Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence
Open accessAbstract
Cellular senescence response is (i) activated by numerous stresses, (ii) is characterized by a stable proliferation arrest, and (iii) by a set of specific features. Timely regulated senescence is thought to be beneficial, whereas chronic senescence such as during normal or premature aging is deleterious as it favors most, if not all, age-related diseases. In this study, using in-house or publicly available microarray analyses of transcriptomes of senescent cells, as well as analyses of the level of expression of several DNA repair genes by RT-qPCR and immunoblot, we show that repression of DNA repair gene expression is associated with cellular senescence. This repression is mediated by the RB/E2F pathway and it may play a causal role in senescence induction, as single DNA repair gene repression by siRNA induced features of premature senescence. Importantly, activating RB independently of direct DNA damage also results in repression of DNA repair genes and in the subsequent induction of DNA damage and senescence. The dogma is that DNA damage observed during cellular senescence is directly provoked by DNA lesions following genotoxic attack (UV, IR, and ROS) or by induction of replicative stress upon oncogenic activation. Our in vitro results support a largely unsuspected contribution of the loss of DNA repair gene expression in the induction and the accumulation of the DNA damage observed in most, if not all, kinds of cellular senescence, and thus in the induction of cellular senescence. Further demonstration using in vivo models will help to generalize our findings.
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Knocking down specific DNA repair genes is sufficient to induce premature senescence in vivo.
“Knocking down specific DNA repair genes is sufficient to induce premature senescence in vivo [22]”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [22]
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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works
An Oncogene-Induced DNA Damage Model for Cancer Development
Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851 · see citing works
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819 · see citing works
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works
Self-citationSenescence surveillance of pre-malignant hepatocytes limits liver cancer development
Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621 · see citing works
p53 mutant mice that display early ageing-associated phenotypes
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · see citing works
Cellular senescence promotes adverse effects of chemotherapy and cancer relapse
Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338 · see citing works
Living on a break: cellular senescence as a DNA-damage response
d'Adda di Fagagna, F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2440 · Cited by 1,170 · see citing works
Ren, B., Cam, H., Takahashi, Y., Volkert, T., Terragni, J., Young, R. A., & Dynlacht, B. D. (2002) · Genes & Development · doi:10.1101/gad.949802 · Cited by 1,125 · see citing works
Senescence in tumours: evidence from mice and humans
Collado, M., & Serrano, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2772 · Cited by 1,124 · see citing works
Senescence and apoptosis: dueling or complementary cell fates?
Childs, B. G., Baker, D. J., Kirkland, J. L., Campisi, J., & van Deursen, J. M. (2014) · The EMBO Reports · doi:10.15252/embr.201439245 · Cited by 915 · see citing works
Boyer, S. N., Wazer, D. E., & Band, V. (1996) · PubMed · Cited by 909 · see citing works
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works
Modulation of mammalian life span by the short isoform of p53
Maier, B., Gluba, W., Bernier, B., Turner, T., Mohammad, K., Guise, T., Sutherland, A., Thorner, M., & Scrable, H. (2004) · Genes & Development · doi:10.1101/gad.1162404 · Cited by 586 · see citing works
E2F target genes: unraveling the biology
