Helper T cell differentiation

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265

Alteration in gut microbiota accompanied by increased intestinal permeability and Tfh/Tfr imbalance in patients with active SLE

Chu, X., Li, S., Wang, Y., Guo, D., Zhao, N., Han, Y., & Xing, Q. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1565416 · Cited by 13

Empowering single-cell analysis with emerging active microfluidic devices

Ruan, Q., Guo, W., Yang, R., Sun, T., Yang, Q., & Ren, Y. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123617 · Cited by 13

PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis

Blanco, D. B., Chapman, N. M., Raynor, J. L., Xu, C., Su, W., Anil, K. C., Li, W., Lim, S. A., Schattgen, S., Shi, H., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-01011-w · Cited by 13

Deficiencies and Dysregulation of STAT Pathways That Drive Inborn Errors of Immunity: Lessons from Patients and Mouse Models of Disease

Toth, K. A., Schmitt, E. G., & Cooper, M. A. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200905 · Cited by 13

Crude Tieguanyin oolong tea polysaccharides regulate intestinal immune and gut microflora in dextran sulfate sodium‐induced mice colitis

Zhang, Y., Pan, Y., Lin, H., Chen, X., He, P., Wang, Y., Chen, P., & Chu, Q. (2023) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13206 · Cited by 13

Interaction Between Dendritic Cells and Candida krusei β-Glucan Partially Depends on Dectin-1 and It Promotes High IL-10 Production by T Cells

Dinh, T. T. H., Tummamunkong, P., Padungros, P., Ponpakdee, P., Boonprakong, L., Saisorn, W., Leelahavanichkul, A., Kueanjinda, P., & Ritprajak, P. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.566661 · Cited by 13

Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells

Gallardo-Dodd, C. J., Oertlin, C., Record, J., Galvani, R. G. A., Sommerauer, C., Kuznetsov, N. V., Doukoumopoulos, E., Ali, L., Oliveira, M. M. S., Seitz, C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg1610 · Cited by 13

Peripheral immune characteristics and subset disorder in reproductive females with endometriosis

Lin, K.-R., Li, P.-X., Zhu, X., Mao, X., Peng, J.-L., Chen, X.-P., Situ, C.-Y., Zhang, L., Luo, W., Han, Y.-B., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1431175 · Cited by 12

Functional characterization of grass carp (Ctenopharyngodon idella) interleukin-2 in head kidney leukocytes

Lv, M., Wang, X., Qiu, X., Zeng, T., Feng, S., Yin, L., Zhou, H. Y., Zhang, A., & YANG, K. Y. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.12.077 · Cited by 12

Immunouniverse of SARS-CoV-2

Jiménez, D., & Arias, M. T. (2022) · Immunological Medicine · doi:10.1080/25785826.2022.2066251 · Cited by 12

Formaldehyde exposure induces differentiation of regulatory T cells via the NFAT-mediated T cell receptor signalling pathway in Yucatan minipigs

Park, J., Kang, G.-H., Kim, Y., Lee, J. Y., Song, J. A., & Hwang, J. H. (2022) · Scientific Reports · doi:10.1038/s41598-022-12183-8 · Cited by 12

Long Noncoding RNAs as Orchestrators of CD4+ T-Cell Fate

Liu, C., Zhang, Y., Ma, Z., & Yi, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.831215 · Cited by 12

A comprehensive pancancer analysis reveals the potential value of RAR-related orphan receptor C (RORC) for cancer immunotherapy

He, S., Yu, J., Sun, W., Sun, Y., Tang, M., Meng, B., Liu, Y., & Li, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.969476 · Cited by 12

Antibody and T-Cell Subsets Analysis Unveils an Immune Profile Heterogeneity Mediating Long-term Responses in Individuals Vaccinated Against SARS-CoV-2

Agallou, M., Koutsoni, O. S., Michail, M., Zisimopoulou, P., Tsitsilonis, O., & Karagouni, E. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac421 · Cited by 12

Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin

Dhume, K., Kaye, B., & McKinstry, K. K. (2022) · Biomolecules · doi:10.3390/biom12111549 · Cited by 12

