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Brain macrophage development, diversity and dysregulation in health and disease
Open accessAbstract
Brain macrophages include microglia in the parenchyma, border-associated macrophages in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages that infiltrate the brain under various disease conditions. The vast heterogeneity of these cells has been elucidated over the last decade using revolutionary multiomics technologies. As such, we can now start to define these various macrophage populations according to their ontogeny and their diverse functional programs during brain development, homeostasis and disease pathogenesis. In this review, we first outline the critical roles played by brain macrophages during development and healthy aging. We then discuss how brain macrophages might undergo reprogramming and contribute to neurodegenerative disorders, autoimmune diseases, and glioma. Finally, we speculate about the most recent and ongoing discoveries that are prompting translational attempts to leverage brain macrophages as prognostic markers or therapeutic targets for diseases that affect the brain.
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“With aging, or premature death, perivascular macrophages are replaced by monocyte-derived macrophages that appear to be more prone to induce inflammation [382,383,384].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [384]
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Metadata
- Authors
- Silvin, A., Qian, J., & Ginhoux, F.
- Affiliations
- Inserm (FR)
- Shanghai Jiao Tong University (CN)
- Agency for Science, Technology and Research (SG)
- Corresponding author
- Ginhoux, Florent
- Venue
- Cellular & Molecular Immunology
- Published
- 2023-06-26
- Volume
- 20
- Issue
- 11
- Pages
- 1277-1289
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC10616292
- OpenAlex
- W4382181798
- Cited by
- 137
- References
- 165
- Citations by year
- 2026: 41 · 2025: 53 · 2024: 37 · 2023: 6
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cellular and Molecular Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain macrophages, microglia, border-associated macrophages, meningeal macrophages, choroid plexus macrophages, perivascular macrophages, monocyte-derived macrophages, macrophage heterogeneity, macrophage ontogeny, brain development, healthy aging, neurodegenerative diseases, glioma, macrophage reprogramming, prognostic factors, therapeutic target
- MeSH terms
- Autoimmune Diseases, Brain, Humans, Macrophages, Meninges, Microglia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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