Brain macrophage development, diversity and dysregulation in health and disease

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526

Alzheimer's disease: the amyloid cascade hypothesis

Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245

Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371

Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury

Lan, Y., Zhang, X., Liu, S., Guo, C., Jin, Y., Li, H., Wang, L., Zhao, J., Hao, Y., Li, Z., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.01.008 · Cited by 108

Border-associated macrophages in the central nervous system

Sun, R., & Jiang, H. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03059-x · Cited by 120

Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity

Zhao, J., Andreev, I., & Silva, H. M. (2024) · Science Immunology · doi:10.1126/sciimmunol.add1967 · Cited by 109

Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration

Fumagalli, L., Nazlie Mohebiany, A., Premereur, J., Polanco Miquel, P., Bijnens, B., Van de Walle, P., Fattorelli, N., & Mancuso, R. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01931-4 · Cited by 90

From Homeostasis to Neuroinflammation: Insights into Cellular and Molecular Interactions and Network Dynamics

Müller, L., Benedetto, S. D., & Müller, V. (2025) · Cells · doi:10.3390/cells14010054 · Cited by 102

The role of microglia in early neurodevelopment and the effects of maternal immune activation

Mastenbroek, L., Kooistra, S. M., Eggen, B. J. L., & Prins, J. R. (2024) · Seminars in Immunopathology · doi:10.1007/s00281-024-01017-6 · Cited by 82

The m6A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia

Wu, X., Liu, H., Wang, J., Zhang, S., Hu, Q., Wang, T., Cui, W., Shi, Y., Bai, H., Zhou, J., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01329-y · Cited by 68

Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker

Martins, T. A., Kaymak, D., Tatari, N., Gerster, F., Hogan, S., Ritz, M.-F., Sabatino, V., Wieboldt, R., Bartoszek, E. M., McDaid, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54129-w · Cited by 54

Choroid plexus mast cells drive tumor-associated hydrocephalus

Li, Y., Di, C., Song, S., Zhang, Y., Lu, Y., Liao, J., Lei, B., Zhong, J., Guo, K., Zhang, N., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.001 · Cited by 55

Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease?

Mesquita, S. D., & Rua, R. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.03.007 · Cited by 46

Suppression of the JAK/STAT pathway inhibits neuroinflammation in the line 61-PFF mouse model of Parkinson’s disease

Hong, H., Wang, Y., Menard, M. A., Buckley, J. A., Zhou, L., Volpicelli‐Daley, L. A., Standaert, D. G., Qin, H., & Benveniste, E. N. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03210-8 · Cited by 44

Influenza A virus during pregnancy disrupts maternal intestinal immunity and fetal cortical development in a dose- and time-dependent manner

Otero, A. M., Connolly, M. G., Gonzalez-Ricon, R., Wang, S. S., Allen, J. M., & Antonson, A. M. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02648-9 · Cited by 33

Crosstalk between macrophages and immunometabolism and their potential roles in tissue repair and regeneration

Ma, H., Gao, L., Chang, R., Zhai, L., & Zhao, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38018 · Cited by 30

The role of angiogenic growth factors in the immune microenvironment of glioma

Ge, Z., Zhang, Q., Lin, W. J., Jiang, X., & Zhang, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1254694 · Cited by 24

CD300LF+ microglia impede the neuroinflammation following traumatic brain injury by inhibiting STING pathway

Lu, Z., Liu, Z., Wang, C., Jiang, R., Wang, Z., Liao, W., Wang, W., Chen, J., Zhu, X., Zhao, J., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14824 · Cited by 23

Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications

Tian, M., Kawaguchi, R., Shen, Y., Machnicki, M., Villegas, N. G., Cooper, D. R., Montgomery, N., Cai, Y., Haring, J., Lan, R., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.002 · Cited by 24

Brain macrophage senescence in glioma

Li, L., Zhang, T. C., Xiao, M., Lu, Y., & Gao, L. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.07.005 · Cited by 22

Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health

Tsourmas, K. I., Butler, C. A., Kwang, N. E., Sloane, Z. R., Dykman, K. J. G., Maloof, G. O., Choudhury, B., Paulchakrabarti, M., Prekopa, C. A., Tabaie, E. Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63237-0 · Cited by 25

Gut-immune-brain interactions during neurodevelopment: from a brain-centric to a multisystem perspective

Volpedo, G., Riva, A., Nobili, L., Zara, F., Ravizza, T., & Striano, P. (2025) · BMC Medicine · doi:10.1186/s12916-025-04093-z · Cited by 21

Emerging roles for innate and adaptive immunity in tauopathies

Johnson, A. M., & Lukens, J. R. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116232 · Cited by 19

Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeutic Targets

Ahremenko, E. A., Andreev, A., Apushkin, D., & Korkotian, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411995 · Cited by 20

Manipulation of protein corona for nanomedicines

Li, T., Wang, Y., & Zhou, D. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1982 · Cited by 16

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure

LaBelle, J. J., Haase, R. D., Beck, A., Haase, J., Jiang, L., de Biagi, C. A. O., Neyazi, S., Englinger, B., Liu, I., Trissal, M. C., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102095 · Cited by 16

Microglia signaling in health and disease – Implications in sex-specific brain development and plasticity

Pramanik, S., Harini Devi, M., Chakrabarty, S., Paylar, B., Pradhan, A., Thaker, M., Ayyadhury, S., Manavalan, A., Olsson, P., Pramanik, G., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105834 · Cited by 18

CCR2 + monocyte-derived macrophages drive cardiac hypertrophy in early HFpEF

Raman, J., Simmonds, S. J., Caluwé, E., van Leeuwen, R. E. W., Walschap, C., Stroobants, M., Cöl, Ü., Vandervoort, P., Heymans, S. R. B., & Jones, E. A. V. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00022.2025 · Cited by 16

Fusion of glioma-associated mesenchymal stem/stromal cells with glioma cells promotes macrophage recruitment and M2 polarization via m6A modification of CSF1

Liu, Z., Gu, S., Peng, Z., Wang, Y., Li, H., Zeng, X., Wang, H., Lv, P., Wu, Y., Zhou, Y., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07678-x · Cited by 13

The heart-brain crosstalk in age related cardiovascular and neurodegenerative diseases

Fahim, M. A., Yao, Y., Tipparaju, S. M., & Xuan, W. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00700-6 · Cited by 13

Microglia in systemic neuroimmune communication: functions beyond phagocytosis

Di Pietro, A. A., Powley, S., Perciballi, E., Stewart, M., Therrien, M., & Scott-Hewitt, N. (2026) · Trends in Immunology · doi:10.1016/j.it.2025.12.002 · Cited by 13

Polygonatum sibiricum Polysaccharides Alleviate Depressive-like Symptoms in Chronic Restraint Stress-Induced Mice via Microglial Regulation in Prefrontal Cortex

Yuan, Z.-Y., Zhang, X., Yu, Z., Wang, X., Zeng, Z.-H., Wei, M.-X., Qiu, M., Wang, J., Cheng, J., & Yi, L. (2024) · Polymers · doi:10.3390/polym16162358 · Cited by 13

Efferocytosis: A new therapeutic target for stroke

Gao, L., Manaenko, A., Zeng, F., Li, J., Liu, L., Xie, R., Zhang, X., Zhang, J. H., Mei, Q., Tang, J., et al. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003363 · Cited by 13

Macrophage membrane coated functionalized nanoparticles for targeted drug delivery and neural function repair in cerebral ischemia–reperfusion injury

Li, T., Wang, W., Liu, W., Sun, M., Wang, Q., Li, Z., Hao, J., & Yu, Y. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125329 · Cited by 12

Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder

Warden, A. S., Salem, N. A., Brenner, E. A., Sutherland, G. T., Stevens, J., Kapoor, M., Goate, A., & Mayfield, R. D. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.02.895 · Cited by 15

Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy

Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11

Gut–Brain–Microbiome Axis in the Regulation of Cancer Immune Escape and Immunotherapy in Tumors

Xu, W., Xu, Q., Luo, P., Qu, X., Guo, D., Xie, Z., Hang, N., Kuang, M., Chen, E., Wang, L., et al. (2025) · Research · doi:10.34133/research.0885 · Cited by 12

Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors

Suda, Y., Nakamura, K., Matsuyama, F., Hamada, Y., Makabe, H., Narita, M., Nagumo, Y., Mori, T., Kuzumaki, N., & Narita, M. (2024) · Molecular Brain · doi:10.1186/s13041-024-01091-9 · Cited by 11

Role of macrophages in vascular calcification: From the perspective of homeostasis

Dong, R., Ji, Z., Wang, M., & Ma, G. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113635 · Cited by 11

Cellular Components of the Blood-Brain Barrier and Their Involvement in Aging-Associated Cognitive Impairment

Shen, K., Shi, Y., Wang, X., & Leung, S. W. S. (2024) · Aging and Disease · doi:10.14336/ad.202.0424 · Cited by 12

Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance

Lehtonen, H., Jokela, H., Hofmann, J. I., Tola, L., Mehmood, A., Ginhoux, F., Becher, B., Greter, M., Yegutkin, G. G., Salmi, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115227 · Cited by 9

The choroid plexus: a command center for brain–body communication during inflammation

Xu, H., Hehnly, C., & Lehtinen, M. K. (2025) · Current Opinion in Immunology · doi:10.1016/j.coi.2025.102540 · Cited by 13

The Meninges as CNS Interfaces and the Roles of Meningeal Macrophages

Hiraki, C., & Tsuruta, F. (2025) · Biomolecules · doi:10.3390/biom15040497 · Cited by 12

Glial Cells and Aging: From the CNS to the Cerebellum

Sala, G. L., & Farini, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157553 · Cited by 12

Cannabinoid Receptor 2 (CB2) in Macrophages: A Promising Clinical Target for Immune Disorders

Yoon, H. H., & Grimsey, N. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178657 · Cited by 10

Spatiotemporal dynamics of the CD11c+ microglial population in the mouse brain and spinal cord from developmental to adult stages

Nomaki, K., Fujikawa, R., Masuda, T., & Tsuda, M. (2024) · Molecular Brain · doi:10.1186/s13041-024-01098-2 · Cited by 9

Cannabis Use and Cannabidiol Modulate HIV-Induced Alterations in TREM2 Expression: Implications for Age-Related Neuropathogenesis

Avalos, B., Kulbe, J. R., Ford, M. K., Laird, A. E., Walter, K., Mante, M., Florio, J. B., Boustani, A., Chaillon, A., Schlachetzki, J. C. M., et al. (2024) · Viruses · doi:10.3390/v16101509 · Cited by 11

Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ

Petit, M., Weber-Delacroix, E., Lanthiez, F., Barthélémy, S., Guillou, N., Firpion, M., Bonduelle, O., Hume, D. A., Combadière, C., & Boissonnas, A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114847 · Cited by 9

Structural optimization of naturally derived Ar-turmerone, as novel neuroinflammation suppressors effective in an Alzheimer mouse model

Zhou, W., Chang, Y., Xiao, Q., Deng, Z., Zhang, L., Yuan, Z., & Du, Z. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.118014 · Cited by 9

IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications

Zhang, N., Park, K., Chung, S., & Yim, Y. S. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101139 · Cited by 12

F4/80, the plasma membrane antigen of mouse macrophages, an historic journey

Gordon, S., Roberti, A., Yona, S., & Lin, H. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf126 · Cited by 8

More than microglia: myeloid cells and biomarkers in neurodegeneration

Kodosaki, E., Bell, R., Sogorb‐Esteve, A., Wiltshire, K., Zetterberg, H., & Heslegrave, A. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1499458 · Cited by 6

iPSC-derived macrophages: An in vitro model to study human disease-relevant macrophage biology

Sauer, J., Schloesser, D., Koeppen, K., Fundel‐Clemens, K., Simone-Roach, C., Hall, K., Ivovic, A., Makings, J., Reiss, D., Traub, M., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf184 · Cited by 6

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation

Vincow, E. S., Thomas, R. E., Milstein, G., Pareek, G., Bammler, T. K., MacDonald, J. W., & Pallanck, L. J. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011105 · Cited by 6

Multifunctional Photonic Nanomaterials and Devices for Digital Photomedicine via Neuro‐Immune Cross‐Talks

Kim, S., Kim, T., Kim, H., Kim, J., Rogers, J. A., & Hahn, S. K. (2024) · Advanced Materials · doi:10.1002/adma.202413189 · Cited by 6

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune InfiltrationPreprint

Dolan, M.-J., Rakosi-Schmidt, R., Garcia, E., Lin, Y., Nadaf, N. M., Dixon, J., Guo, S., Morshed, N., Depp, C., Doman, J. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.22.649486 · Cited by 6

Brain metastases exhibit distinct spatial patterns of resident and infiltrating macrophages

Ratzabi, A., Caspit, I. M., Telechi, I., Kim, J.-S., Vaknine, H., Blinder, P., Jung, S., & Stein, R. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-03084-0 · Cited by 8

Mechanisms and therapeutic advances of gut metabolites in the regulation of neuroimmune inflammatory diseases

Shen, X., Zheng, C., Lin, R., Wang, J., & Chen, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1795042 · Cited by 5

Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets

Wang, N., Liu, Z. H., Wang, Y., Cao, F., & Xu, D. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00489-2 · Cited by 5

Macrophages Modulate Optic Nerve Crush Injury Scar Formation and Retinal Ganglion Cell Function

Liu, Y., Liu, X., Dorizas, C. A., Hao, Z., & Lee, R. K. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.10.22 · Cited by 5

Hematopoietic Growth Factors Regulate the Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5

Ren, X. S., He, J., Li, S., Hu, H., Kyle, M. M., Kohsaka, S., & Zhao, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168898 · Cited by 5

Anti-inflammatory effects of 64Zn-aspartate is accompanied by cognitive improvements in rats with Aβ1-40-induced alzheimer disease

Temnik, M., Rudyk, M. P., Balakin, A., Gurin, S., Dovbynchuk, T., Byshovets, R., Dziubenko, N., Tolstanova, G. M., & Skivka, L. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-97830-6 · Cited by 6

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

Jiang, M., Li, Q., Chen, J., Li, R., Yao, J., Hu, Y., Zhang, H., Cai, L., Luo, M., Sun, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202417733 · Cited by 6

Depletion of CD169+ border-associated macrophages induces Parkinson’s disease-like behavior

Ohki, T., Kitamura, K., Tokutake, K., Saeki, S., Yamamoto, M., Takasu, M., & Hirata, H. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1688394 · Cited by 4

Sequential ultrasound‐driven dynamic control of macrophage polarization combined with hydrogel for mechano‐chemical synergistic tissue repair

Man, F., Wang, K., Yang, Z., An, L., You, C., Li, R., Cai, Y., Li, Y., Chen, L., Liu, Y., et al. (2026) · Interdisciplinary medicine · doi:10.1002/inmd.70076 · Cited by 4

Reprogramming brain-resident macrophages: from disease drivers to therapeutic allies in neurological disorders

Zhao, P., Li, S., Liu, Q., Peng, X.-C., Liu, L., Yang, F.-Y., Wang, C., Qian, F., & Tang, F.-R. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1726194 · Cited by 6

Nanotechnology-enabled strategies to overcome the blood–brain barrier for glioma treatment

Xuan, Y., Luo, J., Zhang, M., Zhao, Y., & Zhang, S. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101643 · Cited by 5

Aging and neurodegeneration: when systemic dysregulations affect brain macrophage heterogeneity

Joly, P., Labsy, R., & Silvin, A. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkae034 · Cited by 5

Identification of an Immune-Related Gene Signature for Prognostic Prediction in Glioblastoma: Insights from Integrated Bulk and Single-Cell RNA Sequencing

Chen, J., Wu, Q., Berglund, A., Macaulay, R. J. B., Mulé, J. J., & Etame, A. B. (2025) · Cancers · doi:10.3390/cancers17111799 · Cited by 4

A specific and adaptable approach to track CD206+ macrophages by molecular MRI and fluorescence imaging

Wang, C., Motlagh, N. J., Wojtkiewicz, G. R., Yang, H., Kim, H.-H., & Chen, J. W. (2024) · Theranostics · doi:10.7150/thno.96488 · Cited by 4

Key mechanisms of angiogenesis in the infarct core: association of macrophage infiltration with venogenesis

Xue, L., Ouyang, W., Qi, P., Zhu, Y., Qi, X., Zhang, X., Zhang, X., Wang, L., & Cui, L. (2025) · Molecular Brain · doi:10.1186/s13041-025-01182-1 · Cited by 4

Neuroimmunology: reviews and perspectives on recent advances

Qi, H. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01092-z · Cited by 4

Myeloid-derived β-hexosaminidase is essential for neuronal health and lysosome function: implications for Sandhoff diseasePreprint

Tsourmas, K. I., Butler, C. A., Kwang, N. E., Sloane, Z. R., Dykman, K. J. G., Maloof, G. O., Prekopa, C. A., Krattli, R. P., El-Khatib, S. M., Swarup, V., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.21.619538 · Cited by 4

HOXA5 Inhibits Microglia Pyroptosis in Cerebral Stroke by Regulating FTO ‐Mediated TMEM59 m 6 A Demethylation

Mou, L., Zheng, L., Wang, B., Quan, Z., Xiao, X., Fu, X., & Wu, L. (2025) · The FASEB Journal · doi:10.1096/fj.202501334r · Cited by 3

Glioinflammation: disease-associated microglia and astrocytes in psychiatric disorders, neurodegeneration, and senescence

Uemura, K., Hiro, S., Attachaipanich, S., Du, R., Yusof, N. I. S. M., Kinoshita, M., Hikosaka, M., & Ohtsuki, G. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1669272 · Cited by 5

Inflammation-Associated Mechanisms of Blood–Brain Barrier Disruption and Depression Pathogenesis in People with and Without HIV

Hills, C., Hernandez, C. A., Gabbay, V., & Berman, J. W. (2026) · Cells · doi:10.3390/cells15050399 · Cited by 3

Targeting the tumor microenvironment: reprogramming macrophages as a novel therapeutic strategy in FUOM-deficient glioblastoma

Lu, B., Xu, M., Zhang, H., Zhang, X., Sun, P., Yang, L., Shi, J., & Huang, J. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08701-5 · Cited by 3

Maternal immune activation causes sex-specific impairment of microglial function during prefrontal cortex development

Liu, C., Li, T., Ji, J.-J., Li, Z., Samsom, J., Liu, K., Lu, Q., Zhu, W., & Liu, F. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106770 · Cited by 4

Pivotal Role of Cranial Irradiation-Induced Peripheral, Intrinsic, and Brain-Engrafting Macrophages in Malignant Glioma

Richard, S. A., Roy, S. K., & Asiamah, E. A. (2024) · Clinical Medicine Insights Oncology · doi:10.1177/11795549241282098 · Cited by 3

The immune response within Alzheimer's disease: from the lense of peripheral monocyte-derived macrophages

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Cuffaro, D., Ceni, C., Capitini, C., Gabbia, D., Zanotto, I., Bertolini, A., Mirabeni, M., Bertini, S., Saba, A., Martin, S. D., et al. (2025) · eFood · doi:10.1002/efd2.70094 · Cited by 2

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Intravital observation of neuronal and immune cell dynamics in the developing mammalian brain

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Wang, W., Wen, R., Li, Q., Cai, Z., Ou, Z., & Zheng, L. (2025) · Aggregate · doi:10.1002/agt2.70182 · Cited by 1

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Zhan, Y., Wang, Y., Bai, M., Feng, J., Wei, J., & Wang, J. (2026) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00858 · Cited by 1

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García‐Cosamalón, J., Marchena, M., Villar‐Suárez, V., Ley, L., & de Castro, F. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1785072 · Cited by 1

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Microglia and macrophages in brain homeostasis and disease

Li, Q., & Barres, B. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.125 · Cited by 1,999

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Silvin, A., Uderhardt, S., Piot, C., Da Mesquita, S., Yang, K., Geirsdottir, L., Mulder, K., Eyal, D., Liu, Z., Bridlance, C., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.07.004 · Cited by 368

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