Glucan from Dictyophora rubrovolvata boosts immunity by regulating AKT‐STAT1 pathway to induce dendritic cells maturation and T cells differentiation

Wu, Y., Zhou, W., Feng, R., Zhang, D., Yu, Y., Huang, Z., Yin, J., Zhou, X., & Nie, S. (2023) · Food Frontiers · doi:10.1002/fft2.275 · Cited by 12

Chirality‐Dependent Reprogramming of Macrophages by Chiral Nanozymes

Zhang, Y., Cui, T., Yang, J., Huang, Y., Ren, J., & Qu, X. (2023) · Angewandte Chemie · doi:10.1002/ange.202307076 · Cited by 12

MicroRNA-26b-5p alleviates murine collagen-induced arthritis by modulating Th17 cell plasticity

Zhang, M.-F., Yang, P., Shen, M.-Y., Wang, X., Gao, N.-X., Zhou, X., Zhou, L., & Lü, Y. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104382 · Cited by 12

Th2/Th17 cell associated cytokines found in seroma fluids after breast cancer surgery

Pochert, N., Schneider, M., Köpke, M. B., Wild, C. M., Mattmer, A., Sagasser, J., Golas, M. M., Banys‐Paluchowski, M., Metz, A., Hinske, L. C., et al. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-07074-w · Cited by 12

Comparison and subsets analysis of peripheral CD4+T cells in patients with psoriasis and psoriatic arthritis

Gao, W., Lei, Y., Guo, X., Luo, Y., Zhang, Z., Xi, Y., Wang, W., Xia, W., Wang, Z., Niu, X., et al. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.10.002 · Cited by 11

Helper T cell subsets: Development, function and clinical role in hypersensitivity reactions in the modern perspective

Kan, A. K. C., Tang, W. T., & Li, P. H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30553 · Cited by 11

Immunohistochemistry Analysis in Inflammatory Bowel Disease—Should We Bring to Light Interleukin-10?

Pavel, C. J. V., Diculescu, M., Ilie, M., Plotogea, O., Şandru, V., Enache, V., Gheonea, D. I., Jichitu, A., Constantinescu, A., Șerban, R.-E., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13020406 · Cited by 11

Nanomaterial Adjuvants for Veterinary Vaccines: Mechanisms and Applications

He, L., Pan, R. L., Liang, R., Li, B., Zhang, P., He, S., Li, B., & Li, Y. (2025) · Research · doi:10.34133/research.0761 · Cited by 11

NCAPH is a prognostic biomarker and associated with immune infiltrates in lung adenocarcinoma

Li, C., Meng, J., & Zhang, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-12862-6 · Cited by 11

Effects of soybean meal on immunity and transcriptomics of liver in pearl gentian grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)

Pang, A., Wang, T., Xie, R., Wang, Z., Xin, Y., Tan, B., & Zhang, W. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.101969 · Cited by 11

Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome

Yang, F., Zhou, L., Shen, Y., Wang, X., Fan, X., & Yang, L. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05029-6 · Cited by 11

Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial)

Okuma, H. S., Watanabe, K., Tsuchihashi, K., Machida, R., Sadachi, R., Hirakawa, A., Ariyama, H., Kanai, M., Kamikura, M., Anjo, K., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-1807 · Cited by 10

Identification of Cell-Cell Communications by Single-Cell RNA Sequencing in End Stage Renal Disease Provides New Insights into Immune Cell Heterogeneity

Zhang, R., Liu, X., Ma, Y., Cheng, L., Ren, Y., & Li, R. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s424911 · Cited by 10

PD-1-positive cells contribute to the diagnosis of inflammatory bowel disease and can aid in predicting response to vedolizumab

Kim, M. K., Jo, S. I., Kim, S., Lim, H. K., Kang, H. S., Moon, S., Ye, B. D., Soh, J. S., & Hwang, S. W. (2023) · Scientific Reports · doi:10.1038/s41598-023-48651-y · Cited by 10

Immunostimulation Signaling via Toll-like Receptor 2 Activation: A Molecular Mechanism of Lactococcus lactis OTG1204 In Vitro and In Vivo