Bracken, A. P., Cirò, M., Cocito, A., & Helin, K. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.06.006 · Cited by 583 · see citing works
Agger, K., Cloos, P. A. C., Rudkjær, L., Williams, K., Andersen, G., Christensen, J., & Helin, K. (2009) · Genes & Development · doi:10.1101/gad.510809 · Cited by 427 · see citing works
DNA Replication and Oncogene-Induced Replicative Stress
Hills, S. A., & Diffley, J. F. X. (2014) · Current Biology · doi:10.1016/j.cub.2014.04.012 · Cited by 371 · see citing works
p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
Helman, A., Klochendler, A., Azazmeh, N., Gabai, Y., Horwitz, E., Anzi, S., Swisa, A., Condiotti, R., Granit, R. Z., Nevo, Y., et al. (2016) · Nature Medicine · doi:10.1038/nm.4054 · Cited by 351 · see citing works
Wyatt, P. G., Woodhead, A., Berdini, V., Boulstridge, J. A., Carr, M. G., Cross, D. M., Davis, D., Devine, L. A., Early, T. R., Feltell, R. E., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800382h · Cited by 346 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
DNA Repair Pathways in Clinical Practice: Lessons From Pediatric Cancer Susceptibility Syndromes
Kennedy, R. D., & D’Andrea, A. D. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.4171 · Cited by 283 · see citing works
Wiel, C., Lallet-Daher, H., Gitenay, D., Gras, B., Le Calvé, B., Augert, A., Ferrand, M., Prevarskaya, N., Simonnet, H., Vindrieux, D., et al. (2014) · Nature Communications · doi:10.1038/ncomms4792 · Cited by 231 · see citing works
Self-citationHistone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
Contrepois, K., Coudereau, C., Benayoun, B. A., Schuler, N., Roux, P.-F., Bischof, O., Courbeyrette, R., Carvalho, C., Thuret, J.-Y., Ma, Z., et al. (2017) · Nature Communications · doi:10.1038/ncomms14995 · Cited by 191 · see citing works
Self-citationNongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma
Stühmer, T., Chatterjee, M., Hildebrandt, M., Herrmann, P., Gollasch, H., Gerecke, C., Theurich, S., Cigliano, L., Manz, R. A., Daniel, P. T., et al. (2005) · Blood · doi:10.1182/blood-2005-04-1489 · Cited by 180 · see citing works
Regulation of E2Fs and senescence by PML nuclear bodies
Vernier, M., Bourdeau, V., Gaumont-Leclerc, M.-F., Moiseeva, O., Bégin, V., Saad, F., Mes-Masson, A.-M., & Ferbeyre, G. (2011) · Genes & Development · doi:10.1101/gad.1975111 · Cited by 177 · see citing works
Mao, Z., Tian, X., Van Meter, M., Ke, Z., Gorbunova, V., & Seluanov, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200583109 · Cited by 176 · see citing works
Elimination of p19ARF-expressing cells enhances pulmonary function in mice
Hashimoto, M., Asai, A., Kawagishi, H., Mikawa, R., Iwashita, Y., Kanayama, K., Sugimoto, K., Sato, T., Maruyama, M., & Sugimoto, M. (2016) · JCI Insight · doi:10.1172/jci.insight.87732 · Cited by 162 · see citing works
The M‐type receptor PLA2R regulates senescence through the p53 pathway
Augert, A., Payré, C., de Launoit, Y., Gil, J., Lambeau, G. J., & Bernard, D. (2009) · EMBO Reports · doi:10.1038/embor.2008.255 · Cited by 141 · see citing works
Self-citationSedic, M., Skibinski, A., Brown, N. E., Gallardo, M., Mulligan, P., Martínez, P., Keller, P. J., Glover, E., Richardson, A. L., Cowan, J. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms8505 · Cited by 137 · see citing works
Molecular signature of oncogenic ras-induced senescence
Mason, D. X., Jackson, T. J., & Lin, A. W. (2004) · Oncogene · doi:10.1038/sj.onc.1208172 · Cited by 127 · see citing works
Nassour, J., Martien, S., Martin, N., Deruy, E., Tomellini, E., Malaquin, N., Bouali, F., Sabatier, L., Wernert, N., Pinte, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms10399 · Cited by 124 · see citing works
Oxygen free radicals in cell senescence: Are they signal transducers?
Passos, J. F., & Von Zglinicki, T. (2006) · Free Radical Research · doi:10.1080/10715760600917151 · Cited by 122 · see citing works
Is there more to BARD1 than BRCA1?
Irminger‐Finger, I., & Jefford, C. E. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1878 · Cited by 120 · see citing works
Cellular senescence and tumor promotion: Is aging the key?
