The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
RNA N6-methyladenosine modification in cancers: current status and perspectives
Open accessAbstract
N 6 -methyladenosine (m 6 A), the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), has been shown to play critical roles in various normal bioprocesses such as tissue development, stem cell self-renewal and differentiation, heat shock or DNA damage response, and maternal-to-zygotic transition. The m 6 A modification is deposited by the m 6 A methyltransferase complex (MTC; i.e., writer) composed of METTL3, METTL14 and WTAP, and probably also VIRMA and RBM15, and can be removed by m 6 A demethylases (i.e., erasers) such as FTO and ALKBH5. The fates of m 6 A-modified mRNAs rely on the functions of distinct proteins that recognize them (i.e., readers), which may affect the stability, splicing, and/or translation of target mRNAs. Given the functional importance of the m 6 A modification machinery in normal bioprocesses, it is not surprising that evidence is emerging that dysregulation of m 6 A modification and the associated proteins also contributes to the initiation, progression, and drug response of cancers. In this review, we focus on recent advances in the study of biological functions and the underlying molecular mechanisms of dysregulated m 6 A modification and the associated machinery in the pathogenesis and drug response of various types of cancers. In addition, we also discuss possible therapeutic interventions against the dysregulated m 6 A machinery to treat cancers.
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Cites
N6-methyladenosine-dependent regulation of messenger RNA stability
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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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N6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
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Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
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Cited by
Chang, G., Shi, L., Ye, Y., Shi, H., Zeng, L., Tiwary, S., Huse, J. T., Huo, L., Ma, L., Ma, Y., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.10.004 · Cited by 412
RNA modifications regulating cell fate in cancer
Delaunay, S., & Frye, M. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0319-0 · Cited by 365
Weng, H., Huang, F., Yu, Z., Chen, Z., Prince, E., Kang, Y., Zhou, K., Li, W., Hu, J., Fu, C., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.10.004 · Cited by 336
Self-citationCrosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation
Kan, R. L., Chen, J., & Sallam, T. (2022) · Trends in Genetics · doi:10.1016/j.tig.2021.06.014 · Cited by 308
Self-citationN6-Methyladenosine Modification of ANLN Enhances Hepatocellular Carcinoma Bone Metastasis
Zheng, H., Cheng, Z.-J., Liang, B., Wang, Z.-G., Tao, Y.-P., Huang, S.-Y., Ni, J.-S., Li, H.-F., Yang, L., Yuan, S.-X., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.73570 · Cited by 33
Metadata
- Authors
- Deng, X., Su, R., Weng, H., Huang, H., Li, Z., & Chen, J.
- Venue
- Cell Research
- Published
- 2018-04-23
- Volume
- 28
- Issue
- 5
- Pages
- 507-517
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2800471491
- Cited by
- 845
- References
- 21
- FWCI
- 25.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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