Song, H.-A., Jang, S.-Y., Park, M., Kim, S. W., Kang, C. G., Lee, J. H., Kim, H.-J., Kim, J., Lee, J. K., Chung, K., et al. (2024) · Nutrients · doi:10.3390/nu16213629 · Cited by 10

HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections

Penninger, P., Brezovec, H., Tsymala, I., Teufl, M., Phan-Canh, T., Bitencourt, T. A., Brinkmann, M., Glaser, W., Ellmeier, W., Bonelli, M. M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114993 · Cited by 10

Interleukin-enhanced CAR-engineered immune cells in tumor immunotherapy: current insights and future perspectives

Wang, M., Wang, Z., Zhang, G., & Fan, J. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156973 · Cited by 10

Into the multi-omics era: Progress of T cells profiling in the context of solid organ transplantation

Yao, Z., Li, M., & Lv, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1058296 · Cited by 10

Delimiting MOGAD as a disease entity using translational imaging

Oertel, F. C., Hastermann, M., & Paul, F. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1216477 · Cited by 10

Constitutive activation of Notch signalling and T cell activation characterize a mouse model of autism

Yao, Y., Uddin, M. N., MANLEY, K. M., & Lawrence, D. A. (2022) · Cell Biochemistry and Function · doi:10.1002/cbf.3684 · Cited by 10

The crosstalk between probiotics and T cell immunity

Liu, Y., Cao, X., Liu, H., & Zhang, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1695840 · Cited by 9

T Cell Subsets and Immune Homeostasis

Wu, C., Jiang, M., Pang, T., & Zhang, C. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3754-8_3 · Cited by 10

Mechanisms of Immune Evasion of West Nile Virus

Alghamdi, A., Alissa, M., & Alshehri, M. A. (2025) · Reviews in Medical Virology · doi:10.1002/rmv.70042 · Cited by 9

Short-Term Rapamycin Preconditioning Diminishes Therapeutic Efficacy of Human Adipose-Derived Stem Cells in a Murine Model of Multiple Sclerosis

Wise, R. M., Harrison, M. A. A., Sullivan, B. N., Al-Ghadban, S. I., Aleman, S. J., Vinluan, A. T., Monaco, E. R., Donato, U. M., Pursell, I. A., & Bunnell, B. A. (2020) · Cells · doi:10.3390/cells9102218 · Cited by 9

Monophosphoryl Lipid A and Poly I:C Combination Adjuvant Promoted Ovalbumin-Specific Cell Mediated Immunity in Mice Model

Ahn, S. Y., Le, C. T. T., & Ko, E. (2021) · Biology · doi:10.3390/biology10090908 · Cited by 9

SKA3 is a prognostic biomarker and associated with immune infiltration in bladder cancer

Wang, C., Liu, S., Zhang, X., Wang, Y., Guan, P., Bu, F., Wang, H., Wang, D., Fan, Y., Hou, S., et al. (2022) · Hereditas · doi:10.1186/s41065-022-00234-z · Cited by 9

Immunopathology of Behcet’s Disease: An Overview of the Metagenomic Approaches

Shimizu, J., Murayama, M. A., Miyabe, Y., & Suzuki, N. (2022) · Rheumato · doi:10.3390/rheumato2030010 · Cited by 10

Synovial Macrophages Expression of OX40L Is Required for Follicular Helper T Cells Differentiation in the Joint Microenvironment

Cai, X. T., Zhang, M., Ren, F., Fei, W., Zhang, X., Zhao, Y., Yao, Y., & Lin, N. (2022) · Cells · doi:10.3390/cells11203326 · Cited by 9

The m1A modification of tRNAs: a translational accelerator of T-cell activation

Chen, C., & Ye, L. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00942-6 · Cited by 9

mRNA Vaccine Mitigates SARS-CoV-2 Infections and COVID-19

Kackos, C. M., Surman, S. L., Jones, B. G., Sealy, R. E., Jeevan, T., Davitt, C. J. H., Pustylnikov, S., Darling, T. L., Boon, A. C. M., Hurwitz, J. L., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04240-22 · Cited by 9

Lactobacillus reuteri for chronic periodontitis: focus on underlying mechanisms and future perspectives

