D., Tu, K., & Xu, Q. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01875-9 · Cited by 14
System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma
Zhao, S., Zhu, Y., Liu, H., He, X., & Xie, J. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04513-9 · Cited by 14
Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review
da Rocha, L. D. O. S., de Morais, É. F., de Oliveira, L. Q. R., Barbosa, A. V., Lambert, D., Rocha, C. A. G., & Coletta, R. D. (2024) · Biology · doi:10.3390/biology13020103 · Cited by 14
Periodontitis and lipopolysaccharides: How far have we understood?
Banavar, S. R., Tan, E. L., Davamani, F. A., & Khoo, S. P. (2024) · Exploration of Immunology · doi:10.37349/ei.2024.00133 · Cited by 14
Mechanism of PANoptosis in metabolic dysfunction-associated steatotic liver disease
Ni, K., & Meng, L. (2024) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2024.102381 · Cited by 14
Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches
Gu, G., Yu, H., Zou, H., Kou, W., Zhang, P., Gu, G., Lu, J., Shi, W., Chu, P., Zhang, Y., et al. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2906210 · Cited by 14
Mesenchymal stem cells-derived exosomes attenuate mouse non-heart-beating liver transplantation through Mir-17-5p-regulated Kupffer cell pyroptosis
Tian, Y., Jin, M., Ye, N., Gao, Z., Jiang, Y., & Yan, S. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04169-w · Cited by 14
Fundamental mechanisms of cell death for polycystic ovary syndrome
Li, Y., Peng, Y., Yang, Y., Xu, N., Shi, T., Liu, R., Luan, Y., & Yin, C.-H. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102043 · Cited by 14
The capsaicin receptor TRPV1 reduces sepsis-associated brain injury in mice by inhibiting pyroptosis
Long, M., Hu, Z., Long, F., Chen, Y., Liu, L., & Wang, M. (2025) · Anesthesiology and Perioperative Science · doi:10.1007/s44254-025-00115-4 · Cited by 14
Dynasore protects ocular surface mucosal epithelia subjected to oxidative stress by maintaining UPR and calcium homeostasis
Martínez-Carrasco, R., Argüeso, P., & Fini, M. E. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.002 · Cited by 14
Protein A Modulates Neutrophil and Keratinocyte Signaling and Survival in Response to Staphylococcus aureus
Ledo, C., Gonzalez, C. D., Garófalo, A. N., Sabbione, F., Keitelman, I. A., Giai, C., Stella, I., Trevani, A. S., & Gómez, M. I. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.524180 · Cited by 14
The diverse roles of myeloid derived suppressor cells in mucosal immunity
Ashkenazi‐Preiser, H., Mikula, I., & Baniyash, M. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104361 · Cited by 14
The Host‐Defense‐Peptide‐Mimicking Synthetic Polypeptides Effectively Enhance Antitumor Immunity through Promoting Immunogenic Tumor Cell Death
Wang, Y., Shen, W. H., Liu, S., Zhu, G., Meng, X., Mao, K., Wang, J., Yang, Y., Xiao, C., & Sun, T. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202100171 · Cited by 14
Spinal Tuina Improves Cognitive Impairment in Cerebral Palsy Rats through Inhibiting Pyroptosis Induced by NLRP3 and Caspase-1
Niu, F., Wang, C., Zhong, H., Ren, N., Wang, X., & Li, B. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/1028909 · Cited by 14
Escherichia coli infection mediates pyroptosis via activating p53-p21 pathway-regulated apoptosis and cell cycle arrest in bovine mammary epithelial cells
Zhuang, C., Zhao, J., Zhang, S., & Shahid, M. S. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106338 · Cited by 14
Attenuates reactive oxygen species: induced pyroptosis via activation of the Nrf2/HO-1 signal pathway in models of trigeminal neuralgia
Liu, M., Wang, Y., Li, S., Hou, X., Li, T., Xu, Z., Chen, F., Zhou, Y., Xia, L., & Wang, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-44013-w · Cited by 14
Development and Validation of a Novel Survival Model for Cutaneous Melanoma Based on Necroptosis-Related Genes
Niu, Z., Wang, X., Xu, Y., Yan, L., Gong, X., Zeng, Q., Zhang, B., Xi, J., Pei, X., Yue, W., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.852803 · Cited by 14
