Cited by 1,062Inflammasome and immune disordersCell death mechanisms and regulationImmune Response and Inflammation

The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Open access

Frank, Daniel, Vince, James E.·2019·Cell Death & Differentiation

DOI 10.1038/s41418-018-0212-6PMC PMC6294779

Open this paper in CoChat — free account Open PDF

Abstract

Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death. Although these cell death programmes can protect the host against microbial pathogens, their dysregulation has been implicated in a variety of autoimmune and auto-inflammatory conditions. The disease-promoting potential of necroptosis and pyroptosis is likely a consequence of their ability to induce a lytic cell death. This cell suicide mechanism, distinct from apoptosis, allows the release of immunogenic cellular content, including damage-associated molecular patterns (DAMPs), and inflammatory cytokines such as interleukin-1β (IL-1β), to trigger inflammation. In this Review, we discuss recent discoveries that have advanced our understanding on the primary functions of pyroptosis and necroptosis, including evidence for the specific cytokines and DAMPs responsible for driving inflammation. We compare the similar and unique aspects of pyroptotic- and necroptotic-induced membrane damage, and explore how these may functionally impact distinct intracellular organelles and signalling pathways. We also examine studies highlighting the crosstalk that can occur between necroptosis and pyroptosis signalling, and evidence supporting the physiological significance of this convergence. Ultimately, a better understanding of the similarities, unique aspects and crosstalk of pyroptosis and necroptosis will inform as to how these cell death pathways might be manipulated for therapeutic benefit.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41418-018-0212-6

Cites

170 of 170 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,980
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,777
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500

Show all 170 references

Research works printed but not linked: 1

Rickard JA, O’Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers TW, et al. RIPK1 regulates RIPK3-MLKL driven systemic inflammation and emergency hematopoiesis. Cell. 2014;157:1175–88. · DOI