Zhou, K., Xie, J., Su, Y., & Fang, J. (2023) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2023.2183617 · Cited by 9

Green tea extract improves cyclophosphamide-induced immunosuppression in mouse spleen and enhances the immune activity of RAW 264.7 cells

Kim, J., Kim, J., Kim, C.-Y., Jeong, J.-S., Ko, J.-W., & Kim, T. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22062 · Cited by 9

A Role for Human Renal Tubular Epithelial Cells in Direct Allo-Recognition by CD4+ T-Cells and the Effect of Ischemia-Reperfusion

Eleftheriadis, T., Pissas, G., Crespo, M., Nikolaou, E., Liakopoulos, V., & Stefanidis, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041733 · Cited by 9

A comparison of the physicochemical properties, allergenicity, and stability of recombinant β-lactoglobulin: Development of standard bovine milk allergens

Xie, F., Hu, W., Meng, X., Hu, C., Li, X., & Chen, H. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104956 · Cited by 8

Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells

Tang, J., Hu, Y., Fang, J., Zhu, W., Xu, W., Yu, D., Zheng, Z., Zhou, Q., Fu, H., & Zhang, W. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s468608 · Cited by 8

Dietary Sucralose Exacerbates Ovalbumin-Induced Food Allergy via Dendritic Cells Modulation: In Vitro and In Vivo Studies

Li, Y., Xu, Z., Madjirebaye, P., Xiang, Z., Tang, Z., Deng, X., Fan, Y., Feng, X., Yang, Z., & Wu, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c08929 · Cited by 8

Dietary Sodium Nitrite Promotes Food Allergy through Dendritic Cell-Mediated Immune Disruption

Yang, Z., Feng, X., Madjirebaye, P., Fan, Y., Li, Y., Xu, Z., & Wu, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c10031 · Cited by 8

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

Fu, Y., Ge, Z., Cao, Q., Li, Z., Zhang, A., Zhu, H., & Teng, G. (2026) · MedComm · doi:10.1002/mco2.70594 · Cited by 8

Balancing inflammation and regeneration: immune cell dynamics in nerve repair: a comprehensive review

Anjum, A., & Lokanathan, Y. (2026) · Inflammation Research · doi:10.1007/s00011-026-02207-8 · Cited by 8

Unravelling the imbalanced Th17-like cell differentiation by single-cell RNA sequencing in multiple myeloma

Wan, Y., Jiang, J., Chen, M., Han, X., Zhong, L., Xiao, F., Liu, J., Liu, J., Li, H., Huang, H., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110852 · Cited by 8

Long-term consequences of regulatory T-cell-specific knockout of Notch2 in immune homeostasis

Fan, H., Qiao, Y.-L., Liu, Y., Xu, S., Ni, H., Jiao, W.-E., Tao, Z., & Chen, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111069 · Cited by 8

Discovery of an immunosuppressive functional metabolite from the insect-derived endophytic Aspergillus taichungensis SMU01

Ren, J., Wu, P.-P., Xue, J.-H., Zhao, W., Zhu, Y.-H., Chen, Y., Yang, Q.-J., Luo, Q., Cheng, X., & Bi, E. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.106007 · Cited by 8

Comparison of stromal vascular fraction cell composition between Coleman fat and extracellular matrix/stromal vascular fraction gel

Li, X., Zhang, G., Wang, M., Lu, C., Zhang, G., Chen, Z., & Ji, Y. (2024) · Adipocyte · doi:10.1080/21623945.2024.2360037 · Cited by 8

Synergistic Photothermal Tumor Immunotherapy by 1-MT Based on Zeolitic Imidazolate Framework-8 with pH-High Sensitivity

Su, R., Yang, Y., Wu, H., Лю, Б., Tian, X., Zhou, C., Hu, Y., & Liu, T. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s449820 · Cited by 8

Aiolos promotes CXCR3 expression on Th1 cells via positive regulation of IFN-γ/STAT1 signaling

Leonard, M. R., Jones, D. M., Read, K. A., Pokhrel, S., Tuazon, J. A., Warren, R. T., Yount, J. S., & Oestreich, K. J. (2024) · JCI Insight · doi:10.1172/jci.insight.180287 · Cited by 8