Loaiza, N., & Demaria, M. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.01.007 · Cited by 101 · see citing works
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging
Singh, D. K., Ahn, B., & Bohr, V. A. (2008) · Biogerontology · doi:10.1007/s10522-008-9205-z · Cited by 95 · see citing works
Conserved senescence associated genes and pathways in primary human fibroblasts detected by RNA-seq
Marthandan, S., Baumgart, M., Priebe, S., Groth, M., Schaer, J., Kaether, C., Guthke, R., Cellerino, A., Platzer, M., Diekmann, S., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154531 · Cited by 91 · see citing works
Takebayashi, S., Tanaka, H., Hino, S., Nakatsu, Y., Igata, T., Sakamoto, A., Narita, M., & Nakao, M. (2015) · Aging Cell · doi:10.1111/acel.12351 · Cited by 84 · see citing works
The Senescent Side of Tumor Suppression
Collado, M., & Serrano, M. (2005) · Cell Cycle · doi:10.4161/cc.4.12.2260 · Cited by 79 · see citing works
DNA damage response to the Mdm2 inhibitor Nutlin-3
Verma, R., Rigatti, M. J., Belinsky, G. S., Godman, C. A., & Giardina, C. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.020 · Cited by 76 · see citing works
PLA2R1 Mediates Tumor Suppression by Activating JAK2
Vindrieux, D., Augert, A., Girard, C. A. J., Gitenay, D., Lallet-Daher, H., Wiel, C., Calvé, B. L., Gras, B., Ferrand, M., Verbeke, S., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0318 · Cited by 74 · see citing works
Self-citationp53 downregulates the Fanconi anaemia DNA repair pathway
Jaber, S., Toufektchan, E., Lejour, V., Bardot, B., & Toledo, F. (2016) · Nature Communications · doi:10.1038/ncomms11091 · Cited by 61 · see citing works
Vitamin D/vitamin D receptor axis regulates DNA repair during oncogene-induced senescence
Graziano, S., Johnston, R., Deng, O., Zhang, J., & Gonzalo, S. (2016) · Oncogene · doi:10.1038/onc.2016.77 · Cited by 60 · see citing works
The Focinator - a new open-source tool for high-throughput foci evaluation of DNA damage
Oeck, S., Malewicz, N. M., Hurst, S., Rudner, J., & Jendrossek, V. (2015) · Radiation Oncology · doi:10.1186/s13014-015-0453-1 · Cited by 55 · see citing works
Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation
Lallet-Daher, H., Wiel, C., Gitenay, D., Navaratnam, N., Augert, A., Calvé, B. L., Verbeke, S., Carling, D., Aubert, S., Vindrieux, D., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3690 · Cited by 51 · see citing works
Self-citationHuman papillomavirus type 16 E7 regulates E2F and contributes to mitogenic signalling.
Morris, J. P., Crook, T., Bandara, L. R., Davies, R. C., Thangue, N. B. L., & Kh, V. (1993) · PubMed · Cited by 47 · see citing works
MicroRNA 299-3p modulates replicative senescence in endothelial cells
Jong, H.-L., Mustafa, M. R., Vanhoutte, P. M., AbuBakar, S., & Wong, P. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00071.2012 · Cited by 34 · see citing works
Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape
Wiel, C., Gras, B., Vindrieux, D., Warnier, M., Gitenay, D., Calvé, B. L., Ferrand, M., Augert, A., & Bernard, D. (2015) · Oncogene · doi:10.1038/onc.2015.218 · Cited by 5 · see citing works
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Ho, C. Y., & Dreesen, O. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111525 · Cited by 164 · see citing works
Toufektchan, E., & Toledo, F. (2018) · Cancers · doi:10.3390/cancers10050135 · Cited by 133 · see citing works
Murayama, T., Nakayama, J., Jiang, X., Miyata, K., Morris, A. D., Cai, K. Q., Prasad, R. M., Ma, X., Efimov, A., Belani, N., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0486 · Cited by 101 · see citing works
Human papillomavirus 16 promotes microhomology-mediated end-joining
Leeman, J. E., Li, Y., Bell, A., Hussain, S. S., Majumdar, R., Rong, X., Blecua, P., Damerla, R. R., Narang, H., Ravindran, P. T., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906120116 · Cited by 92 · see citing works
Nicaise, A., Willis, C. M., Crocker, S., & Pluchino, S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00247 · Cited by 65 · see citing works
p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells
Janelle, V., Neault, M., Lebel, M., Sousa, D. M. D., Boulet, S., Durrieu, L., Carli, C., Muzac, C., Lemieux, S., Labrecque, N., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.698565 · Cited by 58 · see citing works
Yu, J., Shi, J., Zhang, Y., Zhang, Y., Huang, Y., Chen, Z., & Yang, J. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.24635 · Cited by 59 · see citing works
Zhao, Z., Wang, Y., Yun, D., Huang, Q., Meng, D., Li, Q., Zhang, P., Wang, C., Chen, H., & Lu, D. (2020) · PubMed Central · Cited by 58 · see citing works
Kandhaya‐Pillai, R., Miró‐Mur, F., Alijotas‐Reig, J., Tchkonia, T., Schwartz, S., Kirkland, J. L., & Oshima, J. (2023) · Aging · doi:10.18632/aging.204743 · Cited by 53 · see citing works