Sorted by citations

Items 201–300 of 1,000

Inhibitory pattern recognition receptors
Rumpret, M., von Richthofen, H. J., Peperzak, V., & Meyaard, L. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211463 · Cited by 51
Pyroptosis in periodontitis: From the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects
Xu, X., Zhang, T., Xia, X., Yin, Y., Yang, S., Ai, D., Qin, H., Zhou, M., & Song, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.953277 · Cited by 50
Ablation of NLRP3 inflammasome attenuates muscle atrophy via inhibiting pyroptosis, proteolysis and apoptosis following denervation
You, Z., Huang, X., Xiang, Y., Dai, J., Xu, L., Jiang, J., & Xu, J. (2022) · Theranostics · doi:10.7150/thno.74831 · Cited by 50
Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1
Karaba, A. H., Figueroa, A., Massaccesi, G., Botto, S., DeFilippis, V. R., & Cox, A. L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229570 · Cited by 50
Pyroptosis in Kidney Disease
Wang, Y., Li, Y., & Xu, Y. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167290 · Cited by 50
Tetrahedral Framework Nucleic Acids Inhibit Skin Fibrosis via the Pyroptosis Pathway
Jiang, Y., Li, S., Zhang, T., Zhang, M., Chen, Y., Wu, Y., Liu, Y., Liu, Z., & Lin, Y. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c02877 · Cited by 50
Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing
Song, J., Zhu, K., Wang, H., Wu, M., Wu, Y., & Zhang, Q. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.88461 · Cited by 49
Gefitinib initiates sterile inflammation by promoting IL-1β and HMGB1 release via two distinct mechanisms
Noguchi, T., Sekiguchi, Y., Kudoh, Y., Naganuma, R., Kagi, T., Nishidate, A., Maeda, K., Ishii, C., Toyama, T., Hirata, Y., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03335-7 · Cited by 49
Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy
Qi, X., Li, Q., Che, X., Wang, Q., & Wu, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.837293 · Cited by 48
Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia
Jiménez‐Morales, S., Aranda-Uribe, I. S., Pérez-Amado, C. J., Ramírez‐Bello, J., & Hidalgo‐Miranda, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.737340 · Cited by 47
Autophagy promotes GSDME-mediated pyroptosis via intrinsic and extrinsic apoptotic pathways in cobalt chloride-induced hypoxia reoxygenation-acute kidney injury
Liu, W., Gan, Y., Ding, Y., Zhang, L., Jiao, X., Liu, L., Cao, H., Gu, Y., Yan, L., Wang, Y., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113881 · Cited by 47
Bone marrow mesenchymal stem cell-derived exosomal miR-30e-5p ameliorates high-glucose induced renal proximal tubular cell pyroptosis by inhibiting ELAVL1
Lv, J., Hao, Y., Wang, X., Lu, W., Xie, L., & Niu, D. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2177082 · Cited by 47
Transition Metal‐Based Therapies for Inflammatory Diseases
Song, Y., You, Q., & Chen, X. S. (2023) · Advanced Materials · doi:10.1002/adma.202212102 · Cited by 47
Nanomedicine-mediated regulated cell death in cancer immunotherapy
Sun, Y. L., Lian, T., Huang, Q., Chang, Y., Li, Y., Guo, X., Kong, W., Yang, Y., Zhang, K., Wang, P., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.032 · Cited by 47
BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis
Wang, H., Shu, L., Lv, C., Liu, N., Long, Y., Peng, X., Ling, H., Tao, T., Tang, J., Cheng, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202304263 · Cited by 48
DAMPs in Unilateral Ureteral Obstruction
Wyczanska, M., & Lange-Sperandio, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.581300 · Cited by 47
Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses
Scarpitta, A., Hacker, U. T., Büning, H., Boyer, O., & Adriouch, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.731598 · Cited by 47
Caspase mechanisms in the regulation of inflammation
Bibo‐Verdugo, B., & Salvesen, G. S. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101085 · Cited by 46
NLRP3-Dependent Pyroptosis: A Candidate Therapeutic Target for Depression