Construction of In Situ Personalized Cancer Vaccines by Bioorthogonal Catalytic Microneedles for Augmented Melanoma Immunotherapy

Xu, Q., Yin, X., Chen, Z., Huang, E., Yao, X., Li, X., & Liu, P. N. (2025) · Small · doi:10.1002/smll.202500015 · Cited by 8

Envelope Glycoprotein based multi-epitope vaccine against a co-infection of Human Herpesvirus 5 and Human Herpesvirus 6 using in silico strategies

Gandhamaneni, B. S., Krishnamoorthy, H. R., Veerappapillai, S., Mohapatra, S. R., & Ramanathan, K. (2022) · Glycoconjugate Journal · doi:10.1007/s10719-022-10083-7 · Cited by 8

Impact of interleukin-32α on T helper cell-related cytokines, transcription factors, and proliferation in patients with type 2 diabetes mellitus

Borzouei, S., Gholamian-Hamadan, M., & Behzad, M. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2138430 · Cited by 8

Clinical significance of serum Th1/Th2 cytokines in patients with endometriosis

Xia, T., Zeng, K., Qingmei, P., Wu, X., & Lei, X. (2022) · Women & Health · doi:10.1080/03630242.2022.2144986 · Cited by 8

Mitochondrial ROS-dependent CD4+PD-1+T cells are pathological expansion in patients with primary immune thrombocytopenia

Li, W., Bai, Z., Liu, J., Tang, Y., Jin, M., Jin, M., Mu, L., & Li, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110597 · Cited by 8

Key pathways and genes that are altered during treatment with hyperbaric oxygen in patients with sepsis due to necrotizing soft tissue infection (HBOmic study)

Vinkel, J., Rib, L., Buil, A., Hedetoft, M., & Hyldegaard, O. (2023) · European journal of medical research · doi:10.1186/s40001-023-01466-z · Cited by 8

The transcriptional landscape of cancer stem-like cell functionality in breast cancer

Baldasici, O., Şoriţău, O., Roman, A., Lisencu, C., Vișan, S., Maja, L. I., Pop, B., Fetică, B., Cismaru, C. A., Vlase, L., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05281-w · Cited by 8

The Role of CD4+T Cells in Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma

Miao, Y., Li, Z., Feng, J., Lei, X., Shan, J., Qian, C., & Li, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136895 · Cited by 8

In vitro-generated alloantigen-specific Th9 cells mediate antileukemia cytotoxicity in the absence of graft-versus-host disease

Reisser, T., Halbgebauer, D., Scheurer, J., Wolf, L., Leithäuser, F., Beyersdorf, N., Fischer‐Posovszky, P., Debatin, K., & Strauß, G. (2020) · Leukemia · doi:10.1038/s41375-020-0731-2 · Cited by 8

Type 1 T Helper Cell-Based Molecular Subtypes and Signature Are Associated with Clinical Outcome in Pancreatic Ductal Adenocarcinoma

Wei, R., Zhang, H., Cao, J., Qin, D., Deng, W., & Li, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.839893 · Cited by 8

TGF-β from the Porcine Intestinal Cell Line IPEC-J2 Induced by Porcine Circovirus 2 Increases the Frequency of Treg Cells via the Activation of ERK (in CD4+ T Cells) and NF-κB (in IPEC-J2)

Liu, X., Wang, Y., Cheng, H., Li, Q., Hou, X., Song, Q., Zhou, S., & Li, H. (2022) · Viruses · doi:10.3390/v14112466 · Cited by 8

HCNetlas: A reference database of human cell type-specific gene networks to aid disease genetic analyses

Yu, J., Cha, J., Koh, G., & Lee, I. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3002702 · Cited by 7

Single-cell transcriptional responses of T cells during microsporidia infection

Tang, Y., Cao, L., Jin, J., Li, T., Chen, Y., Lu, Y., Li, T., Weiss, L. M., Pan, G., Bao, J., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07990-4 · Cited by 7

Prognostic value and potential mechanism of long non-coding RNA Lnc-SMIM20-1 in acute myeloid leukemia

