The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics
Open accessAbstract
Plague is a vector-borne disease caused by Yersinia pestis. Transmitted by fleas from rodent reservoirs, Y. pestis emerged <6000 years ago from an enteric bacterial ancestor through events of gene gain and genome reduction. It is a highly remarkable model for the understanding of pathogenic bacteria evolution, and a major concern for public health as highlighted by recent human outbreaks. A complex set of virulence determinants, including the Yersinia outer-membrane proteins (Yops), the broad-range protease Pla, pathogen-associated molecular patterns (PAMPs), and iron capture systems play critical roles in the molecular strategies that Y. pestis employs to subvert the human immune system, allowing unrestricted bacterial replication in lymph nodes (bubonic plague) and in lungs (pneumonic plague). Some of these immunogenic proteins as well as the capsular antigen F1 are exploited for diagnostic purposes, which are critical in the context of the rapid onset of death in the absence of antibiotic treatment (less than a week for bubonic plague and <48 h for pneumonic plague). Here, we review recent research advances on Y. pestis evolution, virulence factor function, bacterial strategies to subvert mammalian innate immune responses, vaccination, and problems associated with pneumonic plague diagnosis.
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Cites
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Cited by
Yersinia pestis: the Natural History of Plague
Barbieri, R., Signoli, M., Chevé, D., Costedoat, C., Tzortzis, S., Aboudharam, G., Raoult, D., & Drancourt, M. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00044-19 · Cited by 257
RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis
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Identification and characterization of P2-like bacteriophages of Yersinia pestis
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Metadata
- Authors
- Demeure, C. E., Dussurget, O., Mas Fiol, G., Le Guern, A.-S., Savin, C., & Pizarro-Cerdá, J.
- Venue
- Genes & Immunity
- Published
- 2019-04-03
- Volume
- 20
- Issue
- 5
- Pages
- 357-370
- ISSN
- 1466-4879 (ISSN-L)
- 1476-5470
- OpenAlex
- W2930171358
- Cited by
- 256
- References
- 115
- FWCI
- 14.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Demeure, C. E., Dussurget, O., Mas Fiol, G., Le Guern, A.-S., Savin, C., & Pizarro-Cerdá, J. (2019). Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics. Genes & Immunity. https://doi.org/10.1038/s41435-019-0065-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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