Wang, Y., Liu, L., Song, Y., Yu, X., & Deng, H. (2022) · Protein & Cell · doi:10.1007/s13238-021-00894-z · Cited by 49 · see citing works
DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders
Provasek, V. E., Mitra, J., Malojirao, V. H., & Hegde, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094653 · Cited by 43 · see citing works
Insights into replicative senescence of human testicular peritubular cells
Schmid, N., Flenkenthaler, F., Stöckl, J. B., Dietrich, K.-G., Köhn, F. M., Schwarzer, J. U., Kunz, L., Luckner, M., Wanner, G., Arnold, G. J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51380-w · Cited by 49 · see citing works
Shen, T., Li, H., Song, Y., Li, L., Lin, J., Wei, G., & Ni, T. (2019) · Aging · doi:10.18632/aging.101836 · Cited by 48 · see citing works
Growth hormone in the tumor microenvironment
Chesnokova, V., & Melmed, S. K. (2019) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000186 · Cited by 48 · see citing works
DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
Schwab, N., Grenier, K., & Hazrati, L.-N. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0822-3 · Cited by 47 · see citing works
Vančurová, M., Hanzlíková, H., Knoblochová, L., Kosla, J., Majera, D., Mistrík, M., Burdová, K., Hodný, Z., & Bártek, J. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.04.001 · Cited by 45 · see citing works
Rubin de Celis, M. F., Garcia-Martin, R., Syed, I., Lee, J., Aguayo-Mazzucato, C., Bonner-Weir, S., & Kahn, B. B. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2206923119 · Cited by 39 · see citing works
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Wu, N., Pan, Y., Liu, Q., Shahidi, F., Li, H., Chen, F., Deng, Z., & Zhang, Z. (2024) · Food & medicine homology. · doi:10.26599/fmh.2025.9420029 · Cited by 35 · see citing works
Wéra, A.-C., Lobbens, A., Stoyanov, M., Lucas, S., & Michiels, C. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1632640 · Cited by 35 · see citing works
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Schwab, N., Leung, E., & Hazrati, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.742632 · Cited by 33 · see citing works
Sun, J., Chen, X., Ji, X., Meng, S., Wang, W., Wang, P., Bai, J., Li, Z., & Chen, Y. (2022) · Bioengineered · doi:10.1080/21655979.2022.2042134 · Cited by 26 · see citing works
Raynard, C., Ma, X., Huna, A., Tessier, N., Massemin, A., Zhu, K., Flaman, J., Moulin, F., Goehrig, D., Médard, J., et al. (2022) · Aging Cell · doi:10.1111/acel.13632 · Cited by 26 · see citing works
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Huna, A., Griveau, A., Vindrieux, D., Jaber, S., Flaman, J., Goehrig, D., Martin, L. A., Médard, J., Djebali, S., Hernández‐Vargas, H., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03468-3 · Cited by 23 · see citing works
Self-citationTombuloglu, A., Çöpoğlu, H., Son, Y. A., & Güray, T. (2020) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2020.126573 · Cited by 24 · see citing works
Schwartz, R. E., Shokhirev, M. N., Andrade, L. R., Gutkind, J. S., Iglesias-Bartolome, R., & Shadel, G. S. (2021) · Aging · doi:10.18632/aging.202658 · Cited by 23 · see citing works
Hufnagel, M., Neuberger, R., Wall, J., Link, M., Friesen, A., & Hartwig, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095044 · Cited by 22 · see citing works
Rentscher, K. E., Carroll, J. E., Polsky, L. R., & Lamkin, D. M. (2022) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2022.100461 · Cited by 21 · see citing works
Schwarzenbach, C., Rinke, J., Vilar, J. B., Sallbach, J., Tatsch, L., Schmidt, A., Schöneis, A., Rasenberger, B., Kaina, B., Tomicic, M. T., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07651-8 · Cited by 21 · see citing works
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Venkataraman, A., Kordic, I., Li, J., Zhang, N. Y., Bharadwaj, N. S., Fang, Z., Das, S., & Coskun, A. F. (2024) · npj Aging · doi:10.1038/s41514-024-00178-w · Cited by 22 · see citing works
Sha, J., Arbesman, J., & Harter, M. L. (2020) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12888 · Cited by 19 · see citing works
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Frey, Y., Haj, M., Ziv, Y., Elkon, R., & Shiloh, Y. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1257 · Cited by 18 · see citing works
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Prochownik, E. V., & Wang, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1244321 · Cited by 14 · see citing works
Uncoupling of mTORC1 from E2F activity maintains DNA damage and senescence
Daigh, L. H., Saha, D., Rosenthal, D. L., Ferrick, K. R., & Meyer, T. (2024) · Nature Communications · doi:10.1038/s41467-024-52820-6 · Cited by 14 · see citing works
Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?