Liu, S., Sun, Z., Zhu, M., Liu, M., Wei, M., Pan, X., & Huang, S. (2022) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2022.2093720 · Cited by 7

Correlations between Immune Response and Etiopathogenic Factors of Medication-Related Osteonecrosis of the Jaw in Cancer Patients Treated with Zoledronic Acid

Ciobanu, G. A., Mogoantă, L., Popescu, S. M., Ionescu, M., Munteanu, C. M., Staicu, I. E., Mercuţ, R., Georgescu, C. C., Scrieciu, M., Vlad, D., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814345 · Cited by 7

Rocaglamide promotes infiltration and differentiation of T cells and coordinates with PD-1 inhibitor to overcome checkpoint resistance in multiple tumor models

Luo, J., Ng, W., Liu, Y., Wang, L., Gong, C., Zhou, Y., Cheng, F., Zhu, S., & Yao, C. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03706-5 · Cited by 7

Mast Cells Promote Inflammatory Th17 Cells and Impair Treg Cells Through an IL-1β and PGE2 Axis

Leveque, E., Joulia, R., Battut, L., Laurent, C., Valitutti, S., Cénac, N., Dietrich, G., & Espinosa, É. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s509931 · Cited by 7

Pathogen Dose in Animal Models of Hemorrhagic Fever Virus Infections and the Potential Impact on Studies of the Immune Response

Warner, B. M. (2021) · Pathogens · doi:10.3390/pathogens10030275 · Cited by 7

T follicular helper and memory B cells in IgE recall responses

Koenig, J. F. E. (2024) · Allergology International · doi:10.1016/j.alit.2024.10.003 · Cited by 7

Epigenetic regulation of T cells by Polycomb group proteins

Melo, G. A., Calôba, C., Brum, G., Passos, T. O., Martínez, G., & Pereira, R. M. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.2ri0122-039r · Cited by 7

Single-cell profiling reveals immunoregulation of artemisinin on CD8+GZMB+ T cells via JAK2-STAT3 in malaria-infected mice

Chen, J., Gao, P., He, X., Hu, Y., Zhou, W., Liu, Y., Wang, J., Liu, X., Bai, Y., Chen, L., et al. (2025) · The Innovation · doi:10.1016/j.xinn.2025.101080 · Cited by 6

Harnessing the dual immunomodulatory function of myeloid-derived suppressor cells to reshape the inflammatory microenvironment for osteoarthritis therapy

Guo, Z., Chen, T., Wen, X., Fu, Q., Lai, J., Chen, J., Weng, J., Zheng, L., Wang, W. J., Cao, Q., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102332 · Cited by 6

Molecular requirements of pathogenic Th2 cell differentiation in allergic airway disease

Khan, M., Fuhrmann, V., Cavanagh, L. L., & Boucheron, N. (2026) · Immunology Letters · doi:10.1016/j.imlet.2026.107143 · Cited by 6

Beyond Conventional Transcriptional Regulation Function: FOXP3 as an Integrative Hub for Chromatin Interactions and Protein Complexes in Immune Regulation

Chang, H., Wang, Y., Gao, L., & Zheng, S. J. (2026) · Biology · doi:10.3390/biology15030254 · Cited by 6

Immune Dysregulation during and after COVID-19: “Tomorrow Never Dies” Situation

Patil, S. V., Patil, S., Gondhali, G., & Toshniwal, S. (2023) · Journal of Translational Critical Care Medicine · doi:10.1097/jtccm-d-22-00024 · Cited by 6

Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis

Deng, J., Hu, M., Meng, X., Wang, T., Wang, Y., Chen, X., Xu, D., He, W., Zhang, H., Guo, W., et al. (2025) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-025-06087-z · Cited by 6

Enhancement of CD4+ T Cell Function as a Strategy for Improving Antibiotic Therapy Efficacy in Tuberculosis: Does It Work?

