The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Matrix degradability controls multicellularity of 3D cell migration
Open accessAbstract
A major challenge in tissue engineering is the development of materials that can support angiogenesis, wherein endothelial cells from existing vasculature invade the surrounding matrix to form new vascular structures. To identify material properties that impact angiogenesis, here we have developed an in vitro model whereby molded tubular channels inside a synthetic hydrogel are seeded with endothelial cells and subjected to chemokine gradients within a microfluidic device. To accomplish precision molding of hydrogels and successful integration with microfluidics, we developed a class of hydrogels that could be macromolded and micromolded with high shape and size fidelity by eliminating swelling after polymerization. Using this material, we demonstrate that matrix degradability switches three-dimensional endothelial cell invasion between two distinct modes: single-cell migration and the multicellular, strand-like invasion required for angiogenesis. The ability to incorporate these tunable hydrogels into geometrically constrained settings will enable a wide range of previously inaccessible biomedical applications.
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Cites
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Self-citationVascularization Strategies for Tissue Engineering
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Self-citation
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Organs-on-chips: into the next decade
Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0079-3 · Cited by 1,029
Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise
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Self-citationAdvances in Hydrogels in Organoids and Organs‐on‐a‐Chip
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Mechanotransduction in tumor progression: The dark side of the force
Broders-Bondon, F., Nguyen Ho-Bouldoires, T. H., Fernandez-Sanchez, M.-E., & Farge, E. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201701039 · Cited by 319
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Metadata
- Authors
- Trappmann, B., Baker, B. M., Polacheck, W. J., Choi, C. K., Burdick, J. A., & Chen, C. S.
- Venue
- Nature Communications
- Published
- 2017-08-29
- Volume
- 8
- Issue
- 1
- Pages
- 371-371
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2745585661
- Cited by
- 264
- References
- 31
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- gold
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- Trappmann, B., Baker, B. M., Polacheck, W. J., Choi, C. K., Burdick, J. A., & Chen, C. S. (2017). Matrix degradability controls multicellularity of 3D cell migration. Nature Communications. https://doi.org/10.1038/s41467-017-00418-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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