Location-Specific Thickness Patterns in Intermediate Age-Related Macular Degeneration Reveals Anatomical Differences in Multiple Retinal Layers
Open accessAbstract
Purpose: To examine individual retinal layers' location-specific patterns of thicknesses in intermediate age-related macular degeneration (iAMD) using optical coherence tomography (OCT). Methods: OCT macular cube scans were retrospectively acquired from 84 iAMD eyes of 84 participants and 84 normal eyes of 84 participants propensity-score matched on age, sex, and spherical equivalent refraction. Thicknesses of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer + Henle's fiber layer (ONL+HFL), inner- and outer-segment layers (IS/OS), and retinal pigment epithelium to Bruch's membrane (RPE-BM) were calculated across an 8 × 8 grid (total 24° × 24° area). Location-specific analysis was performed using cluster(normal) and grid(iAMD)-to-cluster(normal) comparisons. Results: In iAMD versus normal eyes, the central RPE-BM was thickened (mean difference ± SEM up to 27.45% ± 7.48%, P < 0.001; up to 7.6 SD-from-normal), whereas there was thinned outer (OPL, ONL+HFL, and non-central RPE-BM, up to -6.76% ± 2.47%, P < 0.001; up to -1.6 SD-from-normal) and inner retina (GCL and IPL, up to -4.83% ± 1.56%, P < 0.01; up to -1.7 SD-from-normal) with eccentricity-based effects. Interlayer correlations were greater against the ONL+HFL (mean |r| ± SEM 0.19 ± 0.03, P = 0.14 to < 0.0001) than the RPE-BM (0.09 ± 0, P = 0.72 to < 0.0001). Conclusions: Location-specific analysis suggests altered retinal anatomy between iAMD and normal eyes. These data could direct clinical diagnosis and monitoring of AMD toward targeted locations.
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The central macula shows the most significant thickening of the RPE-BrM complex in AMD.
“The central macula shows the most significant thickening [94].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [94]
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Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works
Trinh, M., Kalloniatis, M., Alonso-Caneiro, D., & Nivison-Smith, L. (2022) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.63.5.36 · Cited by 29 · see citing works
Self-citation
- Authors
- Trinh, M., Khou, V., Kalloniatis, M., & Nivison-Smith, L.
- Affiliations
- UNSW Sydney (AU)
- Centre for Eye Health, University of New South Wales, Sydney, Australia
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2021-10-18
- Volume
- 62
- Issue
- 13
- Pages
- 13
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- PMC
- PMC8525852
- OpenAlex
- W3207663742
- Cited by
- 14
- References
- 146
- Citations by year
- 2026: 4 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 1
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Investigative Ophthalmology & Visual Science (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- intermediate age-related macular degeneration, retinal thickness, retinal layer thickness, retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer, retinal pigment epithelium, Bruch's membrane, retinal anatomy
- MeSH terms
- Aged, Female, Follow-Up Studies, Humans, Macular Degeneration, Male, Middle Aged, Retinal Ganglion Cells, Retrospective Studies, Visual Acuity, Bruch Membrane, Tomography, Optical Coherence, Retinal Pigment Epithelium, Propensity Score
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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