Costa, D. L., Amaral, E. P., Namasivayam, S., Mittereder, L. R., Andrade, B. B., & Sher, A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.672527 · Cited by 6

Network meta‐analysis of the molecular mechanisms and signaling pathways underlying alcohol‐induced thymic atrophy

Rengifo, T. P., Bishir, M., Huang, W., Snyder, M., & Chang, S. L. (2024) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15292 · Cited by 6

Alkali injury–induced pathological lymphangiogenesis in the iris facilitates the infiltration of T cells and ocular inflammation

Liu, Z., Liu, K., Shi, S., Chen, X., Gu, X., Wang, W., Mao, K., Yibulayi, R., Wu, W., Zeng, L., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.175479 · Cited by 6

Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

Pahl, M. C., Sharma, P. K., Thomas, R. M., Thompson, Z., Mount, Z., Pippin, J. A., Morawski, P. A., Sun, P., Su, C., Campbell, D., et al. (2024) · eLife · doi:10.7554/elife.96852 · Cited by 6

Multi-epitope vaccines Xlc and Ddc against Glaesserella parasuis infection in mice

Dai, L., Wan, J., Zhang, R., Xie, T., Jia, Y., Lu, Z., Zhang, F., Ke, W., Liu, F., & Lei, L. (2025) · Veterinary Microbiology · doi:10.1016/j.vetmic.2025.110491 · Cited by 6

Role of CD4+ T-cells in the pathology of non-alcoholic fatty liver disease and related diseases

Seike, T., Mizukoshi, E., & Kaneko, S. (2021) · Hepatoma Research · doi:10.20517/2394-5079.2021.46 · Cited by 6

Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model

Wei, H., Xu, L., Sun, P., Xing, H., Zhu, Z., & Liu, J. (2022) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320221109529 · Cited by 6

Altered expression of Tim family molecules and an imbalanced ratio of Tim-3 to Tim-1 expression in patients with type 1 diabetes

Liu, Y., Chen, Z., Xiao, Y., Chen, H., & Zhou, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.937109 · Cited by 6

Insight analysis of the cross-sensitization of multiple fish parvalbumins via the Th1/Th2 immunological balance and cytokine release from the perspective of safe consumption of fish

Wu, Y., Lü, Y., Huang, Y., Lin, H., Dang, X., Jing, Y., Meng, Z., Wang, X., & Li, Z. (2022) · Food Quality and Safety · doi:10.1093/fqsafe/fyac056 · Cited by 6

Identification and validation of endocrine resistance-related and immune-related long non-coding RNA (lncRNA) signatures for predicting endocrinotherapy response and prognosis in breast cancer

Yang, M. J., Sun, Y., Ji, H., & Zhang, Q. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-6158 · Cited by 6

Elevated profiles of peripheral Th22, Th17, Th2 cells, and decreased percentage of Th1 cells in breast cancer patients

Peng, Z., Dong, X., He, M., Zhao, Y., Liu, Y., Li, M., Li, G., Wang, X., Li, L., & Hu, Y. (2023) · Thoracic Cancer · doi:10.1111/1759-7714.15119 · Cited by 6

Insulin resistance in nonobese type 2 diabetic Goto Kakizaki rats is associated with a proinflammatory T lymphocyte profile

Lobato, T. B., Manoel, R., Pereira, A. C. G., Correa, I. S., Iser‐Bem, P. N., Santos, E. S. D. S., Pereira, J. N. B., de Araújo, M. J. L., Borges, J. C. D. O., Pauferro, J. R. B., et al. (2024) · FEBS Letters · doi:10.1002/1873-3468.14977 · Cited by 6

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells

O’Shea, J. J., & Paul, W. E. (2010) · Science · doi:10.1126/science.1178334 · Cited by 1,401

Basic Aspects of T Helper Cell Differentiation

Gagliani, N., & Huber, S. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6548-9_2 · Cited by 100

Review of the Diversity, Differentiation and Physiological Function of “CD4+ T cells” in Animals

ALmasoodi, S. Z. (2026) · Kerbala Journal of Veterinary Medical Sciences · doi:10.65639/kjvm.2026.135

T Helper Cell Differentiation, Heterogeneity, and PlasticityPreprint

Zhu, J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a030338 · Cited by 374

Molecular Mechanisms of T Helper Cell Differentiation and Functional Specialization

Lee, G. R. (2023) · Immune Network · doi:10.4110/in.2023.23.e4 · Cited by 53