Lidsky, P. V., Yuan, J.-J., Rulison, J. M., & Andino-Pavlovsky, R. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922120021 · Cited by 10 · see citing works
Structure of an Intranucleosomal DNA Loop That Senses DNA Damage during Transcription
Gerasimova, N. S., Игоревна, В. О., Pestov, N. A., Алексеевич, А. Г., Kirpichnikov, M. P., Shaytan, A. К., Sokolova, O. S., & Studitsky, V. M. (2022) · Cells · doi:10.3390/cells11172678 · Cited by 9 · see citing works
Zhou, J.-X., Liu, K., Bauer, C., Bendner, G., Dietrich, H., Slivka, J. P., Wink, M., Wong, M. B., Chan, M. K. S., & Skutella, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076748 · Cited by 8 · see citing works
The multi-level effect of chlorpyrifos during clownfish metamorphosis
Reynaud, M., Vianello, S., Lee, S., Salis, P., Wu, K., Frédérich, B., Lecchini, D., Laurence Besseau, A., Roux, N., & Laudet, V. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112535 · Cited by 7 · see citing works
Beyond polarization: macrophage senescence in immunoregulation and cancer therapy
Mei, S., Zhang, L., Dai, X., Ji, S., Shen, J., & He, W. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.115921 · Cited by 7 · see citing works
Sangsuwan, T., Khavari, A. P., Blomberg, E., Romell, T., Godoy, P. R. D. V., Harms‐Ringdahl, M., & Haghdoost, S. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2811296 · Cited by 7 · see citing works
Gallant, K. L., Bektas, A., Kaileh, M., Lustig, A., Ferrucci, L., Pegoraro, G., & Misteli, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-10018-0 · Cited by 5 · see citing works
Deryabin, P. I., & Бородкина, А. В. (2021) · Cell and Tissue Biology · doi:10.1134/s1990519x2106002x · Cited by 4 · see citing works
Cellular Senescence Triggered by Food and Environmental Genotoxins
Kaina, B., Tomicic, M. T., & Christmann, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052389 · Cited by 3 · see citing works
González, I., Arredondo, S. B., & Maldonado‐Agurto, R. (2025) · Biogerontology · doi:10.1007/s10522-025-10191-5 · Cited by 3 · see citing works
Effects of p53 and ATRX inhibition on telomeric recombination in aging fibroblasts
Udroiu, I., Marinaccio, J., & Sgura, A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1322438 · Cited by 3 · see citing works
Ballhysa, E., Ripa, R., Hochhard, N., Nguyen, T. T. M., Brazell, J. T., Ferreri, B., Hoffmann, E., Steiner, J. D., & Antebi, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.08.617203 · Cited by 3 · see citing works
Samareh, P., Agudelo-Garcia, P. A., Zhang, Z., Gilbert, M. B., Mendoza, M. R., Huang, H., Wu, J. E., Baxter, A. E., Chen, Z., Alexander, K., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf188 · Cited by 2 · see citing works
Herrera‐Sánchez, M. P., Rodríguez‐Hernández, R., & Rondón‐Barragán, I. S. (2025) · Veterinary Medicine International · doi:10.1155/vmi/3041254 · Cited by 2 · see citing works
Liao, Z., Li, M., Chen, Z., Yao, Z., Wu, Y., Tan, Z. W., Qian, J., Yang, C., Huang, L. C., Xue, L., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01962-6 · Cited by 2 · see citing works
MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER+ Breast Cancer
Wörthmüller, J., Disler, S., Pradervand, S., Richard, F., Haerri, L., Buendía, G. A. R., Fournier, N., Desmedt, C., & Rüegg, C. (2023) · Cells · doi:10.3390/cells12151929 · Cited by 2 · see citing works
Rad, A. N., Sperger, S., Marsh, L. M., Höetzenecker, K., Lämmermann, I., & Grillari, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.16.623933 · Cited by 2 · see citing works
Early Neutrophil Sensing Shapes the Innate Response to Preneoplastic Mammary CellsPreprint
Debiesse, A., Pereira-Abrantes, M., Moudombi, L., Voissière, A., Lefèvre, L., Lecot, P., Rodriguez, C., Malfroy, M., Moskalevska, I., Vanacker, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.17.633444 · Cited by 2 · see citing works
Senescence-like Phenotype After Chronic Exposure to Isoproterenol in Primary Quiescent Immune Cells
Laumann, M., Palombo, P., Fieres, J., Thomas, M., Saretzki, G. C., Bürkle, A., & Moreno‐Villanueva, M. (2024) · Biomolecules · doi:10.3390/biom14121528 · Cited by 1 · see citing works
Selvarani, R., Lee, S., Saminathan, M., Boovalingam, P., Kurup, K., Pham, K., Wolf, R. F., Freeman, W. M., Unnikrishnan, A., & Richardson, A. G. (2025) · GeroScience · doi:10.1007/s11357-025-01994-y · Cited by 1 · see citing works
Pillai, R. K., Miró‐Mur, F., Alijotas‐Reig, J., Tchkonia, T., Schwartz, S., Kirkland, J. L., & Oshima, J. (2022) · Research Square · doi:10.21203/rs.3.rs-2106211/v1
Santos, F. M., Ramírez-Carracedo, R., Ciordia, S., Clavaín, L., Hernández-Fonseca, J. P., Jouve, B. M., Bodega, G., Ramı́rez, R., Ruiz‐Torres, M. P., López-Granero, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.25.690417
Romaniello, D., Gelfo, V., Pagano, F., Ferlizza, E., Sgarzi, M., Mazzeschi, M., Morselli, A., Miano, C., D’Uva, G., & Lauriola, M. (2022) · Figshare · doi:10.6084/m9.figshare.19297937
Romaniello, D., Gelfo, V., Pagano, F., Ferlizza, E., Sgarzi, M., Mazzeschi, M., Morselli, A., Miano, C., D’Uva, G., & Lauriola, M. (2022) · Figshare · doi:10.6084/m9.figshare.19297931
Romaniello, D., Gelfo, V., Pagano, F., Ferlizza, E., Sgarzi, M., Mazzeschi, M., Morselli, A., Miano, C., D’Uva, G., & Lauriola, M. (2022) · Figshare · doi:10.6084/m9.figshare.19297928
Implication de la voie p53 dans les syndromes d'insuffisance médullaire
Toufektchan, E. (2018) · theses.fr (ABES) · doi:10.70675/58dfec7cz94b0z449fz96a6z9051bf80c551
Impact of G-quadruplex (G4) structure stabilisation on the human genome; a multi-omics approach
Lombardi, E. P. (2019) · theses.fr (ABES) · doi:10.70675/37896269zd0a9z4754zbb6aze154c59ec230
Chen, X., Liu, H., Shu, Q., Tang, Y., Zhang, J., Yu, W., & Li, S. (2026) · Cells · doi:10.3390/cells15121123
Loss of killifish cGAS attenuates age-related signatures but does not affect organismal life span
Ballhysa, E., Ripa, R., Hochhard, N., Nguyen, T. T. M., Brazzell, J. L., Park, Y., Ferreri, B., Hoffmann, E., Laboy, R., Steiner, J. D., et al. (2026) · EMBO Reports · doi:10.1038/s44319-026-00917-y · Cited by 3 · see citing works
- Authors
- Collin, G., Huna, A., Warnier, M., Flaman, J.-M., & Bernard, D.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Bernard, David
- Venue
- Cell Death & Disease
- Published
- 2018-02-15
- Volume
- 9
- Issue
- 3
- Pages
- 259-259
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC5833687
- OpenAlex
- W2790950086
- Cited by
- 71
- References
- 50
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 9 · 2023: 5 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 3
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cell Death and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-14-CE12-0003)
- Fondation pour la Recherche Médicale
- Fondation ARC pour la Recherche sur le Cancer
- Ligue Contre le Cancer
- Fondation de France
- Institut National Du Cancer
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- cellular senescence, DNA repair genes, transcriptional repression, Rb/E2F pathway, RB1, premature senescence, DNA damage, senescence-associated DNA damage, aging, age-related diseases, siRNA knockdown
- MeSH terms
- Cells, Cultured, DNA Repair, Epithelial Cells, Humans, Transcription, Genetic, Signal Transduction, Down-Regulation, Tumor Suppressor Protein p53, Retinoblastoma Protein, Cellular Senescence, Mammary Glands, Human, DNA Repair Enzymes, E2F Transcription Factors
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