Wan, T., Li, X., Fu, M., Gao, X., Li, P., & Guo, W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.863426 · Cited by 46
Macrophages in aseptic loosening: Characteristics, functions, and mechanisms
Cong, Y., Wang, Y., Yuan, T., Zhang, Z., Ge, J., Meng, Q., Li, Z., & Sun, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1122057 · Cited by 47
Endoplasmic reticulum stress-mediated cell death in cardiovascular disease
An, Y., Wang, X., Guan, X., Yuan, P., Liu, Y., Wei, L., Wang, F., & Qi, X. (2024) · Cell Stress and Chaperones · doi:10.1016/j.cstres.2023.12.003 · Cited by 46
Endoplasmic Reticulum-Mitochondria Contacts: A Potential Therapy Target for Cardiovascular Remodeling-Associated Diseases
Wang, Y., Zhang, X., Wen, Y., Li, S., Lu, X., Xu, R., & Li, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.774989 · Cited by 46
Ferroptosis, necroptosis and cuproptosis: Novel forms of regulated cell death in diabetic cardiomyopathy
Ke, D., Zhang, Z., Liu, J., Chen, P., Li, J., Sun, X., Chu, Y., & Li, L. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1135723 · Cited by 45
STING-Dependent Sensing of Self-DNA Driving Pyroptosis Contributes to Radiation-Induced Lung Injury
Zhang, Y., Li, Z., Hong, W., Hsu, S.-J., Wang, B., Zeng, Z., & Du, S. (2023) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2023.05.029 · Cited by 45
Inhibition of SF3B1 improves the immune microenvironment through pyroptosis and synergizes with αPDL1 in ovarian cancer
Wang, S., Liu, Y., Xiao, H., Chen, Z., Yang, X., Yin, J., Li, Y., Yuan, C., Yan, S., Chen, G., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06301-1 · Cited by 45
Recent strategies for evoking immunogenic Pyroptosis in antitumor immunotherapy
He, Z., Feng, D., Zhang, C., Chen, Z., Wang, H., Hou, J., Li, S., & Wei, X. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.023 · Cited by 45
Engineering pyroptotic vesicles as personalized cancer vaccines
Li, Z., Wang, Y., Mo, F., Wolter, T., Hong, R., Barrett, A., Richmond, N., Liu, F., Chen, Y., Yang, X., et al. (2025) · Nature Nanotechnology · doi:10.1038/s41565-025-01931-2 · Cited by 45
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation
Chen, J., Jiang, Z., Zhou, X., Sun, X., Cao, J., Liu, Y., & Wang, X. (2019) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-019-06857-1 · Cited by 45
Irisin Protects Against LPS-Stressed Cardiac Damage Through Inhibiting Inflammation, Apoptosis, and Pyroptosis
Li, Q., Zhang, M., Zhao, Y., & Dong, M. (2021) · Shock · doi:10.1097/shk.0000000000001775 · Cited by 45
Significance of Mast Cell Formed Extracellular Traps in Microbial Defense
Komi, D. E. A., & Kuebler, W. M. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08861-6 · Cited by 45
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death
Weir, A. L., & Vince, J. E. (2022) · Biochemical Journal · doi:10.1042/bcj20210711 · Cited by 45
Self-citation
Death and fire—the concept of necroinflammation
Linkermann, A. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0218-0 · Cited by 45
The role of pyroptosis in hepatocellular carcinoma
Zou, Z., Zhao, M., Yang, Y., Xie, Y., Li, Z., Zhou, L., Shang, R., & Zhou, P. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00787-9 · Cited by 44
The ideal treatment timing for diabetic retinopathy: the molecular pathological mechanisms underlying early-stage diabetic retinopathy are a matter of concern
Sun, W., An, X., Zhang, Y., Zhao, X., Sun, Y., Yang, C., Kang, X., Jiang, L., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1270145 · Cited by 44
Sea Hare Hydrolysate-Induced Reduction of Human Non-Small Cell Lung Cancer Cell Growth through Regulation of Macrophage Polarization and Non-Apoptotic Regulated Cell Death Pathways
Nyiramana, M. M., Cho, S. B., Kim, E., Kim, M. J., Ryu, J. H., Nam, H. J., Kim, N.-G., Park, S., Choi, Y. J., Kang, S. S., et al. (2020) · Cancers · doi:10.3390/cancers12030726 · Cited by 44
Cell Death in the Tumor Microenvironment: Implications for Cancer Immunotherapy
Gadiyar, V., Lahey, K. C., Calianese, D. C., Devoe, C., Mehta, D., Bono, K. R., Desind, S. Z., Davra, V., & Birge, R. B. (2020) · Cells · doi:10.3390/cells9102207 · Cited by 44
Pyroptosis and Its Regulation in Diabetic Cardiomyopathy
Lu, Y., Lu, Y., Meng, J., & Wang, Z. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.791848 · Cited by 44
A necroptosis related prognostic model of pancreatic cancer based on single cell sequencing analysis and transcriptome analysis
Chen, L., Zhang, X., Zhang, Q., Zhang, T., Xie, J., Wei, W., Wang, Y., Yu, H., & Zhou, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1022420 · Cited by 43
Pyroptosis: shedding light on the mechanisms and links with cancers
You, H., Wang, L., Meng, H., Huang, C., Fang, G.-Y., & Li, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1290885 · Cited by 43
Pyroptosis: Induction and inhibition strategies for immunotherapy of diseases
Wu, J., Wang, H., Gao, P., & Ouyang, S. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.06.026 · Cited by 43
Enterococcus Faecalis activates NLRP3 inflammasomes leading to increased interleukin-1 beta secretion and pyroptosis of THP-1 macrophages
Ran, S., Huang, J., Liu, B., Gu, S., Jiang, W., & Liang, J. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.104761 · Cited by 43
Artesunate relieves acute kidney injury through inhibiting macrophagic Mincle‐mediated necroptosis and inflammation to tubular epithelial cell
Lei, X., Tan, R., Jia, J., Wu, S., Wen, C., Lin, X., Wang, H., Shi, Z., Li, B., Kang, Y. M., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16833 · Cited by 43
Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism
Jin, H., Xie, W., He, M., Li, H., Xiao, W., & Li, Y. (2022) · Cells · doi:10.3390/cells11071078 · Cited by 43
RIP3 impedes transcription factor EB to suppress autophagic degradation in septic acute kidney injury
Li, R., Zhao, X., Zhang, S., Dong, W., Zhang, L., Chen, Y., Li, Z., Yang, H. M., Huang, Y., Xie, Z., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03865-8 · Cited by 42
Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection
O’Connor, J. T., Stevens, A. C., Shannon, E. K., Akbar, F. B., LaFever, K. S., Narayanan, N. P., Gailey, C. D., Hutson, M. S., & Page, A. W. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.06.020 · Cited by 42
Cytoplasmic HMGB1 induces renal tubular ferroptosis after ischemia/reperfusion
Zhao, Z., Li, G., Wang, Y., Li, Y., Xu, H., Liu, W., Hao, W., Yao, Y., & Zeng, R. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109757 · Cited by 42
The Emerging Role of the Innate Immune Response in Idiosyncratic Drug Reactions
Sernoskie, S. C., Jee, A., & Uetrecht, J. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000090 · Cited by 41
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway
Zhang, K., Chai, B., Ji, H., Chen, L., Ma, Y., Zhu, L., Xu, J., Wu, Y., Lan, Y., Li, H., et al. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00675-6 · Cited by 41
Targeting AMPK signaling in ischemic/reperfusion injury: From molecular mechanism to pharmacological interventions
Paskeh, M. D. A., Asadi, A., Mirzaei, S., Hashemi, M., Entezari, M., Raesi, R., Hushmandi, K., Zarrabi, A., Ertaş, Y. N., Aref, A. R., et al. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110323 · Cited by 41
Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p/HDAC2/SNRK
Xie, Z., Tang, J., Chen, Z., Wei, L., Chen, J., & Liu, Q. (2023) · Inflammation Research · doi:10.1007/s00011-022-01653-4 · Cited by 41
Necroptosis-Related LncRNA Signatures for Prognostic Prediction in Uterine Corpora Endometrial Cancer
Lin, Z., Fan, W., Sui, X., Wang, J., & Zhao, J. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-01023-9 · Cited by 40
Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy
Li, W., Sun, J., Zhou, X., Lu, Y., Cui, W., & Miao, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.780790 · Cited by 40
The pathogenesis of organ fibrosis: Focus on necroptosis
Hao, M., Han, X., Yao, Z., Zhang, H., Zhao, M., Peng, M., Wang, K., Shan, Q., Sang, X., Wu, X., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15952 · Cited by 40
The Immune Pathogenesis of Acute-On-Chronic Liver Failure and the Danger Hypothesis
Qiang, R., Liu, X.-Z., & Xu, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.935160 · Cited by 39
ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives
Waqas, S. F., Sohail, A., Nguyen, A. H. H., Usman, A., Ludwig, T., Wegner, A., Malik, M. N. H., Schuchardt, S., Geffers, R., Winterhoff, M., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.931 · Cited by 39
Pyroptosis-related crosstalk in osteoarthritis: Macrophages, fibroblast-like synoviocytes and chondrocytes
Kuang, S., Sheng, W., Meng, J., Liu, W., Xiao, Y., Tang, H., Fu, X., Kuang, M., He, Q., & Gao, S. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.06.014 · Cited by 39
Immunological mechanisms in steatotic liver diseases: An overview and clinical perspectives
Yan, M., Man, S., Ma, L., Guo, L., Huang, L., & Gao, W. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0315 · Cited by 39
Molecular mechanisms and roles of pyroptosis in acute lung injury
Wei, T., Zhang, C., & Song, Y. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002425 · Cited by 38
Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death
Mishra, S. K., Gao, Y., Zou, X., Stephenson, D., Malinina, L. V., Hinchcliffe, E. H., Chalfant, C. E., & Brown, R. E. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101031 · Cited by 38
Oridonin ameliorates noise-induced hearing loss by blocking NLRP3 - NEK7 mediated inflammasome activation
Li, M., Zhang, Y., Qiu, S., Zhuang, W., Jiang, W., Wang, C., Zhang, S., Zhou, Z., Sun, T., Ke, Z., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107576 · Cited by 38
Potential therapeutic role of pyroptosis mediated by the NLRP3 inflammasome in type 2 diabetes and its complications
Li, X., Xiao, G.-Y., Guo, T., Song, Y., & Li, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.986565 · Cited by 38
Advances in cell death mechanisms involved in viral myocarditis
Yang, Y., Li, W., You, B., & Zhou, C. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.968752 · Cited by 37
Albumin-based formononetin nanomedicines for lung injury and fibrosis therapy via blocking macrophage pyroptosis
Ouyang, B., Deng, L., Yang, F., Shi, H., Wang, N., Tang, W., Huang, X. X., Zhou, Y., Yu, H., Wei, Y., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100643 · Cited by 37
Age-related noncanonical TRMT6–TRMT61A signaling impairs hematopoietic stem cells
He, H., Wang, Y., Zhang, X., Li, X., Liu, C., Yan, D., Deng, H., Sun, W., Yi, C., & Wang, J. (2024) · Nature Aging · doi:10.1038/s43587-023-00556-1 · Cited by 37
NLRP3 Inflammasome-mediated pyroptosis in acute lung injury: Roles of main lung cell types and therapeutic perspectives
Wang, J., Li, L.-L., Zhao, Z., Niu, C., & Zhao, Z.-G. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114560 · Cited by 37
NETosis occurs independently of neutrophil serine proteases
Kasperkiewicz, P., Hempel, A., Janiszewski, T., Kołt, S., Snipas, S. J., Drąg, M., & Salvesen, G. S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015682 · Cited by 37
Tricalcium phosphate particles promote pyroptotic death of calvaria osteocytes through the ROS/NLRP3/Caspase-1 signaling axis in amouse osteolysis model
Zhang, Y., Yan, M., Niu, W., Mao, H., Yang, P., Xu, B., & Sun, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108699 · Cited by 37
MiR-1656 targets GPX4 to trigger pyroptosis in broilers kidney tissues by activating NLRP3 inflammasome under Se deficiency
Gu, X., Wang, Y., He, Y., Zhao, B., Zhang, Q., & Li, S. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109001 · Cited by 37
Regulation of Inflammatory Cell Death by Phosphorylation
Xu, W., & Huang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.851169 · Cited by 36
Ag/Au Bimetallic Nanoparticles Trigger Different Cell Death Pathways and Affect Damage Associated Molecular Pattern Release in Human Cell Lines
Katifelis, H., Nikou, M.-P., Mukha, I., Vityuk, N., Lаgopati, N., Piperi, C., Farooqı, A. A., Pippa, Ν., EFSTATHOPOULOS, E. P., & Gazouli, M. (2022) · Cancers · doi:10.3390/cancers14061546 · Cited by 36
BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer
Huo, J., Shen, Y., Zhang, Y., & Shen, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.963928 · Cited by 36
Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages
Han, Z., Ma, J., Han, Y., Yuan, G., Jiao, R., & Meng, A. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5235 · Cited by 35
Schisandrin A regulates the Nrf2 signaling pathway and inhibits NLRP3 inflammasome activation to interfere with pyroptosis in a mouse model of COPD
Zeng, J., Liao, S., Liang, Z., Li, C., Luo, Y., Wang, K., Zhang, D., Lan, L., Hu, S., Li, W., et al. (2023) · European journal of medical research · doi:10.1186/s40001-023-01190-8 · Cited by 35
Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy
Fan, Y., Guan, B., Xu, J., Zhang, H., Liang, Y., & Yang, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115493 · Cited by 35
FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion
Xia, M., Li, X., Ye, S., Zhang, Q., Zhao, T., Li, R., Zhang, Y., Xian, M., Li, T., Li, H., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00816-4 · Cited by 35
Heat shock protein 90 facilitates SARS-CoV-2 structural protein-mediated virion assembly and promotes virus-induced pyroptosis
Zhao, Z., Xu, L.-D., Zhang, F., Liang, Q., Jiao, Y., Shi, F., He, B., Xu, P., & Huang, Y. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104668 · Cited by 35
NLRP3 inflammasome activation after ischemic stroke
Han, P.-P., Han, Y., Shen, X.-Y., Gao, Z.-K., & Bi, X. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114578 · Cited by 35
Baicalin Induces Gastric Cancer Cell Pyroptosis through the NF-κB-NLRP3 Signaling Axis
Liu, J., Qi, X., Gu, P., Wang, L., Song, S., & Shu, P. (2023) · Journal of Cancer · doi:10.7150/jca.89986 · Cited by 34
Neuroinflammation across the Spectrum of Neurodegenerative Diseases: Mechanisms and Therapeutic Frontiers
Alemán-Villa, K. M., Armienta-Rojas, D. A., Camberos-Barraza, J., Rábago-Monzón, Á. R., Camacho-Zamora, A., Osuna‐Ramos, J. F., Magaña‐Gómez, J. A., Guadrón‐Llanos, A. M., Calderón-Zamora, L., Norzagaray-Valenzuela, C. D., et al. (2025) · NeuroImmunoModulation · doi:10.1159/000548021 · Cited by 34
Necroptosis in CNS diseases: Focus on astrocytes
Mitroshina, Е. V., Saviuk, M. O., & Vedunova, M. V. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1016053 · Cited by 34
The double sides of NLRP3 inflammasome activation in sepsis
Vigneron, C., Py, B. F., Monneret, G., & Venet, F. (2023) · Clinical Science · doi:10.1042/cs20220556 · Cited by 34
Therapeutic strategies targeting the NLRP3‑mediated inflammatory response and pyroptosis in cerebral ischemia/reperfusion injury (Review)
Duan, W.-L., Wang, X.-J., Ma, Y., Sheng, Z.-M., Dong, H., Zhang, L., Zhang, B., & He, M. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13170 · Cited by 33
Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives
Lu, S., Liu, Z., Qi, M., Wang, Y., Chang, L., Bai, X., Jiao, Y., Chen, X., & Zhen, J. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1510390 · Cited by 33
Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer
Fu, L., Yonemura, A., Yasuda‐Yoshihara, N., Umemoto, T., Zhang, J., Yasuda, T., Uchihara, T., Akiyama, T., Kitamura, F., Yamashita, K., et al. (2022) · Gastric Cancer · doi:10.1007/s10120-022-01283-z · Cited by 34
Regulating pyroptosis by mesenchymal stem cells and extracellular vesicles: A promising strategy to alleviate intervertebral disc degeneration
Yang, S., Zhang, Y., Peng, Q., Meng, B., Wang, J., Sun, H., Chen, L., Dai, R., & Zhang, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116001 · Cited by 33
Cell Membrane Perforation: Patterns, Mechanisms and Functions
Zhu, X., Shi, Z., Mao, Y. Q., Lächelt, U., & Huang, R. (2024) · Small · doi:10.1002/smll.202310605 · Cited by 32
The critical impacts of cytokine storms in respiratory disorders
Tramboo, S. R., Elkhalifa, A. M. E., Khursheed, S. Q., Ali, S. I., Shah, N. N., Taifa, S., Rakhshan, R., Shah, I. H., Mir, M. A., Malik, M., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29769 · Cited by 32
Immunologic role of macrophages in sepsis-induced acute liver injury
Xu, W., Hou, H., Yang, W., Tang, W., & Sun, L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113492 · Cited by 32
Lesions and Cellular Tropism of Natural Rift Valley Fever Virus Infection in Young Lambs
Odendaal, L., Davis, A. S., Fosgate, G. T., & Clift, S. J. (2019) · Veterinary Pathology · doi:10.1177/0300985819882633 · Cited by 32
Role of Apoptotic Cell Clearance in Pneumonia and Inflammatory Lung Disease
Zheng, D. J., Taka, M. A., & Heit, B. (2021) · Pathogens · doi:10.3390/pathogens10020134 · Cited by 32
SARS-CoV-2 infection of phagocytic immune cells and COVID-19 pathology: Antibody-dependent as well as independent cell entry
Matveeva, O. V., Nechipurenko, Y. D., Lagutkin, D., Yegorov, Y. E., & Kzhyshkowska, J. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1050478 · Cited by 32
DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury
Zhou, Z., Shang, L., Zhāng, Q., Hu, X., Huang, J.-F., & Xiong, K. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119433 · Cited by 32
SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis
Mao, X., Wu, W., Nan, Y., Sun, W., & Wang, Y. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03136-1 · Cited by 32
Nanomedicine-induced programmed cell death enhances tumor immunotherapy
Lu, J., Tai, Z., Wu, J., Li, L., Zhang, T., Liu, J., Zhu, Q., & Chen, Z. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.09.018 · Cited by 32
Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma
Fu, L., Bao, J.-H., Li, J., Li, Q., Lin, H., Zhou, Y., Li, J., Yan, Y., Langston, M. E., Sun, T., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1021935 · Cited by 31
Induction of ASC pyroptosis requires gasdermin D or caspase-1/11-dependent mediators and IFNβ from pyroptotic macrophages
Zhang, C., Zhao, C., Chen, X., Tao, R., Wang, S., Meng, G., Liu, X., Shao, C., & Su, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2664-0 · Cited by 31
Ginsenoside Rb2 Alleviated Atherosclerosis by Inhibiting M1 Macrophages Polarization Induced by MicroRNA-216a
Wang, S., Yang, S., Chen, Y., Chen, Y., Li, R., Han, S., Kamili, A., Wu, Y., & Zhang, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.764130 · Cited by 31
Artemisinin-Type Drugs in Tumor Cell Death: Mechanisms, Combination Treatment with Biologics and Nanoparticle Delivery
Zhou, X., Suo, F., Haslinger, K., & Quax, W. J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020395 · Cited by 31
The IRG1-Itaconate axis: A regulatory hub for immunity and metabolism in macrophages
Li, Y., Gong, W., Li, W., Liu, P., Liu, J., Jiang, H., Zheng, T., Wu, J., Wu, X., Zhao, Y., et al. (2022) · International Reviews of Immunology · doi:10.1080/08830185.2022.2067153 · Cited by 31
NLRP3 Inflammasome and Inflammatory Response in Aging Disorders: The Entanglement of Redox Modulation in Different Outcomes
Chhunchha, B., Kubo, E., Lehri, D., & Singh, D. P. (2025) · Cells · doi:10.3390/cells14130994 · Cited by 30

Authors: Frank, D., & Vince, J. E.
Affiliations: The University of Melbourne (AU)
Corresponding author: Vince, James E.
ORCID: Frank, Daniel
Vince, James E.
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2018-10-19
Volume: 26
Issue: 1
Pages: 99-114
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/s41418-018-0212-6
PMC: PMC6294779
OpenAlex: W2895833591
Cited by: 1,062
References: 170
Citations by year: 2026: 88 · 2025: 142 · 2024: 151 · 2023: 202 · 2022: 237 · 2021: 137 · 2020: 68 · 2019: 34 · 2018: 1
FWCI: 5.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Melbourne
National Health and Medical Research Council (1141466)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: pyroptosis, necroptosis, necrosis, damage-associated molecular patterns, IL-1β, inflammation, autoimmune disease, autoinflammation, membrane damage, intracellular signaling
MeSH terms: Alarmins, Pyroptosis, Necroptosis, Gasdermins, Animals, Humans, Inflammation, Necrosis, Protein Kinases, Signal Transduction, Cytokines, Caspase 1, HMGB1 Protein, Phosphate-Binding Proteins, Intracellular Signaling Peptides and Proteins, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks