The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
Open accessAbstract
Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell death. Although these cell death programmes can protect the host against microbial pathogens, their dysregulation has been implicated in a variety of autoimmune and auto-inflammatory conditions. The disease-promoting potential of necroptosis and pyroptosis is likely a consequence of their ability to induce a lytic cell death. This cell suicide mechanism, distinct from apoptosis, allows the release of immunogenic cellular content, including damage-associated molecular patterns (DAMPs), and inflammatory cytokines such as interleukin-1β (IL-1β), to trigger inflammation. In this Review, we discuss recent discoveries that have advanced our understanding on the primary functions of pyroptosis and necroptosis, including evidence for the specific cytokines and DAMPs responsible for driving inflammation. We compare the similar and unique aspects of pyroptotic- and necroptotic-induced membrane damage, and explore how these may functionally impact distinct intracellular organelles and signalling pathways. We also examine studies highlighting the crosstalk that can occur between necroptosis and pyroptosis signalling, and evidence supporting the physiological significance of this convergence. Ultimately, a better understanding of the similarities, unique aspects and crosstalk of pyroptosis and necroptosis will inform as to how these cell death pathways might be manipulated for therapeutic benefit.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In contrast, SCI is typically triggered by DAMPs in the absence of an acute infectious insult or activation of PAMPs30–32.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [32]
In the citing paper
“The inflammasome is a multimolecular cytosolic sensor that detects pathogenic microorganisms and sterile stressors and activates caspase-1 during the process of pyroptosis, which, in turn, causes the inactive precursor forms of interleukin-1β and interleukin-18 to become the active forms.”
From Cytokine storm (2020) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,773
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500
Research works printed but not linked: 1
- Rickard JA, O’Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers TW, et al. RIPK1 regulates RIPK3-MLKL driven systemic inflammation and emergency hematopoiesis. Cell. 2014;157:1175–88. · DOI
Cited by
Sorted by citations
Chronic inflammation in the etiology of disease across the life span
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915
Fajgenbaum, D. C., & June, C. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2026131 · Cited by 3,196
Pyroptosis: Mechanisms and Diseases
Yu, P., Zhang, X., Liu, N., Tang, L., Peng, C., & Chen, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00507-5 · Cited by 2,353
NLRP3 inflammasome activation and cell death
Huang, Y., Xu, W., & Zhou, R. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00740-6 · Cited by 1,527
Reactive Oxygen Species: Drivers of Physiological and Pathological Processes
Checa, J., & Aran, J. M. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s275595 · Cited by 1,068
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 1,007
Role of pyroptosis in inflammation and cancer
Xiang, W. D., Xie, F., Zhou, X., Wu, Y., Yan, H., Liu, T., Huang, J. S., Wang, F., Zhou, F., & Zhang, L. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00905-x · Cited by 728
Cell death due to electroporation – A review
Napotnik, T. B., Polajžer, T., & Miklavčič, D. (2021) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2021.107871 · Cited by 594
Hsu, S., Li, C., Lin, I., Syue, W.-J., Chen, Y., Cheng, K., Teng, Y., Lin, Y., Yen, C., & Chiu, C. (2021) · Theranostics · doi:10.7150/thno.62521 · Cited by 502
A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer
Ye, Y., Dai, Q., & Qi, H. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00451-x · Cited by 454
Wicherska‐Pawłowska, K., Wróbel, T., & Rybka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413397 · Cited by 451
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity
Meier, P., Legrand, A. J., Adam, D., & Silke, J. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00674-x · Cited by 435
Necroptosis: a crucial pathogenic mediator of human disease
Choi, M. E., Price, D. R., Ryter, S. W., & Choi, A. M. K. (2019) · JCI Insight · doi:10.1172/jci.insight.128834 · Cited by 428
Targeting RIPK1 for the treatment of human diseases
Degterev, A., Ofengeim, D., & Yuan, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901179116 · Cited by 415
TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages
Wajant, H., & Siegmund, D. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00091 · Cited by 415
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
Flerlage, T., Boyd, D. F., Meliopoulos, V., Thomas, P. G., & Schultz‐Cherry, S. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00542-7 · Cited by 419
Pyroptosis in health and disease: mechanisms, regulation and clinical perspective
Liu, Y., Pan, R., Ouyang, Y., Gu, W., Xiao, T., Yang, H., Tang, L. Y., Wang, H., Xiang, B., & Chen, P. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01958-2 · Cited by 391
Signaling pathways and intervention therapies in sepsis
Zhang, Y., & Ning, B. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00816-9 · Cited by 369
Yang, W., Wang, L., Mettenbrink, E. M., DeAngelis, P. L., & Wilhelm, S. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-032320-110338 · Cited by 366
The therapeutic potential of targeting regulated non-apoptotic cell death
Hadian, K., & Stockwell, B. R. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00749-8 · Cited by 349
Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics
Pedrera, L., Espiritu, R. A., Ros, U., Weber, J., Schmitt, A. M., Stroh, J., Hailfinger, S., von Karstedt, S., & García‐Sáez, A. J. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00691-x · Cited by 322
Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke
Mao, R., Zong, N., Hu, Y., Chen, Y., & Xu, Y. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00859-0 · Cited by 296
He, J., Liu, D., Zhao, L., Zhou, D., Rong, J., Zhang, L., & Xia, Z. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11357 · Cited by 287
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes
Ferreira, A. C., Soares, V. C., de Azevedo-Quintanilha, I. G., Dias, S. D. S. G., Rodrigues, N. F., Sacramento, C. Q., Mattos, M., de Freitas, C. S., Temerozo, J. R., Teixeira, L., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00428-w · Cited by 283
Beckwith, K. S., Beckwith, M. S., Ullmann, S., Sætra, R. S., Kim, H., Marstad, A., Åsberg, S. E., Strand, T. A., Haug, M., Niederweis, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16143-6 · Cited by 282
Zhang, J., Huang, L., Shi, X., Yang, L., Hua, F., Ma, J., Zhu, W., Liu, X., Xuan, R., Shen, Y., et al. (2020) · Aging · doi:10.18632/aging.202143 · Cited by 272
Caspase-8: The double-edged sword
Mandal, R., Compte, J., Kostova, I., Becker, S., & Strebhardt, K. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188357 · Cited by 261
Guidelines for evaluating myocardial cell death
Mishra, P. K., Adameová, A., Hill, J. A., Baines, C. P., Kang, P. M., Downey, J. M., Narula, J., Takahashi, M., Abbate, A., Piristine, H. C., et al. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00259.2019 · Cited by 246
Programmed cell death in atherosclerosis and vascular calcification
Li, M., Wang, Z., Fang, L., Cheng, S.-Q., Wang, X., & Liu, N. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04923-5 · Cited by 243
Insights into N6-methyladenosine and programmed cell death in cancer
Liu, L., Li, H., Hu, D., Wang, Y., Shao, W., Zhong, J., Yang, S., Liu, J., & Zhang, J. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01508-w · Cited by 241
Immunological mechanisms and therapeutic targets of fatty liver diseases
Wang, H., Mehal, W. Z., Nagy, L. E., & Rotman, Y. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00579-3 · Cited by 234
Lytic cell death in metabolic liver disease
Gautheron, J., Gores, G. J., & Rodrigues, C. M. P. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.001 · Cited by 225
“A substantial number of DAMPs, including HMGB1, heat shock proteins (HSPs), ATP, and interleukins, have been differentially involved in pyroptosis, necroptosis or ferroptosis [65, 66].”
BackgroundWang, J., Zhu, P., Li, R., Ren, J. T., & Zhou, H. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101415 · Cited by 225
Ferroptosis as a potential target for cancer therapy
Chen, Z., Wang, W., Razak, S. R. A., Han, T., Ahmad, N. H., & Li, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05930-w · Cited by 223
Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway
Shen, S., He, F., Cheng, C., Xu, B., & Sheng, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110990 · Cited by 221
PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis
Shi, C., Cao, P., Wang, Y., Zhang, Q., Zhang, D., Wang, Y., Wang, L., & Gong, Z. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s403819 · Cited by 217
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy
Li, Y., Yuan, Y., Huang, Z., Chen, H., Lan, R., Wang, Z., Lai, K., Chen, H., Chen, Z., Zou, Z., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00755-6 · Cited by 212
Fighting age-related orthopedic diseases: focusing on ferroptosis
Ru, Q., Li, Y., Xie, W., Ding, Y., Chen, L., Xu, G., Wu, Y., & Wang, F. (2023) · Bone Research · doi:10.1038/s41413-023-00247-y · Cited by 211
Zhu, H., Tan, Y., Du, W., Li, Y., Toan, S., Mui, D., Tian, F., & Zhou, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101777 · Cited by 188
PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment
Gao, J., Xiong, A., Liu, J., Li, X., Wang, J., Zhang, L., Liu, Y., Xiong, Y., Li, G., & He, X. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00765-9 · Cited by 188
Wang, J., Toan, S., & Zhou, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104771 · Cited by 187
Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond
Dho, S. H., Cho, M., Woo, W., Jeong, S., & Kim, L. K. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01470-9 · Cited by 175
Pyroptosis in inflammation-related respiratory disease
Feng, Y., Li, M., Yangzhong, X., Zhang, X., Zu, A., Hou, Y., Li, L., & Sun, S. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00909-1 · Cited by 171
TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses
Rienzo, M. D., Romagnoli, A., Antonioli, M., Piacentini, M., & Fimia, G. M. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0495-2 · Cited by 173
Kalinski, A. L., Yoon, C., Huffman, L. D., Duncker, P. C., Kohen, R., Passino, R., Hafner, H., Johnson, C. N., Kawaguchi, R., Carbajal, K. S., et al. (2020) · eLife · doi:10.7554/elife.60223 · Cited by 168
Elhamouly, N. A., Hewedy, O. A., Zaitoon, A., Miraples, A., Elshorbagy, O. T., Hussien, S. M., El-Tahan, A. M., & Peng, D. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1044896 · Cited by 164
Roles of NLRP3 inflammasome in intervertebral disc degeneration
Chao-yang, G., Peng, C., & Hai-hong, Z. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.02.204 · Cited by 162
Targeting pyroptosis as a preventive and therapeutic approach for stroke
Long, J., Sun, Y., Liu, S., Yang, S., Chen, C., Zhang, Z., Chu, S., Yang, Y., Pei, G., Lin, M., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01440-y · Cited by 158
Stringer, J. M., Alesi, L. R., Winship, A., & Hutt, K. J. (2023) · Human Reproduction Update · doi:10.1093/humupd/dmad005 · Cited by 157
Human and environmental safety of carbon nanotubes across their life cycle
Kim, M., Goerzen, D., Jena, P. V., Zeng, E., Pasquali, M., Meidl, R. A., & Heller, D. A. (2023) · Nature Reviews Materials · doi:10.1038/s41578-023-00611-8 · Cited by 154
Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke
Zhou, Y., Liao, J., Mei, Z., Liu, X., & Ge, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9991001 · Cited by 151
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
Anderton, H., Wicks, I. P., & Silke, J. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0455-8 · Cited by 152
Innate Immune Responses to Acute Viral Infection During Pregnancy
Cornish, E. F., Filipovic, I., Åsenius, F., Williams, D. J., & McDonnell, T. C. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.572567 · Cited by 149
Liu, M., Li, H., Yang, R., Ji, D., & Xia, X. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02626-4 · Cited by 149
The gasdermin family: emerging therapeutic targets in diseases
Zhu, C., Xu, S., Jiang, R., Yu, Y., Bian, J., & Zou, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01801-8 · Cited by 149
Mitochondrial quality surveillance as a therapeutic target in myocardial infarction
Zhu, H., Toan, S., Mui, D., & Zhou, H. (2020) · Acta Physiologica · doi:10.1111/apha.13590 · Cited by 142
Lymphopenia Caused by Virus Infections and the Mechanisms Beyond
Guo, Z., Zhang, Z., Prajapati, M., & Li, Y. (2021) · Viruses · doi:10.3390/v13091876 · Cited by 141
Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy
Luo, T., Jia, X., Feng, W.-D., Wang, J., Xie, F., Kong, L., Wang, X., Lian, R., Liu, X., Chu, Y.-J., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01094-7 · Cited by 140
Hu, Y., Liu, Y., Zong, L., Zhang, W., Liu, R., Xing, Q., Liu, Z., Yan, Q., Li, W., Lei, H., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06382-y · Cited by 140
Fan, R., Sui, J., Dong, X., Jing, B., & Gao, Z. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.009 · Cited by 139
RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis
Chen, H., Li, Y., Wu, J., Li, G., Tao, X., Lai, K., Yuan, Y., Zhang, X., Zou, Z., & Xu, Y. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0524-1 · Cited by 138
Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy
Lin, H., Xiong, W. G., Fu, L., Yi, J., & Yang, J. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00305-3 · Cited by 137
Russo, A. J., Vasudevan, S. O., Méndez‐Huergo, S. P., Kumari, P. H., Ménoret, A., Duduskar, S. N., Wang, C., Sáez, J. M. P., Fettis, M. M., Li, C., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00844-7 · Cited by 132
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
Sena-dos-Santos, C., Braga-da-Silva, C., Marques, D., Pinheiro, J. A. D. S., Ribeiro‐dos‐Santos, Â., & Cavalcante, G. C. (2021) · Cells · doi:10.3390/cells10020479 · Cited by 132
Chen, W., Chen, S., Yan, C., Zhang, Y., Zhang, R., Chen, M., Zhong, S., Fan, W., Zhu, S., Zhang, D., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01255-6 · Cited by 132
Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review
Ohnishi, T., Iwasaki, N., & Sudo, H. (2022) · Cells · doi:10.3390/cells11030394 · Cited by 130
Banerjee, A., Billey, L. O., & Shelver, W. L. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260803 · Cited by 128
Significance of the cGAS-STING Pathway in Health and Disease
Zhou, J., Zhuang, Z., Li, J., & Feng, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713316 · Cited by 129
TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis
Wu, J., Lin, S., Chen, W., Lian, G., Wu, W., Chen, A., Sagor, M. I. H., Luo, L., Wang, H., & Xie, L. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01365-6 · Cited by 122
Oxidants, Antioxidants and Thiol Redox Switches in the Control of Regulated Cell Death Pathways
Benhar, M. (2020) · Antioxidants · doi:10.3390/antiox9040309 · Cited by 122
Le, X., Mu, J., Peng, W., Tang, J., Xiang, Q., Tian, S., Feng, Y., He, S., Qiu, Z., Ren, G., et al. (2020) · Theranostics · doi:10.7150/thno.45631 · Cited by 121
Rashidi, M., Simpson, D. S., Hempel, A., Frank, D. O., Petrie, E. J., Vince, A. J., Feltham, R., Murphy, J., Chatfield, S. M., Salvesen, G. S., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900228 · Cited by 120
Self-citationTargeting regulated cell death in tumor nanomedicines
Zeng, Q., Ma, X., Song, Y., Chen, Q., Jiao, Q., & Zhou, L. (2021) · Theranostics · doi:10.7150/thno.67932 · Cited by 120
Shi, M., Chen, J., Liu, T., Dai, W., Zhou, Z., Chen, L., & Xie, Y. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s344240 · Cited by 124
Roles of Macrophages in Atherogenesis
Farahi, L., Sinha, S. K., & Lusis, A. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.785220 · Cited by 117
Different types of cell death in diabetic endothelial dysfunction
Shen, J., San, W., Zheng, Y., Zhang, S., Cao, D., Chen, Y., & Meng, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115802 · Cited by 117
The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials
Mata, R., Yao, Y., Cao, W., Ding, J., Zhou, T., Zhai, Z., & Gao, C. (2021) · Research · doi:10.34133/2021/4189516 · Cited by 116
Chai, S., Yang, Y., Wei, L., Cao, Y., Ma, J., Zheng, X., Teng, J., & Qin, N. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155516 · Cited by 116
Wang, H., Wang, T., Yan, S., Tang, J., Zhang, Y., Wang, L., Xu, H., & Tu, C. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02183-9 · Cited by 122
Current evidence and therapeutic implication of PANoptosis in cancer
Ocansey, D. K. W., Qian, F., Cai, P., Ocansey, S., Amoah, S., Qian, Y.-C., & Mao, F. (2023) · Theranostics · doi:10.7150/thno.91814 · Cited by 114
Buja, L. M. (2022) · Cardiology in Review · doi:10.1097/crd.0000000000000440 · Cited by 108
Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases
Lawlor, K. E., Murphy, J. M., & Vince, J. E. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.011 · Cited by 108
Self-citationGuo, Z., Liu, Y., Chen, D., Sun, Y., Li, D., Meng, Y., Zhou, Q., Zeng, F., Deng, G., & Chen, X. (2025) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2025-0004 · Cited by 111
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy
Wei, J., Zhao, Y., Liang, H., Du, W., & Wang, L. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.08.026 · Cited by 108
ZBP1: A Powerful Innate Immune Sensor and Double-Edged Sword in Host Immunity
Yu, H., Yang, B., Yang, J., Shi, X., Yang, X., Zhang, D., Zhao, D., Yan, W., Chen, L., Zheng, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810224 · Cited by 106
Wang, Q., Xu, J., Li, X., Liu, Z., Han, Y., Xu, X., Li, X., Tang, Y., Liu, Y., Tao, Y., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28918 · Cited by 105
Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus
Yang, F., He, Y., Zhai, Z., & Sun, E. (2019) · Journal of Immunology Research · doi:10.1155/2019/3638562 · Cited by 105
Induction of Pyroptosis: A Promising Strategy for Cancer Treatment
Wang, L., Qin, X., Liang, J., & Ge, P. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.635774 · Cited by 105
Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases
Okude, H., Ori, D., & Kawai, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.625833 · Cited by 104
Zhang, H., Ran, C., Teame, T., Ding, Q., Hoseinifar, S. H., Xie, M., Zhang, Z., Yang, Y., Olsen, R. E., Gatlin, D. M., et al. (2020) · Reviews in Fish Biology and Fisheries · doi:10.1007/s11160-020-09614-y · Cited by 102
Different types of cell death and their interactions in myocardial ischemia–reperfusion injury
Du, B., Fu, Q., Yang, Q., Yang, Y., Li, R. Q., Yang, X., Yang, Q., Li, S., Tian, J., & Liu, H. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02372-5 · Cited by 104
Zhang, H., Ni, W., Yu, G., Geng, Y., Lou, J., Qi, J., Chen, Y., Li, F., Ye, H., Ma, H., et al. (2023) · Theranostics · doi:10.7150/thno.78370 · Cited by 101
Role of pyroptosis in the pathogenesis of various neurological diseases
Oladapo, A., Jackson, T., Menolascino, J., & Periyasamy, P. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.001 · Cited by 101
Xin, T., & Lu, C. (2020) · Aging · doi:10.18632/aging.102899 · Cited by 99
Gu, L., Sun, M., Li, R., Zhang, X., Tao, Y., Yuan, Y., Xu, L., & Xie, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.810582 · Cited by 99
Curcumin Activates ROS Signaling to Promote Pyroptosis in Hepatocellular Carcinoma HepG2 Cells
Liang, W., Gong, Y.-X., Li, H., Sun, F., LI, W.-L., Chen, D., XIE, D.-P., Ren, C., Guo, X., Wang, Z., et al. (2021) · In Vivo · doi:10.21873/invivo.12253 · Cited by 97
Inflammatory Caspases Drive Pyroptosis in Acute Lung Injury
Liu, B., He, R., Zhang, L., Hao, B., Jiang, W., Wang, W., & Geng, Q. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.631256 · Cited by 97
Cai, M., Zhuang, W., Lv, E., Liu, Z., Wang, Y., Zhang, W., & Fu, W. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105221 · Cited by 97
Gong, Z., Guo, J., Liu, B., Guo, Y., Cheng, C., Jiang, Y., Liang, N., Hu, M., Song, T., Yang, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1287857 · Cited by 97
Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging
Barbu, E., Popescu, M.-R., Popescu, A.-C., & Balanescu, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020963 · Cited by 96
Metadata
- Authors
- Frank, D., & Vince, J. E.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Vince, James E.
- Venue
- Cell Death & Differentiation
- Published
- 2018-10-19
- Volume
- 26
- Issue
- 1
- Pages
- 99-114
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC6294779
- OpenAlex
- W2895833591
- Cited by
- 1,062
- References
- 170
- Citations by year
- 2026: 88 · 2025: 142 · 2024: 151 · 2023: 202 · 2022: 237 · 2021: 137 · 2020: 68 · 2019: 34 · 2018: 1
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Melbourne
- National Health and Medical Research Council (1141466)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- pyroptosis, necroptosis, necrosis, damage-associated molecular patterns, IL-1β, inflammation, autoimmune disease, autoinflammation, membrane damage, intracellular signaling
- MeSH terms
- Alarmins, Pyroptosis, Necroptosis, Gasdermins, Animals, Humans, Inflammation, Necrosis, Protein Kinases, Signal Transduction, Cytokines, Caspase 1, HMGB1 Protein, Phosphate-Binding Proteins, Intracellular Signaling Peptides and Proteins, Inflammasomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