Caspase-8-driven NLRP3 inflammasome activation exacerbates bronchopulmonary dysplasia by increasing the apoptosis and pyroptosis crosstalk of alveolar epithelial cells
Huang, D., Xu, D., You, C., Li, B., Li, L., Yang, Q., Zhou, W., Meng, Q., & Liang, Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115025 · Cited by 13
Molecular docking, ADMET profiling of gallic acid and its derivatives (N-alkyl gallamide) as an anti-breast cancer agent
Arsianti, A., Azizah, N. N., & Erlina, L. (2022) · F1000Research · doi:10.12688/f1000research.127347.3 · Cited by 13
Cadmium (Cd) and 2,2′,4,4′‐tetrabromodiphenyl ether ( BDE ‐47) co‐exposure induces acute kidney injury through oxidative stress and RIPK3 ‐dependent necroptosis
Tang, J., Zhang, N., Chen, S., Hu, K., Li, Y., Fang, Y., Wu, Z., Zhang, Y., & Xu, L. (2023) · Environmental Toxicology · doi:10.1002/tox.23869 · Cited by 13
Necrostatin-1 protects corneal epithelial cells by inhibiting the RIPK1/RIPK3/MLKL cascade in a benzalkonium chloride-induced model of necroptosis
Yan, X., Yan, Y., Liu, J., Jing, Y., Hao, P., Chen, X., & Li, X. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110030 · Cited by 14
Programmed cell death in nasopharyngeal carcinoma: Mechanisms and therapeutic targets
Qian, S., Tan, G., Lei, G., Zhang, X., & Xie, Z. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189265 · Cited by 13
Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines
Cruz‐López, O., Ner, M., Nerín-Fonz, F., Jiménez-Martínez, Y., Araripe, D. A., Marchal, J. A., Boulaiz, H., Gutiérrez‐de‐Terán, H., Rosa, J. M. C., & Conejo‐García, A. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1948841 · Cited by 13
Ceramide-1-phosphate and its transfer proteins in eukaryotes
Zhang, Y., Zhang, X., Lu, M., & Zou, X. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2021.105135 · Cited by 13
The Roles of Gasdermin D in Coronavirus Infection and Evasion
Liu, X., Ding, S., & Liu, P. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.784009 · Cited by 13
Poly-l-lysine-caused cell adhesion induces pyroptosis in THP-1 monocytes
Yu, C., Zhao, W., Duan, C., Xie, J., & Yin, W. (2022) · Open Life Sciences · doi:10.1515/biol-2022-0028 · Cited by 13
New Insights of Early Brain Injury after Subarachnoid Hemorrhage: A Focus on the Caspase Family
Wang, X., Xu, P., Liu, Y., Wang, Z., Lenahan, C., Fang, Y., Lü, J., Zheng, J., Wang, K., Wang, W., et al. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220420115925 · Cited by 13
Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives
Lin, W., Chen, M., Cissé, Y., Chen, X., & Bai, L. (2022) · Journal of Ophthalmology · doi:10.1155/2022/2695212 · Cited by 13
Pyroptosis-Related lncRNA Prognostic Model for Renal Cancer Contributes to Immunodiagnosis and Immunotherapy
Zhou, X., Yao, L., Zhou, X., Cong, R., Luan, J., Wei, X., Zhang, X., & Song, N. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.837155 · Cited by 13
Cell death mechanisms in retinal phototoxicity
Françon, A., & Torriglia, A. (2023) · Journal of Photochemistry and Photobiology · doi:10.1016/j.jpap.2023.100185 · Cited by 13
METTL3 promotes hyperoxia-induced pyroptosis in neonatal bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy
Xu, L., Shi, Z., Pan, Z., & Wu, R. (2023) · Clinics · doi:10.1016/j.clinsp.2023.100253 · Cited by 13
Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury
Saad, K. M., Salles, É. L., Naeini, S. E., Baban, B., Abdelmageed, M. E., Abdelaziz, R. R., Suddek, G. M., & Elmarakby, A. A. (2024) · Pharmacological Reports · doi:10.1007/s43440-023-00565-2 · Cited by 13
NLRP3 promotes radiation‐induced brain injury by regulating microglial pyroptosis
Zhang, W., Wu, Q., Zhang, X., Qin, Y., Gao, L., Hu, S., Du, S., & Ren, C. (2024) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12992 · Cited by 13
Perspectives on Non-BLT Humanized Mouse Models for Studying HIV Pathogenesis and Therapy
Terahara, K., Iwabuchi, R., & Tsunetsugu‐Yokota, Y. (2021) · Viruses · doi:10.3390/v13050776 · Cited by 13
Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression
Liu, X., Leng, Y., Lv, X., Lv, J., Zhang, M., & Shi, Y. (2021) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-021-09922-3 · Cited by 13
Poly(ADP-ribose) Polymerase (PARP) is Critically Involved in Liver Ischemia/Reperfusion-injury
Haga, S., Kanno, A., Morita, N., Jin, S., Matoba, K., Ozawa, T., & Ozaki, M. (2021) · Journal of Surgical Research · doi:10.1016/j.jss.2021.09.008 · Cited by 13
Antileukemic Natural Product Induced Both Apoptotic and Pyroptotic Programmed Cell Death and Differentiation Effect
Leu, W., Chang, H., Chen, I., Guh, J., & Chan, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011239 · Cited by 13
Maintenance of Germinal Center B Cells by Caspase-9 through Promotion of Apoptosis and Inhibition of Necroptosis
Zhang, J., Kodali, S., Chen, M., & Wang, J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000359 · Cited by 13
Construction and Validation of a Necroptosis-Related Signature Associated With the Immune Microenvironment in Liver Hepatocellular Carcinoma
Wang, G., Ding, B., Sun, L., Guo, J., Wang, S., Li, W., Zhang, Y., Lv, J., & Qiu, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.859544 · Cited by 12
Neferine Targeted the NLRC5/NLRP3 Pathway to Inhibit M1-type Polarization and Pyroptosis of Macrophages to Improve Hyperuricemic Nephropathy
Yin, W., Wang, J., Liang, Y., Liu, K., Chen, Y., & Chen, Y. (2024) · Current Molecular Medicine · doi:10.2174/0115665240272051240122074511 · Cited by 12
Pyroptosis‐Inducing Self‐Adaptor to Potentiate Immune Checkpoint Blockade Therapy for Breast Cancer by Reeducating the Treatment‐Recruited Macrophages
Qiu, Z., Zhong, Y., Lu, Z., Zhang, K., Li, Z., Nie, J., & Cheng, H. B. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202414847 · Cited by 12
Mechanistic studies of Ca2+-induced classical pyroptosis pathway promoting renal adhesion on calcium oxalate kidney stone formation
Xiang, J., Lv, M., Yuhui, L., Ke, K., Zhang, B., Wang, M., Zhang, K., & Li, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-91460-8 · Cited by 12
Exploring combinations of dihydroartemisinin for cancer therapy: A comprehensive review
Rani, K., Sahu, R. C., Chaudhuri, A., Kumar, D. N., Arora, S., Kumari, V., & Agrawal, A. K. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151854 · Cited by 12
Mechanism of cell death and its application in the repair of inflammatory bowel disease by mesenchymal stem cells
Akanyibah, F. A., He, C., Cai, P., Xiu, W., Wang, Y., & Mao, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1597462 · Cited by 12
Targeting glial fibrillary acidic protein in glaucoma: a monoclonal antibody approach to modulate glial reactivity and neuroinflammation for neuroprotection
Guan, C., Zhang, L., Fomo, K. N., Yang, J., Pfeiffer, N., & Grus, F. H. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03482-8 · Cited by 12
GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis
Yang, X., Cong, T., He, H., & Wang, J. (2020) · Blood Science · doi:10.1097/bs9.0000000000000064 · Cited by 12
Single Nucleotide Polymorphisms in Neonatal Necrotizing Enterocolitis
Donda, K., Torres, B. A., Khashu, M., & Maheshwari, A. (2022) · Current Pediatric Reviews · doi:10.2174/1573396318666220117091621 · Cited by 12
A Glimpse of Programmed Cell Death Among Bacteria, Animals, and Plants
Zhuang, J., Xie, L., & Zheng, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.790117 · Cited by 12
Hepatic HRC induces hepatocyte pyroptosis and HSCs activation via NLRP3/caspase-1 pathway
Wu, J., Zhang, M., Xia, S., Han, P., Zhao, K., Peng, K., Zhou, W., Tian, D., Liao, J., & Liu, J. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02270-8 · Cited by 12
Downregulation of miR-137 Facilitates CD4+ T Cell Pyroptosis in Systemic Lupus Erythematosus via Stimulating AMPK Pathway
Gong, A., Mi, L., Wei, F., Zhuang, Y., Song, Y., Pan, C., Zhang, X., Lin, G., Wu, Z., & Liu, Y. (2023) · Journal of Immunology Research · doi:10.1155/2023/1241774 · Cited by 12
Panax notoginseng Saponins Alleviate LPS-induced Fibrosis of HK-2 Cells by Inhibiting the Activation of NLRP3 Inflammasome and Pyroptosis
Xie, J., Ma, X., Li, X., Mao, N., Ren, S., & Fan, J. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201024666230417084507 · Cited by 12
Human Gasdermin D and MLKL Disrupt Mitochondria, Endocytic Traffic and TORC1 Signaling in Budding Yeast
Valenti, M., Molina, M., & Cid, V. J. (2022) · Open Biology · doi:10.1098/rsob.220366 · Cited by 12
Pyroptosis Inhibition in Disease Treatment: Opportunities and Challenges
Bandharam, N., Lockey, R. F., & Kolliputi, N. (2023) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-023-01181-w · Cited by 12
Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages
Leinardi, R., Petriglieri, J. R., Pochet, A., Yakoub, Y., Lelong, M., Lescoat, A., Turci, F., Lecureur, V., & Huaux, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015145 · Cited by 12
Dissecting cell death pathways in fed‐batch bioreactors
Mentlak, D. A., Raven, J. A., Moses, T., Massie, F., Barber, N., Hoare, R., Burton, G., Young, A., Pybus, L. P., Rosser, S. J., et al. (2023) · Biotechnology Journal · doi:10.1002/biot.202300257 · Cited by 12
Zinc finger E-Box binding homeobox 2 (ZEB2)-induced astrogliosis protected neuron from pyroptosis in cerebral ischemia and reperfusion injury
Zhao, Z., Hu, X., Wang, J., Wang, J., Hou, Y., & Chen, S. (2021) · Bioengineered · doi:10.1080/21655979.2021.2012551 · Cited by 12
Construction and validation of the diagnostic model of keloid based on weighted gene co-expression network analysis (WGCNA) and differential expression analysis
Xie, J., Zhang, X., Zhang, K., Wu, C., Yao, G., Shi, J., Chen, L., Hu, Y., Wu, D., Yin, G., et al. (2022) · Journal of Plastic Surgery and Hand Surgery · doi:10.1080/2000656x.2021.2024557 · Cited by 12
The analysis of the pyroptosis-related genes and hub gene TP63 ceRNA axis in osteosarcoma
Han, J., Hu, Y., Ding, S., Liu, S., & Wang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.974916 · Cited by 12
A novel pyroptosis-related signature predicts prognosis and indicates immunotherapy in oral squamous cell carcinoma
Gao, Y., Zhang, X., Li, Y., Gao, J., Liu, S., Cai, H., & Zhang, J. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05074-6 · Cited by 12
Muscone attenuates susceptibility to ventricular arrhythmia by inhibiting NLRP3 inflammasome activation in rats after myocardial infarction
Yang, S., Bi, Y., Wei, Y., Li, W., Liu, J., Mao, T., & Tang, Y. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23458 · Cited by 11
Construction and validation of a PANoptosis-related lncRNA signature for predicting prognosis and targeted drug response in thyroid cancer
Li, R., Zhao, M., Sun, M., Miao, C., & Lu, J. (2023) · PeerJ · doi:10.7717/peerj.15884 · Cited by 11
Identification of necroptosis-related features in diabetic nephropathy and analysis of their immune microenvironent and inflammatory response
Hu, K., He, R., Xu, M., Zhang, D., Han, G., Han, S., Xiao, L., Xia, P., Ling, J., Wu, T., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1271145 · Cited by 11
LncRNA SNHG1 Alleviates Myocardial Ischaemia–Reperfusion Injury by Regulating the miR-137-3p/KLF4/TRPV1 Axis
Tang, R., Li, W., Lü, Y., Wang, X., & Gao, S. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14660 · Cited by 11
Therapeutic targets and potential delivery systems of melatonin in osteoarthritis
Xiong, Z., Peng, G., Deng, J., Liu, M., Ning, X., Zhuang, Y., Yang, H., & Sun, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331934 · Cited by 11
Fecal microbiota transplantation alleviates neuronal Apoptosis, necroptosis and reactive microglia activation after ischemic stroke
Chen, D., Xie, J., Chen, X., Qin, B., Kong, D., & Luo, J. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.10.053 · Cited by 11
Eleutheroside B Ameliorates Cardiomyocytes Necroptosis in High-Altitude-Induced Myocardial Injury via Nrf2/HO-1 Signaling Pathway
Duan, H., Han, Y., Zhang, H., Zhou, T., Wu, C., Wang, Z., & He, Y. (2025) · Antioxidants · doi:10.3390/antiox14020190 · Cited by 11
Salvianolic Acid B Inhibits ZBP1 ‐Mediated PANoptosis in Mycobacterium tuberculosis ‐Infected Macrophages by Targeting TNFR1
Shen, J., Fu, Y., Liu, F., Wu, J., Zhang, H., Sun, J., Miao, Z., & Jiang, X. (2025) · Phytotherapy Research · doi:10.1002/ptr.70042 · Cited by 11
15-lipoxygenase blockade switches off pan-organ ischaemia-reperfusion injury by inhibiting pyroptosis
Li, J., Zhang, H., Dai, M., & Huang, Y. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00325-z · Cited by 11
The GAR/RGG motif defines a family of nuclear alarmins
Wu, S., Teo, B. H. D., Wee, S. Y. K., Chen, J., & Lu, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03766-w · Cited by 11
Vitamin E Can Ameliorate Oxidative Damage of Ovine Hepatocytes In Vitro by Regulating Genes Expression Associated with Apoptosis and Pyroptosis, but Not Ferroptosis
Jian, L., Xue, Y., Gao, Y., Wang, B., Qu, Y., Li, S., Li, H., Li, Z., Wang, B., & Luo, H. (2021) · Molecules · doi:10.3390/molecules26154520 · Cited by 11
The Pyroptosis-Related Signature Predicts Diagnosis and Indicates Immune Characteristic in Major Depressive Disorder
Deng, Z., Liu, J., Shen, H., & Gao, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.848939 · Cited by 11
Cross-talk between necroptosis-related lncRNAs to construct a novel signature and predict the immune landscape of lung adenocarcinoma patients
Wu, J., Song, D., Zhao, G. S., Chen, S., Ren, H., & Zhang, B. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.966896 · Cited by 11
Lyso-globotriaosylsphingosine induces endothelial dysfunction via autophagy-dependent regulation of necroptosis
Hwang, A.-R., Park, S., & Woo, C.-H. (2023) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2023.27.3.231 · Cited by 11
Macrophage polarization during Streptococcus agalactiae infection is isolate specific
Janžič, L., Repas, J., Pavlin, M., Jokhadar, Š. Z., Ihan, A., & Kopitar, A. N. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1186087 · Cited by 11
Pan-cancer analysis of cuproptosis-promoting gene signature from multiple perspectives
Ma, J., Gong, B., & Zhao, Q. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01108-y · Cited by 11
A review focusing on the role of pyroptosis in prostate cancer
Liu, Z., Kuang, S., & Chen, Q. (2023) · Medicine · doi:10.1097/md.0000000000036605 · Cited by 11
Engineered Extracellular Vesicles Driven by Erythrocytes Ameliorate Bacterial Sepsis by Iron Recycling, Toxin Clearing and Inflammation Regulation
Li, Y., Qu, G., Dou, G., Ren, L., Dang, M., Kuang, H., Bao, L., Ding, F., Xu, G., Zhang, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202306884 · Cited by 11

Authors: Frank, D., & Vince, J. E.
Affiliations: The University of Melbourne (AU)
Corresponding author: Vince, James E.
ORCID: Frank, Daniel
Vince, James E.
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2018-10-19
Volume: 26
Issue: 1
Pages: 99-114
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/s41418-018-0212-6
PMC: PMC6294779
OpenAlex: W2895833591
Cited by: 1,062
References: 170
Citations by year: 2026: 88 · 2025: 142 · 2024: 151 · 2023: 202 · 2022: 237 · 2021: 137 · 2020: 68 · 2019: 34 · 2018: 1
FWCI: 5.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Melbourne
National Health and Medical Research Council (1141466)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: pyroptosis, necroptosis, necrosis, damage-associated molecular patterns, IL-1β, inflammation, autoimmune disease, autoinflammation, membrane damage, intracellular signaling
MeSH terms: Alarmins, Pyroptosis, Necroptosis, Gasdermins, Animals, Humans, Inflammation, Necrosis, Protein Kinases, Signal Transduction, Cytokines, Caspase 1, HMGB1 Protein, Phosphate-Binding Proteins, Intracellular Signaling Peptides and Proteins, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks