Changes in volume of various retinal layers over time in early and intermediate age-related macular degeneration
Open accessAbstract
Purpose To evaluate longitudinally volume changes in inner and outer retinal layers in early and intermediate age-related macular degeneration (AMD) compared to healthy control eyes using optical coherence tomography (OCT).Methods 71 eyes with AMD and 31 control eyes were imaged at two time points: baseline and after 2 years. Automated OCT layer segmentation was performed using Orion TM. This software is able to measure volumes of retinal layers with distinct boundaries including Retinal Nerve Fibre Layer (RNFL), Ganglion Cell-Inner Plexiform Layer (GCIPL), Inner Nuclear Layer (INL), Outer Plexiform Layer (OPL), Outer Nuclear Layer (ONL), Photoreceptors (PR) and Retinal Pigment Epithelium-Bruch's Membrane complex (RPE-BM). The mean retinal layer volumes and volume changes at 2 years were compared between groups.Results Mean GCIPL and INL volumes were lower, while PR and RPE-BM volumes were higher in AMD eyes than controls at baseline (all P < 0.05) and year 2 (all P < 0.05). In AMD eyes, RNFL and ONL volumes decreased by 0.0232 (P = 0.033) and 0.0851 (P = 0.001), respectively. In contrast, OPL and RPE-BM volumes increased in AMD eyes by 0.0391 (P = 0.000) and 0.0209 (P = 0.000) respectively. Moreover, there were significant differences in longitudinal volume change of OPL (P = 0.02), ONL (P = 0.008) and RPE-BM (P = 0.02) between AMD eyes and controls.Conclusions There were abnormal retinal layer volumes and volume changes in eyes with early and intermediate AMD.
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Eyes with early and/or intermediate AMD have a thicker RPE-BrM complex than healthy eyes according to global and/or low-density OCT spatial analysis.
“Eyes with early and/or intermediate AMD have a thicker RPE–BrM complex than healthy eyes according to global and/or low-density OCT spatial analysis [92,93].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [93]
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- Authors
- Lamin, A., Oakley, J. D., Dubis, A. M., Russakoff, D. B., & Sivaprasad, S.
- Affiliations
- Moorfields Eye Hospital NHS Foundation Trust (GB)
- Corresponding author
- Sivaprasad, Sobha
- Venue
- Eye
- Published
- 2018-10-11
- Volume
- 33
- Issue
- 3
- Pages
- 428-434
- ISSN
- 0078-5334 (ISSN-L)
- 0950-222X
- 1476-5454
- PMC
- PMC6460706
- OpenAlex
- W2897522670
- Cited by
- 57
- References
- 34
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 13 · 2020: 13 · 2019: 7
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Eye (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- National Institute for Health and Care Research
- Moorfields Eye Hospital NHS Foundation Trust
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- age-related macular degeneration, retinal nerve fiber layer, ganglion cell-inner plexiform layer, inner nuclear layer, outer nuclear layer, outer plexiform layer, photoreceptors, retinal pigment epithelium, Bruch's membrane, early AMD, intermediate AMD
- MeSH terms
- Aged, Female, Humans, Macular Degeneration, Male, Middle Aged, Retina, Retinal Ganglion Cells, Retrospective Studies, Visual Acuity, Bruch Membrane, Disease Progression, Tomography, Optical Coherence, Retinal Pigment Epithelium
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